The genotype determines the B cell response in mercury-treated mice

International Archives of Allergy and Immunology

Volumn 116, Issue 4, 1998, Pages 295-305

  Johansson, Uno ^a   Hansson Georgiadis, Helén ^a   Hultman, Per ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Antifibrillarin antibodies; B cells; Mercury; Polyclonal response

Indexed keywords

2,4 DINITROPHENOL; AUTOANTIBODY; CD71 ANTIGEN; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; MERCURIC CHLORIDE; MERCURY; SINGLE STRANDED DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENOTYPE; HAPLOTYPE; IMMUNOFLUORESCENCE; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOCYTE PROLIFERATION; MERCURIALISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; SPLEEN CELL;

ANIMALS; ANTIBODIES, ANTINUCLEAR; AUTOIMMUNITY; B-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENOTYPE; MERCURY; MICE; MICE, INBRED STRAINS; SPECIES SPECIFICITY;

EID: 0031851304     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000023959     Document Type: Article

References (50)

1. Stiller-Winkler R, Radaszkiewicz T, Gleichmann E: Immunopathological signs in mice treated with mercury compounds. I. Identification by the popliteal lymph node assay of responder and non-responder. Int J Immunopharmacol 1988;10:475-484.
2. Hultman P, Eneström S: The induction of immune-complex deposits in mice by peroral and and parenteral administration of mercuric chloride. Clin Exp Immunol 1987;67:283-292.
3. 2 and gold sodium thiomalate enhance serum IgE and IgG concentrations in susceptible mouse strains. Int Arch Allergy Appl Immunol 1989;90:47-53.
4. Hultman P, Eneström S, Pollard KM, Tan EM: Antifibrillarin antibodies in mercury-treated mice. Clin Exp Immunol 1989;78:470-477.
5. Reuter R, Tessars G, Vohr HW, Gleichmann E, Lührmann R: Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice. Proc Natl Acad Sci USA 1989;86:237-245.
6. Hultman P, Bell LJ, Eneström S, Pollard KM: Murine susceptibility to mercury. I. Autoantibody profiles and systemic immune deposits in inbred. congenic, and intra-H-2-recombinant strains. Clin Immunol Immunopathol 1992;65: 98-109.
7. Hultman P, Bell LJ, Eneström S, Pollard KM: Murine susceptibility to mercury. II. Autoantibody profiles and renal immune deposits in hybrid, backcross, and H-2d congenic mice. Clin Immunol Immunopathol 1993;68:9-20.
8. 2-induced antinucleolar antibodies. Eur J Immunol 1989;12:2257-2261.
9. Dieter MP, Luster MI, Boorman GA, Jameson CW, Dean JH, Cox JW: Immunological and biochemical response in mice treated with mercuric chloride. Toxicol Appl Pharmacol 1983;68:218-228.
10. Hultman P, Eneström S: Mercury-induced B cell activation and antinuclear antibodies in mice. J Clin Lab Immunol 1989;28:143-150.
11. Hultman P, Eneström S: Murine mercury-induced immune-complex disease: Effect of cyclophosphamide treatment and importance of T cells. Br J Exp Pathol 1989;70:227-236.
12. Brunet S, Guertin F, Flipo D, Fournier M, Krzystyniak K: Cytometric profiles of bone marrow and spleen lymphoid cells after mercury exposure in mice. Int J Immunopharmacol 1993;15:811-819.
13. Kubicka-Muranyi M, Behmer O, Uhrberg M, Klonowski H, Bister J, Gleichmann E: Murine systemic autoimmune disease induced by mercuric chloride (HgCl2): Hg-specific helper T-cells react to antigen stored in macrophages. Int J Immunopharmacol 1993;15:151-161.
14. van Vliet E, Uhrberg M, Stein C, Gleichmann E: MHC control of IL-4 dependent enhancement of B cell Ia expression and Ig class switching in mice treated with mercuric chloride. Int Arch Allergy Appl Immunol 1993: 101:392-401.
15. Hultman P, Johansson U, Dagnaes-Hansen F: Murine mercury-induced autoimmunity: The importance of T cells. J Autoimmun 1995;8: 809-824.
16. Al-Balaghi S, Möller E, Möller G, Abedi-Valugerdi M: Mercury induces polyclonal B-cell activation, autoantibody production and renal immune complex deposits in young (NZBx NZW)F1 hybrids. Eur J Immunol 1996;26: 1519-1526.
17. Johansson U, Sander B, Hultman P: Effects of the murine genotype on T cell activation and cytokine production in murine mercury-induced autoimmunity. J Autoimmun 1997;10: 347-355.
18. β TCR. Int Immunol 1996;11:1729-1736.
19. Hu H, Abedi-Valugerdi M, Möller G: Pretreatment of lymphocytes with mercury in vitro induces a response in T cells from genetically determined low-responders and a shift of the interleukin profile. Immunology 1997;90:198-204.
20. d mice is mediated by interferon-gamma (IFN-γ). Clin Exp Immunol 1997;109: 149-156.
21. Ochel M, Vohr HW, Pfeiffer C, Gleichmann E: IL-4 is required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride. J Immunol 1991;146:3006-3011.
22. Hultman P, Turley SJ, Eneström S, Lindh U, Pollard KM: Murine genotype influences the specificity, magnitude and persistence of murine mercury-induced autoimmunity. J Autoimmun 1996;9:139-149.
23. Johansson U, Hansson-Georgiadis H, Hultman P: Murine silver-induced autoimmunity: Silver shares induction of antinucleolar antibodies with mercury, but causes less activation of the immune system. Int Arch Allergy Immunol 1997;113:432-443.
24. Warfvinge K, Hansson H, Hultman P: Systemic autoimmunity due to mercury vapor in genetically susceptible mice: Dose-response studies. Toxicol Appl Pharmacol 1995;132: 299-309.
25. Jachez B, Montecino-Rodriguez E, Fonteueau P, Loor F: Partial expression of the lpr locus in the heterozygote state. Immunology 1988;64: 31-36.
26. Izui S, Kobayakawa T, Zryd MJ, Louis J, Lambert PH: Mechanism for induction of anti-DNA antibodies by bacterial lipopolysaccharides in mice. II. Correlation between anti-DNA induction and polyclonal antibody formation by various polyclonal B lymphocyte activators. J Immunol 1977;119:2157-2168.
27. Hultman P, Ganowiak K, Turely SJ, Pollard KM: Genetic susceptibility to silver-induced antifibrillarin autoantibodies in mice. Clin Immunol Immunopathol 1995;77:291-297.
28. Reimer G, Steen VD, Penninger CA, Medsger TA, Tan EM: Correlates between autoantibodies to nuclear antigens and clinical features in patients with systemic sclerosis (scleroderma). Arthritis Rheum 1988;31:525-532.
29. Raska I, Andrade L, Ochs R, Chan E, Chang C, Roos G, Tan E: Immunological and ultrastructural studies of the nuclear coiled body with autoimmune antibodies. Exp Cell Res 1991; 195:27-37.
30. Conrad DH, Waldschmidt TJ, Lee WT, Rao M, Keegan AD, Noelle RJ, Lynch RG, Kehry MR: Effect of B cell stimulatory factor-1 (interleukin 4) of Fcε, and Fcγ receptor expression on murine B lymphocytes and B cell lines. J Immunol 1987;139:2290-2296.
31. Richard ML, Katz DH: Regulation of the murine FcεRII (CD23) gene. J Immunol 1994; 152:3453-3466.
32. Yoshimoto T, Bendelac A, Hu-Li J, Paul WE: Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly induce interleukin 4. Proc Natl Acad Sci USA 1995;92:11931-11934.
33. Beutner U, Launois P, Ohteki T, Louis JA, MacDonald HR: Natural killer-like T cells develop in SJL mice despite genetically distinct defects in NK1.1 expression and in inducible interleukin-4 production. Eur J Immunol 1997; 27:928-934.
34. Prigent P, Saoudi A, Pannetier C, Graber P, Bonnefoy JY, Druet P, Hirsch F: Mercuric chloride, a chemical responsible for Th2-mediated autoimmunity in Brown-Norway rats directly triggers T cells to produce IL-4. J Clin Invest 1995;96:1481-1489.
35. Pollard KM, Landberg G, Tan EM: In vitro mitogenic response of murine lymphocytes to mercuric chloride: Comparison of autoimmune sensitive and resistant strains (abstract): in Bautz EKF, Homma M, Kalden JR, Nossal G, Shulman LE, Tan EM (eds): Molecular and Cell Biology of Autoantibodies and Autoimmunity. 3rd International Workshop Schloss Elmau. Dordrecht, Kluwer Academic Publishers. 1993, p 81.
36. 2 on murine lymphocytes. I. Preferable activation of CD4+ T cells in a responder strain. J Immunol 1995;154:3138-3146.
37. Kuhn R, Rajewski K, Mueller W: Generation and analysis of interleukin-4 deficient mice. Science 1991;254:707-710.
38. Kopf M. G. LG, Bachmann M, Lamers MC, Bluethmann H, Köhler G: Disruption of the IL-4 gene blocks Th2 cytokine response. Nature 1993;362:245-247.
39. Snapper CM, Paul WE: Interferon-γ and B-cell stimulatory factor reciprocally regulate Ig iso-type production. J Immunol 1990;236:944-947.
40. Goter-Robinson CJ, Balazs T, Egorov IK: Mercuric chloride-, gold sodium thiomalate-. and penicillamine-induced antinuclear antibodies in mice. Toxicol Appl Pharmacol 1986; 86:159-169.
41. Klein J: Natural History of the Major Histo-compatibility Complex. New York, Wiley, 1986.
42. Oliveira D: Immunological aspects of renal disease; in Oliveira D, Peters D, Weetman A (eds): Cambridge Reviews in Clinical Immunology. Cambridge, Cambridge University Press, 1992, pp 1-22.
43. Hultman P, Eneström S: Mercury induced antinuclear antibodies in mice: Characterization and correlation with renal immune complex deposits. Clin Exp Immunol 1988;71: 269-274.
44. Burlingame R, Rubin R, Balderas R, Theofilopoulos A: Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen. J Clin Invest 1993;91:1687-1696.
45. Hultman P, Eneström S, Turley SJ, Pollard KM: Selective induction of anti-fibrillarin autoantibodies by silver nitrate. Clin Exp Immunol 1994;96:285-291.
46. Griem P, Gleichmann E: Metal-ion induced autoimmunity. Curr Opin Immunol 1995;7:831-838.
47. Pollard KM, Hultman P: Effects of mercury on tlhe immune system: in Siegel S, Siegel A (eds): Mercury and Its Effects of Environment and Biology. Basel, Dekker, 1997, pp 421-440.
48. Pollard KM, Blüthner M, Casiano CA, Tan EM: Heavy metal induced autoimmunity is associated with apoptolic-like cell death and changes in the cellular localization and molecular structure and integrity of fibrillann (abstract); in Bautz EKF. Homma M, Kalden JR, Nossal G, Shulman LE, Tan EM (eds): 4th International Workshop on the Molecular and Cell Biology of Autoantibodies and Autoimmunity. Melbourne. Walter and Eliza Hall Institute of Medical Research. 1995.
49. Kubicka-Muranyi M, Kremer J, Rottmann N, Lübben B, Albers R, Bloksma N, Lührmann R, Gleichmann E: Murine systemic autoimmune disease induced by mercuric chloride: T helper cells reacting to self proteins. Int Arch Allergy Immunol 1996;109:11-20.
50. Reimer G, Pollard KM, Penning CA, Ochs RL, Lischwe MA, Busch H, Tan EM: Monoclonal autoantibody from a (New Zealand Black × New Zealand White)F1 mouse and some human scleroderma sera target an M, 34,000 nucleolar protein of the U3 RNP particle. Arthritis Rheum 1987;30:793-800.