Quantitative patch and repeated open application testing in hydroxyisohexyl 3-cyclohexene carboxaldehyde sensitive-patients

Contact Dermatitis

Volumn 61, Issue 3, 2009, Pages 152-162

  Schnuch, Axel ^a   Uter, Wolfgang ^b   Dickel, Heinrich ^c   Szliska, Christiane ^d   Schliemann, Sibylle ^e   Eben, Ricarda ^f   Ruëff, Franziska ^f   Gimenez Arnau, Ana ^g   Löffler, Harald ^h   Aberer, Werner ⁱ   Frambach, Yvonne ^j   Worm, Margitta ^k   Niebuhr, Margarete ^l   Hillen, Uwe ^m   Martin, Vera ⁿ   Jappe, Uta ^o   Frosch, Peter J ^p   Mahler, Vera ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d Bethesda Hospital   (Germany)

^e FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^f LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^g UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^h SLK Kliniken Heilbronn   (Germany)

ⁱ MEDICAL UNIVERSITY OF GRAZ   (Austria)

^j UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^k CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^l HANNOVER MEDICAL SCHOOL   (Germany)

^m UNIVERSITY OF DUISBURG ESSEN   (Germany)

ⁿ Dermatologicum   (Germany)

^o UNIVERSITY OF HEIDELBERG   (Germany)

^p UNIVERSITY OF WITTEN HERDECKE   (Germany)

more..

Author keywords

Allergic contact dermatitis; CAS 31906 04 4; Dose response relationship; Elicitation; Hydroxyisohexyl 3 cyclohexene carboxaldehyde; NOEL

Indexed keywords

ALDEHYDE; HYDROXYISOHEXYL 3 CYCLOHEXENE CARBOXALDEHYDE; UNCLASSIFIED DRUG;

ALLERGIC REACTION; ARTICLE; PATCH TEST; SENSITIVITY AND SPECIFICITY; SKIN SENSITIZATION;

ALDEHYDES; ALLERGENS; CYCLOHEXENES; DERMATITIS, ALLERGIC CONTACT; DOSE-RESPONSE RELATIONSHIP, DRUG; EUROPE; HUMANS; OINTMENTS; PATCH TESTS; PERFUME; SENSITIVITY AND SPECIFICITY;

EID: 70349550028     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/j.1600-0536.2009.01601.x     Document Type: Article

References (45)

1. Frosch P J, Johansen J D, White I R. Fragrances. Beneficial and Adverse Effects. Berlin, Heidelberg, New York, Springer, 1998.
2. Schnuch A, Geier J, Uter W et al. National rates and regional differences in sensitization to allergens of the standard series. Population adjusted frequencies of sensitization (PAFS) in 40000 patients from a multicenter study (IVDK). Contact Dermatitis 1997 : 37 : 200 209.
3. Frosch P J, Johansen J D, Menné T et al. Further important sensitizers in patients sensitive to fragrances. I. Reactivity to frequently used chemicals. Contact Dermatitis 2002 : 47 : 78 85. (Pubitemid 35316224)
4. Militello G, James W. Lyral: a fragrance allergen. Dermatitis 2005 : 16 : 41 44.
5. Frosch P J, Pilz B, Andersen K E et al. Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes. Contact Dermatitis 1995 : 33 : 333 342.
6. Frosch P J, Johansen J D, Menné T et al. Lyral® is an important sensitizer in patients sensitive to fragrances. Br J Dermatol 1999 : 141 : 1076 1083.
7. Hausen B M, Bottenbruch S. Lyral®-Allergie. Akt Dermatol 2001 : 27 : 310 314.
8. ® has been included in the patch test standard series in Germany. Contact Dermatitis 2002 : 46 : 295 297.
9. Baxter K F, Wilkinson S M, Kirk S J. Hydroxymethyl pentylcyclohexene- carboxaldehyde (Lyral) as a fragrance allergen in the UK. Contact Dermatitis 2003 : 48 : 117 118.
10. Johansen J D, Frosch P J, Svedman C, Andersen K E, Bruze M, Pirker C, Menné T. Hydroxyisohexyl 3-cyclohexene carboxaldehyde- known as Lyral: quantitative aspects and risk assessment of an important fragrance allergen. Contact Dermatitis 2003 : 48 : 310 316.
11. Jorgensen P H, Jensen C D, Rastogi S, Andersen K E, Johansen J D. Experimental elicitation with hydroxyisohexyl-3-cyclohexene carboxaldehyde- containing deodorants. Contact Dermatitis 2007 : 56 : 146 150.
12. Schnuch A, Geier J, Uter W, Frosch P J. Sensitization to 26 fragrances to be labelled according to current European regulation. Contact Dermatitis 2007 : 57 : 1 10.
13. Nardelli A, Carbonez A, Ottoy W, Drieghe J, Goossens A. Frequency of and trends in fragrance allergy over a 15-year period. Contact Dermatitis 2008 : 58 : 134 141.
14. ®) is still a frequent allergen. Contact Dermatitis 2008 : 59 : 187 188.
15. Belsito D V, Fowler J F, Sasseville D, Marks J G, DeLeo V A, Storrs F J. Delayed-type hypersensitivity to fragrance materials in a select North Amercian population. Dermatitis 2006 : 17 : 23 28.
16. Bruze M, Andersen K E, Goossens A. Recommendation to include fragrance mix2 and hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) in the European baseline patch test series. Contact Dermatitis 2008 : 58 : 129 133.
17. Frosch P J, Pirker C, Rastogi S et al. The new fragrance mixII-test results of a multicentre European study. Contact Dermatitis 2004 : 50 : 149.
18. Frosch P J, Pirker C, Rastogi S C et al. Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix. Contact Dermatitis 2005 : 52 : 207 215.
19. Frosch P J, Rastogi S C, Pirker C et al. Patch testing with a new fragrance mix- reactivity to the individual constituents and chemical detection in relevant cosmetic products. Contact Dermatitis 2005 : 52 : 216 225.
20. Geier J, Lessmann H, Uter W, Schnuch A. Experiences with the fragrance mixII-the German perspective. Contact Dermatitis 2006 : 55 (Suppl. 1 12.
21. Scientific Committee on Consumer Products (SCCP). Opinion on Hydroxyisohexyl 3-cyclohexene carboxaldehyde (sensitisation only). Adopted 7 December 2004. SCCP/0838/04 2004.
22. Uter W, Schnuch A, Geier J, Frosch P J. Epidemiology of contact dermatitis: the information network of the departments of dermatology (IVDK) in Germany-a surveillance system on contact allergies. Eur J Dermatol 1998 : 8 : 36 40.
23. Johansen J D, Bruze M, Andersen K E et al. The repeated open application test: suggestions for a scale of evaluation. Contact Dermatitis 1998 : 39 : 95 96.
24. Johansen J D, Andersen K E, Menné T. Quantitative aspects of isoeugenol contact allergy assessed by use and patch tests. Contact Dermatitis 1996 : 34 : 414 418. (Pubitemid 26316922)
25. Fregert S. Manual of Contact Dermatitis. On behalf of the International Contact Dermatitis Research Group and the North American Contact Dermatitis Group, 2nd edition. Copenhagen, Munksgaard Publishers, 1981.
26. Schnuch A, Aberer W, Agathos M, Brasch J, Frosch P J, Richter G. Leitlinien der Deutschen Dermatologischen Gesellschaft (DDG) zur Durchf ührung des Epikutantests mit Kontaktallergenen. Hautarzt 2001 : 52 : 864 866.
27. Bhatia S P, Lalko J, Brain K R, Green D M, Api A M. In-vitro human skin penetration of the fragrance material HMPCC. Toxicologist 2007 : 96 : 432 (Abs 2091).
28. Bronaugh R L, Wester R C, Bucks D, Maibach H I, Sarason R. In vivo percutaneous absorption of fragrance ingredients in rhesus monkeys and humans. Food Chem Toxicol 1990 : 28 : 369 373. (Pubitemid 20226719)
29. Saiyasombati P, Kasting G B. Two-stage kinetic analysis of fragrance evaporation and absorption from skin. Int J Cosmet Sci 2003 : 25 : 235 243.
30. Smith C K, Hotchkiss S A M. Allergic Contact Dermatitis. Chemical and Metabolic Mechanisms. London, Taylor and Francis, 2001.
31. Cal K. How does the type of vehicle influence the in vitro skin absorption and elimination kinetics of terpenes? Arch Dermatol Res 2006 : 297 : 311 315.
32. Johansen J D, Skov L, Volund A, Andersen K, Menné T. Allergens in combination have a synergistic effect on the elicitation response: a study of fragrance-sensitized individuals. Br J Dermatol 1998 : 139 : 264 270.
33. Schnuch A, Kelterer D, Bauer A et al. Quantitative patch and repeated open application testing in Methyldibromo glutaronitrile-sensitive patients-results of the IVDK. Contact Dermatitis 2005 : 52 : 197 206. (Pubitemid 40676599)
34. Villarama C D, Maibach H I. Correlations of patch test reactivity and the repeated open application test (ROAT)/provocative use test (PUT). Food Chem Toxicol 2004 : 42 : 1719 1725.
35. Schnuch A, Uter W, Geier J, Gefeller O. Epidemiology of contact allergy: an estimation of morbidity employing the clinical epidemiology and drug utilisation research (CE-DUR) approach. Contact Dermatitis 2002 : 47 : 32 39.
36. Thyssen J P, Uter W, Schnuch A, Linneberg A, Johansen J D. 10-year prevalence of contact allergy in the general population in Denmark estimated through the CE-DUR method. Contact Dermatitis 2007 : 57 : 265 272.
37. Schnuch A. Der IVDK - eine kurze Synopsis. Akt Dermatologie 2009 : 35 : 94 98.
38. IFRA. International Fragrance Association. IFRA standards (37th amendment). 3- and 4- (4-Hydroxy-4-menthylpentyl)-3- cyclohexene-1- carboxaldehyde (HMPCC), April 2003. Available at: www.ifraorg.org (last accessed 16 January 2009).
39. IFRA. International Fragrance Associations. IFRA standards (43rd amendment). 3- and 4- (4-Hydroxy-4-menthylpentyl)-3- cyclohexene-1- carboxaldehyde (HMPCC), April 2003. Available at: www.ifraorg.org (last accessed 16 January 2009).
40. Rastogi S C, Johansen J D, Bossi R. Selected important fragrance sensitizers in perfumes-current exposures. Contact Dermatitis 2007 : 56 : 201 204.
41. Fenn R S. Aroma chemical usage trends in modern perfumery. Perfumer Flavorist 1989 : 14 : 1 10.
42. Rastogi S C, Johansen J D, Frosch P et al. Deodorants on the European market: quantitative chemical analysis of 21 fragrances. Contact Dermatitis 1998 : 38 : 29 35.
43. Rastogi S C, Johansen J D, Menné T et al. Contents of fragrance allergens in children's cosmetics and cosmetic-toys. Contact Dermatitis 1999 : 41 : 84 88.
44. Rastogi S C, Heydorn S, Johansen J D, Basketter D A. Fragrance chemicals in domestic and occupational products. Contact Dermatitis 2001 : 45 : 221 225.
45. Hostynek J J, Maibach H I. Thresholds of elicitation depend on induction conditions. Could low level exposure induce sub- clinical allergic states that are only elicited under the severe conditions of clinical diagnosis? Food Chem Toxicol 2004 : 42 : 1859 1865.