Modulation of arsenic trioxide-induced apoptosis by genistein and functionally related agents in U937 human leukaemia cells. Regulation by ROS and mitogen-activated protein kinases

Chemico-Biological Interactions

Volumn 182, Issue 1, 2009, Pages 37-44

  Sánchez, Yolanda ^a   Calle, Consuelo ^a,b   de Blas, Elena ^a   Aller, Patricio ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Apoptosis; Arsenic trioxide; Genistein; Mitogen activated protein kinases; Tyrosine kinase inhibitors; U937 leukaemia cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ADAPHOSTIN; ARSENIC TRIOXIDE; BUTHIONINE SULFOXIMINE; DAIDZEIN; EPIGALLOCATECHIN GALLATE; ESTRADIOL; ETOPOSIDE; GENISTEIN; GLUTATHIONE; HERBIMYCIN A; HYDROGEN PEROXIDE; ISOFLAVONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; ORTHOVANADIC ACID; PROTEIN TYROSINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIZATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA CELL;

ADAMANTANE; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; ARSENICALS; CATECHIN; CELL CYCLE; DRUG SYNERGISM; ENZYME ACTIVATION; ESTRADIOL; ETOPOSIDE; GENISTEIN; HL-60 CELLS; HUMANS; HYDROQUINONES; IMMUNOBLOTTING; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDES; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; U937 CELLS;

EID: 70349498783     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.08.015     Document Type: Article

References (51)

1. Garg A.K., Buchholz T.A., and Aggarwal B.B. Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid. Redox Signal. 7 (2005) 1630-1647
2. Banerjee S., Li Y., Wang Z., and Sarkar F.H. Multi-targeted therapy of cancer by genistein. Cancer Lett. 269 (2008) 226-242
3. Sanchez Y., Amran D., Fernandez C., de Blas E., and Aller P. Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK). Int. J. Cancer 123 (2008) 1205-1214
4. Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S., Itoh N., Shibuya M., and Fukami Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262 (1987) 5592-5595
5. Bandele O.J., and Osheroff N. Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry 46 (2007) 6097-6108
6. Klein C.B., and King A.A. Genistein genotoxicity: critical considerations of in vitro exposure dose. Toxicol. Appl. Pharmacol. 224 (2007) 1-11
7. McCollum G., Keng P.C., States J.C., and McCabe Jr. M.J. Arsenite delays progression through each cell cycle phase and induces apoptosis following G2/M arrest in U937 myeloid leukemia cells. J. Pharmacol. Exp. Ther. 313 (2005) 877-887
8. Uslu R., Sanli U.A., Sezgin C., Karabulut B., Terzioglu E., Omay S.B., and Goker E. Arsenic trioxide-mediated cytotoxicity and apoptosis in prostate and ovarian carcinoma cell lines. Clin. Cancer Res. 6 (2000) 4957-4964
9. Wang W., Qin S.K., Chen B.A., and Chen H.Y. Experimental study on antitumor effect of arsenic trioxide in combination with cisplatin or doxorubicin on hepatocellular carcinoma. World J. Gastroenterol. 7 (2001) 702-705
10. Martin P.M., Horwitz K.B., Ryan D.S., and McGuire W.L. Phytoestrogen interaction with estrogen receptors in human breast cancer cells. Endocrinology 103 (1978) 1860-1867
11. Kuiper G.G., Carlsson B., Grandien K., Enmark E., Haggblad J., Nilsson S., and Gustafsson J.A. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138 (1997) 863-870
12. Huang E.J., Wu C.C., Huang H.P., Liu J.Y., Lin C.S., Chang Y.Z., Lin J.A., Lin J.G., Chen L.M., Lee S.D., Kuo W.W., and Huang C.Y. Apoptotic and anti-proliferative effects of 17beta-estradiol and 17beta-estradiol-like compounds in the Hep3B cell line. Mol. Cell. Biochem. 290 (2006) 1-7
13. Mor G., Sapi E., Abrahams V.M., Rutherford T., Song J., Hao X.Y., Muzaffar S., and Kohen F. Interaction of the estrogen receptors with the Fas ligand promoter in human monocytes. J. Immunol. 170 (2003) 114-122
14. Garcia-Arencibia M., Davila N., Campion J., Carmen Carranza M., and Calle C. Identification of two functional estrogen response elements complexed with AP-1-like sites in the human insulin receptor gene promoter. J. Steroid. Biochem. Mol. Biol. 94 (2005) 1-14
15. Rius C., Zorrilla A.R., Cabañas C., Mata F., Bernabeu C., and Aller P. Differentiation of human promonocytic leukemia U-937 cells with DNA topoisomerase II inhibitors: induction of vimentin gene expression. Mol. Pharmacol. 39 (1991) 442-448
16. Ramos A.M., and Aller P. Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines. Biochem. Pharmacol. 75 (2008) 1912-1923
17. Troyano A., Fernandez C., Sancho P., de Blas E., and Aller P. Effect of glutathione depletion on antitumor drug toxicity (apoptosis and necrosis) in U-937 human promonocytic cells. The role of intracellular oxidation. J. Biol. Chem. 276 (2001) 47107-47115
18. Galan A., Garcia-Bermejo M.L., Troyano A., Vilaboa N.E., de Blas E., Kazanietz M.G., and Aller P. Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells. J. Biol. Chem. 275 (2000) 11418-11424
19. Garcia-Arencibia M., Molero S., Davila N., Carranza M.C., and Calle C. 17beta-Estradiol transcriptionally represses human insulin receptor gene expression causing cellular insulin resistance. Leuk. Res. 29 (2005) 79-87
20. Fukazawa H., Li P.M., Yamamoto C., Murakami Y., Mizuno S., and Uehara Y. Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro. Biochem. Pharmacol. 42 (1991) 1661-1671
21. Sepp-Lorenzino L., Ma Z., Lebwohl D.E., Vinitsky A., and Rosen N. Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases. J. Biol. Chem. 270 (1995) 16580-16587
22. Shimizu M., and Weinstein I.B. Modulation of signal transduction by tea catechins and related phytochemicals. Mutat. Res. 591 (2005) 147-160
23. Fridrich D., Teller N., Esselen M., Pahlke G., and Marko D. Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation. Mol. Nutr. Food. Res. 52 (2008) 815-822
24. Kaur G., Narayanan V.L., Risbood P.A., Hollingshead M.G., Stinson S.F., Varma R.K., and Sausville E.A. Synthesis, structure-activity relationship, and p210(bcr-abl) protein tyrosine kinase activity of novel AG 957 analogs. Bioorg. Med. Chem. 13 (2005) 1749-1761
25. Rock K.L., Gramm C., Rothstein L., Clark K., Stein R., Dick L., Hwang D., and Goldberg A.L. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78 (1994) 761-771
26. Huang P., Feng L., Oldham E.A., Keating M.J., and Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 407 (2000) 390-395
27. Bailey H.H. L-S,R-buthionine sulfoximine: historical development and clinical issues. Chem. Biol. Interact. 111-112 (1998) 239-254
28. Kurata S. Selective activation of p38 MAPK cascade and mitotic arrest caused by low level oxidative stress. J. Biol. Chem. 275 (2000) 23413-23416
29. Fernandez C., Ramos A.M., Sancho P., Amran D., de Blas E., and Aller P. 12-O-tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells. Regulation by extracellular signal-regulated protein kinases and glutathione. J. Biol. Chem. 279 (2004) 3877-3884
30. 2-terminal kinase and up-regulation of death receptors. Cancer Res. 66 (2006) 11416-11423
31. Frey R.S., and Singletary K.W. Genistein activates p38 mitogen-activated protein kinase, inactivates ERK1/ERK2 and decreases Cdc25C expression in immortalized human mammary epithelial cells. J. Nutr. 133 (2003) 226-231
32. Akimoto T., Nonaka T., Ishikawa H., Sakurai H., Saitoh J.I., Takahashi T., and Mitsuhashi N. Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: possible involvement of inhibition of survival signal transduction pathways. Int. J. Radiat. Oncol. Biol. Phys. 50 (2001) 195-201
33. Torres M., and Forman H.J. Redox signaling and the MAP kinase pathways. Biofactors 17 (2003) 287-296
34. Sanchez Y., Amran D., de Blas E., and Aller P. Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4). Protein kinase modulation and reactive oxygen species generation. Biochem. Pharmacol. 77 (2009) 384-396
35. Dasmahapatra G., Rahmani M., Dent P., and Grant S. The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism. Blood 107 (2006) 232-240
36. Yi J., Gao F., Shi G., Li H., Wang Z., Shi X., and Tang X. The inherent cellular level of reactive oxygen species: one of the mechanisms determining apoptotic susceptibility of leukemic cells to arsenic trioxide. Apoptosis 7 (2002) 209-215
37. Diaz Z., Colombo M., Mann K.K., Su H., Smith K.N., Bohle D.S., Schipper H.M., and Miller Jr. W.H. Trolox selectively enhances arsenic-mediated oxidative stress and apoptosis in APL and other malignant cell lines. Blood 105 (2005) 1237-1245
38. Wei H., Bowen R., Cai Q., Barnes S., and Wang Y. Antioxidant and antipromotional effects of the soybean isoflavone genistein. Proc. Soc. Exp. Biol. Med. 208 (1995) 124-130
39. Huang G., Liu Y., Chang H., Zhang X., Ren D., Wilson J.X., and Cao X. Effects of genistein on oxidative injury in endotelial cells. J. Nutr. Sci. Vitaminol. 54 (2008) 402-408
40. Muranaka S., Fujita H., Fujiwara T., Ogino T., Sato E.F., Akiyama J., Imada I., Inoue M., and Utsumi K. Mechanisms and characteristics of stimuli-dependent ROS generation in undifferentiated HL-60 cells. Antioxid. Redox Signal. 7 (2005) 1367-1376
41. Si H., and Liu D. Phytochemical genistein in the regulation of vascular function: new insights. Curr. Med. Chem. 14 (2007) 2581-2589
42. Sava I.G., Battaglia V., Rossi C.A., Salvi M., and Toninello A. Free radical scavenging action of the natural polyamine spermine in rat liver mitochondria. Free Radic. Biol. Med. 41 (2006) 1272-1281
43. Hwang J.T., Park I.J., Shin J.I., Lee Y.K., Lee S.K., Baik H.W., Ha J., Park O.J., and Genistein. EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinases. Biochem. Biophys. Res. Commun. 338 (2005) 694-699
44. Shin J.I., Shim J.H., Kim K.H., Choi H.S., Kim J.W., Lee H.G., Kim B.Y., Park S.N., Park O.J., and Yoon D.Y. Sensitization of the apoptotic effect of gamma-irradiation in genistein-pretreated CaSki cervical cancer cells. J. Microbiol. Biotechnol. 18 (2008) 523-531
45. Salvi M., Brunati A.M., Clari G., and Toninello A. Interaction of genistein with the mitochondrial electron transport chain results in opening of the membrane transition pore. Biochim. Biophys. Acta 1556 (2002) 187-196
46. Chan M.M., Soprano K.J., Weinstein K., and Fong D. Epigallocatechin-3-gallate delivers hydrogen peroxide to induce death of ovarian cancer cells and enhances their cisplatin susceptibility. J. Cell. Physiol. 207 (2006) 389-396
47. Simizu S., Imoto M., Masuda N., Takada M., and Umezawa K. Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. Cancer Res. 56 (1996) 4978-4982
48. Le S.B., Hailer M.K., Buhrow S., Wang Q., Flatten K., Pediaditakis P., Bible K.C., Lewis L.D., Sausville E.A., Pang Y.P., Ames M.M., Lemasters J.J., Holmuhamedov E.L., and Kaufmann S.H. Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity. J. Biol. Chem. 282 (2007) 8860-8872
49. Ortiz C., Caja L., Sancho P., Bertran E., and Fabregat E. Inhibition of EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatome cells: role of reactive oxygen species production and glutathione depletion. Biochem. Pharmacol. 75 (2008) 1935-1945
50. Miller Jr. W.H., Schipper H.M., Lee J.S., Singer J., and Waxman S. Mechanisms of action of arsenic trioxide. Cancer Res. 62 (2002) 3893-3903
51. Evens A.M., Tallman M.S., and Gartenhaus R.B. The potential of arsenic trioxide in the treatment of malignant disease: past, present, and future. Leuk. Res. 28 (2004) 891-900