α-synuclein expression in substantia nigra and cortex in Parkinson's disease

Movement Disorders

Volumn 14, Issue 3, 1999, Pages 417-422

  Neystat, Michael ^a   Lynch, Timothy ^a   Przedborski, Serge ^a   Kholodilov, Nikolai ^a   Rzhetskaya, Margarita ^a   Burke, Robert E ^a,b  

^a Columbia University ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

synuclein; Parkinson's disease; Ribonuclease protection assay; Substantia nigra

Indexed keywords

ALPHA SYNUCLEIN; COMPLEMENTARY DNA; MESSENGER RNA;

ADULT; AGED; ARTICLE; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIBONUCLEASE PROTECTION ASSAY; SUBSTANTIA NIGRA;

ADULT; AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; CEREBRAL CORTEX; DNA, RECOMBINANT; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; PARKINSON DISEASE; PHOSPHOPROTEINS; POINT MUTATION; SUBSTANTIA NIGRA; SYNUCLEINS;

EID: 0033405487     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8257(199905)14:3<417::AID-MDS1005>3.0.CO;2-X     Document Type: Article

References (20)

1. Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-2047.
2. Kruger R, Kuhn W, Muller T, et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease [Letter]. Nat Genet 1998;18:106-108.
3. Chan P, Tanner CM, Jiang X, Langston JW. Failure to find the alpha-synuclein gene missense mutation (G209A) in 100 patients with younger onset Parkinson's disease. Neurology 1998;50:513-514.
4. Vaughan JR, Fairer MJ, Wszolek ZK, et al. Sequencing of the alpha-synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations. Hum Mol Genet 1998;7:751-753.
5. Anonymous. Alpha-synuclein gene and Parkinson's disease. The French Parkinson's Disease Study Group [Letter]. Science 1998; 279:1116-1117.
6. Munoz E, Oliva R, Obach V, et al. Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the alpha-synuclein gene in early onset patients. Neurosci Lett 1997;235:57-60.
7. van Leeuwen FW, Burbach JP, Hol EM. Mutations in RNA: a first example of molecular misreading in Alzheimer's disease. Trends Neurosci 1998;21:331-335.
8. Lin C-L, Bristol LA, Jin L, et al. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron 1998; 20:589-602.
9. Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer's disease. Proc Natl Acad Sci USA 1993;90:11282-11286.
10. Ueda K, Saitoh T, Mori H. Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid. Biochem Biophys Res Commun 1994;205:1366-1372.
11. Hoffman BJ, Hansson SR, Mezey E, Palkovits M. Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system. Front Neuroendocrinol 1998;19:187-231.
12. Maroteaux L, Campanelli JT, Scheller RH. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 1988;8:2804-2815.
13. Maroteaux L, Scheller RH. The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain Res Mol Brain Res 1991;11:335-343.
14. Iwai A, Masliah E, Yoshimoto M, et al. The precursor protein of non-Ab component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 1995;14:467-475.
15. Irizarry MC, Kim TW, McNamara M, et al. Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system. J Neuropathol Exp Neurol 1996;55:889-895.
16. George JM, Jin H, Woods WS, Clayton DF. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 1995;15:361-372.
17. Spillantini MG, Schmidt ML, Lee VMY, Trojanowski JQ, Jakes R, Goedert M. α-Synuclein in Lewy bodies. Nature 1997;388:839-840.
18. Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M. Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 1998;95:6469-6473.
19. Gibb WRG. Melanin, tyrosine hydroxylase, calbindin and substance P in the human midbrain and substantia nigra in relation to nigrostriatal projections and differential neuronal susceptibility in Parkinson's disease. Brain Res 1992;581:283-291.
20. Kholodilov NG, Neystat M, Burke RE. mRNAs overexpressed during induced apoptosis in substantia nigra identified by RNA differential display. Soc Neurosci Abstr 1997;23:631.