메뉴 건너뛰기




Volumn 41, Issue 9, 2009, Pages 665-677

JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis

Author keywords

Anthra(1,9 cd)pyrazol 6(2H) one; Apoptosis; Cell cycle; Cyclin dependent kinase inhibitor p21; JNK mitogen activated protein kinases; Microtubule; Proto oncogene proteins c bcl 2

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CYCLIN DEPENDENT KINASE 2; PROTEIN BCL 2; PROTEIN P21; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TUBULIN;

EID: 70349459750     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2009.41.9.073     Document Type: Article
Times cited : (41)

References (48)
  • 1
    • 0030451851 scopus 로고    scopus 로고
    • Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state
    • Andreassen PR, Martineau SN, Margolis RL. Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state. Mutat Res 1996;372:181-194
    • (1996) Mutat Res , vol.372 , pp. 181-194
    • Andreassen, P.R.1    Martineau, S.N.2    Margolis, R.L.3
  • 4
    • 0034689774 scopus 로고    scopus 로고
    • P21(Waf1/Cip1/Sdi1)-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
    • Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC, Roninson IB. p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene 2000;19:2165-2170 (Pubitemid 30251382)
    • (2000) Oncogene , vol.19 , Issue.17 , pp. 2165-2170
    • Chang, B.-D.1    Broude, E.V.2    Fang, J.3    Kalinichenko, T.V.4    Abdryashitov, R.5    Poole, J.C.6    Roninson, I.B.7
  • 5
    • 7044224792 scopus 로고    scopus 로고
    • Toward a comprehensive model for induced endoreduplication
    • DOI 10.1016/j.lfs.2004.08.006, PII S0024320504007635
    • Cortes F, Mateos S, Pastor N, Dominguez I. Toward a comprehensive model for induced endoreduplication. Life Sci 2004;76:121-135 (Pubitemid 39425219)
    • (2004) Life Sciences , vol.76 , Issue.2 , pp. 121-135
    • Cortes, F.1    Mateos, S.2    Pastor, N.3    Dominguez, I.4
  • 7
    • 1642523573 scopus 로고    scopus 로고
    • Inhibition of Cell Proliferation and Cell Cycle Progression by Specific Inhibition of Basal JNK Activity: Evidence that mitotic bcl-2 phosphorylation is JNK-independent
    • DOI 10.1074/jbc.M304935200
    • Du L, Lyle CS, Obey TB, Gaarde WA, Muir JA, Bennett BL, Chambers TC. Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent. J Biol Chem 2004;279:11957-11966 (Pubitemid 38401701)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.12 , pp. 11957-11966
    • Du, L.1    Lyle, C.S.2    Obey, T.B.3    Gaarde, W.A.4    Muir, J.A.5    Bennett, B.L.6    Chambers, T.C.7
  • 8
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • Elledge SJ. Cell cycle checkpoints: preventing an identity crisis. Science 1996;274:1664-1672
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 9
    • 0030056380 scopus 로고    scopus 로고
    • Application of fluorescence in situ hybridisation to study the relationship between cytotoxicity, chromosome aberrations, and changes in chromosome number after treatment with the topoisomerase II inhibitor amsacrine
    • DOI 10.1002/(SICI)1098-2280(1996)27:4<255::AID-EM2>3.0.CO;2-C
    • Ferguson LR, Whiteside G, Holdaway KM, Baguley BC. Application of fluorescence in situ hybridization to study the relationship between cytotoxicity, chromosome aberrations, and changes in chromosome number after treatment with the topoisomerase II inhibitor amsacrine. Environ Mol Mutagen 1996;27:255-262 (Pubitemid 26233411)
    • (1996) Environmental and Molecular Mutagenesis , vol.27 , Issue.4 , pp. 255-262
    • Ferguson, L.R.1    Whiteside, G.2    Holdaway, K.M.3    Baguley, B.C.4
  • 11
    • 33747877023 scopus 로고    scopus 로고
    • The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function
    • DOI 10.1158/0008-5472.CAN-05-3353
    • Gizatullin F, Yao Y, Kung V, Harding MW, Loda M, Shapiro GI. The aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function. Cancer Res 2006;66:7668-7677 (Pubitemid 44289225)
    • (2006) Cancer Research , vol.66 , Issue.15 , pp. 7668-7677
    • Gizatullin, F.1    Yao, Y.2    Kung, V.3    Harding, M.W.4    Loda, M.5    Shapiro, G.I.6
  • 13
    • 0029964257 scopus 로고    scopus 로고
    • Taxol induces bcl-2 phosphorylation and death of prostate cancer cells
    • Haldar S, Chintapalli J, Croce CM. Taxol induces bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res 1996;56:1253-1255 (Pubitemid 26080965)
    • (1996) Cancer Research , vol.56 , Issue.6 , pp. 1253-1255
    • Haldar, S.1    Chintapalli, J.2    Croce, C.M.3
  • 15
    • 2142744812 scopus 로고    scopus 로고
    • Mutations in alpha- and beta-tubulin that stabilize microtubules and confer resistance to colcemid and vinblastine
    • Hari M, Wang Y, Veeraraghavan S, Cabral F. Mutations in alpha- and beta-tubulin that stabilize microtubules and confer resistance to colcemid and vinblastine. Mol Cancer Ther 2003;2:597-605
    • (2003) Mol Cancer Ther , vol.2 , pp. 597-605
    • Hari, M.1    Wang, Y.2    Veeraraghavan, S.3    Cabral, F.4
  • 16
    • 0024425887 scopus 로고
    • Checkpoints: Controls that ensure the order of cell cycle events
    • Hartwell LH, Weinert TA. Checkpoints: controls that ensure the order of cell cycle events. Science 1989;246:629-634
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 17
    • 0030828073 scopus 로고    scopus 로고
    • Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
    • DOI 10.1007/s004120050256
    • Hendzel MJ, Wei Y, Mancini MA, Van Hooser A, Ranalli T, Brinkley BR, Bazett-Jones DP, Allis CD. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 1997;106:348-360 (Pubitemid 27510848)
    • (1997) Chromosoma , vol.106 , Issue.6 , pp. 348-360
    • Hendzel, M.J.1    Wei, Y.2    Mancini, M.A.3    Van Hooser, A.4    Ranalli, T.5    Brinkley, B.R.6    Bazett-Jones, D.P.7    Allis, C.D.8
  • 18
    • 0345732500 scopus 로고    scopus 로고
    • Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines
    • Hideshima T, Hayashi T, Chauhan D, Akiyama M, Richardson P, Anderson K. Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines. Oncogene 2003;22:8797-8801
    • (2003) Oncogene , vol.22 , pp. 8797-8801
    • Hideshima, T.1    Hayashi, T.2    Chauhan, D.3    Akiyama, M.4    Richardson, P.5    Anderson, K.6
  • 19
    • 85047700485 scopus 로고    scopus 로고
    • Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis
    • DOI 10.1038/sj/onc/1205348
    • Hochedlinger K, Wagner EF, Sabapathy K. Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis. Oncogene 2002;21:2441-2445 (Pubitemid 34407304)
    • (2002) Oncogene , vol.21 , Issue.15 , pp. 2441-2445
    • Hochedlinger, K.1    Wagner, E.F.2    Sabapathy, K.3
  • 20
    • 0026516994 scopus 로고
    • Mechanism of action of taxol
    • Horwitz SB. Mechanism of action of taxol. Trends Pharmacol Sci 1992;13:134-136
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 134-136
    • Horwitz, S.B.1
  • 22
    • 3242810564 scopus 로고    scopus 로고
    • Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines
    • Jacobs-Helber SM, Sawyer ST. Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines. Blood 2004;104:696-703
    • (2004) Blood , vol.104 , pp. 696-703
    • Jacobs-Helber, S.M.1    Sawyer, S.T.2
  • 24
    • 0030020158 scopus 로고    scopus 로고
    • Mitotic block induced in HeLa cells by low concentrations of paclitaxel (taxol) results in abnormal mitotic exit and apoptotic cell death
    • Jordan MA, Wendell K, Gardiner S, Derry WB, Copp H, Wilson L. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996;56:816-825 (Pubitemid 26055472)
    • (1996) Cancer Research , vol.56 , Issue.4 , pp. 816-825
    • Jordan, M.A.1    Wendell, K.2    Gardiner, S.3    Derry, W.B.4    Copp, H.5    Wilson, L.6
  • 25
    • 0037119470 scopus 로고    scopus 로고
    • The stress-activated protein kinases p38α and JNK1 stabilize p21Cip1 by phosphorylation
    • Kim GY, Mercer SE, Ewton DZ, Yan Z, Jin K, Friedman E. The stress-activated protein kinases p38α and JNK1 stabilize p21Cip1 by phosphorylation. J Biol Chem 2002;277:29792-29802
    • (2002) J Biol Chem , vol.277 , pp. 29792-29802
    • Kim, G.Y.1    Mercer, S.E.2    Ewton, D.Z.3    Yan, Z.4    Jin, K.5    Friedman, E.6
  • 26
    • 0024997935 scopus 로고
    • Pp54 microtubule-associated protein 2 kinase: A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine
    • Kyriakis JM, Avruch J. pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine. J Biol Chem 1990;265:17355-17363 (Pubitemid 20334287)
    • (1990) Journal of Biological Chemistry , vol.265 , Issue.28 , pp. 17355-17363
    • Kyriakis, J.M.1    Avruch, J.2
  • 28
    • 0032563202 scopus 로고    scopus 로고
    • Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis
    • DOI 10.1074/jbc.273.30.18984
    • Ling YH, Tornos C, Perez-Soler R. Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis. J Biol Chem 1998;273:18984-18991 (Pubitemid 28366289)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.30 , pp. 18984-18991
    • Ling, Y.-H.1    Tornos, C.2    Perez-Soler, R.3
  • 30
    • 61849127776 scopus 로고    scopus 로고
    • Transcription of the protein kinase C-δ gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin
    • Min BW, Kim CG, Ko J, Lim Y, Lee YH, Shin SY. Transcription of the protein kinase C-δ gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin. Exp Mol Med 2008;40:699-708
    • (2008) Exp Mol Med , vol.40 , pp. 699-708
    • Min, B.W.1    Kim, C.G.2    Ko, J.3    Lim, Y.4    Lee, Y.H.5    Shin, S.Y.6
  • 31
    • 0842329801 scopus 로고    scopus 로고
    • Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells
    • DOI 10.1038/sj.onc.1207147
    • Mingo-Sion AM, Marietta PM, Koller E, Wolf DM, Van Den Berg CL. Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells. Oncogene 2004;23:596-604 (Pubitemid 38175015)
    • (2004) Oncogene , vol.23 , Issue.2 , pp. 596-604
    • Mingo-Sion, A.M.1    Marietta, P.M.2    Koller, E.3    Wolf, D.M.4    Van Den Berg, C.L.5
  • 32
    • 0033735581 scopus 로고    scopus 로고
    • Cell cycle checkpoints and their inactivation in human cancer
    • DOI 10.1046/j.1365-2184.2000.00191.x
    • Molinari M. Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif 2000;33:261-274 (Pubitemid 30807736)
    • (2000) Cell Proliferation , vol.33 , Issue.5 , pp. 261-274
    • Molinari, M.1
  • 33
    • 0031961995 scopus 로고    scopus 로고
    • 2/M cell cycle transitions: PRb is a critical determinant in blocking DNA replication and in preventing endoreduplication
    • 2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 1998;18:629-643
    • (1998) Mol Cell Biol , vol.18 , pp. 629-643
    • Niculescu III, A.B.1    Chen, X.2    Smeets, M.3    Hengst, L.4    Prives, C.5    Reed, S.I.6
  • 34
    • 0031693211 scopus 로고    scopus 로고
    • WAF1 is dynamically associated with JNK in human T-lymphocytes during cell cycle progression
    • WAF1 is dynamically associated with JNK in human T-lymphocytes during cell cycle progression. J Cell Sci 1998;111:2247-2255
    • (1998) J Cell Sci , vol.111 , pp. 2247-2255
    • Patel, R.1    Bartosch, B.2    Blank, J.L.3
  • 35
    • 0033969883 scopus 로고    scopus 로고
    • Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner
    • DOI 10.1128/MCB.20.5.1713-1722.2000
    • Potapova O, Gorospe M, Dougherty RH, Dean NM, Gaarde WA, Holbrook NJ. Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Mol Cell Biol 2000;20:1713-1722 (Pubitemid 30100190)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.5 , pp. 1713-1722
    • Potapova, O.1    Gorospe, M.2    Dougherty, R.H.3    Dean, N.M.4    Gaarde, W.A.5    Holbrook, N.J.6
  • 37
    • 0031442834 scopus 로고    scopus 로고
    • Paclitaxel pharmacology and other tumor types
    • Rowinsky EK. Paclitaxel pharmacology and other tumor types. Semin Oncol 1997;24:1-12
    • (1997) Semin Oncol , vol.24 , pp. 1-12
    • Rowinsky, E.K.1
  • 39
    • 0034704182 scopus 로고    scopus 로고
    • Waiting for anaphase: Mad2 and the spindle assembly checkpoint
    • DOI 10.1016/S0092-8674(00)00202-6
    • Shah JV, Cleveland DW. Waiting for anaphase: Mad2 and the spindle assembly checkpoint. Cell 2000;103:997-1000 (Pubitemid 32037387)
    • (2000) Cell , vol.103 , Issue.7 , pp. 997-1000
    • Shah, J.V.1    Cleveland, D.W.2
  • 40
    • 0035971493 scopus 로고    scopus 로고
    • AP-1 in cell proliferation and survival
    • Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene 2001;20:2390-2400
    • (2001) Oncogene , vol.20 , pp. 2390-2400
    • Shaulian, E.1    Karin, M.2
  • 41
    • 79959300836 scopus 로고    scopus 로고
    • Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer
    • Shore GC, Viallet J. Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer. Hematology 2005;1:226-230
    • (2005) Hematology , vol.1 , pp. 226-230
    • Shore, G.C.1    Viallet, J.2
  • 42
    • 0032952584 scopus 로고    scopus 로고
    • Waf1/Cip1 inhibition of cyclinE/Cdk2 activity prevents endoreduplication after mitotic spindle disruption
    • Waf1/Cip1 inhibition of cyclinE/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. Mol Cell Biol 1999;19:205-215
    • (1999) Mol Cell Biol , vol.19 , pp. 205-215
    • Stewart, Z.A.1    Leach, S.D.2    Pietenpol, J.A.3
  • 43
    • 0032447327 scopus 로고    scopus 로고
    • Induction of diplochromosomes in mammalian cells by inhibitors of topoisomerase II
    • DOI 10.1007/s004120050333
    • Sumner AT. Induction of diplochromosomes in mammalian cells by inhibitors of topoisomerase II. Chromosoma 1998;107:486-490 (Pubitemid 29057542)
    • (1998) Chromosoma , vol.107 , Issue.6-7 , pp. 486-490
    • Sumner, A.T.1
  • 46
    • 0036593631 scopus 로고    scopus 로고
    • Fortuitous convergences: The beginnings of JUN
    • Vogt PK. Fortuitous convergences: the beginnings of JUN. Nat Rev Cancer 2002;2:465-469
    • (2002) Nat Rev Cancer , vol.2 , pp. 465-469
    • Vogt, P.K.1
  • 47
    • 0030014783 scopus 로고    scopus 로고
    • DNA topoisomerases
    • Wang JC. DNA topoisomerases. Annu Rev Biochem 1996;65:635-692
    • (1996) Annu Rev Biochem , vol.65 , pp. 635-692
    • Wang, J.C.1
  • 48
    • 0032510035 scopus 로고    scopus 로고
    • Continuous Cyclin e expression inhibits progression through endoreduplication cycles in Drosophila
    • Weiss A, Herzig A, Jacobs H, Lehner CF. Continuous cyclin E expression inhibits progression through endoreduplication cycles in Drosophila. Curr Biol 1998;8:239-242 (Pubitemid 28131564)
    • (1998) Current Biology , vol.8 , Issue.4 , pp. 239-242
    • Weiss, A.1    Herzig, A.2    Jacobs, H.3    Lehner, C.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.