Induction of diplochromosomes in mammalian cells by inhibitors of topoisomerase II

Chromosoma

Volumn 107, Issue 6-7, 1998, Pages 486-490

  Sumner, Adrian T ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMSACRINE; DEMECOLCINE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; ETOPOSIDE; MITOXANTRONE;

ANIMAL CELL; CHO CELL; CHROMATID; CONFERENCE PAPER; DNA REPLICATION; INTERPHASE; MAMMAL CELL; METAPHASE; NONHUMAN;

AMSACRINE; ANIMALS; CHO CELLS; CHROMATIDS; CHROMOSOME ABERRATIONS; CHROMOSOME SEGREGATION; CRICETINAE; DEMECOLCINE; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; ETOPOSIDE; INTERPHASE; METAPHASE; MITOXANTRONE; NUCLEIC ACID SYNTHESIS INHIBITORS;

ANIMALIA; MAMMALIA;

EID: 0032447327     PISSN: 00095915     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004120050333     Document Type: Conference Paper

References (22)

1. Andoh T, Sato M, Narita T, Ishida R (1993) Role of DNA topoisomerase II in chromosome dynamics in mammalian cells. Biotechnol Appl Biochem 18:165-174
2. Bhat MA, Philp AV, Glover DM, Bellen HJ (1996) Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with topoisomerase II. Cell 87:1103-1114
3. Bickel SE, Wyman DW, Orr-Weaver TL (1997) Mutational analysis of the Drosophila sister-chromatid cohesion protein ORD and its role in the maintenance of centromeric cohesion. Genetics 146:1319-1331
4. Buchenau P, Saumweber H, Arndt-Jovin DJ (1993) Consequences of topoisomerase II inhibition in early embryogenesis of Drosophila revealed by in vivo confocal laser scanning microscopy. J Cell Sci 104:1175-1185
5. Clarke DJ, Johnson RT, Downes CS (1993) Topoisomerase II inhibition prevents anaphase chromatid segregation in mammalian cells independently of the generation of DNA strand breaks. J Cell Sci 105:563-569
6. Cummings J, Sumner AT, Slavotinek A, Meikle I, Macpherson JS, Smyth JF (1995) Cytogenetic evaluation of the mechanism of cell death induced by the novel anthracenyl-amino acid topoisomerase II catalytic inhibitor NU/ICRF 500. Mutat Res 344:55-62
7. di Nardo S, Voelkel K, Sternglanz R (1984) DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication. Proc Natl Acad Sci USA 81:2616-2620
8. Downes CS, Mullinger AM, Johnson RT (1991) Inhibitors of DNA topoisomerase II prevent chromatid separation in mammalian cells but do not prevent exit from mitosis. Proc Natl Acad Sci USA 88:8895-8899
9. Ghosh S, Paweletz N (1992) Okadaic acid inhibits sister chromatid separation in mammalian cells. Exp Cell Res 200:215-217
10. Gorbsky GJ (1994) Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane: ADR-529] and ICRF-159 (Razoxane). Cancer Res 54:1042-1048
11. Holloway SL, Glotzer M, King RW, Murray AW (1993) Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell 73:1393-1402
12. Holm C, Stearns T, Botstein D (1989) DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage. Mol Cell Biol 9:159-168
13. Ishida R, Miki T, Narita T, Yui R, Sato M, Utsumi KR, Tanabe K, Andoh T (1991) Inhibition of intracellular topoisomerase II by antitumour bis(2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors. Cancer Res 51:4909-4916
14. Ishida R, Sato M, Narita T, Utsumi KR, Nishimoto T, Morita T, Nagata H, Andoh T (1994) Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events. J Cell Biol 126:1341-1351
15. Jörgensen P-M, Brundell E, Starborg M, Höög C (1998) A subunit of the anaphase-promoting complex is a centromere-associated protein in mammalian cells. Mol Cell Biol 18:468-476
16. Koshland D, Hartwell LH (1987) The structure of sister minichromosome DNA before anaphase in Saccharomyces cerevisiae. Science 238:1713-1716
17. Michaelis C, Ciosk R, Nasmyth K (1997) Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell 91:35-45
18. Sumner AT (1992) Inhibitors of topoisomerases do not block the passage of human lymphocyte chromosomes through mitosis. J Cell Sci 103:105-115
19. Sumner AT (1995) Inhibitors of topoisomerase II delay progress through mitosis and induce a doubling of the DNA content in CHO cells. Exp Cell Res 217:440-447
20. Uemura T, Yanagida M (1986) Mitotic spindle pulls but fails to separate chromosome in type II DNA topoisomerase mutants: uncoordinated mitosis. EMBO J 5:1003-1010
21. Uemura T, Ohkura H, Adachi Y, Morino K, Shiozaki K, Yanagida M (1987) DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe. Cell 50:917-925
22. Zucker RM, Adams DJ, Bair KW, Elstein KH (1991) Polyploidy induction as a consequence of topoisomerase inhibition. A flow cytometric assessment. Biochem Pharmacol 42:2199-2208