Fortuitous convergences: The beginnings of JUN

Nature Reviews Cancer

Volumn 2, Issue 6, 2002, Pages 465-469

  Vogt, Peter K ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN FOS; PROTEIN JUN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR;

BINDING AFFINITY; BINDING KINETICS; CARCINOGENICITY; CHROMOSOME TRANSLOCATION; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETIC TRANSFORMATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; NEOPLASM; PHYSIOLOGY;

GENE EXPRESSION REGULATION; HUMANS; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0036593631     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc818     Document Type: Review

References (68)

1. Lucchini, G., Hinnebusch, A. G., Chen, C. & Fink, G. R. Positive regulatory interactions of the HIS4 gene of Saccharomyces cerevisiae. Mol. Cell. Biol. 4, 1326-1333 (1984).
2. Thireos, G., Penn, M. D. & Greer, H. 5′ untranslated sequences are required for the translational control of a yeast regulatory gene. Proc. Natl Acad. Sci. USA 81, 5096-5100 (1984).
3. Hope, I. A. & Struhl, K. GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast. Cell 43, 177-188 (1985).
4. Hope, I. A. & Struhl, K. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell 46, 885-894 (1986).
5. Hinnebusch, A. G. A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 5, 2349-2360 (1985).
6. Hinnebusch, A. G. The general control of amino acid biosynthetic genes in the yeast Saccharomyces cerevisiae. CRC Crit. Rev. Biochem. 21, 277-317 (1986).
7. Hope, I. A. & Struhl, K. GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA. EMBO J. 6, 2781-2784 (1987).
8. Lee, W., Haslinger, A., Karin, M. & Tjian, R. Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature 325, 368-372 (1987).
9. Lee, W., Mitchell, P. & Tjlan, R. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell 49, 741-752 (1987).
10. Angel, R. et al. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49, 729-739 (1987).
11. Pulciani, S., Santos, E., Lauver A. V., Long, L. K. & Barbacid, M. Transforming genes in human tumors. J. Cell. Biochem. 50, 51-61 (1982).
12. Der, C. J., Krontiris, T. G. & Cooper, G. M. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc. Natl Acad. Sci. USA 79, 3637-3640 (1982).
13. Parada, L. F., Tabin, C. J., Shih, C. & Weinberg, R. A. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 297, 474-478. (1982).
14. Maki, Y., Bos, T. J., Davis, C., Starbuck, M. & Vogt, P. K. Avian sarcoma virus 17 carries the Jun oncogene. Proc. Natl. Acad. Sci. USA 84, 2848-2852 (1987).
15. Vogt, P. K., Bos, T. J. & Doolittle, R. F. Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun. Proc. Natl Acad. Sci. USA 84, 3316-3319 (1987).
16. Struhl, K. The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous. Cell 50, 841-846 (1987).
17. Bohmann, D. et al. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238, 1386-1392 (1987).
18. Angel, R. et al. Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature 332, 166-171 (1988).
19. Curran, T. & Teich, N. M. Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000-dalton phosphoprotein. J. Virol. 42, 114-122 (1982).
20. Curran, T., Peters, G., Van Beveren, C., Teich, N. M. & Verma, I. M. FBJ mudne osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA. J. Virol. 44, 674-682 (1982).
21. Curran, T. & Teich, N. M. Identification of a 39,000-dalton protein in cells transformed by the FBJ murine osteosarcoma virus. Virology 116, 221-235 (1982).
22. Rauscher, F. J., Sambucetti, L. C., Curran, T., Distel, R. J. & Spiegelman, B. M. Common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell 52, 471-480 (1988).
23. Franza, B. R. Jr, Rauscher, F. J., Josephs, S. F. & Curran, T. The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science 239, 1150-1153 (1988).
24. Rauscher, F. J. et al. Fos-associated protein p39 is the product of the jun proto-oncogene. Science 240, 1010-1016 (1988).
25. Sassone-Corsi, P., Lamph, W. W., Kamps, M. & Verma, I. M fos-associated cellular p39 is related to nuclear transcription factor AP-1. Cell 54, 553-560 (1988).
26. Landschulz, W. H., Johnson, P. F. & McKnight, S. L. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240, 1759-1764 (1988).
27. O'Shea, E. K., Rutkowski, R. & Kim, P. S. Mechanism of specificity in the Fos-Jun oncoprotein heterodimer. Cell 68, 699-708 (1992).
28. O'Shea, E. K., Rutkowski, R., Stafford, W. F. & Kim, P. S. Preferential heterodimer formation by isolated leucine zippers from fos and jun. Science 245, 646-648 (1989).
29. Gentz, R., Rauscher, F. J., Abate, C. & Curran, T. Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains. Science 243, 1695-1699 (1989).
30. Hai, T. & Curran, T. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl Acad. Sci. USA 68, 3720-3724 (1991).
31. Ivashkiv, L. B. et al. mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element. Mol. Cell. Biol. 10, 1609-1621 (1990).
32. Benbrook, D. M. & Jones, N. C. Heterodimer formation between CREB and JUN proteins. Oncogene 5, 295-302 (1990).
33. Sassone-Corsi, P., Ransone, L. J., Lamph, W. W. & Verma, I. M. Direct Interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain. Nature 336, 692-695 (1988).
34. Rauscher, F. J., Voulalas, R. J., Franza, B. R. Jr & Curran, T. Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev. 2, 1687-1699 (1988).
35. Halazonetis, T. D., Georgopoulos, K., Greenberg, M. E. & Leder, P. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 55, 917-924 (1988).
36. Turner, R. & Tjian, R. Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers. Science 243, 1689-1694 (1989).
37. Ransone, L. J., Visvader, J., Lamph, W. W., Sassone-Corsi, R. & Verma, I. M. fos and jun interaction: the role of the leucine zipper. Int. J. Cancer Suppl. 4, 10-21 (1989).
38. Kouzarides, T. & Ziff, E. Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding. Nature 340, 568-571 (1989).
39. Angel, P., Smeal, T., Meek, J. & Karin, M. Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner. New Biol. 1, 35-43 (1989).
40. Nakabeppu, Y. & Nathans, D. The basic region of Fos mediates specific DNA binding. EMBO J. 8, 3833-3841 (1989).
41. Smeal, T., Angel, P., Meek, J. & Karin, M. Different requirements for formation of Jun:Jun and Jun:Fos complexes. Genes Dev. 3, 2091-2100 (1989).
42. Ryder, K., Lau, L. F. & Nathans, D. A gene activated by growth factors is related to the oncogene v-jun. Proc. Natl Acad. Sci. USA 85, 1487-1491 (1988).
43. Nakabeppu, Y., Ryder, K. & Nathans, D. DNA binding activities of three murine Jun proteins: stimulation by Fos. Cell 55, 907-915 (1988).
44. Hirai, S. I., Ryseck, R. P., Mechta, F., Bravo, R. & Yaniv, M. Characterization of junD: a new member of the jun proto-oncogene family. EMBO J. 8, 1433-1439 (1989).
45. Cohen, D. R. & Curran, T. fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen. Mol. Cell. Biol. 8, 2063-2069 (1988).
46. Foletta, V. C. et al. Cloning and characterisation of the mouse fra2 gene. Oncogene 9, 3305-3311 (1994).
47. Zerial, M. et al. The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. EMBO J. 8, 805-813 (1989).
48. Glover, J. N. & Harrison, S. C. Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature 373, 257-261 (1995).
49. Hilberg, F., Aguzzi, A., Howells, N. & Wagner, E. F. c-Jun is essential for normal mouse development and hepatogenesis. Nature 365, 179-181 (1993).
50. Hilberg, F. & Wagner, E. F. Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity. Oncogene 7, 2371-2380 (1992).
51. Wang, Z. Q. et al. Bone and haematopoietic defects in mice lacking c-fos. Nature 360, 741-745 (1992).
52. Pulverer, B. J. et al. Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukaemic cells. Oncogene 8, 407-415 (1993).
53. Hibi, M., Lin, A., Smeal, T., Minden, A. & Karin, M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7, 2135-2148 (1993).
54. Derijard, B. et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037 (1994).
55. Bos, T. J. et al. Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences. Genes Dev. 4, 1677-1687 (1990).
56. Adler, V., Polotskaya, A., Wagner, F. & Kraft, A. S. Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity J. Biol. Chem. 267, 17001-17005 (1992).
57. Adler, V., Unlap, T. & Kraft, A. S. A peptide encoding the c-Jun delta domain inhibits the activity of a c-jun amino-terminal protein kinase. J. Biol. Chem. 269, 11186-11191 (1994).
58. Dai, T. et al. Stress-activated protein knases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function. Oncogene 10, 840-855 (1995).
59. Black, E. J., Catling, A. D., Woodgett, J. R., Kilbey, A. & Gillespie, D. A. Transcriptional activation by the v-Jun oncoprotein is independent of positive regulatory phosphorylation. Oncogene 9, 2363-2368 (1994).
60. Hussain, S., Kilbey, A. & Gillespie, D. A. v-Jun represses c-jun proto-oncogene expression in vivo through a 12-O-tetradecanoylphorbol-13-acetate-responsive element in the proximal gene promoter. Cell Growth Differ. 9, 677-686 (1998).
61. Kilbey, A., Black, E. J., Unlu, M. & Gillespie, D. A. The v-Jun oncoprotein replaces p39 c-Jun as the predominant AP-1 constituent in ASV17-transformed fibroblasts: implications for SAPK/JNK-mediated signal transduction. Oncogene 12, 2409-2418 (1996).
62. May, G. H., Allen, K. E., Clark, W., Funk, M. & Gillespie, D. A. Analysis of the interaction between c-Jun and c-Jun N-terminal kinase in vivo. J. Biol. Chem. 273, 33429-33435 (1998).
63. van Dam, H. & Castellazzi, M. Distinct roles of Jun: Fos and Jun:ATF dimers in oncogenesis. Oncogene 20, 2453-2464 (2001).
64. Vogt, P. K. Jun, the oncoprotein. Oncogene 20, 2365-2377 (2001).
65. Stam, K. et al. Evidence of a new chimeric BCR/c-ABL mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome. N. Engl. J. Med. 313, 1429-1433 (1985).
66. Kakizuka, A. et al. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses PARα with a novel putative transcription factor, PML. Cell 68, 663-674 (1991).
67. Galili, N. et al. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Nature Genet. 5, 230-235 (1993).
68. Hollstein, M., Sidransky, D., Vogelstein, B. & Harris, C. C. p53 mutations in human cancers. Science 253, 49-53 (1991).