메뉴 건너뛰기




Volumn 9, Issue 5, 2009, Pages 594-601

Marine snail venoms: use and trends in receptor and channel neuropharmacology

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CONOTOXIN; ALPHAD CONOTOXIN DERIVATIVE; ALPHAJ CONOTOXIN DERIVATIVE; ALPHAS CONOTOXIN DERIVATIVE; CONANTOKIN DERIVATIVE; CONOPEPTIDE DERIVATIVE; CONOPEPTIDE Y; CONOPRESSIN DERIVATIVE; CONTRYPHAN DERIVATIVE; CONTULAKIN DERIVATIVE; DELTA CONOTOXIN DERIVATIVE; G PROTEIN COUPLED RECEPTOR; IOTA CONOTOXIN DERIVATIVE; KAPPA CONOTOXIN DERIVATIVE; KAPPAA CONOTOXIN DERIVATIVE; KAPPAI CONOTOXIN DERIVATIVE; KAPPAJ CONOTOXIN DERIVATIVE; KAPPAM CONOTOXIN DERIVATIVE; MU CONOTOXIN; MU CONOTOXIN DERIVATIVE; MUO CONOTOXIN DERIVATIVE; OMEGA CONOTOXIN; OMEGA CONOTOXIN MVIIA; PEPTIDE DERIVATIVE; PROTEIN DERIVATIVE; RHO CONOPEPTIDE DERIVATIVE; SNAIL VENOM; SODIUM CHANNEL BLOCKING AGENT; T1 CONOTOXIN DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 70349414436     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2009.05.006     Document Type: Review
Times cited : (39)

References (53)
  • 1
    • 38449110166 scopus 로고    scopus 로고
    • Approaching the golden age of natural product pharmaceuticals from venom libraries: an overview of toxins and toxin-derivatives currently involved in therapeutic or diagnostic applications
    • Fox J.W., and Serrano S.M. Approaching the golden age of natural product pharmaceuticals from venom libraries: an overview of toxins and toxin-derivatives currently involved in therapeutic or diagnostic applications. Curr Pharm Des 13 (2007) 2927-2934
    • (2007) Curr Pharm Des , vol.13 , pp. 2927-2934
    • Fox, J.W.1    Serrano, S.M.2
  • 3
    • 33745258459 scopus 로고    scopus 로고
    • Catalog of Recent and fossil turrids (Mollusca: Gastropoda)
    • Tucker J.K. Catalog of Recent and fossil turrids (Mollusca: Gastropoda). Zootaxa 682 (2004) 1-1295
    • (2004) Zootaxa , vol.682 , pp. 1-1295
    • Tucker, J.K.1
  • 4
    • 84882875442 scopus 로고    scopus 로고
    • Conus snail venom peptides
    • Kastin A.J. (Ed), Academic Press
    • Olivera B.M. Conus snail venom peptides. In: Kastin A.J. (Ed). Handbook of Biologically Active Peptides (2006), Academic Press 381-388
    • (2006) Handbook of Biologically Active Peptides , pp. 381-388
    • Olivera, B.M.1
  • 6
    • 33644887475 scopus 로고    scopus 로고
    • Genes expressed in a turrid venom duct: divergence and similarity to conotoxins
    • This is the first broad study of a turrid's venom demonstrating the presence of various gene families. Importantly, the coded precursors are shown to share homologies with cone snail superfamilies, thus opening new perspectives in conopeptide discovery and in venom evolution studies within the Conoidea superfamily.
    • Watkins M., Hillyard D.R., and Olivera B.M. Genes expressed in a turrid venom duct: divergence and similarity to conotoxins. J Mol Evol 62 (2006) 247-256. This is the first broad study of a turrid's venom demonstrating the presence of various gene families. Importantly, the coded precursors are shown to share homologies with cone snail superfamilies, thus opening new perspectives in conopeptide discovery and in venom evolution studies within the Conoidea superfamily.
    • (2006) J Mol Evol , vol.62 , pp. 247-256
    • Watkins, M.1    Hillyard, D.R.2    Olivera, B.M.3
  • 7
    • 0038661000 scopus 로고    scopus 로고
    • A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo
    • Sandall D.W., Satkunanathan N., Keays D.A., Polidano M.A., Liping X., Pham V., Down J.G., Khalil Z., Livett B.G., and Gayler K.R. A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo. Biochemistry 42 (2003) 6904-6911
    • (2003) Biochemistry , vol.42 , pp. 6904-6911
    • Sandall, D.W.1    Satkunanathan, N.2    Keays, D.A.3    Polidano, M.A.4    Liping, X.5    Pham, V.6    Down, J.G.7    Khalil, Z.8    Livett, B.G.9    Gayler, K.R.10
  • 8
    • 34249310680 scopus 로고    scopus 로고
    • From the identification of gene organization of alpha conotoxins to the cloning of novel toxins
    • Yuan D.D., Han Y.H., Wang C.G., and Chi C.W. From the identification of gene organization of alpha conotoxins to the cloning of novel toxins. Toxicon 49 (2007) 1135-1149
    • (2007) Toxicon , vol.49 , pp. 1135-1149
    • Yuan, D.D.1    Han, Y.H.2    Wang, C.G.3    Chi, C.W.4
  • 9
    • 47849085599 scopus 로고    scopus 로고
    • Alpha-conopeptides specifically expressed in the salivary gland of Conus pulicarius
    • For the first time, conopeptide expression is related to a tissue different from the venom gland. This not only extends conopeptide investigations in a tissue-specific manner but may also give insights into the venomous system evolution in cone snails.
    • Biggs J.S., Olivera B.M., and Kantor Y.I. Alpha-conopeptides specifically expressed in the salivary gland of Conus pulicarius. Toxicon 52 (2008) 101-105. For the first time, conopeptide expression is related to a tissue different from the venom gland. This not only extends conopeptide investigations in a tissue-specific manner but may also give insights into the venomous system evolution in cone snails.
    • (2008) Toxicon , vol.52 , pp. 101-105
    • Biggs, J.S.1    Olivera, B.M.2    Kantor, Y.I.3
  • 11
    • 66349108725 scopus 로고    scopus 로고
    • Rapid sensitive analysis of cysteine rich peptide venom components
    • Authors present a technically useful approach for complete elucidation of conopeptide primary structures using mass spectrometry. Beyond the technical aspects, this demonstrates how much information can now be obtained from small amount of venoms.
    • Ueberheide B.M., Fenyo D., Alewood P.F., and Chait B.T. Rapid sensitive analysis of cysteine rich peptide venom components. Proc Natl Acad Sci USA 106 (2009) 6910-6915. Authors present a technically useful approach for complete elucidation of conopeptide primary structures using mass spectrometry. Beyond the technical aspects, this demonstrates how much information can now be obtained from small amount of venoms.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6910-6915
    • Ueberheide, B.M.1    Fenyo, D.2    Alewood, P.F.3    Chait, B.T.4
  • 13
    • 33644541469 scopus 로고    scopus 로고
    • 'Venomics' or: the venomous systems genome project
    • This is a founding article on the worldwide venomics initiative aiming at integrating all aspects of the venomous systems. The genomic, transcriptomic, proteomic, bioactivity and ecological aspects are laid down with the important opportunities and challenges offered.
    • Menez A., Stocklin R., and Mebs D. 'Venomics' or: the venomous systems genome project. Toxicon 47 (2006) 255-259. This is a founding article on the worldwide venomics initiative aiming at integrating all aspects of the venomous systems. The genomic, transcriptomic, proteomic, bioactivity and ecological aspects are laid down with the important opportunities and challenges offered.
    • (2006) Toxicon , vol.47 , pp. 255-259
    • Menez, A.1    Stocklin, R.2    Mebs, D.3
  • 14
    • 0013458375 scopus 로고    scopus 로고
    • Proteomics of venom peptides
    • Menez A. (Ed), John Wiley & Sons Ltd., Chichester, UK
    • Stocklin R., and Favreau P. Proteomics of venom peptides. In: Menez A. (Ed). Perspectives in Molecular Toxinology (2002), John Wiley & Sons Ltd., Chichester, UK 107-123
    • (2002) Perspectives in Molecular Toxinology , pp. 107-123
    • Stocklin, R.1    Favreau, P.2
  • 15
  • 16
    • 35349014163 scopus 로고    scopus 로고
    • Diversity of the neurotoxic conus peptides: a model for concerted pharmacological discovery
    • Olivera B.M., and Teichert R.W. Diversity of the neurotoxic conus peptides: a model for concerted pharmacological discovery. Mol Interv 7 (2007) 251-260
    • (2007) Mol Interv , vol.7 , pp. 251-260
    • Olivera, B.M.1    Teichert, R.W.2
  • 17
    • 33845992556 scopus 로고    scopus 로고
    • Conus peptides: biodiversity-based discovery and exogenomics
    • In cone snail venoms, the genes encoding conotoxins are quickly evolving, leading to a diversification in functional proteins, driven by environmental interactions. This lays the basis of 'exogenomics'.
    • Olivera B.M. Conus peptides: biodiversity-based discovery and exogenomics. J Biol Chem 281 (2006) 31173-31177. In cone snail venoms, the genes encoding conotoxins are quickly evolving, leading to a diversification in functional proteins, driven by environmental interactions. This lays the basis of 'exogenomics'.
    • (2006) J Biol Chem , vol.281 , pp. 31173-31177
    • Olivera, B.M.1
  • 18
    • 50449088156 scopus 로고    scopus 로고
    • Integrating the discovery pipeline for novel compounds targeting ion channels
    • Bulaj G. Integrating the discovery pipeline for novel compounds targeting ion channels. Curr Opin Chem Biol 12 (2008) 441-447
    • (2008) Curr Opin Chem Biol , vol.12 , pp. 441-447
    • Bulaj, G.1
  • 19
    • 46849122906 scopus 로고    scopus 로고
    • Probing peptide libraries from Conus achatinus using mass spectrometry and cDNA sequencing: identification of delta and omega-conotoxins
    • Gowd K.H., Dewan K.K., Iengar P., Krishnan K.S., and Balaram P. Probing peptide libraries from Conus achatinus using mass spectrometry and cDNA sequencing: identification of delta and omega-conotoxins. J Mass Spectrom 43 (2008) 791-805
    • (2008) J Mass Spectrom , vol.43 , pp. 791-805
    • Gowd, K.H.1    Dewan, K.K.2    Iengar, P.3    Krishnan, K.S.4    Balaram, P.5
  • 23
    • 19644387101 scopus 로고    scopus 로고
    • Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors
    • Teichert R.W., Jimenez E.C., and Olivera B.M. Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors. Biochemistry 44 (2005) 7897-7902
    • (2005) Biochemistry , vol.44 , pp. 7897-7902
    • Teichert, R.W.1    Jimenez, E.C.2    Olivera, B.M.3
  • 27
    • 33746647402 scopus 로고    scopus 로고
    • Chemical sensitivity in Caenorhabditis elegans
    • Bergamasco C., and Bazzicalupo P. Chemical sensitivity in Caenorhabditis elegans. Cell Mol Life Sci 63 (2006) 1510-1522
    • (2006) Cell Mol Life Sci , vol.63 , pp. 1510-1522
    • Bergamasco, C.1    Bazzicalupo, P.2
  • 28
    • 54449083070 scopus 로고    scopus 로고
    • Control of feeding behavior in C. elegans by human G protein-coupled receptors permits screening for agonist-expressing bacteria
    • Teng M.S., Shadbolt P., Fraser A.G., Jansen G., and McCafferty J. Control of feeding behavior in C. elegans by human G protein-coupled receptors permits screening for agonist-expressing bacteria. Proc Natl Acad Sci USA 105 (2008) 14826-14831
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14826-14831
    • Teng, M.S.1    Shadbolt, P.2    Fraser, A.G.3    Jansen, G.4    McCafferty, J.5
  • 29
    • 42149181885 scopus 로고    scopus 로고
    • Structural diversity of G protein-coupled receptors and significance for drug discovery
    • Lagerstrom M.C., and Schioth H.B. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov 7 (2008) 339-357
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 339-357
    • Lagerstrom, M.C.1    Schioth, H.B.2
  • 30
    • 0033290612 scopus 로고    scopus 로고
    • A review on conotoxins targeting ion channels and acetylcholine receptors of the vertebrate neuromuscular junction
    • Favreau P., Le Gall F., Benoit E., and Molgo J. A review on conotoxins targeting ion channels and acetylcholine receptors of the vertebrate neuromuscular junction. Acta Physiol Pharmacol Ther Latinoam 49 (1999) 257-267
    • (1999) Acta Physiol Pharmacol Ther Latinoam , vol.49 , pp. 257-267
    • Favreau, P.1    Le Gall, F.2    Benoit, E.3    Molgo, J.4
  • 32
    • 0032844209 scopus 로고    scopus 로고
    • A new conotoxin isolated from Conus consors venom acting selectively on axons and motor nerve terminals through a Na+-dependent mechanism
    • Le Gall F., Favreau P., Benoit E., Mattei C., Bouet F., Menou J.L., Menez A., Letourneux Y., and Molgo J. A new conotoxin isolated from Conus consors venom acting selectively on axons and motor nerve terminals through a Na+-dependent mechanism. Eur J Neurosci 11 (1999) 3134-3142
    • (1999) Eur J Neurosci , vol.11 , pp. 3134-3142
    • Le Gall, F.1    Favreau, P.2    Benoit, E.3    Mattei, C.4    Bouet, F.5    Menou, J.L.6    Menez, A.7    Letourneux, Y.8    Molgo, J.9
  • 35
    • 58149172098 scopus 로고    scopus 로고
    • Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation
    • v2.2 calcium channels. This introduces a new mode of action for conopeptides and offer insights in pain treatments.
    • v2.2 calcium channels. This introduces a new mode of action for conopeptides and offer insights in pain treatments.
    • (2008) J Neurosci , vol.28 , pp. 10943-10951
    • Callaghan, B.1    Haythornthwaite, A.2    Berecki, G.3    Clark, R.J.4    Craik, D.J.5    Adams, D.J.6
  • 36
    • 34347364721 scopus 로고    scopus 로고
    • Pharmacology of alpha-conotoxin MII-sensitive subtypes of nicotinic acetylcholine receptors isolated by breeding of null mutant mice
    • Salminen O., Drapeau J.A., McIntosh J.M., Collins A.C., Marks M.J., and Grady S.R. Pharmacology of alpha-conotoxin MII-sensitive subtypes of nicotinic acetylcholine receptors isolated by breeding of null mutant mice. Mol Pharmacol 71 (2007) 1563-1571
    • (2007) Mol Pharmacol , vol.71 , pp. 1563-1571
    • Salminen, O.1    Drapeau, J.A.2    McIntosh, J.M.3    Collins, A.C.4    Marks, M.J.5    Grady, S.R.6
  • 37
    • 34548056414 scopus 로고    scopus 로고
    • AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity
    • This is the first publication demonstrating the use of AChBP in a ligand-fishing strategy to discover new α-conotoxins from crude cone snail venoms. Additionally, data established molecular determinants that are involved in the interaction between α-conotoxins to AChBPs and nAChR subtypes.
    • Dutertre S., Ulens C., Buttner R., Fish A., van E.R., Kendel Y., Hopping G., Alewood P.F., Schroeder C., Nicke A., et al. AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. EMBO J 26 (2007) 3858-3867. This is the first publication demonstrating the use of AChBP in a ligand-fishing strategy to discover new α-conotoxins from crude cone snail venoms. Additionally, data established molecular determinants that are involved in the interaction between α-conotoxins to AChBPs and nAChR subtypes.
    • (2007) EMBO J , vol.26 , pp. 3858-3867
    • Dutertre, S.1    Ulens, C.2    Buttner, R.3    Fish, A.4    van, E.R.5    Kendel, Y.6    Hopping, G.7    Alewood, P.F.8    Schroeder, C.9    Nicke, A.10
  • 38
    • 33747652956 scopus 로고    scopus 로고
    • Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors
    • Talley T.T., Olivera B.M., Han K.H., Christensen S.B., Dowell C., Tsigelny I., Ho K.Y., Taylor P., and McIntosh J.M. Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors. J Biol Chem 281 (2006) 24678-24686
    • (2006) J Biol Chem , vol.281 , pp. 24678-24686
    • Talley, T.T.1    Olivera, B.M.2    Han, K.H.3    Christensen, S.B.4    Dowell, C.5    Tsigelny, I.6    Ho, K.Y.7    Taylor, P.8    McIntosh, J.M.9
  • 39
    • 40849129937 scopus 로고    scopus 로고
    • Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues
    • Ellison M., Feng Z.P., Park A.J., Zhang X., Olivera B.M., McIntosh J.M., and Norton R.S. Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues. J Mol Biol 377 (2008) 1216-1227
    • (2008) J Mol Biol , vol.377 , pp. 1216-1227
    • Ellison, M.1    Feng, Z.P.2    Park, A.J.3    Zhang, X.4    Olivera, B.M.5    McIntosh, J.M.6    Norton, R.S.7
  • 40
    • 33845212316 scopus 로고    scopus 로고
    • Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors
    • This is the first publication where selective inhibition of α9α10 nicotinic acetylcholine receptors is suggested as a new molecular mediator for the treatment of neuropathic pain. Interestingly, the activity is shown to be associated with reduction of macrophage and T cells number.
    • Vincler M., Wittenauer S., Parker R., Ellison M., Olivera B.M., and McIntosh J.M. Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors. Proc Natl Acad Sci USA 103 (2006) 17880-17884. This is the first publication where selective inhibition of α9α10 nicotinic acetylcholine receptors is suggested as a new molecular mediator for the treatment of neuropathic pain. Interestingly, the activity is shown to be associated with reduction of macrophage and T cells number.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17880-17884
    • Vincler, M.1    Wittenauer, S.2    Parker, R.3    Ellison, M.4    Olivera, B.M.5    McIntosh, J.M.6
  • 42
    • 31544458674 scopus 로고    scopus 로고
    • Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor
    • Teichert R.W., Lopez-Vera E., Gulyas J., Watkins M., Rivier J., and Olivera B.M. Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor. Biochemistry 45 (2006) 1304-1312
    • (2006) Biochemistry , vol.45 , pp. 1304-1312
    • Teichert, R.W.1    Lopez-Vera, E.2    Gulyas, J.3    Watkins, M.4    Rivier, J.5    Olivera, B.M.6
  • 43
    • 66049155827 scopus 로고    scopus 로고
    • Novel d-conopeptides and their precursors identified by cDNA cloning define the d-conotoxin superfamily
    • Loughnan M., Nicke A., Lawrence N., and Lewis R. Novel d-conopeptides and their precursors identified by cDNA cloning define the d-conotoxin superfamily. Biochemistry 48 (2009) 3717-3729
    • (2009) Biochemistry , vol.48 , pp. 3717-3729
    • Loughnan, M.1    Nicke, A.2    Lawrence, N.3    Lewis, R.4
  • 45
    • 33747080261 scopus 로고    scopus 로고
    • Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern
    • Peng C., Tang S., Pi C., Liu J., Wang F., Wang L., Zhou W., and Xu A. Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern. Peptides 27 (2006) 2174-2181
    • (2006) Peptides , vol.27 , pp. 2174-2181
    • Peng, C.1    Tang, S.2    Pi, C.3    Liu, J.4    Wang, F.5    Wang, L.6    Zhou, W.7    Xu, A.8
  • 46
    • 34547637063 scopus 로고    scopus 로고
    • alphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists
    • Jimenez E.C., Olivera B.M., and Teichert R.W. alphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry 46 (2007) 8717-8724
    • (2007) Biochemistry , vol.46 , pp. 8717-8724
    • Jimenez, E.C.1    Olivera, B.M.2    Teichert, R.W.3
  • 48
    • 44249086114 scopus 로고    scopus 로고
    • Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7
    • Fiedler B., Zhang M.M., Buczek O., Azam L., Bulaj G., Norton R.S., Olivera B.M., and Yoshikami D. Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochem Pharmacol 75 (2008) 2334-2344
    • (2008) Biochem Pharmacol , vol.75 , pp. 2334-2344
    • Fiedler, B.1    Zhang, M.M.2    Buczek, O.3    Azam, L.4    Bulaj, G.5    Norton, R.S.6    Olivera, B.M.7    Yoshikami, D.8
  • 50
    • 53749086169 scopus 로고    scopus 로고
    • Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA
    • Yao S., Zhang M.M., Yoshikami D., Azam L., Olivera B.M., Bulaj G., and Norton R.S. Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA. Biochemistry 47 (2008) 10940-10949
    • (2008) Biochemistry , vol.47 , pp. 10940-10949
    • Yao, S.1    Zhang, M.M.2    Yoshikami, D.3    Azam, L.4    Olivera, B.M.5    Bulaj, G.6    Norton, R.S.7
  • 52
    • 20444387572 scopus 로고    scopus 로고
    • Identification of a novel pharmacophore for peptide toxins interacting with K+ channels
    • Verdier L., Al-Sabi A., Rivier J.E., Olivera B.M., Terlau H., and Carlomagno T. Identification of a novel pharmacophore for peptide toxins interacting with K+ channels. J Biol Chem 280 (2005) 21246-21255
    • (2005) J Biol Chem , vol.280 , pp. 21246-21255
    • Verdier, L.1    Al-Sabi, A.2    Rivier, J.E.3    Olivera, B.M.4    Terlau, H.5    Carlomagno, T.6
  • 53
    • 52949118506 scopus 로고    scopus 로고
    • Conus venoms-a rich source of peptide-based therapeutics
    • Han T.S., Teichert R.W., Olivera B.M., and Bulaj G. Conus venoms-a rich source of peptide-based therapeutics. Curr Pharm Des 14 (2008) 2462-2479
    • (2008) Curr Pharm Des , vol.14 , pp. 2462-2479
    • Han, T.S.1    Teichert, R.W.2    Olivera, B.M.3    Bulaj, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.