Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern

Peptides

Volumn 27, Issue 9, 2006, Pages 2174-2181

  Peng, Can ^a   Tang, Shaojun ^a   Pi, Canhui ^a   Liu, Junliang ^a   Wang, Fang ^b   Wang, Lei ^a   Zhou, Wenliang ^b   Xu, Anlong ^a  

^a The Open Laboratory for Marine Functional Genomics of State High Tech Development Program   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cone snails; Conotoxin gene expression; Conus; Conus litteratus; Nicotinic acetylcholine receptor; Venom duct

Indexed keywords

ALPHA CONOTOXIN MII; COMPLEMENTARY DNA; CONOTOXIN; METHIONYLCYSTEINYLPROLYLPROLYLLEUCYLCYSTEINYLLYSYLPROLYLSERYLCYSTEINYL THREONYLASPARAGINYLCYSTEINAMIDE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALGESIC ACTIVITY; ANTINOCICEPTION; ARTICLE; CONE SNAIL; CONUS LITTERATUS; DNA LIBRARY; DRUG SYNTHESIS; GENE EXPRESSION; GENE SEQUENCE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SNAIL;

AMINO ACID SEQUENCE; ANIMALS; ANURA; BASE SEQUENCE; CELLS, CULTURED; CONOTOXINS; CYSTEINE; FEMALE; MICE; MOLECULAR SEQUENCE DATA; NICOTINIC ANTAGONISTS; RATS; RECEPTORS, NICOTINIC;

CONUS LITTERATUS; CONUS QUERCINUS; GASTROPODA;

EID: 33747080261     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2006.04.016     Document Type: Article

References (29)

1. Brown M.A., Begley G.S., Czerwiec E., Stenberg L.M., Jacobs M., Kalume D.E., et al. Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs γ-carboxylation. Biochemistry 44 (2005) 9150-9159
2. Buczek P., Buczek O., and Bulaj G. Total chemical synthesis and oxidative folding of δ-conotoxin PVIA containing an N-terminal propeptide. Biopolymers 80 (2005) 50-57
3. Buczek O., Olivera B.M., and Bulaj G. Propeptide does not act as an intramolecular chaperone but facilitates protein disulfide isomerase-assisted folding of a conotoxin precursor. Biochemistry 43 (2004) 1093-1101
4. Bulaj G., Buczek O., Goodsell I., Jimenez E.C., Kranski J., Nielsen J.S., et al. Efficient oxidative folding of conotoxins and the radiation of venomous cone snails. Proc Natl Acad Sci USA 100 Suppl 2 (2003) 14562-14568
5. Chagot B., Pimentel C., Dai L., Pil J., Tytgat J., Nakajima T., et al. An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis. Biochem J 388 (2005) 263-271
6. Chivian E., Roberts C.M., and Bernstein A.S. The threat to cone snails. Science 302 (2003) 391
7. Conticello S.G., Kowalsman N.D., Jacobsen C., Yudkovsky G., Sato K., Elazar Z., et al. The prodomain of a secreted hydrophobic mini-protein facilitates its export from the endoplasmic reticulum by hitchhiking on sorting receptors. J Biol Chem 278 (2003) 26311-26314
8. Corpuz G.P., Jacobsen R.B., Jimenez E.C., Watkins M., Walker C., Colledge C., et al. Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms. Biochemistry 44 (2005) 8176-8186
9. Di Angelantonio S., Matteoni C., Fabbretti E., and Nistri A. Molecular biology and electrophysiology of neuronal nicotinic receptors of rat chromaffin cells. Eur J Neurosci 17 (2003) 2313-2322
10. Fan C.X., Chen X.K., Zhang C., Wang L.X., Duan K.L., He L.L., et al. A Novel conotoxin from Conus betulinus, κ-BtX, unique in cysteine pattern and in function as a specific BK channel modulator. J Biol Chem 278 (2003) 12624-12633
11. Fuller E., Green B.R., Catlin P., Buczek O., Nielsen J.S., Olivera B.M., et al. Oxidative folding of conotoxins sharing an identical disulfide bridging framework. FEBS J 272 (2005) 1727-1738
12. Garrett J.E., Buczek O., Watkins M., Olivera B.M., and Bulaj G. Biochemical and gene expression analyses of conotoxins in Conus textile venom ducts. Biochem Biophys Res Commun 328 (2005) 362-367
13. Loughnan M.L., and Alewood P.F. Physico-chemical characterization and synthesis of neuronally active α-conotoxins. Eur J Biochem 271 (2004) 2294-2304
14. McIntosh J.M., Santos A.D., and Olivera B.M. Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes. Annu Rev Biochem 68 (1999) 59-88
15. Moller C., Rahmankhah S., Lauer-Fields J., Bubis J., Fields G.B., and Mari F. A novel conotoxin framework with a helix-loop-helix (Cs α/α) fold. Biochemistry 44 (2005) 15986-15996
16. Nelson L. Venomous snails: one slip, and you're dead. Nature 429 (2004) 798-799
17. Nicke A. Learning about structure and function of neuronal nicotinic acetylcholine receptors. Lessons from snails. Eur J Biochem 271 (2004) 2293
18. 4/7-conotoxin with an extended N-terminal sequence. J Biol Chem 278 (2003) 3137-3144
19. Olivera B.M. Conus venom peptides: reflections from the biology of clades and species. Annu Rev Ecol Syst 33 (2002) 25-47
20. Olivera B.M., and Cruz L.J. Conotoxins, in retrospect. Toxicon 39 (2001) 7-14
21. Olivera B.M., Rivier J., Clark C., Ramilo C.A., Corpuz G.P., Abogadie F.C., et al. Diversity of Conus neuropeptides. Science 249 (1990) 257-263
22. Ramilo C.A., Zafaralla G.C., Nadasdi L., Hammerland L.G., Yoshikami D., Gray W.R., et al. Novel α- and ω-conotoxins from Conus striatus venom. Biochemistry 31 (1992) 9919-9926
23. Shon K., Grilley M., Jacobsen R., Cartier G.E., Hopkins C., Gray W.R., et al. A noncompetitive peptide inhibitor of the nicotinic acetylcholine receptor from Conus purpurascens venom. Biochemistry 36 (1997) 9581-9587
24. Sollod B.L., Wilson D., Zhaxybayeva O., Gogarten J.P., Drinkwater R., and King G.F. Were arachnids the first to use combinatorial peptide libraries. Peptides 26 (2005) 131-139
25. Srinivasan K.N., Sivaraja V., Huys I., Sasaki T., Cheng B., Kumar T.K.S., et al. κ-Hefutoxin-1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function: importance of the functional diad in potassium channel selectivity. J Biol Chem 277 (2002) 30040-30047
26. Teichert R.W., Jimenez R.W., and Olivera B.M. αS-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors. Biochemistry 44 (2005) 7897-7902
27. Teichert R.W., Rivier J., Dykert J., Cervini L., Gulyas J., Bulaj G., et al. αA-conotoxin OIVA defines a new αA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors. Toxicon 44 (2004) 207-214
28. Terlau H., and Olivera B.M. Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol Rev 84 (2004) 41-68
29. Zafaralla G.C., Ramilo C., Gray W.R., Karlstrom R., Olivera B.M., and Cruz L.J. Phylogenetic specificity of cholinergic ligands: α-conotoxin SI. Biochemistry 27 (1988) 7102-7105