Inhibition of neuronal nicotinic acetylcholine receptor subtypes by α-conotoxin GID and analogues

Journal of Biological Chemistry

Volumn 284, Issue 8, 2009, Pages 4944-4951

  Millard, Emma L ^a   Nevin, Simon T ^a   Loughnan, Marion L ^a   Nicke, Annette ^b   Clark, Richard J ^a   Alewood, Paul F ^a   Lewis, Richard J ^a   Adams, David J ^a   Craik, David J ^a   Daly, Norelle L ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHRONIC PAIN; CONOTOXIN; CONOTOXINS; MAMMALIAN BRAIN; N-TERMINAL; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHR); PROLINE RESIDUES; SELECTIVE LIGANDS; SEQUENCE VARIATIONS; STRUCTURE ACTIVITY RELATIONSHIPS; THERAPEUTIC AGENTS; THERAPEUTIC APPLICATION; TRUNCATION MUTANTS;

AMINES; BINDING ENERGY; MAMMALS;

BINDING SITES;

ALANINE; ALPHA CONOTOXIN GID; ARGININE; ASPARAGINE; ASPARTIC ACID; BUNGAROTOXIN RECEPTOR; CHOLINERGIC RECEPTOR; CONOTOXIN; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA2; NICOTINIC RECEPTOR ALPHA4BETA2; PROLINE; UNCLASSIFIED DRUG; NICOTINIC RECEPTOR BLOCKING AGENT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHOLINERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN QUATERNARY STRUCTURE; RESIDUE ANALYSIS; STRUCTURE ACTIVITY RELATION; ANIMAL; BRAIN; CONUS SNAIL; GENETICS; METABOLISM; MISSENSE MUTATION; PROTEIN TERTIARY STRUCTURE; RAT; XENOPUS;

CONUS GEOGRAPHUS; MAMMALIA;

AMINO ACID SUBSTITUTION; ANIMALS; BRAIN; CONOTOXINS; CONUS SNAIL; MUTATION, MISSENSE; NICOTINIC ANTAGONISTS; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 64149099634     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804950200     Document Type: Article

References (39)

1. Dutton, J. L., and Craik, D. J. (2001) Curr. Med. Chem. 8, 327-344
2. McIntosh, J. M., Santos, A. D., and Olivera, B. M. (1999) Annu. Rev. Biochem. 68, 59-88
3. Dwoskin, L. P., and Crooks, P. A. (2001) J. Pharmacol. Exp. Ther. 298, 395-402
4. Dutertre, S., and Lewis, R. J. (2006) Biochem. Pharmacol. 72, 661-670
5. O'Neill, M. J., Murray, T. K., Lakics, V., Visanji, N. P., and Duty, S. (2002) Curr. Drug Targets CNS Neurol. Disord. 1, 399-411
6. Geerts, H., Finkel, L., Carr, R., and Spiros, A. (2002) J. Neural. Transm. Suppl. 203-216
7. Sciamanna, M. A., Griesmann, G. E., Williams, C. L., and Lennon, V. A. (1997) J. Neurochem. 69, 2302-2311
8. Codignola, A., McIntosh, J. M., Cattaneo, M. G., Vicentini, L. M., Clementi, F., and Sher, E. (1996) Neurosci. Lett. 206, 53-56
9. Nicke, A., Loughnan, M. L., Millard, E. L., Alewood, P. F., Adams, D. J., Daly, N. L., Craik, D. J., and Lewis, R. J. (2003) J. Biol. Chem. 278, 3137-3144
10. Lam, S., and Patel, P. N. (2007) Cardiol. Rev. 15, 154-161
11. Schnölzer, M., Alewood, P., Jones, A., Alewood, D., and Kent, S. B. H. (1992) Int. J. Pept. Protein Res. 40, 180-193
12. Bidlingmeyer, B. A., Cohen, S. A., and Tarvin, T. L. (1984) J. Chromatogr. 336, 93-104
13. Gloor, S., Pongs, O., and Schmalzing, G. (1995) Gene (Amst.) 160, 213-217
14. Nicke, A., Baumert, H. G., Rettinger, J., Eichele, A., Lambrecht, G., Mutschler, E., and Schmalzing, G. (1998) EMBO J. 17, 3016-3028
15. Dutertre, S., Nicke, A., and Lewis, R. J. (2005) J. Biol. Chem. 280, 30460-30468
16. Vibat, C. R., Lasalde, J. A., McNamee, M. G., and Ochoa, E. L. (1995) Cell. Mol. Neurobiol. 15, 411-425
17. Meyer, E. M., Kuryatov, A., Gerzanich, V., Lindstrom, J., and Papke, R. L. (1998) J. Pharmacol. Exp. Ther. 287, 918-925
18. Nevin, S. T., Clark, R. J., Klimis, H., Christie, M. J., Craik, D. J., and Adams, D. J. (2007) Mol. Pharmacol. 72, 1406-1410
19. Eccles, C., Guntert, P., Billeter, M., and Wüthrich, K. (1991) J. Biomol. NMR 1, 111-130
20. Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, pp. 117-176, Wiley-Interscience, New York
21. Guntert, P., Mumenthaler, C., and Wüthrich, K. (1997) J. Mol. Biol. 273, 283-298
22. Rice, L. M., and Brünger, A. T. (1994) Proteins 19, 277-290
23. Linge, J. P., and Nilges, M. (1999) J. Biomol. NMR 13, 51-59
24. Hutchinson, E. G., and Thornton, J. M. (1996) Protein Sci. 5, 212-220
25. Laskowski, R. A., Moss, D. S., and Thornton, J. M. (1993) J. Mol. Biol. 231, 1049-1067
26. Millard, E. L., Daly, N. L., and Craik, D. J. (2004) Eur. J. Biochem. 271, 2320-2326
27. Hu, S. H., Gehrmann, J., Alewood, P. F., Craik, D. J., and Martin, J. L. (1997) Biochemistry 36, 11323-11330
28. Jin, A. H., Brandstaetter, H., Nevin, S. T., Tan, C. C., Clark, R. J., Adams, D. J., Alewood, P. F., Craik, D. J., and Daly, N. L. (2007) BMC Struct. Biol. 7, 28
29. Gehrmann, J., Alewood, P. F., and Craik, D. J. (1998) J. Mol. Biol. 278, 401-415
30. Hill, J. M., Oomen, C. J., Miranda, L. P., Bingham, J. P., Alewood, P. F., and Craik, D. J. (1998) Biochemistry 37, 15621-15630
31. Kang, T. S., Vivekanandan, S., Jois, S. D., and Kini, R. M. (2005) Angew. Chem. Int. Ed. Engl. 44, 6333-6337
32. Everhart, D., Cartier, G. E., Malhotra, A., Gomes, A. V., McIntosh, J. M., and Luetje, C. W. (2004) Biochemistry 43, 2732-2737
33. Ellison, M., McIntosh, J. M., and Olivera, B. M. (2003) J. Biol. Chem. 278, 757-764
34. Celie, P. H. N., Kasheverov, I. E., Mordvintsev, D. Y., Hogg, R. C., van Nierop, P., van Elk, R., van Rossum-Fikkert, S. E., Zhmak, M. N., Bertrand, D., Tsetlin, V., Sixma, T. K., and Smit, A. B. (2005) Nat. Struct. Mol. Biol. 12, 582-588
35. Hansen, S. B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., and Bourne, Y. (2005) EMBO J. 24, 3635-3646
36. Ulens, C., Hogg, R. C., Celie, P. H., Bertrand, D., Tsetlin, V., Smit, A. B., and Sixma, T. K. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 3615-3620
37. Dutertre, S., and Lewis, R. J. (2004) Eur. J. Biochem. 271, 2327-2334
38. Fainzilber, M., Hasson, A., Oren, R., Burlingame, A. L., Gordon, D., Spira, M. E., and Zlotkin, E. (1994) Biochemistry 33, 9523-9529
39. Cartier, G. E., Yoshikami, D., Gray, W. R., Luo, S., Olivera, B. M., and McIntosh, J. M. (1996) J. Biol. Chem. 271, 7522-7528