Understanding the role of aneuploidy in tumorigenesis

Biochemical Society Transactions

Volumn 37, Issue 4, 2009, Pages 910-913

  Bannon, John H ^a   Mc Gee, Margaret M ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Aneuploidy; Centrosome; Genome stability; Mitotic checkpoint

Indexed keywords

ALPHA TUBULIN; ANTINEOPLASTIC AGENT; AURORA KINASE INHIBITOR; BETA TUBULIN; BRCA1 PROTEIN; CELL CYCLE PROTEIN 20; KINESIN SPINDLE PROTEIN; PACLITAXEL; UNCLASSIFIED DRUG;

ANEUPLOIDY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER GROWTH; CANCER THERAPY; CARCINOGENESIS; CELL CYCLE REGULATION; CELL FATE; CENTROSOME; CHROMOSOME DUPLICATION; CONFERENCE PAPER; DRUG DESIGN; DRUG TARGETING; GENOMIC INSTABILITY; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MICROTUBULE ORGANIZING CENTER; MITOSIS; MITOSIS INHIBITION; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; GENETICS; METABOLISM; NEOPLASM; PHYSIOLOGY; REVIEW;

ANEUPLOIDY; ANIMALS; CENTROSOME; GENOMIC INSTABILITY; HUMANS; NEOPLASMS;

EID: 70349335236     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0370910     Document Type: Conference Paper

References (47)

1. Boveri, T. (1914) Zur Frage der Entstehung maligner Tumoren, Gustav Fischer, Jena
2. Mao, Y., Abrieu, A. and Cleveland, D.W. (2003) Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. Cell 114, 87-98
3. Wassmann, K., Liberal, V. and Benzera, R. (2003) Mad2 phosphorylation regulates its association with Mad1 and the APC/C. EMBO J. 22, 797-806
4. Taylor, S.S., Scott, M.I. and Holland, A.J. (2004) The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation. Chromosome Res. 12, 599-616
5. Sudakin, V., Chan, G.K. and Yen, T.J. (2001) Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BubR1, Bub3, Cdc20 and Mad2. J. Cell Biol. 154, 925-936
6. Hwang, L.H., Lau, L.F., Smith, D.L., Mistrot, C.A., Hardwick, K.G., Hwang, E.S., Amon, A. and Murray, A.W. (1998) Budding yeast Cdc20: a target of the spindle checkpoint. Science 279, 1041-1044
7. Hoyt, M.A., Totis, L. and Roberts, B.T. (1991) S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66, 507-517
8. Weaver, B.A. and Cleveland, D.W. (2007) Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res. 67, 10103-10105
9. Weaver, B.A. and Cleveland, D.W. (2005) Decoding the links between mitosis, cancer, and chemotherapy: the mitotic checkpoint, adaptation, and cell death. Cancer Cell 8, 7-12
10. Jelluma, N., Brenkman, A.B., McLeod, I., Yates, 3rd, J.R., Cleveland, D.W., Medema, R.H. and Kops, G.J. (2008) Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS ONE 3, e2415
11. Weaver, B.A., Bonday, Z.Q., Putkey, F.R., Kops, G.J., Silk, A.D. and Cleveland, D.W. (2003) Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J. Cell Biol. 162, 551-563
12. Jegananthan, K., Malureanu, L., Baker, D.J., Abraham, S.C. and van Deursen, J.M. (2007) Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J. Cell Biol. 179, 255-267
13. Mao, Y., Abrieu, A. and Cleveland, D.W. (2003) Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. Cell 114, 87-98
14. Mao, Y., Desai, A. and Cleveland, D.W. (2005) Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J. Cell Biol. 170, 873-880
15. Michel, L.S., Liberal, V., Chatterjee, A., Kirchwegger, R., Pasche, B., Gerald, W., Dobles, M., Sorger, P.K., Murty, V.V. and Benezra, R. (2001) MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409, 355-359
16. Baker, D.J., Jeganathan, K.B., Cameron, J.D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R.B., de Groen, P.C., Roche, P. and van Deursen, J.M. (2004) BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat. Genet. 36, 744-749
17. Kops, G.J., Foltz, D.R. and Cleveland, D.W. (2004) Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc. Natl. Acad. Sci. U.S.A. 101, 8699-8704
18. Zheng, Y., Wong, M.L., Alberts, B. and Mitchison, T. (1995) Nucleation of microtubule assembly by a γ-tubulin-containing ring complex. Nature 378, 578-583
19. Rieder, C.L., Faruki, S. and Khodjakov, A. (2001) The centrosome in vertebrates: more than a microtubule-organizing center. Trends Cell Biol. 11, 413-419
20. Sankaran, S. and Parvin, J.D. (2006) Centrosome function in normal and tumor cells. J. Cell Biochem. 99, 1240-1250
21. Andersen, J.S., Wilkinson, C.J., Mayor, T., Mortensen, P., Nigg, E.A. and Mann, M. (2003) Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426, 570-574
22. Morris, V.B., Brammall, J., Noble, J. and Reddel, R. (2000) p53 localizes to the centrosomes and spindles of mitotic cells in the embryonic chick epiblast, human cell lines, and a human primary culture: an immunofluorescence study. Exp. Cell Res. 256, 122-130
23. Fisk, H.A., Mattison, C.P. and Winey, M. (2002) Centrosomes and tumour suppressors. Curr. Opin. Cell Biol. 14, 700-705
24. Haruka, S. and Maru, Y. (2007) LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin. FASEB J. 21, 2086-2100
25. Hsu, L.C. and White, R.L. (1998) BRCA1 is associated with the centrosome during mitosis. Proc. Natl. Acad. Sci. U.S.A. 95, 12983-12988
26. Marumoto, T., Honda, S., Hara, T., Nitta, M., Hirota, T., Kohmura, E. and Saya, H. (2003) Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J. Biol. Chem. 278, 51786-51795
27. Li, X., Sakashita, G., Matsuzaki, H., Sugimoto, K., Kimura, K., Hanaoka, F., Taniguchi, H., Furukawa, K. and Urano, T. (2004) Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J. Biol. Chem. 279, 47201-47211
28. Trachana, V., van Wely, K.H., Guerrero, A..A., Fütterer, A. and Martínez-A., C. (2007) Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability. Proc. Natl. Acad. Sci. U.S.A. 104, 2691-2696
29. Xu, Y.X. and Manley, J.L. (2007) The prolyl isomerase Pin1 functions in mitotic chromosome condensation. Mol. Cell 26, 287-300
30. Yeh, E.S. and Means, A.R. (2007) PIN1, the cell cycle and cancer. Nat. Rev. Cancer 7, 381-388
31. Yeh, E.S., Lew, B.O. and Means, A.R. (2006) The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. J. Biol. Chem. 281, 241-251
32. Ryo, A., Uemura, H., Ishiguro, H., Saitoh, T., Yamaguchi, A., Perrem, K., Kubota, Y., Lu, K.P. and Aoki, I. (2005) Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer. Clin. Cancer Res. 11, 7523-7531
33. Wulf, G.M., Ryo, A., Wulf, G.G., Lee, S.W., Niu, T., Petkova, V. and Lu, K.P. (2001) Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J. 20, 3459-3472
34. Mollinedo, F. and Gajate, C. (2003) Microtubules, microtubule-interfering agents and apoptosis. Apoptosis 8, 413-450
35. Jordan, M.A. and Wilson, L. (2004) Microtubules as a target for anticancer drugs. Nat. Rev. Cancer 4, 253-265
36. Blagosklonny, M.V. (2007) Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive events. Cell Cycle 6, 70-74
37. Vakifahmetoglu, H., Olsson, M. and Zhivotovsky, B. (2008) Death through a tragedy: mitotic catastrophe. Cell Death Differ. 15, 1153-1162
38. Li, F., Ambrosini, G., Chu, E.Y., Plescia, J., Tognin, S., Marchisio, P.C. and Altieri, D.C. (1998) Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396, 580-584
39. Puthalakath, H., Huang, D.C., O'Reilly, L.A., King, S.M. and Strasser, A. (1999) The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol. Cell 3, 287-296
40. Terradillos, O., Montessuit, S., Huang, D.C. and Martinou, J.C. (2002) Direct addition of BimL to mitochondria does not lead to cytochrome c release. FEBS Lett. 522, 29-34
41. Kanda, A., Kawai, H., Suto, S., Kitajima, S., Sato, S., Takata, T. and Tatsuka, M. (2005) Aurora-B/AIM-1 kinase activity is involved in Ras-mediated cell transformation. Oncogene 24, 7266-7272
42. Bischoff, J.R. and Plowman, G.D. (1999) The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell Biol. 9, 454-459
43. Giet, R. and Prigent, C. (1999) Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. J. Cell Sci. 112, 3591-3601
44. Adams, R.R., Carmena, M. and Earnshaw, W.C. (2001) Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol. 11, 49-54
45. Ditchfield, C., Johnson, V.L., Tighe, A., Ellston, R., Haworth, C., Johnson, T., Mortlock, A., Keen, N. and Taylor, S.S. (2003) Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 161, 267-280
46. Cox, C.D., Coleman, P.J., Breslin, M.J., Whitman, D.B., Garbaccio, R.M., Fraley, M.E., Buser, C.A., Walsh, E.S., Hamilton, K., Schaber, M.D. et al. (2008) Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1- methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5- dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. J. Med. Chem. 51, 4239-4252
47. Kaelin, Jr, W.G. (2005) The concept of synthetic lethality in the context of anticancer therapy. Nat. Rev. Cancer 5, 689-698