Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants

Journal of Biomedical Science

Volumn 16, Issue 1, 2009, Pages

  Yu, Yang ^a,b   Szczepek, Agnieszka J ^a   Haupt, Heidemarie ^a   Mazurek, Birgit ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GELDANAMYCIN; GENTAMICIN; HEAT SHOCK PROTEIN 70; MESSENGER RNA; BENZOQUINONE DERIVATIVE; HSPA1B PROTEIN, RAT; MACROCYCLIC LACTAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORTI ORGAN; DRUG ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HAIR CELL; IMMUNOFLUORESCENCE; NEWBORN; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE CELL; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; ORGAN CULTURE TECHNIQUE; PERCEPTION DEAFNESS; WISTAR RAT;

ANIMALIA; RATTUS;

ANIMALS; BENZOQUINONES; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENTAMICINS; HAIR CELLS, AUDITORY, INNER; HAIR CELLS, AUDITORY, OUTER; HEARING LOSS, SENSORINEURAL; HSP70 HEAT-SHOCK PROTEINS; LACTAMS, MACROCYCLIC; MICROSCOPY, CONFOCAL; ORGAN CULTURE TECHNIQUES; ORGAN OF CORTI; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 70349326087     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-16-79     Document Type: Article

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