Increased expression of heat shock protein (HSP)72 in a human proximal tubular cell line (HK-2) with gentamicin-induced injury

Journal of Toxicological Sciences

Volumn 31, Issue 1, 2006, Pages 61-70

  Zhipeng, Wang ^a   Li, Liu ^a   Qibing, Mei ^a   Linna, Liu ^a   Yuhua, Ran ^a   Rong, Zhang ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cytotoxicity; Gentamicin; Heat shock protein; Nephrotoxicity

Indexed keywords

GENTAMICIN; HEAT SHOCK PROTEIN 72; LACTATE DEHYDROGENASE; MALONALDEHYDE; MANGANESE CHLORIDE; N ACETYL BETA GLUCOSAMINIDASE; SUPEROXIDE DISMUTASE; TETRAZOLIUM;

ARTICLE; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; KIDNEY PROXIMAL TUBULE; OXIDATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 33644856223     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.31.61     Document Type: Article

References (29)

1. Abe, T., Gotoh, S. and Higashi, K. (1999): Higher induction of heat shock protein 72 by heat stress in cisplatin-resistant than in cisplatin-sensitive cancer cells. Biochim Biophys Acta Gene Struct. Expr., 1445, 123-133.
2. Ali, B.H., Al-Qarawi, A.A. and Mousa, H.M. (2002): The effect of calcium load and the calcium channel blocker verapamil on gentamicin nephrotoxicity in rats. Food Chem. Toxicol., 40, 1843-1847.
3. Baliga, R., Ueda, N., Walker, P.D. and Shah, S.V. (1999): Oxidant mechanisms in toxic acute renal failure. Drug Metab. Rev., 31, 971-997.
4. Bennet, W.M., Elliot, W.C.D., Houghton, C., Gilbert, D.N., Fehr, J. De and McCarron, D.A. (1982): Reduction of experimental gentamicin nephrotoxicity in rats by dietary calcium loading. Antimicrob. Agents Chemother., 22. 508-512.
5. Brown, M.A., Upender, R.P., Hightower, L.E. and Renfro, J.I. (1992): Thermoprotection of functional epithelium:Heat stress effects on transepithelial transport by flounder renal tubule in primary monolayer culture. Proc. Natl. Acad. Sci. USA., 89, 3246-3250.
6. 2+ in liver of cadmium-intoxicated rats. Comp. Biochem. Physiol. Part C 133, 625-632.
7. Donati, Y.R.A., Slosman, D.O. and Polla, B.S. (1990): Oxidative injury and the heat shock response. Biochem. Pharmacol., 40, 2571-2577.
8. Draper, H.H. and Hadley, M. (1990): Malondialdehyde determination as an index of lipid peroxidation, Methods in Enzymology, 186, 421-431.
9. Eisenberg, J.M., Koffer, H., Glick, H.A., Connell, M.L., Loss, L.E., Talbot, G.H., Shusterman, N.H. and Strom, B.L. (1987): What is the cost of nephrotoxicity associated with aminoglycosides. Ann. Intern. Med., 107, 900-909.
10. Emami, A., Schwartz, J.H. and Borkan, S.C. (1991): Transient ischemia or heat stress induces a cytoprotectant protein in rat kidney. A.m. J. Physiol., 260, F479-F485.
11. Freeman, B.C. and Morimoto, R.I. (1996): The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding. The EMBO Journal, 15, 2969-2979.
12. Itoh, H and Tashima, Y. (1991): The stress (heat shock) proteins. Int J Biochem., 23, 1185-1191.
13. Karl, Y.H. and Lucia, B.H. (1982): Inhibition of Kidney Lysosomal Phospholipases A and C by Aminoglycoside Antibiotics: Possible Mechanism of Aminoglycoside Toxicity. Proc. Natl. Acad. Sci. U. S. A., 79, 1663-1667.
14. Komatsuda, A., Wakui, H., Oyama, Y., Imai, H., Miura, A.B., Itoh, H. and Tashima, Y. (1999): Overexpression of the human 72 kDa heat shock protein in renal tubular cells confers resistance against oxidative injury and cisplatin toxicity. Nephrol. Dial. Transplant., 14, 1385-1390.
15. Komatsuda, A., Wakui, H., Satoh, K., Yasuda, T., Imai, H., Nakamoto, Y., Miura, A. B., Itoh, H. and Tashima, Y. (1993): Altered localization of 73-kilodalton heat-shock protein in rat kidneys with gentamicin-induced acute tubular injury. Lab. Invest., 68, 687-695.
16. Li, C.-Y., Suardet, L. and Little, J. B. (1995): Potential role of WAF1/Cip1/p21 as a mediator of TGF-β cytoinhibitory effect. J. Biol. Chem., 270, 4971-4974.
17. Lindquist, S. (1980): Varying patterns of protein synthesis in Drosophila during heat shock: implications for regulation. Dev. Biol., 77, 463-479.
18. Martinez-Salgado, C., Eleno, N., Morales, A.I., Perez-Barriocanal, F., Arevalo, M. and Lopez-Novoa, J.M. (2004): Gentamicin treatment induces simultaneous mesangial proliferation and apoptosis in rats. Kidney Int., 65, 2161-2171.
19. Miyazaki, T., Sagawa, R., Honma, T., Noguchi, S., Harada, T., Komatsuda, A., Ohtani, H., Wakui, H., Sagawa, K., Otaka, M., Watanabe, S., Jikei, M., Ogawa, N., Hamada, F. and Itoh, H. (2004): 73-kDa Molecular Chaperone HSP73 Is a Direct Target of Antibiotic Gentamicin. J. Biol. Chem. 279, 17295-17300.
20. Morita, K., Wakui, H., Komatsuda, A., Ohtani, H., Miura, A.B., Ith, H. and Tashima, Y. (1995): Induction of heat-shock proteins HSP73 and HSP90 in rat kidneys after ischemia. Ren Fail., 17, 405-419.
21. Nadia, R., Gianfranco, T. and Elisabetta, C. (2002): Influence of Different Chemicals on MDR-1 P-Glycoprotein Expression and Activity in the HK-2 Proximal Tubular Cell Line. Toxicol. and applied pharmcol., 183, 83-91.
22. Polla, B.S., Kantengwa, S., Francois, D., Salvioli, S., Franceschi, C., Marsac, C. and Cossarizza, A. (1996). Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. Proc. Natl. Acad. Sci. USA., 93, 6458-6463.
23. Ryan, M.J., Johnson, G., Kirk, J., Fuerstenberg, S.M., Zager, R.A. and Torok-Storb, B. (1994): HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int., 45, 48-57.
24. Satoh, K., Wakui, H., Komatsuda, A, Nakamoto, Y., Miura, A.B., Ith, H. and Tashima ,Y. (1994): Induction and altered localization of 90-kDa heat-shock protein in rat kidneys with cisplatin-induced acute renal failure. Renal. Fail., 16, 313-323.
25. Turman, M.A. and Rosenfeld, S.L. (1999): Heat shock protein 70 overexpression protects LLC-PK1 tubular cells from heat shock but not hypoxia. Kidney Int ., 55, 189-197.
26. Van Why, S.K., Hildebrandt, F., Ardito, T., Mann, A.S., Siegel, N.J. and Kashgarian, M. (1992): Induction and intracellular localization of HSP72 after renal ischemia. Am. J. Physiol., 263, F769-F775.
27. Walker, P.D., Barri, Y. and Shah, S.V. (1999): Oxidant mechanisms in gentamicin nephrotoxicity. Ren Fail., 21, 433-442.
28. Zheng, W., Ren, S. and Graziano, J.H. (1998): Manganese inhibits mitochondrial aconitase: A mechanism of manganese neurotoxicity. Brain Res., 799, 334-342.
29. Zhou, H., Kato, A., Yasuda, H., Odamaki, M., Itoh, H. and Hishida, A. (2003): The induction of heat shock protein-72 attenuates cisplatin-induced acute renal failure in rats. Journal of Physiology, 446, 116-124.