-
1
-
-
2342590065
-
The global burden of asthma: Executive summary of the GINA Dissemination Committee report
-
Masoli, M., Fabian, D., Holt, S. and Beasley, R. (2004) The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 59, 469-478
-
(2004)
Allergy
, vol.59
, pp. 469-478
-
-
Masoli, M.1
Fabian, D.2
Holt, S.3
Beasley, R.4
-
2
-
-
33846017302
-
Severe asthma: Lessons from the Severe Asthma Research Program
-
Wenzel, S.E. and Busse, W.W. (2007) Severe asthma: lessons from the Severe Asthma Research Program. J. Allergy Clin. Immunol. 119, 14-21
-
(2007)
J. Allergy Clin. Immunol
, vol.119
, pp. 14-21
-
-
Wenzel, S.E.1
Busse, W.W.2
-
3
-
-
62549084077
-
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-α blockade in severe persistent asthma
-
Wenzel, S.E., Barnes, P.J., Bleecker, E.R., Bousquet, J., Busse, W., Dahlen, S.E., Holgate, S.T., Meyers, D.A., Rabe, K.F. and Antczak, A. (2009) A randomized, double-blind, placebo-controlled study of tumor necrosis factor-α blockade in severe persistent asthma. Am. J. Respir. Crit. Care Med. 179, 549-558
-
(2009)
Am. J. Respir. Crit. Care Med
, vol.179
, pp. 549-558
-
-
Wenzel, S.E.1
Barnes, P.J.2
Bleecker, E.R.3
Bousquet, J.4
Busse, W.5
Dahlen, S.E.6
Holgate, S.T.7
Meyers, D.A.8
Rabe, K.F.9
Antczak, A.10
-
4
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
Haldar, P., Brightling, C.E., Hargadon, B., Gupta, S., Monteiro, W., Sousa, A., Marshall, R.P., Bradding, P., Green, R.H., Wardlaw, A.J. and Pavord, I.D. (2009) Mepolizumab and exacerbations of refractory eosinophilic asthma. N. Engl. J. Med. 360, 973-984
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 973-984
-
-
Haldar, P.1
Brightling, C.E.2
Hargadon, B.3
Gupta, S.4
Monteiro, W.5
Sousa, A.6
Marshall, R.P.7
Bradding, P.8
Green, R.H.9
Wardlaw, A.J.10
Pavord, I.D.11
-
5
-
-
61849155730
-
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
-
Nair, P., Pizzichini, M.M., Kjarsgaard, M., Inman, M.D., Efthimiadis, A., Pizzichini, E., Hargreave, F.E. and O'Byrne, P.M. (2009) Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N. Engl. J. Med. 360, 985-993
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 985-993
-
-
Nair, P.1
Pizzichini, M.M.2
Kjarsgaard, M.3
Inman, M.D.4
Efthimiadis, A.5
Pizzichini, E.6
Hargreave, F.E.7
O'Byrne, P.M.8
-
6
-
-
6444222929
-
New drugs for asthma
-
Barnes, P.J. (2004) New drugs for asthma. Nat. Rev. Drug Discov. 3, 831-844
-
(2004)
Nat. Rev. Drug Discov
, vol.3
, pp. 831-844
-
-
Barnes, P.J.1
-
7
-
-
40849117947
-
Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems
-
De Bosscher, K., Van, C.K., Meijer, O.C. and Haegeman, G. (2008) Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems. Eur. J. Pharmacol. 583, 290-302
-
(2008)
Eur. J. Pharmacol
, vol.583
, pp. 290-302
-
-
De Bosscher, K.1
Van, C.K.2
Meijer, O.C.3
Haegeman, G.4
-
8
-
-
33845987340
-
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
-
Moore, W.C., Bleecker, E.R., Curran-Everett, D., Erzurum, S.C., Ameredes, B.T., Bacharier, L., Calhoun, W.J., Castro, M., Chung, K.F. and Clark, M.P. (2007) Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J. Allergy Clin. Immunol. 119, 405-413
-
(2007)
J. Allergy Clin. Immunol
, vol.119
, pp. 405-413
-
-
Moore, W.C.1
Bleecker, E.R.2
Curran-Everett, D.3
Erzurum, S.C.4
Ameredes, B.T.5
Bacharier, L.6
Calhoun, W.J.7
Castro, M.8
Chung, K.F.9
Clark, M.P.10
-
9
-
-
42149156064
-
Steroid resistance in asthma: Mechanisms and treatment options
-
Adcock, I.M., Ford, P.A., Bhavsar, P., Ahmad, T. and Chung, K.F. (2008) Steroid resistance in asthma: mechanisms and treatment options. Curr. Allergy Asthma Rep. 8, 171-178
-
(2008)
Curr. Allergy Asthma Rep
, vol.8
, pp. 171-178
-
-
Adcock, I.M.1
Ford, P.A.2
Bhavsar, P.3
Ahmad, T.4
Chung, K.F.5
-
10
-
-
52049113214
-
New targets for drug development in asthma
-
Adcock, I.M., Caramori, G. and Chung, K.F. (2008) New targets for drug development in asthma. Lancet 372, 1073-1087
-
(2008)
Lancet
, vol.372
, pp. 1073-1087
-
-
Adcock, I.M.1
Caramori, G.2
Chung, K.F.3
-
11
-
-
34447318645
-
Epithelial cell proliferation contributes to airway remodeling in severe asthma
-
Cohen, L., E, X., Tarsi, J., Ramkumar, T., Horiuchi, T.K., Cochran, R., DeMartino, S., Schechtman, K.B., Hussain, I., Holtzman, M.J. and Castro, M. (2007) Epithelial cell proliferation contributes to airway remodeling in severe asthma. Am. J. Respir. Crit. Care Med. 176, 138-145
-
(2007)
Am. J. Respir. Crit. Care Med
, vol.176
, pp. 138-145
-
-
Cohen, L.E.X.1
Tarsi, J.2
Ramkumar, T.3
Horiuchi, T.K.4
Cochran, R.5
DeMartino, S.6
Schechtman, K.B.7
Hussain, I.8
Holtzman, M.J.9
Castro, M.10
-
12
-
-
0036231010
-
p38 mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma
-
Irusen, E., Matthews, J.G., Takahashi, A., Barnes, P.J., Chung, K.F. and Adcock, I.M. (2002) p38 mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J. Allergy Clin. Immunol. 109, 649-657
-
(2002)
J. Allergy Clin. Immunol
, vol.109
, pp. 649-657
-
-
Irusen, E.1
Matthews, J.G.2
Takahashi, A.3
Barnes, P.J.4
Chung, K.F.5
Adcock, I.M.6
-
13
-
-
2342567291
-
Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients
-
Matthews, J.G., Ito, K., Barnes, P.J. and Adcock, I.M. (2004) Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J. Allergy Clin. Immunol. 113, 1100-1108
-
(2004)
J. Allergy Clin. Immunol
, vol.113
, pp. 1100-1108
-
-
Matthews, J.G.1
Ito, K.2
Barnes, P.J.3
Adcock, I.M.4
-
14
-
-
51249109929
-
Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared to non-severe asthma
-
Bhavsar, P., Hew, M., Khorasani, N., Torrego, A., Barnes, P.J., Adcock, I.M. and Chung, K.F. (2008) Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared to non-severe asthma. Thorax 63, 784-790
-
(2008)
Thorax
, vol.63
, pp. 784-790
-
-
Bhavsar, P.1
Hew, M.2
Khorasani, N.3
Torrego, A.4
Barnes, P.J.5
Adcock, I.M.6
Chung, K.F.7
-
15
-
-
49449089908
-
Molecular mechanisms of corticosteroid resistance
-
Adcock, I.M. and Barnes, P.J. (2008) Molecular mechanisms of corticosteroid resistance. Chest 134, 394-401
-
(2008)
Chest
, vol.134
, pp. 394-401
-
-
Adcock, I.M.1
Barnes, P.J.2
-
16
-
-
3442876677
-
Dysfunctional interaction of C/EBPα and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells
-
Roth, M., Johnson, P.R., Borger, P., Bihl, M.P., Rudiger, J.J., King, G.G., Ge, Q., Hostettler, K., Burgess, J.K., Black, J.L. and Tamm, M. (2004) Dysfunctional interaction of C/EBPα and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. N. Engl. J. Med. 351, 560-574
-
(2004)
N. Engl. J. Med
, vol.351
, pp. 560-574
-
-
Roth, M.1
Johnson, P.R.2
Borger, P.3
Bihl, M.P.4
Rudiger, J.J.5
King, G.G.6
Ge, Q.7
Hostettler, K.8
Burgess, J.K.9
Black, J.L.10
Tamm, M.11
-
17
-
-
26844520628
-
Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients
-
Hakonarson, H., Bjornsdottir, U.S., Halapi, E., Bradfield, J., Zink, F., Mouy, M., Helgadottir, H., Gudmundsdottir, A.S., Andrason, H. and Adalsteinsdottir, A.E. (2005) Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients. Proc. Natl. Acad. Sci. U.S.A. 102, 14789-14794
-
(2005)
Proc. Natl. Acad. Sci. U.S.A
, vol.102
, pp. 14789-14794
-
-
Hakonarson, H.1
Bjornsdottir, U.S.2
Halapi, E.3
Bradfield, J.4
Zink, F.5
Mouy, M.6
Helgadottir, H.7
Gudmundsdottir, A.S.8
Andrason, H.9
Adalsteinsdottir, A.E.10
-
18
-
-
0037248247
-
Update on glucocorticoid action and resistance
-
Leung, D.Y. and Bloom, J.W. (2003) Update on glucocorticoid action and resistance. J. Allergy Clin. Immunol. 111, 3-22
-
(2003)
J. Allergy Clin. Immunol
, vol.111
, pp. 3-22
-
-
Leung, D.Y.1
Bloom, J.W.2
-
19
-
-
33644834415
-
Increased glucocorticoid receptor β alters steroid response in glucocorticoid-insensitive asthma
-
Goleva, E., Li, L.B., Eves, P.T., Strand, M.J., Martin, R.J. and Leung, D.Y. (2006) Increased glucocorticoid receptor β alters steroid response in glucocorticoid-insensitive asthma. Am. J. Respir. Crit. Care Med. 173, 607-616
-
(2006)
Am. J. Respir. Crit. Care Med
, vol.173
, pp. 607-616
-
-
Goleva, E.1
Li, L.B.2
Eves, P.T.3
Strand, M.J.4
Martin, R.J.5
Leung, D.Y.6
-
20
-
-
33947247588
-
Human glucocorticoid receptor β binds RU-486 and is transcriptionally active
-
Lewis-Tuffin, L.J., Jewell, C.M., Bienstock, R.J., Collins, J.B. and Cidlowski, J.A. (2007) Human glucocorticoid receptor β binds RU-486 and is transcriptionally active. Mol. Cell. Biol. 27, 2266-2282
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 2266-2282
-
-
Lewis-Tuffin, L.J.1
Jewell, C.M.2
Bienstock, R.J.3
Collins, J.B.4
Cidlowski, J.A.5
-
21
-
-
41549119065
-
Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways
-
Liu, W., Liang, Q., Balzar, S., Wenzel, S., Gorska, M. and Alam, R. (2008) Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways. J. Allergy Clin. Immunol. 121, 893-902
-
(2008)
J. Allergy Clin. Immunol
, vol.121
, pp. 893-902
-
-
Liu, W.1
Liang, Q.2
Balzar, S.3
Wenzel, S.4
Gorska, M.5
Alam, R.6
-
22
-
-
59149087048
-
IFN-γ reverses IL-2- and IL-4-mediated T-cell steroid resistance
-
Goleva, E., Li, L.B. and Leung, D.Y. (2009) IFN-γ reverses IL-2- and IL-4-mediated T-cell steroid resistance. Am. J. Respir. Cell Mol. Biol. 40, 223-230
-
(2009)
Am. J. Respir. Cell Mol. Biol
, vol.40
, pp. 223-230
-
-
Goleva, E.1
Li, L.B.2
Leung, D.Y.3
-
23
-
-
54449097818
-
Role of dual specificity phosphatases in biological responses to glucocorticoids
-
Clark, A.R., Martins, J.R. and Tchen, C.R. (2008) Role of dual specificity phosphatases in biological responses to glucocorticoids. J. Biol. Chem. 283, 25765-25769
-
(2008)
J. Biol. Chem
, vol.283
, pp. 25765-25769
-
-
Clark, A.R.1
Martins, J.R.2
Tchen, C.R.3
-
24
-
-
33746674992
-
Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients
-
Loke, T.K., Mallett, K.H., Ratoff, J., O'Connor, B.J., Ying, S., Meng, Q., Soh, C., Lee, T.H. and Corrigan, C.J. (2006) Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients. J. Allergy Clin. Immunol. 118, 368-375
-
(2006)
J. Allergy Clin. Immunol
, vol.118
, pp. 368-375
-
-
Loke, T.K.1
Mallett, K.H.2
Ratoff, J.3
O'Connor, B.J.4
Ying, S.5
Meng, Q.6
Soh, C.7
Lee, T.H.8
Corrigan, C.J.9
-
25
-
-
33745746529
-
Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma
-
Hew, M., Bhavsar, P., Torrego, A., Meah, S., Khorasani, N., Barnes, P.J., Adcock, I. and Chung, K.F. (2006) Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am. J. Respir. Crit. Care Med. 174, 134-141
-
(2006)
Am. J. Respir. Crit. Care Med
, vol.174
, pp. 134-141
-
-
Hew, M.1
Bhavsar, P.2
Torrego, A.3
Meah, S.4
Khorasani, N.5
Barnes, P.J.6
Adcock, I.7
Chung, K.F.8
-
26
-
-
33751104763
-
Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease
-
Bilodeau, S., Vallette-Kasic, S., Gauthier, Y., Figarella-Branger, D., Brue, T., Berthelet, F., Lacroix, A., Batista, D., Stratakis, C. and Hanson, J. (2006) Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease. Genes Dev. 20, 2871-2886
-
(2006)
Genes Dev
, vol.20
, pp. 2871-2886
-
-
Bilodeau, S.1
Vallette-Kasic, S.2
Gauthier, Y.3
Figarella-Branger, D.4
Brue, T.5
Berthelet, F.6
Lacroix, A.7
Batista, D.8
Stratakis, C.9
Hanson, J.10
-
27
-
-
58749085209
-
Oral prednisolone for preschool children with acute virus-induced wheezing
-
Panickar, J., Lakhanpaul, M., Lambert, P.C., Kenia, P., Stephenson, T., Smyth, A. and Grigg, J. (2009) Oral prednisolone for preschool children with acute virus-induced wheezing. N. Engl. J. Med. 360, 329-338
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 329-338
-
-
Panickar, J.1
Lakhanpaul, M.2
Lambert, P.C.3
Kenia, P.4
Stephenson, T.5
Smyth, A.6
Grigg, J.7
-
28
-
-
58749100297
-
Preemptive use of high-dose fluticasone for virus-induced wheezing in young children
-
Ducharme, F.M., Lemire, C., Noya, F.J., Davis, G.M., Alos, N., Leblond, H., Savdie, C., Collet, J.P., Khomenko, L., Rivard, G. and Platt, R.W. (2009) Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. N. Engl. J. Med. 360, 339-353
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 339-353
-
-
Ducharme, F.M.1
Lemire, C.2
Noya, F.J.3
Davis, G.M.4
Alos, N.5
Leblond, H.6
Savdie, C.7
Collet, J.P.8
Khomenko, L.9
Rivard, G.10
Platt, R.W.11
-
29
-
-
26144467138
-
Rhinovirus infection reduces glucocorticoid receptor nuclear translocation in airway epithelial cells
-
Bellattato, C., Adcock, I.M., Ito, K., Caramori, G., Casolari, P., Ciaccia, A., Barnes, P.J., Johnston, S.L. and Papi, A. (2003) Rhinovirus infection reduces glucocorticoid receptor nuclear translocation in airway epithelial cells. Eur. Respir. J. 22, (Suppl.), 565S
-
(2003)
Eur. Respir. J
, vol.22
, Issue.SUPPL.
-
-
Bellattato, C.1
Adcock, I.M.2
Ito, K.3
Caramori, G.4
Casolari, P.5
Ciaccia, A.6
Barnes, P.J.7
Johnston, S.L.8
Papi, A.9
-
30
-
-
33745742455
-
Effects of smoking cessation on lung function and airway inflammation in smokers with asthma
-
Chaudhuri, R., Livingston, E., McMahon, A.D., Lafferty, J., Fraser, I., Spears, M., McSharry, C.P. and Thomson, N.C. (2006) Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am. J. Respir. Crit. Care Med. 174, 127-133
-
(2006)
Am. J. Respir. Crit. Care Med
, vol.174
, pp. 127-133
-
-
Chaudhuri, R.1
Livingston, E.2
McMahon, A.D.3
Lafferty, J.4
Fraser, I.5
Spears, M.6
McSharry, C.P.7
Thomson, N.C.8
-
31
-
-
24144465889
-
Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors
-
Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R.K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M.G. and Glass, C.K. (2005) Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors. Cell 122, 707-721
-
(2005)
Cell
, vol.122
, pp. 707-721
-
-
Ogawa, S.1
Lozach, J.2
Benner, C.3
Pascual, G.4
Tangirala, R.K.5
Westin, S.6
Hoffmann, A.7
Subramaniam, S.8
David, M.9
Rosenfeld, M.G.10
Glass, C.K.11
-
32
-
-
44649131942
-
Nuclear receptors: Doubling up in the lung
-
Farrow, S.N. (2008) Nuclear receptors: doubling up in the lung. Curr. Opin. Pharmacol. 8, 275-279
-
(2008)
Curr. Opin. Pharmacol
, vol.8
, pp. 275-279
-
-
Farrow, S.N.1
-
33
-
-
67650617728
-
Bronchodilatory effect of the PPAR-γ agonist rosiglitazone in smokers with asthma
-
Spears, M., Donnelly, I., Jolly, L., Brannigan, M., Ito, K., McSharry, C., Lafferty, J., Chaudhuri, R., Braganza, G. and Bareille, P. (2009) Bronchodilatory effect of the PPAR-γ agonist rosiglitazone in smokers with asthma. Clin. Pharmacol. Ther. 86, 49-53
-
(2009)
Clin. Pharmacol. Ther
, vol.86
, pp. 49-53
-
-
Spears, M.1
Donnelly, I.2
Jolly, L.3
Brannigan, M.4
Ito, K.5
McSharry, C.6
Lafferty, J.7
Chaudhuri, R.8
Braganza, G.9
Bareille, P.10
-
34
-
-
34249742714
-
Chronic obstructive pulmonary disease: A growing but neglected global epidemic
-
Barnes, P.J. (2007) Chronic obstructive pulmonary disease: a growing but neglected global epidemic. PLoS Med. 4, e112
-
(2007)
PLoS Med
, vol.4
-
-
Barnes, P.J.1
-
35
-
-
33750620057
-
Oxidative stress and redox regulation of lung inflammation in COPD
-
Rahman, I. and Adcock, I.M. (2006) Oxidative stress and redox regulation of lung inflammation in COPD. Eur. Respir. J. 28, 219-242
-
(2006)
Eur. Respir. J
, vol.28
, pp. 219-242
-
-
Rahman, I.1
Adcock, I.M.2
-
36
-
-
36249008584
-
Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma
-
Singh, D., Richards, D., Knowles, R.G., Schwartz, S., Woodcock, A., Langley, S. and O'Connor, B.J. (2007) Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. Am. J. Respir. Crit. Care Med. 176, 988-993
-
(2007)
Am. J. Respir. Crit. Care Med
, vol.176
, pp. 988-993
-
-
Singh, D.1
Richards, D.2
Knowles, R.G.3
Schwartz, S.4
Woodcock, A.5
Langley, S.6
O'Connor, B.J.7
-
37
-
-
59649102494
-
-
Kent, L.M., Smyth, L.J., Plumb, J., Clayton, C.L., Fox, S.M., Ray, D.W., Farrow, S.N. and Singh, D. (2009) Inhibition of lipopolysaccharidestimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4- (4-fluoro-2-methylphenyl)-7-oxo-7,8- dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504). J. Pharmacol. Exp. Ther. 328, 458-468
-
Kent, L.M., Smyth, L.J., Plumb, J., Clayton, C.L., Fox, S.M., Ray, D.W., Farrow, S.N. and Singh, D. (2009) Inhibition of lipopolysaccharidestimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4- (4-fluoro-2-methylphenyl)-7-oxo-7,8- dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504). J. Pharmacol. Exp. Ther. 328, 458-468
-
-
-
-
38
-
-
0242441578
-
Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD
-
Culpitt, S.V., Rogers, D.F., Fenwick, P.S., Shah, P., De Matos, C., Russell, R.E., Barnes, P.J. and Donnelly, L.E. (2003) Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD. Thorax 58, 942-946
-
(2003)
Thorax
, vol.58
, pp. 942-946
-
-
Culpitt, S.V.1
Rogers, D.F.2
Fenwick, P.S.3
Shah, P.4
De Matos, C.5
Russell, R.E.6
Barnes, P.J.7
Donnelly, L.E.8
-
39
-
-
51249121642
-
Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2
-
Meja, K.K., Rajendrasozhan, S., Adenuga, D., Biswas, S.K., Sundar, I.K., Spooner, G., Marwick, J.A., Chakravarty, P., Fletcher, D. and Whittaker, P. (2008) Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am. J. Respir. Cell Mol. Biol. 39, 312-323
-
(2008)
Am. J. Respir. Cell Mol. Biol
, vol.39
, pp. 312-323
-
-
Meja, K.K.1
Rajendrasozhan, S.2
Adenuga, D.3
Biswas, S.K.4
Sundar, I.K.5
Spooner, G.6
Marwick, J.A.7
Chakravarty, P.8
Fletcher, D.9
Whittaker, P.10
-
40
-
-
31344446119
-
Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression
-
Ito, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P.J. and Adcock, I.M. (2006) Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression. J. Exp. Med. 203, 7-13
-
(2006)
J. Exp. Med
, vol.203
, pp. 7-13
-
-
Ito, K.1
Yamamura, S.2
Essilfie-Quaye, S.3
Cosio, B.4
Ito, M.5
Barnes, P.J.6
Adcock, I.M.7
-
41
-
-
21044458874
-
Decreased histone deacetylase activity in chronic obstructive pulmonary disease
-
Ito, K., Ito, M., Elliott, W.M., Cosio, B., Caramori, G., Kon, O.M., Barczyk, A., Hayashi, S., Adcock, I.M., Hogg, J.C. and Barnes, P.J. (2005) Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N. Engl. J. Med. 352, 1967-1976
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 1967-1976
-
-
Ito, K.1
Ito, M.2
Elliott, W.M.3
Cosio, B.4
Caramori, G.5
Kon, O.M.6
Barczyk, A.7
Hayashi, S.8
Adcock, I.M.9
Hogg, J.C.10
Barnes, P.J.11
-
42
-
-
34247500507
-
New molecular targets for the treatment of neutrophilic diseases
-
Barnes, P.J. (2007) New molecular targets for the treatment of neutrophilic diseases. J. Allergy Clin. Immunol. 119, 1055-1062
-
(2007)
J. Allergy Clin. Immunol
, vol.119
, pp. 1055-1062
-
-
Barnes, P.J.1
-
43
-
-
0037445151
-
Theophylline: New perspectives for an old drug
-
Barnes, P.J. (2003) Theophylline: new perspectives for an old drug. Am. J. Respir. Crit. Care Med. 167, 813-818
-
(2003)
Am. J. Respir. Crit. Care Med
, vol.167
, pp. 813-818
-
-
Barnes, P.J.1
-
44
-
-
56249130433
-
Oxidative stress modulates theophylline effects on steroid responsiveness
-
Marwick, J.A., Wallis, G., Meja, K., Kuster, B., Bouwmeester, T., Chakravarty, P., Fletcher, D., Whittaker, P.A., Barnes, P.J. and Ito, K. (2008) Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem. Biophys. Res. Commun. 377, 797-802
-
(2008)
Biochem. Biophys. Res. Commun
, vol.377
, pp. 797-802
-
-
Marwick, J.A.1
Wallis, G.2
Meja, K.3
Kuster, B.4
Bouwmeester, T.5
Chakravarty, P.6
Fletcher, D.7
Whittaker, P.A.8
Barnes, P.J.9
Ito, K.10
-
45
-
-
65749115739
-
The role of animal models in the pharmacological evaluation of emerging anti-inflammatory agents for the treatment of COPD
-
Fox, J.C. and Fitzgerald, M.F. (2009) The role of animal models in the pharmacological evaluation of emerging anti-inflammatory agents for the treatment of COPD. Curr. Opin. Pharmacol. 9, 231-242
-
(2009)
Curr. Opin. Pharmacol
, vol.9
, pp. 231-242
-
-
Fox, J.C.1
Fitzgerald, M.F.2
-
46
-
-
66049156186
-
Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of chronic obstructive pulmonary disease
-
Cosio, B.G., Iglesias, A., Rios, A., Noguera, A., Sala, E., Ito, K., Barnes, P.J. and Agusti, A. (2009) Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of chronic obstructive pulmonary disease. Thorax 64, 424-429
-
(2009)
Thorax
, vol.64
, pp. 424-429
-
-
Cosio, B.G.1
Iglesias, A.2
Rios, A.3
Noguera, A.4
Sala, E.5
Ito, K.6
Barnes, P.J.7
Agusti, A.8
-
47
-
-
53649087728
-
A clinical trial demonstrating that low dose theophylline attenuates steroid insensitivity in COPD
-
Ford, P.A., Durham, A.L., Russell, R.E., Adcock, I.M. and Barnes, P.J. (2008) A clinical trial demonstrating that low dose theophylline attenuates steroid insensitivity in COPD. Am. J. Respir. Crit. Care Med. 177, A651
-
(2008)
Am. J. Respir. Crit. Care Med
, vol.177
-
-
Ford, P.A.1
Durham, A.L.2
Russell, R.E.3
Adcock, I.M.4
Barnes, P.J.5
-
48
-
-
66749146095
-
Effect of theophylline plus beclometasone on lung function in smokers with asthma: A pilot study
-
Spears, M., Donnelly, I., Jolly, L., Brannigan, M., Ito, K., McSharry, C., Lafferty, J., Chaudhuri, R., Braganza, G. and Adcock, I.M. (2009) Effect of theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. Eur. Respir. J. 33, 1010-1017
-
(2009)
Eur. Respir. J
, vol.33
, pp. 1010-1017
-
-
Spears, M.1
Donnelly, I.2
Jolly, L.3
Brannigan, M.4
Ito, K.5
McSharry, C.6
Lafferty, J.7
Chaudhuri, R.8
Braganza, G.9
Adcock, I.M.10
-
49
-
-
65249151877
-
Inhibition of PI3Kα restores glucocorticoid function in smoking-induced airway inflammation in mice
-
Marwick, J.A., Caramori, G., Stevenson, C.S., Casolari, P., Jazrawi, E., Barnes, P.J., Ito, K., Adcock, I.M., Kirkham, P.A. and Papi, A. (2009) Inhibition of PI3Kα restores glucocorticoid function in smoking-induced airway inflammation in mice. Am. J. Respir. Crit. Care Med. 179, 542-548
-
(2009)
Am. J. Respir. Crit. Care Med
, vol.179
, pp. 542-548
-
-
Marwick, J.A.1
Caramori, G.2
Stevenson, C.S.3
Casolari, P.4
Jazrawi, E.5
Barnes, P.J.6
Ito, K.7
Adcock, I.M.8
Kirkham, P.A.9
Papi, A.10
-
50
-
-
34250218888
-
Oxidative stress and steroid resistance in asthma and COPD: Pharmacological manipulation of HDAC2 as a therapeutic strategy
-
Marwick, J.A., Ito, K., Adcock, I.M. and Kirkham, P.A. (2007) Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC2 as a therapeutic strategy. Expert Opin. Ther. Targets 11, 745-755
-
(2007)
Expert Opin. Ther. Targets
, vol.11
, pp. 745-755
-
-
Marwick, J.A.1
Ito, K.2
Adcock, I.M.3
Kirkham, P.A.4
|