메뉴 건너뛰기




Volumn 20, Issue 8, 2009, Pages 736-745

Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells

Author keywords

All trans retinoic acid; Breast cancer differentiation; Chloroquine; Histone acetylation; Hydroxychloroquine

Indexed keywords

CHLOROQUINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIMETHYL SULFOXIDE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE H3; HISTONE H4; HYDROXYCHLOROQUINE; PROTEIN P300; RETINOIC ACID;

EID: 70349319850     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e32832f4e50     Document Type: Article
Times cited : (86)

References (51)
  • 1
    • 38949144400 scopus 로고    scopus 로고
    • Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes
    • Klimek VM, Fircanis S, Maslak P, Guernah I, Baum M, Wu N, et al. Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes. Clin Cancer Res 2008; 14:826-832.
    • (2008) Clin Cancer Res , vol.14 , pp. 826-832
    • Klimek, V.M.1    Fircanis, S.2    Maslak, P.3    Guernah, I.4    Baum, M.5    Wu, N.6
  • 2
    • 38949146399 scopus 로고    scopus 로고
    • A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors
    • Steele NL, Plumb JA, Vidal L, Tjornelund J, Knoblauch P, Rasmussen A, et al. A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors. Clin Cancer Res 2008; 14:804-810.
    • (2008) Clin Cancer Res , vol.14 , pp. 804-810
    • Steele, N.L.1    Plumb, J.A.2    Vidal, L.3    Tjornelund, J.4    Knoblauch, P.5    Rasmussen, A.6
  • 3
    • 34347375106 scopus 로고    scopus 로고
    • Epigenetic drugs as pleiotripic agents in cancer treatment: Biomolecular aspects and clinical applications
    • Sigalotti L, Fratta E, Coral S, Cortini E, Covre A, Nicolay HJM, et al. Epigenetic drugs as pleiotripic agents in cancer treatment: biomolecular aspects and clinical applications. J Cell Physiol 2007; 212:330-344.
    • (2007) J Cell Physiol , vol.212 , pp. 330-344
    • Sigalotti, L.1    Fratta, E.2    Coral, S.3    Cortini, E.4    Covre, A.5    Nicolay, H.J.M.6
  • 4
    • 21244464349 scopus 로고    scopus 로고
    • Phase i study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer
    • Kelly WK, O'Connor OA, Krug LM, Chiao JH, Heaney M, Curley T, et al. Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer. J Clin Oncol 2005; 23:3923-3931.
    • (2005) J Clin Oncol , vol.23 , pp. 3923-3931
    • Kelly, W.K.1    O'Connor, O.A.2    Krug, L.M.3    Chiao, J.H.4    Heaney, M.5    Curley, T.6
  • 5
    • 33645950778 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Multifunctional anticancer agents
    • Liu T, Kuljaca S, Tee A, Marshall GM. Histone deacetylase inhibitors: multifunctional anticancer agents. Cancer Treat Rep 2006; 32:157-165.
    • (2006) Cancer Treat Rep , vol.32 , pp. 157-165
    • Liu, T.1    Kuljaca, S.2    Tee, A.3    Marshall, G.M.4
  • 8
    • 0038485588 scopus 로고    scopus 로고
    • Role of caspases, bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA)
    • Henderson C, Mizzau M, Paroni G, Maestro R, Schneider C, Brancolini C. Role of caspases, bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). J Biol Chem 2003; 278:12579-12589.
    • (2003) J Biol Chem , vol.278 , pp. 12579-12589
    • Henderson, C.1    Mizzau, M.2    Paroni, G.3    Maestro, R.4    Schneider, C.5    Brancolini, C.6
  • 9
    • 34547684065 scopus 로고    scopus 로고
    • HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination
    • Boyault C, Sadoul K, Paabion M, Khochbin S. HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene 2007; 26:5468-5476.
    • (2007) Oncogene , vol.26 , pp. 5468-5476
    • Boyault, C.1    Sadoul, K.2    Paabion, M.3    Khochbin, S.4
  • 11
    • 0035300564 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells
    • Munster PN, Srethapakdi M, Moasser MM, Rosen N. Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells. Cancer Res 2001; 61:2945-2952.
    • (2001) Cancer Res , vol.61 , pp. 2945-2952
    • Munster, P.N.1    Srethapakdi, M.2    Moasser, M.M.3    Rosen, N.4
  • 12
    • 0034889853 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 and retinoic acid analogues induce differentiation in breast cancer cells with function-and cell-specific additive effects
    • Wang Q, Lee D, Sysounthone V, Chandraratna RAS, Christakos S, Korah R, Wieder R. 1,25-Dihydroxyvitamin D3 and retinoic acid analogues induce differentiation in breast cancer cells with function-and cell-specific additive effects. Breast Cancer Res Treat 2001; 67:157-168.
    • (2001) Breast Cancer Res Treat , Issue.67 , pp. 157-168
    • Wang, Q.1    Lee, D.2    Sysounthone, V.3    Chandraratna, R.A.S.4    Christakos, S.5    Korah, R.6    Wieder, R.7
  • 13
    • 0035477320 scopus 로고    scopus 로고
    • Synergistic activation of functional estrogen receptor (ER)-a by DNA methyltransferase and histone deacetylase inhibitors in human ER-a-negative breast cancer cells
    • Yang X, Phillips DL, Fergusson AT, Nelson WG, Herman JG, Davidson NE. Synergistic activation of functional estrogen receptor (ER)-a by DNA methyltransferase and histone deacetylase inhibitors in human ER-a-negative breast cancer cells. Cancer Res 2001; 61:7025-7029.
    • (2001) Cancer Res , vol.61 , pp. 7025-7029
    • Yang, X.1    Phillips, D.L.2    Fergusson, A.T.3    Nelson, W.G.4    Herman, J.G.5    Davidson, N.E.6
  • 14
    • 0031665586 scopus 로고    scopus 로고
    • Inhibition of cancer cell growth by all-trans retinoic acid and its analog N-(4-hydroxyphenyl)retinamide: A possible mechanism of action via regulation of retinoid receptor expression
    • Liu G, Wu M, Levi G, Ferrari N. Inhibition of cancer cell growth by all-trans retinoic acid and its analog N-(4-hydroxyphenyl)retinamide: a possible mechanism of action via regulation of retinoid receptor expression. Int J Cancer 1998; 78:248-254.
    • (1998) Int J Cancer , vol.78 , pp. 248-254
    • Liu, G.1    Wu, M.2    Levi, G.3    Ferrari, N.4
  • 15
    • 34447130284 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors deliver their therapeutic benefit by targeting the cell cycle
    • Gabrielli BG. Histone deacetylase inhibitors deliver their therapeutic benefit by targeting the cell cycle. Amer Assoc Cancer Res Education Book 2006; 318-321.
    • (2006) Amer Assoc Cancer Res Education Book , pp. 318-321
    • Gabrielli, B.G.1
  • 16
    • 0034596309 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
    • Marks PA, Richon VM, Rifkind RA. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst 2000; 92:1210-1216.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1210-1216
    • Marks, P.A.1    Richon, V.M.2    Rifkind, R.A.3
  • 17
    • 44849089422 scopus 로고    scopus 로고
    • HADA2a and hADA3: New players in beta catenin signaling
    • Lopez C, Alumkal J, Van Hook K. hADA2a and hADA3: new players in beta catenin signaling. Cancer Biol Ther 2008; 7:129-130.
    • (2008) Cancer Biol Ther , vol.7 , pp. 129-130
    • Lopez, C.1    Alumkal, J.2    Van Hook, K.3
  • 18
    • 15944406847 scopus 로고    scopus 로고
    • 0-deoxycytidine, restores expression of silenced retinoic acid receptor beta2 in breast cancer cells
    • Morgan NP, Gudas LJ. Valproic acid, in combination with all-trans retinoic acid and-aza-20-deoxycytidine, restores expression of silenced retinoic acid receptor beta2 in breast cancer cells. Mol Cancer Ther 2005; 4:477-486.
    • (2005) Mol Cancer Ther , vol.4 , pp. 477-486
    • Morgan, N.P.1    Gudas, L.J.2
  • 20
    • 0036837245 scopus 로고    scopus 로고
    • Myc protein is differentially sensitive to quinidine in tumor versus immortalized breast epithelial cell lines
    • Melkoumian ZK, Martirosyan AR, Strobl JS. Myc protein is differentially sensitive to quinidine in tumor versus immortalized breast epithelial cell lines. Int J Cancer 2002; 102:60-69.
    • (2002) Int J Cancer , vol.102 , pp. 60-69
    • Melkoumian, Z.K.1    Martirosyan, A.R.2    Strobl, J.S.3
  • 21
    • 0034634635 scopus 로고    scopus 로고
    • Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1
    • Zhou Q, Melkoumian ZK, Lucktong A, Moniwa M, Davie JR, Strobl JS. Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1. J Biol Chem 2000; 275:35256-35263.
    • (2000) J Biol Chem , vol.275 , pp. 35256-35263
    • Zhou, Q.1    Melkoumian, Z.K.2    Lucktong, A.3    Moniwa, M.4    Davie, J.R.5    Strobl, J.S.6
  • 22
    • 0036714228 scopus 로고    scopus 로고
    • Control of mammary tumor cell growth in vitro by novel cell differentiation and apoptosis agents
    • Zhou Q, McCracken MA, Strobl JS. Control of mammary tumor cell growth in vitro by novel cell differentiation and apoptosis agents. Breast Cancer Res Treat 2002; 75:107-117.
    • (2002) Breast Cancer Res Treat , vol.75 , pp. 107-117
    • Zhou, Q.1    McCracken, M.A.2    Strobl, J.S.3
  • 23
  • 24
    • 38149141767 scopus 로고    scopus 로고
    • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
    • Maclean KH, Dorsey FC, Cleveland JL, Kastan MB. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest 2008; 118:79-88.
    • (2008) J Clin Invest , vol.118 , pp. 79-88
    • MacLean, K.H.1    Dorsey, F.C.2    Cleveland, J.L.3    Kastan, M.B.4
  • 25
    • 38149136611 scopus 로고    scopus 로고
    • Antimalarial therapy prevents Myc-induced lymphoma
    • Dang CV. Antimalarial therapy prevents Myc-induced lymphoma. J Clin Invest 2008; 118:15-17.
    • (2008) J Clin Invest , vol.118 , pp. 15-17
    • Dang, C.V.1
  • 26
    • 37549032143 scopus 로고    scopus 로고
    • Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis
    • Loehberg CR, Thompson T, Kastan MB, Maclean KH, Edwards DG, Kittrell FS, et al. Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. Cancer Res 2007; 67:12026-12033.
    • (2007) Cancer Res , vol.67 , pp. 12026-12033
    • Loehberg, C.R.1    Thompson, T.2    Kastan, M.B.3    MacLean, K.H.4    Edwards, D.G.5    Kittrell, F.S.6
  • 27
    • 0036011169 scopus 로고    scopus 로고
    • Hydroxychloroquine-induced apoptosis of chronic lymphocytic leukemia involves activation of caspase-3 and modulation of Bcl-2/bax ratio
    • Lagneaux L, Delforge A, Dejeneffe M, Massy M, Bernier M, Bron D. Hydroxychloroquine-induced apoptosis of chronic lymphocytic leukemia involves activation of caspase-3 and modulation of Bcl-2/bax ratio. Leuk Lymphoma 2002; 43:1087-1095.
    • (2002) Leuk Lymphoma , vol.43 , pp. 1087-1095
    • Lagneaux, L.1    Delforge, A.2    Dejeneffe, M.3    Massy, M.4    Bernier, M.5    Bron, D.6
  • 28
    • 0030483522 scopus 로고    scopus 로고
    • Inhibition of HIV-1 replication by hydroxychloroquine: Mechanism of action and comparison with zidovudine
    • Chiang G, Sassaroli M, Louie M, Chen H, Stecher VJ, Sperber VK. Inhibition of HIV-1 replication by hydroxychloroquine: mechanism of action and comparison with zidovudine. Clin Ther 1996; 18:1080-1092.
    • (1996) Clin Ther , vol.18 , pp. 1080-1092
    • Chiang, G.1    Sassaroli, M.2    Louie, M.3    Chen, H.4    Stecher, V.J.5    Sperber, V.K.6
  • 30
    • 34347394714 scopus 로고    scopus 로고
    • Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance
    • Carew JS, Nawrocki ST, Kahue CN, Zhang H, Yang C, Chung L, et al. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 2007; 110:313-322.
    • (2007) Blood , vol.110 , pp. 313-322
    • Carew, J.S.1    Nawrocki, S.T.2    Kahue, C.N.3    Zhang, H.4    Yang, C.5    Chung, L.6
  • 31
    • 0036272067 scopus 로고    scopus 로고
    • Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis
    • Munster T, Gibbs JP, Shen D, Baethge BA, Botstein GR, Caldwell J, et al. Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis. Arthritis Rheum 2002; 46:1460-1469.
    • (2002) Arthritis Rheum , vol.46 , pp. 1460-1469
    • Munster, T.1    Gibbs, J.P.2    Shen, D.3    Baethge, B.A.4    Botstein, G.R.5    Caldwell, J.6
  • 32
    • 0026533695 scopus 로고
    • Chloroquine levels in blood during chronic treatment of patients with rheumatoid arthritis
    • Augustijns P, Geusens P, Verbeke N. Chloroquine levels in blood during chronic treatment of patients with rheumatoid arthritis. Eur J Clin Pharmacol 1992; 42:429-433.
    • (1992) Eur J Clin Pharmacol , vol.42 , pp. 429-433
    • Augustijns, P.1    Geusens, P.2    Verbeke, N.3
  • 33
    • 0033044368 scopus 로고    scopus 로고
    • Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: A randomized, double-blind six week trial with 18-week extension
    • Furst DE, Lindsley H, Baethqe BA, Botstein GR, Caldwell J, Dietz F, Ettlinger R. Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: a randomized, double-blind six week trial with 18-week extension. Arthritis Rheum 1999; 42:357-365.
    • (1999) Arthritis Rheum , vol.42 , pp. 357-365
    • Furst, D.E.1    Lindsley, H.2    Baethqe, B.A.3    Botstein, G.R.4    Caldwell, J.5    Dietz, F.6    Ettlinger, R.7
  • 34
    • 0035174411 scopus 로고    scopus 로고
    • Factors associated with low bone mineral density in female patients with systemic lupus erythematosus
    • Lakshminarayanan S,Walsh S, Mohanraj M, Rothfield N. Factors associated with low bone mineral density in female patients with systemic lupus erythematosus. J Rheumatol 2001; 28:102-108.
    • (2001) J Rheumatol , vol.28 , pp. 102-108
    • Lakshminarayanan, S.1    Walsh, S.2    Mohanraj, M.3    Rothfield, N.4
  • 35
    • 14744275269 scopus 로고    scopus 로고
    • Bone mineral density in postmenopausal Chinese patients with systemic lupus erythematosus
    • Mok CC, Mak A, Ma KM. Bone mineral density in postmenopausal Chinese patients with systemic lupus erythematosus. Lupus 2005; 14:106-112.
    • (2005) Lupus , vol.14 , pp. 106-112
    • Mok, C.C.1    Mak, A.2    Ma, K.M.3
  • 36
    • 0031795268 scopus 로고    scopus 로고
    • The cell death response to gamma-radiation in MCF-7 cells is enhanced by a neuroleptic drug, pimozide
    • Strobl JS, Melkoumian Z, Peterson VA, Hylton H. The cell death response to gamma-radiation in MCF-7 cells is enhanced by a neuroleptic drug, pimozide. Breast Cancer Res Treat 1998; 51:83-95.
    • (1998) Breast Cancer Res Treat , vol.51 , pp. 83-95
    • Strobl, J.S.1    Melkoumian, Z.2    Peterson, V.A.3    Hylton, H.4
  • 37
  • 38
    • 33645869877 scopus 로고    scopus 로고
    • Actions of a histone deacetylase inhibitor (NSC3852) (5-nitroso-8- quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells
    • Martirosyan A, Leonard S, Shi X, Griffith B, Gannett P, Strobl J. Actions of a histone deacetylase inhibitor (NSC3852) (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells. J Pharmacol Expt Ther 2006; 317:546-552.
    • (2006) J Pharmacol Expt Ther , vol.317 , pp. 546-552
    • Martirosyan, A.1    Leonard, S.2    Shi, X.3    Griffith, B.4    Gannett, P.5    Strobl, J.6
  • 39
    • 0023183168 scopus 로고
    • Proliferation index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical-pathological variables
    • Barnard NJ, Hall PA, Lemoine NR, Kadar N. Proliferation index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical-pathological variables. J Pathol 1987; 152:287-295.
    • (1987) J Pathol , vol.152 , pp. 287-295
    • Barnard, N.J.1    Hall, P.A.2    Lemoine, N.R.3    Kadar, N.4
  • 41
    • 33644970102 scopus 로고    scopus 로고
    • Chloroquine inhibits growth and induces death in A549 lung cancer cells
    • Fan C, Wang W, Zhao B, Zhang S, Miao J. Chloroquine inhibits growth and induces death in A549 lung cancer cells. Bioorg Med Chem 2006; 14:3218-3222.
    • (2006) Bioorg Med Chem , vol.14 , pp. 3218-3222
    • Fan, C.1    Wang, W.2    Zhao, B.3    Zhang, S.4    Miao, J.5
  • 42
    • 50349093480 scopus 로고    scopus 로고
    • The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine
    • Hu C, Solomon VR, Ulibarri G, Lee H. The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. Bioorg Med Chem 2008; 16:7888-7893.
    • (2008) Bioorg Med Chem , vol.16 , pp. 7888-7893
    • Hu, C.1    Solomon, V.R.2    Ulibarri, G.3    Lee, H.4
  • 43
    • 33847685719 scopus 로고    scopus 로고
    • Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme
    • Briceno E, Calderon A, Sotelo J. Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme. Surg Neurol 2007; 67:388-391.
    • (2007) Surg Neurol , vol.67 , pp. 388-391
    • Briceno, E.1    Calderon, A.2    Sotelo, J.3
  • 44
    • 0036652176 scopus 로고    scopus 로고
    • Histoneacetylation and deacetylation: Identification of acetylation and methylation sites of HeLa histone H4 by mass spectrometry
    • Zhang K, Williams KE, Huang L, Yau P, Siino JS, Bradbury EM, et al. Histoneacetylation and deacetylation: identification of acetylation and methylation sites of HeLa histone H4 by mass spectrometry. Mol Cell Proteomics 2002; 1:500-508.
    • (2002) Mol Cell Proteomics , vol.1 , pp. 500-508
    • Zhang, K.1    Williams, K.E.2    Huang, L.3    Yau, P.4    Siino, J.S.5    Bradbury, E.M.6
  • 45
    • 23744453206 scopus 로고    scopus 로고
    • A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast
    • Ornaghi P, Rotili D, Sbardella G, Mai A, Filetici P. A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast. Biochem Pharmacol 2005; 70:911-917.
    • (2005) Biochem Pharmacol , vol.70 , pp. 911-917
    • Ornaghi, P.1    Rotili, D.2    Sbardella, G.3    Mai, A.4    Filetici, P.5
  • 47
    • 34748861551 scopus 로고    scopus 로고
    • Characterization of novel inhibitors of histone acetyltransferase
    • Eliseeva ED, Valkov V, Jung M, Jung MO. Characterization of novel inhibitors of histone acetyltransferase. Mol Cancer Ther 2007; 6:2391-2398.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2391-2398
    • Eliseeva, E.D.1    Valkov, V.2    Jung, M.3    Jung, M.O.4
  • 50
    • 35348979623 scopus 로고    scopus 로고
    • Retinoic acid receptor-beta silences human papilloma virus-18 oncogene expression by induction of de novo methylation and heterochromatization of the viral control region
    • Arce JD, Gockel-Krzikalla E, Rosl F. Retinoic acid receptor-beta silences human papilloma virus-18 oncogene expression by induction of de novo methylation and heterochromatization of the viral control region. J Biol Chem 2007; 282:28520-28529.
    • (2007) J Biol Chem , vol.282 , pp. 28520-28529
    • Arce, J.D.1    Gockel-Krzikalla, E.2    Rosl, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.