Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model

Biochemical Pharmacology

Volumn 68, Issue 9, 2004, Pages 1729-1738

  Martirosyan, Anna R ^a   Rahim Bata, Rayhana ^a   Freeman, Andrew B ^a   Clarke, Charles D ^a   Howard, Rachael L ^a   Strobl, Jeannine S ^a,b  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

Author keywords

3 (4,5 dimethylthiazol 2 yl) 5 (3 carboxylmethoxyphenyl) 2 (4 sulfophenyl) 2H tetrazolium; Amodiaquin; HDAC; histone deacetylase; MTS; PAMPA; parallel artificial membrane permeation assay; Rb; retinoblastoma protein

Indexed keywords

1 [2,8 BIS(TRIFLUOROMETHYL) 4 QUINOLINYL] 3 (TERT BUTYLAMINO) 1 PROPANOL; 2 [2 (8 HYDROXY 5 METHYL 7 QUINOLYL)VINYL] 1,6 DIMETHYL IODIDE; 4 [2 (2,5 DIMETHOXYPHENYL)VINYL]QUINOLINE; 5 NITROSO 8 QUINOLINOL; AMODIAQUINE; ANTINEOPLASTIC AGENT; CHLOROQUINE; HALOFANTRINE; HISTONE DEACETYLASE; HYDROXYCHLOROQUINE; KI 67 ANTIGEN; MEFLOQUINE; NSC 305819; NSC 3852; NSC 69603; NSC 86371; PRIMAQUINE; QUINIDINE; QUININE; QUINOLINE; QUINOLINE DERIVATIVE; QUINOLINIC ACID; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CANCER THERAPY; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DRUG ACTIVITY; DRUG DESIGN; DRUG INDICATION; DRUG MECHANISM; DRUG POTENCY; ENZYME ASSAY; ENZYME INHIBITION; EXPERIMENTAL MODEL; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID STORAGE; PHARMACODYNAMICS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL CYCLE PROTEINS; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; HELA CELLS; HISTONE DEACETYLASES; HUMANS; QUINOLINES; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 4644330224     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.05.003     Document Type: Article

References (22)

1. Marks P.A., Rifkind R.A., Richon V.M., Breslow R. Inhibitors of histone deacetylase are potentially effective anticancer agents. Clin. Cancer Res. 7:2001;759-760
2. Vigushin D.M., Coombes R.C. Histone deacetylase inhibitors in cancer treatment. Anti-cancer Drugs. 13:2002;1-13
3. Weidle U.H., Grossmann A. Inhibtion of histone deacetylases: a new strategy to target epigenetic modifications for anticancer treatment. Anticancer Res. 20:2000;1471-1486
4. Marks P.A., Richon V.M., Rifkind R.A. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J. Natl. Cancer Inst. 92:2000;1210-1216
5. Darkin-Rattray S.J., Gurnett A.M., Myers R.M., Dulski P.M., Crumley T.M., Allocco J.J., et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc. Natl. Acad. Sci. (U.S.A.). 93:1996;13143-13147
6. Furumai R., Matsuyama A., Kobashi N., Lee K.-H., Nishiyama M., Nakajima H., et al. FK228 (Depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res. 62:2002;4916-4921
7. Zhou Q., Melkoumian Z.K., Lucktong A., Moniwa M., Davie J.R., Strobl J.S. Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1. J. Biol. Chem. 275:2000;35256-35263
8. Melkoumian Z.K., Martirosyan A.R., Strobl J.S. Myc protein is differentially sensitive to quinidine in tumor versus immortalized breast epithelial cell lines. Int. J. Cancer. 102:2002;60-69
9. Zhou Q., McCracken M.A., Strobl J.S. Control of mammary tumor cell growth in vitro by novel cell differentiation and apoptosis agents. Breast Cancer Res. Treat. 75:2001;107-117
10. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl. Acid Res. 11:1983;1475-1489
11. Mehta R.R., Bratescu L., Graves J.M., Green A., Mehta R.G. Differentiation of cultured human breast carcinoma cells by a novel Vitamin D analog: 1-alpha-hydroxyVitamin D5. Int. J. Oncol. 16:2000;65-73
12. Munster P.N., Troso-Sandoval T., Rosen N., Rifkind R., Marks P.A., Richon V.M. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells. Cancer Res. 61:2001;8492-8497
13. Van Dierendonck J.H., Keijzer R., Van de Velde C.J., Cornelisse C.J. Nuclear distribution of the Ki-67 antigen during the cell cycle: comparison with growth fraction in human breast cancer cells. Cancer Res. 49:1989;2999-3006
14. Trimarchi J.M., Lees J.A. Sibling rivalry in the E2F family. Nat. Rev. Mol. Cell Biol. 3:2002;11-20
15. Lipinski C.A., Lombardo F., Dominy B.W., Feeney P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Res. 23:1997;3-25
16. Hidalgo I.J. Assessing the absorption of new pharmaceuticals. Curr. Top. Med. Chem. 1:2001;385-401
17. Dick F.A., Dyson N. pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. Mol. Cell. 12:2003;639-649
18. Wong C.F., Barnes L.M., Dahler A.L., Smith L., Serewko-Auret M.M., Popa C., et al. E2F modulates keratinocyte squamous differentiation: implications for E2F inhibition in squamous cell carcinoma. J. Biol. Chem. 278:2003;28516-28522
19. D'Alo F., Johansen L.M., Nelson E.A., Radomska H.S., Evans E.K., Zhang P., et al. The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells. Blood. 102:2003;3163-3171
20. Orr M.S., Watson N.C., Sundaram S., Randolph J.K., Jain P.T., Gewirtz D.A. Ionizing radiation and teniposide increase p21/waf1/cip1 and promote Rb dephosphorylation but fail to suppress E2F activity in MCF-7 breast tumor cells. Mol. Pharmacol. 52:1997;373-379
21. Brehm A., Miska E.A., McCance D.J., Reid J.L., Bannister A.J., Kouzarides T. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature. 391:1998;597-601
22. Morrison A.J., Sardet C., Herrera R.E. Retinoblastoma protein transcriptional repression through histone deacetylation of a single nucleosome. Mol. Cell Biol. 22:2002;856-865