Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 3, 2007, Pages 1109-1111

  Smith, Aaron T ^a   Livingston, Meredith R ^a   Mai, Antonello ^b   Filetici, Patrizia ^b   Queener, Sherry F ^a   Sullivan Jr , William J ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE ACETYLTRANSFERASE GCN5; MC 1626; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

APICOPLAST; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; NONHUMAN; PLASTID; PRIORITY JOURNAL; TACHYZOITE; TOXOPLASMA GONDII; WESTERN BLOTTING;

ANIMALS; ANTIPROTOZOAL AGENTS; ENZYME INHIBITORS; HISTONE ACETYLTRANSFERASES; ORGANELLES; QUINOLINES; SACCHAROMYCES CEREVISIAE; TOXOPLASMA;

EID: 33847681408     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01256-06     Document Type: Article

References (18)

1. Balasubramanyam, K., M. Altaf, R. A. Varier, V. Swaminathan, A. Ravindran, P. P. Sadhale, and T. K. Kimdu. 2004. Polyisoprenylated benzophenone, garcinol, a natural historic acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J. Biol. Chem. 279: 33716-33726.
2. Balasubramanyam, K., V. Swaminathan, A. Ranganathan, and T. K. Kundu. 2003. Small molecule modulators of histone acetyltransferase p300. J. Biol. Chem. 278:19134-19140.
3. Balasubramanyam, K., R. A. Varier, M. Altaf, V. Swaminathan, N. B. Siddappa, U. Ranga, and T. K. Kundu. 2004. Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase- dependent chromatin transcription. J. Biol. Chem. 279:51163-51171.
4. Bhatti, M. M., M. Livingston, N. Mullapudi, and W. J. Sullivan, Jr. 2006. Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii. Eukaryot. Cell 5:62-76.
5. Biel, M., A. Kretsovali, E. Karatzali, J. Papamatheakis, and A. Giannis. 2004. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5. Angew. Chem. Int. Ed. Engl. 43:3974-3976.
6. Black, M. W., and J. C. Boothroyd. 2000. Lytic cycle of Toxoplasma gondii. Microbiol. Mol. Biol. Rev. 64:607-623.
7. Brownell, J. E., J. Zhou, T. Ranalli, R. Kobayashi, D. G. Edmondson, S. Y. Roth, and C. D. Allis. 1996. Tetrahymena histone acetyltransferase A: a homolog to yeast Gen5p linking histone acetylation to gene activation. Cell 84:843-851.
8. Davis, P. K., and R. K. Brackmann. 2003. Chromatin remodeling and cancer. Cancer Biol. Ther. 2:22-29.
9. Fichera, M. E., and D. S. Roos. 1997. A plastid organelle as a drug target in apicomplexan parasites. Nature 390:407-409.
10. Köhler, S., C. F. Delwiche, P. W. Denny, L. G. Tilney, P. Webster, R. J. Wilson, J. D. Palmer, and D. S. Roos. 1997. A plastid of probable green algal origin in apicomplexan parasites. Science 275:1485-1489.
11. Ornaghi, P., D. Rotili, G. Sbardella, A. Mai, and P. Filetici. 2005. A novel Gen5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast. Biochem. Pharmacol. 70:911-917.
12. Roos, D. S., R. G. Donald, N. S. Morrissette, and A. L. Moulton. 1994. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii. Methods Cell Biol. 45:27-63.
13. Roth, S. Y., J. M. Denu, and C. D. Allis. 2001. Histone acetyltransferases. Annu. Rev. Biochem. 70:81-120.
14. Saksouk, N., M. M. Bhatti, S. Kieffer, A. T. Smith, K. Musset, J. Garin, W. J. Sullivan, Jr., M. F. Cesbron-Delauw, and M. A. Hakimi. 2005. Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii. Mol. Cell. Biol. 25:10301-10314.
15. Stimson, L., M. G. Rowlands, Y. M. Newbatt, N. F. Smith, F. I. Raynaud, P. Rogers, V. Bavetsias, S. Gorsuch, M. Jarman, A. Bannister, T. Kouzarides, E. McDonald, P. Workman, and G. W. Aherne. 2005. Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity. Mol. Cancer Ther. 4:1521-1532.
16. Sun, Y., X. Jiang, S. Chen, and B. D. Price. 2006. Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Lett. 580:4353-4356.
17. Weiss, L. M., and K. Kim. 2000. The development and biology of bradyzoites of Toxoplasma gondii. Front. Biosci. 5:D391-D405.
18. Yang, X. J. 2004. The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res. 32:959-976.