Nitric oxide as a noninvasive biomarker of lipopolysaccharide-induced airway inflammation: Possible role in lung neutrophilia

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 2, 2004, Pages 625-633

  McCluskie, Kerryn ^a   Birrell, Mark A ^a   Wong, Sissie ^a   Belvisi, Maria G ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DEXAMETHASONE; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOPROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; N 3 [(AMINOMETHYL)BENZYL]ACETAMIDINE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

AEROSOL; AIRWAY DYNAMICS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA ANALYSIS; DISEASE MARKER; GENE EXPRESSION; INHIBITION KINETICS; LUNG DISEASE; MALE; NEUTROPHILIA; NON INVASIVE MEASUREMENT; NONHUMAN; PATIENT MONITORING; PRIORITY JOURNAL; RAT; RNA ANALYSIS;

AMIDINES; ANIMALS; BENZYLAMINES; BIOLOGICAL MARKERS; BRONCHIAL DISEASES; DEXAMETHASONE; DRUG INTERACTIONS; GENE EXPRESSION; INFLAMMATION; LIPOPOLYSACCHARIDES; LUNG; MALE; NEUTROPHILS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR; TIME FACTORS;

EID: 6344258223     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.068890     Document Type: Article

References (27)

1. Bachetti T, Pasini E, Suzuki H, and Ferrari R (2003) Species-specific modulation of the nitric oxide pathway after acute experimentally induced endotoxemia. Crit Care Med 31:1509-1514.
2. Belenky SN, Robbins RA, Rennard SI, Gossman GL, Nelson KJ, and Rubinstein I (1993) Inhibitors of nitric oxide synthase attenuate human neutrophil chemotaxis in vitro. J Lab Clin Med 122:388-394.
3. Birrell MA, McCluskie K, Haddad el-B, Battram CH, Webber SE, Foster ML, Yacoub MH, and Belvisi MG (2003) Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of Sephadex-induced airway inflammation. J Pharmacol Exp Ther 304:1285-1291.
4. Corriveau CC, Madara PJ, Van Dervort AL, Tropea MM, Wesley RA, and Danner RL (1998) Effects of nitric oxide on chemotaxis and endotoxin-induced interleukin-8 production in human neutrophils. J Infect Dis 177:116-126.
5. Dippel E, Mayer B, Schonfelder G, Czarnetzki BM, and Paus R (1994) Distribution of constitutive nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in murine telogen and anagen skin. J Investig Dermatol 103:112-115.
6. Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJR, and Knowles RG (1997) 1400W is a slow, tight binding and highly selective inhibitor of inducible nitric oxide synthase in vitro and in vivo. J Biol Chem 272:4959-4963.
7. Haddad El-B, Birrell MA, McCluskie K, Ling A, Webber SE, Foster ML, and Belvisi MG (2001) Role of p38 MAP kinase in LPS-induced airway inflammation in the rat. Br J Pharmacol 132:1715-1724.
8. Hoffman RA, Zhang G, Nussler NC, Gleixner SL, Ford HR, Simmons RL, and Watkins SC (1997) Constitutive expression of inducible nitric oxide synthase in the mouse ileal mucosa. Am J Physiol 272:G383-G392.
9. Kharitonov SA and Barnes PJ (2001) Exhaled markers of inflammation. Curr Opin Allergy Clin Immunol 1:217-224.
10. Kharitonov SA and Barnes PJ (2002) Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers 7:1-32.
11. Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Gaston B, Sugarbaker D, and Stamler JS (1993) Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 9:371-377.
12. Kuo HP, Liu S, and Barnes PJ (1992) The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways. Eur J Pharmacol 221:385-388.
13. Lee RP, Wang D, Kao SJ, and Chen HI (2001) The lung is the major site that produces nitric oxide to induce acute pulmonary edema in endotoxin shock. Clin Exp Pharmacol Physiol 28:315-320.
14. Moncada SR, Palmer M, and Higgs EA (1991) Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43:109-142.
15. Nevin BJ and Broadley KJ (2002) Nitric oxide in respiratory diseases. Pharmacol Ther 95:259-293.
16. Nijkamp FP, van der Linde HJ, and Folkerts G (1993) Nitric oxide synthesis inhibitors induce airway hyperresponsiveness in the guinea pig in vivo and in vitro: role of the epithelium. Am Rev Respir Dis 148:727-734.
17. Okamoto T, Gohil K, Finkelstein EI, Bove P, Akaike T, and van der Vliet A (2004) Multiple contributing roles for NOS2 in LPS-induced acute airway inflammation in mice. Am J Physiol Lung Cell Mol Physiol 286:L198-L209.
18. Rees DD, Palmer RM, Schulz R, Hodson HF, and Moncada S (1990) Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101:746-752.
19. Shanley TP, Zhao B, Macariola DR, Denenberg A, Salzman AL, and Ward PA (2002) Role of nitric oxide in acute lung inflammation: lessons learned from the inducible nitric oxide synthase knockout mouse. Crit Care Med 30:1960-1968.
20. Speyer CL, Neff TA, Warner RL, Guo RF, Sarma JV, Riedemann NC, Murphy ME, Murphy HS, and Ward PA (2003) Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol 163:2319-2328.
21. Steudel W, Kirmse M, Weimann J, Ullrich R, Hromi J, and Zapol WM (2000) Exhaled nitric oxide production by nitric oxide synthase-deficient mice. Am J Respir Crit Care Med 162:1262-1267.
22. Strunk V, Hahnenkamp K, Schneuing M, Fischer LG, and Rich GF (2001) Selective iNOS inhibition prevents hypotension in septic rats while preserving endothelium-dependent vasodilation. Anesth Analg 92:681-687.
23. Taylor-Robinson AW, Liew FY, Severn A, Xu D, McSorley SJ, Garside P, Padron J, and Phillips RS (1994) Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur J Immunol 24:980-984.
24. Underwood SL, Raeburn D, Lawrence C, Foster M, Webber S, and Karlsson JA (1997) RPR 106541, a novel, airways-selective glucocorticoid: effects against antigen-induced CD4+ T lymphocyte accumulation and cytokine gene expression in the Brown Norway rat lung. Br J Pharmacol 122:439-446.
25. Wang D, Wei J, Hsu K, Jau J, Lieu MW, Chao TJ, and Chen HI (1999) Effects of nitric oxide synthase inhibitors on systemic hypotension, cytokines and inducible nitric oxide synthase expression and lung injury following endotoxin administration in rats. J Biomed Sci 6:28-35.
26. Weicker S, Karachi TA, Scott JA, McCormack DG, and Mehta S (2001) Noninvasive measurement of exhaled nitric oxide in a spontaneously breathing mouse. Am J Respir Crit Care Med 163:1113-1116.
27. Zweier JL, Wang P, Samouilov A, and Kuppusamy P (1995) Enzyme-independent formation of nitric oxide in biological tissues. Nat Med 1:804-809.