Grape extract improves antioxidant status and physical performance in elite male athletes

Journal of Sports Science and Medicine

Volumn 8, Issue 3, 2009, Pages 468-480

  Lafay, Sophie ^a   Jan, Caroline ^a   Nardon, Karine ^a   Lemaire, Benoit ^a   Ibarra, Alvin ^b   Roller, Marc ^a   Houvenaeghel, Marc ^c   Juhel, Christine ^d   Cara, Louis ^d  

^a Givaudan SA   (Switzerland)

^b Naturex Inc   (United States)

^c Child and Adolescent Psychopathology Unit Salvator Hospital Public Assistance Marseille Hospitals University Aix Marseille II   (France)

^d Avantage Nutrition   (France)

Author keywords

Botanical extract; Competition; Exercise; Oxidative stress; Physiccal performance; Sportsmen; Training

Indexed keywords

EID: 70349305054     PISSN: None     EISSN: 13032968     Source Type: Journal    
DOI: None     Document Type: Article

References (117)

1. Abu-Amsha Caccetta, R., Burke, V., Mori, T., Beilin, L., Puddey, I. and Croft, K. (2001). Red wine polyphenols, in the absence of alcohol, reduce lipid peroxidative stress in smoking subjects. Free radical Biology & Medicine 30, 636-642.
2. Aguilo, A., Tauler, P., Fuentespina, E., Villa, G., Cordova, A., Tur, J. and Pons, A. (2004). Antioxidant diet supplementation influences blood iron status in endurance athletes. International Journal of Sport Nutrition and Exercise Metabolism 14, 147-160.
3. Aissa Benhaddad, A., Bouix, D., Khaled, S., Micallef, J., Mercier, J., Bringer, J. and Brun, J.F. (1999). Early hemorheologic aspects of overtraining in elite athletes. Clinical Hemorheology and Microcirculation 20, 117-125.
4. Baba, S., Osakabe, N., Natsume, M. and Terao, J. (2002). Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)- epicatechin] in rats. Free Radical Biology & Medicine 33, 142-148.
5. Bai, J., Rodriguez, A.M., Melendez, J.A. and Cederbaum, A.I. (1999). Overexpression of catalase in cytosolic or mitochondrial compartment protects HepG2 cells against oxidative injury. The Journal of Biological Chemistry 274, 26217-26224.
6. Barclay, J.K. and Hansel, M. (1991). Free radicals may contribute to oxidative skeletal muscle fatigue. Canadian Journal of Physiology and Pharmacology 69, 279-284.
7. Basu, S. (2008). F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications. Antioxidants & Redox Signaling 10, 1405-1434.
8. Benzie, I.F. and Strain, J.J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Analytical Biochemistry 239, 70-76.
9. Brites, F.D., Evelson, P.A., Christiansen, M.G., Nicol, M.F., Basilico, M.J., Wikinski, R.W. and Llesuy, S.F. (1999). Soccer players under regular training show oxidative stress but an improved plasma antioxidant status. Clinical Science 96, 381-385.
10. Broadhurst, R.B. and Jones, W.T. (1978). Analysis of condensed tannins using acidified vanillin. Journal of the Science of Food and Agriculture 29, 788-794.
11. Buchheit, M., Laursen, P.B., Kuhnle, J., Ruch, D., Renaud, C. and Ahmaidi, S. (2009). Game-based training in young elite hand-ball players. International Journal of Sports Medicine 30, 251-258.
12. Cao, G., Booth, S., Sadowski, J. and Prior, R. (1998). Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. American Journal of Clinical Nutrition. 68, 1081-1087.
13. Castilla, P., Davalos, A., Teruel, J.L., Cerrato, F., Fernandez-Lucas, M., Merino, J.L., Sánchez-Martín, C.C., Ortuño, J. and Lasunción, M.A. (2008). Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients. American Journal of Clinical Nutrition 87, 1053-1061.
14. Cazzola, R., Russo-Volpe, S., Cervato, G. and Cestaro, B. (2003). Biochemical assessments of oxidative stress, erythrocyte membrane fluidity and antioxidant status in professional soccer players and sedentary controls. European Journal of Clinical Investigation 33, 924-930.
15. Chang, C.K., Tseng, H.F., Hsuuw, Y.D., Chan, W.H. and Shieh, L.C. (2002). Higher LDL oxidation at rest and after a rugby game in weekend warriors. Annals of Nutrition and Metabolism 46, 103-107.
16. Chevion, S., Moran, D.S., Heled, Y., Shani, Y., Regev, G., Abbou, B., Berenshtein, E., Stadtman, E.R. and Epstein Y. (2003). Plasma antioxidant status and cell injury after severe physical exercise. Proceedings of the National Academy of Sciences of the United States of America 100, 5119-5123.
17. Child, R., Brown, S., Day, S., Donnelly, A., Roper, H. and Saxton, J. (1999). Changes in indices of antioxidant status, lipid peroxidation and inflammation in human skeletal muscle after eccentric muscle actions. Clinical Science 96, 105-115.
18. Clarkson, P. and Thompson, H. (2000). Antioxidants: what role do they play in physical activity and health? American Journal of Clinical Nutrition 72, 637S-646S.
19. Coombes, J.S. and McNaughton, L.R. (2000). Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise. Journal of Sports Medicine and Physical Fitness 40, 240-246.
20. da Silva, J., Darmon, N., Fernandez, Y. and Mitjavila, S. (1991). Oxygen free radical scavenger capacity in aqueous models of different procyanidins from grape seeds. Journal of Agricultural and Food Chemistry, 39, 1549-1552.
21. Deisseroth, A. and Dounce, A.L. (1970). Catalase: Physical and chemical properties, mechanism of catalysis, and physiological role. Physiological Reviews 50, 319-375.
22. Devaraj, S., Tang, R., Adams-Huet, B., Harris, A., Seenivasan, T., de Lemos, J.A. and Jialal, I. (2007). Effect of high-dose alphatocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease. American Journal of Clinical Nutrition 86, 1392-1398.
23. Diaz, P.T., Brownstein, E. and Clanton, T.L. (1994). Effects of N-acetylcysteine on in vitro diaphragm function are temperature dependent. Journal of Applied Physiology 77, 2434-2439.
24. Diehl, D.M., Lohman, T.G., Smith, S.C. and Kertzer, R. (1986). Effects of physical training and competition on the iron status of female field hockey players. International Journal of Sports Medicine 7, 264-270.
25. Di Giminiani, R., Tihanyi, J., Safar, S. and Scrimaglio, R. (2009). The effects of vibration on explosive and reactive strength when applying individualized vibration frequencies. Journal of Sports Sciences 27, 169-177.
26. Dominguez de Villota, E.D., Ruiz Carmona, M.T., Rubio, J.J. and de Andrés, S. (1981). Equality of the in vivo and in vitro oxygen-binding capacity of haemoglobin in patients with severe respiratory disease. British Journal of Anaesthesia 53, 1325-1328.
27. Donovan, J., Crespy, V., Manach, C., Morand, C., Besson, C., Scalbert, A. and Rémésy, C. (2000). Absorption and metabolism of cate-chin in-situ perfusion in the small intestine of rats. In: Book of Abstract of the 20th International Conference on Polyphenols, September 11-15, Freising, Germany, 317-318
28. Donovan, J.L., Kasim-Karakas, S., German, J.B. and Waterhouse, A.L. (2002). Urinary excretion of catechin metabolites by human subjects after red wine consumption. British Journal of Nutrition 87, 31-37.
29. Evelson, P., Gambino, G., Travacio, M., Jaita, G., Verona, J., Maroncelli, C., Wikinski, R., Llesuy, S. and Brites, F. (2002). Higher antioxidant defences in plasma and low density lipoproteins from rugby players. European Journal of Clinical Investigation 32, 818-825.
30. Flanagan, E.P., Galvin, L. and Harrison, A.J. (2008). Force production and reactive strength capabilities after anterior cruciate ligament reconstruction. Journal of Athletic Training 43, 249-257.
31. Folin, O. and Denis, W. (1915). A colorimetric method for the determination of phenols (and phenol derivatives) in urine. The Journal of Biological Chemistry 22, 305-308.
32. García-López, J., Peleteiro, J., Rodgríguez-Marroyo, J.A., Morante, J.C., Herrero, J.A. and Villa, J.G. (2005). The validation of a new method that measures contact and flight times during vertical jump. International Journal of Sports Medicine 26, 294-302.
33. Gilligan, D. R., Altschule, M. D. and Katersky, E. M. (1943). Physiological Intravascular Hemolysis of Exercise. Hemoglobinemia and Hemoglobinuria Following Cross-Country Runs. The Journal of Clinical Investigation 22, 859-869.
34. Gomez-Cabrera, M.C., Domenech, E. and Viña J. (2008). Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radical Biology and Medicine 44, 126-131.
35. Gonthier, M.P., Donovan, J.L., Texier, O., Felgines, C., Remesy, C. and Scalbert, A. (2003). Metabolism of dietary procyanidins in rats. Free Radical Biology and Medicine 35, 837-844.
36. Gorinstein, S., Caspi, A., Libman, I., Lerner, H.T., Huang, D., Leontowicz, H., Tashma, Z., Katrich, E., Feng, S. and Trakhtenberg, S. (2006). Red grapefruit positively influences serum triglyceride level in patients suffering from coronary atherosclerosis: studies in vitro and in humans. Journal of Agricultural and Food Chemistry 54, 1887-1892.
37. Hartmann, U. and Mester, J. (2000). Training and overtraining markers in selected sport events. Medicine and Science in Sports and Exercise 32, 209-215.
38. Helgheim, I., Hetland, O., Nilsson, S., Ingjer, F. and Stromme, S.B. (1979). The effects of vitamin E on serum enzyme levels following heavy exercise. European Journal of Applied Physiology and Occupational Physiology 40, 283-289.
39. Holt, R.R., Lazarus, S.A., Sullards, M.C., Zhu, Q.Y., Schramm, D.D., Hammerstone, G.F., Fraga, C.G., Schmitz, H.H. and Keen, C.L. (2002). Procyanidin dimer B2 [epicatechin-(4b-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. The American Journal of Clinical Nutrition 76, 798-804.
40. Huang, D., Ou, B., Hampsch-Woodill, M., Flanagan, J. and Prior, R. (2002). High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. Journal of Agricultural and Food Chemistry 50, 4437-4444.
41. Jakeman, P. and Maxwell, S. (1993). Effect of antioxidant vitamin supplementation on muscle function after eccentric exercise. European Journal of Applied Physiology and Occupational Physiology 67, 426-430.
42. Janssen, G.M., Kuipers, H., Willems, G.M., Does, R.J., Janssen, M.P. and Geurten, P. (1989). Plasma activity of muscle enzymes: quantification of skeletal muscle damage and relationship with metabolic variables. International Journal of Sports Medicine 10, S160-168.
43. Keith, R.E. and Driskell, J.A. (1982). Lung function and treadmill performance of smoking and nonsmoking males receiving ascorbic acid supplements. The American Journal of Clinical Nutrition 36, 840-845.
44. Keith, R.E. and Merrill, E. (1983). The effects of vitamin C on maximum grip strength and muscular endurance. The Journal of Sports Medicine and Physical Fitness 23, 253-256.
45. Keren, G. and Epstein, Y. (1980). The effect of high dosage vitamin C intake on aerobic and anaerobic capacity. The Journal of Sports Medicine and Physical Fitness 20, 145-148.
46. Khawli, F.A. and Reid, M.B. (1994). N-acetylcysteine depresses contractile function and inhibits fatigue of diaphragm in vitro. Journal of Applied Physiology 77, 317-324.
47. Klapcinska, B., Kempa, K., Sobczak, A., Sadowska-Krepa, E., Jagsz, S. and Szoltysek, I. (2005). Evaluation of autoantibodies against oxidized LDL (oLAB) and blood antioxidant status in professional soccer players. International Journal of Sports Medicine 26, 71-78.
48. Kon, M., Tanabe, K., Akimoto, T., Kimura, F., Tanimura, Y., Shimizu, K., Okamoto, T. and Kono, I. (2008). Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. The British Journal of Nutrition 100, 903-909.
49. Lands, L.C., Grey, V.L. and Smountas, A.A. (1999). Effect of supple-mentation with a cysteine donor on muscular performance. Journal of Applied Physiology 87, 1381-1385.
50. Lawrence, J.D., Bower, R.C., Riehl, W.P. and Smith, J.L. (1975a). Effects of alpha-tocopherol acetate on the swimming endurance of trained swimmers. The American Journal of Clinical Nutrition 28, 205-208.
51. Lawrence, J.D., Smith, J.L., Bower, R.C. and Riehl, W.P. (1975b). The effect of alpha tocopherol (vitamin E) and pyridoxine HCL (vitamin B6) on the swimming endurance of trained swimmers. Journal of the American College Health Association 23, 219-222.
52. le Gall, F., Carling, C., Williams, M. and Reilly, T. (2008). Anthropometric and fitness characteristics of international, professional and amateur male graduate soccer players from an elite youth academy. Journal of Science and Medicine in Sport (doi:10.1016/j.jsams.2008.07.004)
53. Lehance, C., Croisier, J. and Bury, T. (2005). Optojump system efficiency in the assessment of lower limbs explosive strength. Science et Sports 20, 131-135.
54. Manach, C., Scalbert, A., Morand, C., Rémésy, C. and Jiménez, L. (2004). Polyphenols: food sources and bioavailability. The American Journal of Clinical Nutrition 79, 727-747.
55. Margaritis, I., Palazzetti, S., Rousseau, A., Richard, M. and Favier, A. (2003). Antioxidant supplementation and tapering exercise improve exercise-induced antioxidant response. Journal of the American College of Nutrition 22, 147-156.
56. Mastaloudis, A., Leonard, S.W. and Traber, M.G. (2001). Oxidative stress in athletes during extreme endurance exercise. Free Radical Biology & Medicine 31, 911-922.
57. Mastaloudis, A., Morrow, J.D., Hopkins, D.W., Devaraj, S. and Traber, M.G. (2004). Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radical Biology & Medicine 36, 1329-1341.
58. Maughan, R.J. (1999). Role of micronutrients in sport and physical activity. British Medical Bulletin 55, 683-690.
59. Mazur, A., Bayle, D., Lab, C., Rock, E. and Rayssiguier, Y. (1999). Inhibitory effect of procyanidin-rich extracts on LDL oxidation in vitro. Atherosclerosis 145, 421-422.
60. McAnulty, S.R., McAnulty, L.S., Nieman, D.C., Morrow, J.D., Shooter, L.A., Holmes, S., Heward, C. and Henson, D.A. (2005). Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise. The Journal of Nutritional Biochemistry 16, 530-537.
61. McAnulty, S.R., McAnulty, L.S., Nieman, D.C., Quindry, J.C., Hosick, P.A., Hudson, M.H., Still, L., Henson, D.A., Milne, G.L., Morrow, J.D., Dumke, C.L., Utter, A.C., Triplett, N.T. and Di-barnardi, A. (2008). Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. AppliedPhysiology, Nutrition, and Metabolism 33, 254-262.
62. Morillas-Ruiz, J., Villegas Garcia, J., Lopez, F., Vidal-Guevara, M. and Zafrilla, P. (2006). Effects of polyphenolic antioxidants on exercise-induced oxidative stress. Clinical Nutrition 25, 444-453.
63. Morillas-Ruiz, J., Zafrilla, P., Almar, M., Cuevas, M. J., Lopez, F.J., Abellan, P., Villegas, J.A. and Gonzalez-Gallego, J. (2005). The effects of an antioxidant-supplemented beverage on exercise-induced oxidative stress: results from a placebo-controlled double-blind study in cyclists. European Journal of Applied Physiology 95, 543-549.
64. Morrow, J.D., Awad, J.A., Boss, H.J., Blair, I.A. and Roberts, L.J., 2nd. (1992). Non-cyclooxygenase-derived prostanoids (F2- isoprostanes) are formed in situ on phospholipids. Proceedings of the National Academy of Sciences of the United States of America 89, 10721-10725.
65. Newton, R.U., Rogers, R.A., Volek, J.S., Häkkinen, K. and Kraemer, W.J. (2006). Four weeks of optimal load ballistic resistance training at the end of season attenuates declining jump performance of women volleyball players. Journal of Strength and Conditioning Research 20, 955-961.
66. Novelli, G.P., Bracciotti, G. and Falsini, S. (1990). Spin-trappers and vitamin E prolong endurance to muscle fatigue in mice. Free Radical Biology & Medicine 8, 9-13.
67. O'Toole, M.L., Hiller, W.D., Roalstad, M.S. and Douglas, P.S. (1988). Hemolysis during triathlon races: its relation to race distance. Medicine and Science in Sports and Exercise 20, 272-275.
68. Ou, B., Hampsch-Woodill, M. and Prior, R. (2001). Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. Journal of Agricultural and Food Chemistry 49, 4619-4626.
69. Ozdemir, G., Ozden, M., Maral, H., Kuskay, S., Cetinalp, P. and Tarkun,I. (2005). Malondialdehyde, glutathione, glutathione peroxidase and homocysteine levels in type 2 diabetic patients with and without microalbuminuria. Annals of Clinical Biochemistry 42, 99-104.
70. Palazzetti, S., Richard, M., Favier, A. and Margaritis, I. (2003). Over-loaded training increases exercise-induced oxidative stress and damage. Canadian Journal of Applied Physiology 28, 588-604.
71. Palazzetti, S., Rousseau, A., Richard, M., Favier, A. and Margaritis, I. (2004). Antioxidant supplementation preserves antioxidant response in physical training and low antioxidant intake. The British Journal of Nutrition 91, 91-100.
72. Pavlovic, P. (1999). Improved endurance by use of antioxidants. European Bulletin of Drug Research 7, 1-4.
73. Peskin, A.V. and Winterbourn, C.C. (2000). A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1). Clinica Chimica Acta 293, 157-166.
74. Pincemail, J., Lecomte, J., Castiau, J., Collard, E., Vasankari, T., Cheramy-Bien, J., Limet, R. and Defraigne, J. (2000). Evaluation of autoantibodies against oxidized LDL and antioxidant status in top soccer and basketball players after 4 months of competition. Free Radical Biology & Medicine 28, 559-565.
75. Powers, S.K. and Hamilton, K. (1999). Antioxidants and exercise. Clinics in Sports Medicine 18, 525-536.
76. Prasad, N.R., Menon, V.P., Vasudev, V. and Pugalendi, K.V. (2005). Radioprotective effect of sesamol on gamma-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes. Toxicology 209, 225-235.
77. Pratico, D., Barry, O.P., Lawson, J.A., Adiyaman, M., Hwang, S.W., Khanapure, S.P., Iuliano, L., Rokach, J. and FitzGerald, G.A. (1998). IPF2alpha-I: an index of lipid peroxidation in humans. Proceedings of the National Academy of Sciences of the United States of America 95, 3449-3454.
78. Preuss, H.G., Wallerstedt, D., Talpur, N., Tutuncuoglu, S.O., Echard, B., Myers, A., Bui, M. and Bagchi, D. (2000). Effects of niacinbound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. Journal of Medicine 31, 227-246.
79. Prior, R. and Cao, G. (1999). In vivo total antioxidant capacity: comparison of different analytical methods. Free Radical Biology & Medicine 27, 1173-1181.
80. Prior, R.L., Gu, L., Wu, X., Jacob, R.A., Sotoudeh, G., Kader, A.A. and Cook, R.A. (2007). Plasma antioxidant capacity changes following a meal as a measure of the ability of a food to alter in vivo antioxidant status. Journal of the American College of Nutrition, 26, 170-181.
81. Radak, Z., Chung, H. Y. and Goto, S. (2008). Systemic adaptation to oxidative challenge induced by regular exercise. Free Radical Biology & Medicine 44, 153-159.
82. Reid, M.B. and Moody, M.R. (1994). Dimethyl sulfoxide depresses skeletal muscle contractility. Journal of Applied Physiology 76, 2186-2190.
83. Rokitzki, L., Logemann, E., Huber, G., Keck, E. and Keul, J. (1994a). alpha-Tocopherol supplementation in racing cyclists during extreme endurance training. International Journal of Sport Nutrition 4, 253-264.
84. Rokitzki, L., Logemann, E., Sagredos, A.N., Murphy, M., Wetzel-Roth, W. and Keul, J. (1994b). Lipid peroxidation and antioxidative vitamins under extreme endurance stress. Acta physiologica Scandinavica 151, 149-158.
85. Sano, A., Yamakoshi, J., Tokutake, S., Tobe, K., Kubota, Y. and Kikuchi, M. (2003). Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract. Bioscience, Biotechnology, and Biochemistry 67, 1140-1143.
86. Santos-Buelga, C. and Scalbert A. (2000). Proanthocyanidins and tannin-like compounds: nature, occurrence, dietary intake and effects on nutrition and health. Journal of the Science of Food and Agriculture 80, 1094-1117.
87. Serafini, M., Bugianesi, R., Maiani, G., Valtuena, S., De Santis, S. and Crozier, A. (2003). Plasma antioxidants from chocolate. Nature 424, 1013.
88. Shafiee, M., Carbonneau, M.A., Urban, N., Descomps, B. and Leger, C. L. (2003). Grape and grape seed extract capacities at protecting LDL against oxidation generated by Cu2+, AAPH or SIN-1 and at decreasing superoxide THP-1 cell production. A comparison to other extracts or compounds. Free Radical Research 37, 573-584.
89. Sharman, I.M., Down, M.G. and Norgan, N.G. (1976). The effects of vitamin E on physiological function and athletic performance of trained swimmers. The Journal of Sports Medicine and Physical Fitness 16, 215-225.
90. Sharman, I.M., Down, M.G. and Sen, R.N. (1971). The effects of vitamin E and training on physiological function and athletic performance in adolescent swimmers. The British Journal of Nutrition 26, 265-276.
91. Shindoh, C., DiMarco, A., Thomas, A., Manubay, P. and Supinski, G. (1990). Effect of N-acetylcysteine on diaphragm fatigue. Journal of Applied Physiology 68, 2107-2113.
92. Simonetti, P., Ciappellano, S., Gardana, C., Bramati, L. and Pietta, P. (2002). Procyanidins from Vitis vinifera seeds: in vivo effects on oxidative stress. Journal of Agricultural and Food Chemistry 50, 6217-6221.
93. Slater, T. (1985). Overview of methods used for detecting lipid peroxidation. Methods in Enzymology 105, 283-293.
94. Smirniotou, A., Katsikas, C., Paradisis, G., Argeitaki, P., Zacharogiannis, E. and Tziortzis, S. (2008). Strength-power parameters as predictors of sprinting performance. The Journal of Sports Medicine and Physical Fitness 48, 447-454.
95. Smith, J.A., Kolbuch-Braddon, M., Gillam, I., Telford, R.D. and Weidemann, M.J. (1995). Changes in the susceptibility of red blood cells to oxidative and osmotic stress following submaximal exercise. European Journal of Applied Physiology and Occupational Physiologyv 70, 427-436.
96. Spencer, J.P., Schroeter, H., Rechner, A.R. and Rice-Evans, C. (2001). Bioavailability of flavan-3-ols and procyanidins: gastrointestinal tract influences and their relevance to bioactive forms in vivo. Antioxidants & Redox Signaling 3, 1023-1039.
97. Spodaryk, K. (2002). Iron metabolism in boys involved in intensive physical training. Physiology & Behavior 75, 201-206.
98. Steensberg, A., Morrow, J., Toft, A.D., Bruunsgaard, H. and Pedersen, B.K. (2002). Prolonged exercise, lymphocyte apoptosis and F2-isoprostanes. European Journal of Applied Physiology 87, 38-42.
99. Su, Q.S., Tian, Y., Zhang, J.G. and Zhang, H. (2008). Effects of allicin supplementation on plasma markers of exercise-induced muscle damage, IL-6 and antioxidant capacity. European Journal of Applied Physiology 103, 275-283.
100. Tauler, P., Aguilo, A., Gimeno, I., Fuentespina, E., Tur, J. and Pons, A. (2006). Response of blood cell antioxidant enzyme defences to antioxidant diet supplementation and to intense exercise. European Journal of Nutrition 45, 187-195.
101. Tauler, P., Aguilo, A., Gimeno, I., Fuentespina, E., Tur, J.A. and Pons, A. (2003). Influence of vitamin C diet supplementation on endogenous antioxidant defences during exhaustive exercise. Pflügers Archiv: European Journal of Physiology 446, 658-664.
102. Teissedre, P.L., Frankel, E.N., Waterhouse, A.L., Peleg, H. and German, J.B. (1996). Inhibition of in vitro human LDL oxidation by phenolic antioxidants from grapes and wines. Journal of the Science of Food and Agriculture 70, 55-61.
103. Tessier, F., Birlouez-Aragon, I., Tjani, C. and Guilland, J.C. (1996). Validation of a micromethod for determining oxidized and reduced vitamin C in plasma by HPLC-fluorescence. International Journal for Vitamin and Nutrition Research 66, 166-170.
104. Tomas-Barberan, F.A., Cienfuegos-Jovellanos, E., Marín, A., Muguerza, B., Gil-Izquierdo, A., Cerda, B., Zafrilla, P., Morillas, J., Mulero, J., Ibarra, A., Pasamar, M.A., Ramón, D. and Espín, J.C. (2007) A new process to develop a cocoa powder with higher flavonoid monomer content and enhanced bioavailability in healthy humans. Journal of Agricultural and Food Chemistry 55, 3926-3935.
105. Travaline, J.M., Sudarshan, S., Roy, B.G., Cordova, F., Leyenson, V. and Criner, G.J. (1997). Effect of N-acetylcysteine on human diaphragm strength and fatigability. American Journal of Respiratory and Critical Care Medicine 156, 1567-1571.
106. Van der Meulen, J.H., Kuipers, H. and Drukker, J. (1991). Relationship between exercise-induced muscle damage and enzyme release in rats. Journal of Applied Physiology 71, 999-1004.
107. Vasankari, T., Kujala, U., Heinonen, O., Kapanen, J. and Ahotupa, M. (1995). Measurement of serum lipid peroxidation during exercise using three different methods: diene conjugation, thiobarbituric acid reactive material and fluorescent chromolipids. Clinica Chimica Acta 234, 63-69.
108. Vasankari, T.J., Kujala, U.M., Vasankari, T.M. and Ahotupa, M. (1998a). Reduced oxidized LDL levels after a 10-month exercise program. Medicine and Science in Sports and Exercise 30, 1496-1501.
109. Vasankari, T.J., Kujala, U.M., Vasankari, T.M., Vuorimaa, T. and Ahotupa, M. (1997b). Increased serum and low-density-lipoprotein antioxidant potential after antioxidant supplementation in endurance athletes. American Journal of Clinical Nutrition 65, 1052-1056.
110. Vasankari, T.J., Kujala, U.M., Vasankari, T.M., Vuorimaa, T. and Ahotupa, M. (1997c). Effects of acute prolonged exercise on-serum and LDL oxidation and antioxidant defences. Free Radical Biology & Medicine 22, 509-513.
111. Vigna, G.B., Costantini, F., Aldini, G., Carini, M., Catapano, A., Schena, F., Tangerini, A., Zanca, R., Bombardelli, E., Morazzoni, P., Mezzetti, A., Fellin, R. and Maffei Facino, R. (2003). Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism 52, 1250-1257.
112. Vitseva, O., Varghese, S., Chakrabarti, S., Folts, J. and Freedman, J. (2005). Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. Journal of Cardiovascular Pharmacology 46, 445-451.
113. Watson, T., MacDonald-Wicks, L. and Garg, M. (2005). Oxidative stress and antioxidants in athletes undertaking regular exercise training. International Journal of Sport Nutrition and Exercise Metabolism 15, 131-146.
114. Wilmot, C. and Campillo, P. (2004). Youth basketball specific effort test. Journal of Science and Medicine in Sport 3, 261-262.
115. Wiseman, H., O'Reilly, J., Adlercreutz, H., Mallet, A., Bowey, E., Rowland, I., and Sanders, T.A. (2000). Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. The American Journal of Clinical Nutrition 72, 395-400.
116. Yilmaz, Y. and Toledo, R.T. (2004). Major flavonoids in grape seeds and skins: Antioxidant capacity of catechin, epicatechin, and gallic acid. Journal of Agricultural and Food Chemistry 52, 255-260.
117. Zern, T., Wood, R., Greene, C., West, K., Liu, Y., Aggarwal, D., Shachter, N.S. and Fernandez, M.L. (2005). Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. The Journal of Nutrition 135, 1911-1917.