Effects of allicin supplementation on plasma markers of exercise-induced muscle damage, IL-6 and antioxidant capacity

European Journal of Applied Physiology

Volumn 103, Issue 3, 2008, Pages 275-283

  Su, Quan Sheng ^a   Tian, Ye ^b   Zhang, Jian Guo ^c   Zhang, Hui ^d  

^a CHENGDU SPORT UNIVERSITY   (China)

^b CHINA INSTITUTE OF SPORT SCIENCE   (China)

^c NANJING NORMAL UNIVERSITY   (China)

^d HENAN UNIVERSITY   (China)

Author keywords

Allicin; Antioxidative capacity; Creatine kinase (CK); Eccentric exercise; Interleukin 6 (IL 6)

Indexed keywords

ALLICIN; ANTIOXIDANT; BIOLOGICAL MARKER; CREATINE KINASE; CREATINE KINASE MM; INTERLEUKIN 6; LACTATE DEHYDROGENASE; PLACEBO; SUPEROXIDE DISMUTASE;

ADULT; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ATHLETE; BIOCHEMISTRY; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENZYME BLOOD LEVEL; FEMALE; HUMAN; MALE; MUSCLE INJURY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; REST; SUPPLEMENTATION; TREADMILL EXERCISE;

ADMINISTRATION, ORAL; ADULT; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BIOLOGICAL MARKERS; CAPSULES; CREATINE KINASE; CREATINE KINASE, MM FORM; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EXERCISE; FEMALE; HUMANS; INTERLEUKIN-6; L-LACTATE DEHYDROGENASE; MALE; MUSCLE, SKELETAL; PAIN; PAIN MEASUREMENT; RUNNING; SULFINIC ACIDS; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 42449132121     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-008-0699-5     Document Type: Article

References (54)

1. Amagase H, Petesch BL, Matsuura H, Kasuga S, Itakura Y (2001) Intake of garlic and its bioactive components. J Nutr 131:955S-962S
2. Amagase H (2006) Clarifying the real bioactive constituents of garlic. J Nutr 136:716S-725S
3. Aoi W, Naito Y, Takanami Y, Kawai Y, Sakuma K, Ichikawa H, Yoshida N, Yoshikawa T (2004) Oxidative stress and delayed-onset muscle damage after exercise. Free Radic Biol Med 37:480-487
4. Augusti KT, Mathew PT (1975) Effect of allicin on certain enzymes of liver after a short term feeding to normal rats. Experientia 31:148-149
5. Borg G (1998) Perceived exertion and pain scale. Human Kinetics, Champaign
6. Brown SJ, Child RB, Day SH, Donnelly AE (1997) Indices of skeletal muscle damage and connective tissue breakdown following eccentric muscle contractions. Eur J Appl Physiol Occup Physiol 75:369-374
7. Clarkson PM, Hubal MJ (2002) Exercise-induced muscle damage in humans. J Phys Med Rehabil 81:S52-69
8. Davis JM, Murphy EA, Carmichael MD, Zielinski MR, Groschwitz CM, Brown AS, Gangemi JD, Ghaffar A, Mayer EP (2007) Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. J Physiol Regul Integr Comp Physiol 292:R2168-73
9. Feng R, He W, Ochi H (2001) A new murine oxidative stress model associated with senescence. Mech Ageing Dev 122:547-559
10. Gleeson M (2000) Interleukins and exercise. J Physiol 529(Pt 1):1
11. Gleeson M, Bishop NC (2000) Special feature for the Olympics: Effects of exercise on the immune system: Modification of immune responses to exercise by carbohydrate, glutamine and anti-oxidant supplements. Immunol Cell Biol 78:554-561
12. Hargreaves M (2004) Muscle glycogen and metabolic regulation. Proc Nutr Soc 63:217-220
13. Hasan N, Yusuf N, Toossi Z, Islam N (2006) Suppression of Mycobacterium tuberculosis induced reactive oxygen species (ROS) and TNF-alpha mRNA expression in human monocytes by allicin. FEBS Lett 580:2517-2522
14. Hasan N, Siddiqui MU, Toossi Z, Khan S, Iqbal J, Islam N (2007) Allicin-induced suppression of Mycobacterium tuberculosis 85B mRNA in human monocytes. Biochem Biophys Res Commun 355:471-476
15. Helge JW, Stallknecht B, Pedersen BK, Galbo H, Kiens B, Richter EA (2003) The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle. J Physiol 546(Pt 1):299-305
16. Hilbert JE, Sforzo GA, Swensen T (2003) The effects of massage on delayed onset muscle soreness. Br J Sports Med 37:72-75
17. Hyatt JP, Clarkson PM (1998) Creatine kinase release and clearance using MM variants following repeated bouts of eccentric exercise. Med Sci Sports Exerc 30:1059-1065
18. Judge AR, Dodd SL (2003) Oxidative damage to skeletal muscle following an acute bout of contractile claudication. Atherosclerosis 171:219-224
19. Kendall B, Eston R (2002) Exercise-induced muscle damage and the potential protective role of estrogen. Sports Med 32:103-123
20. Lawson LD, Gardner CD (2005) Composition, stability, and bioavailability of garlic products used in a clinical trial. J Agric Food Chem 53:6254-6261
21. Li JX, Tong CW, Xu DQ, Chan KM (1999) Changes in membrane fluidity and lipid peroxidation of skeletal muscle mitochondria after exhausting exercise in rats. Eur J Appl Physiol 80:113-117
22. Liu CT, Sheen LY, Lii CK (2007) Does garlic have a role as an antidiabetic agent? Mol Nutr Food Res 51:1353-1364
23. Lu HK, Hsieh CC, Hsu JJ, Yang YK, Chou HN (2006) Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress. Eur J Appl Physiol 98:220-226
24. MacIntyre DL, Reid WD, McKenzie DC (1995) Delayed muscle soreness. The inflammatory response to muscle injury and its clinical implications. Sports Med 20:24-40
25. Makris A, Thornton CE, Xu B, Hennessy A (2005) Garlic increases IL-10 and inhibits TNF alpha and IL-6 production in endotoxin-stimulated human placental explants. Placenta 26:828-834
26. Mathew PT, Augusti KT (1973) Studies on the effect of allicin (diallyl disulphide-oxide) on alloxan diabetes. I. Hypoglycaemic action and enhancement of serum insulin effect and glycogen synthesis. Indian J Biochem Biophys 10:209-212
27. 2 production by alginate, allicin and ascorbic acid in human endothelial cells. Arch Pharm Res 26:244-251
28. Nieman DC, Dumke CL, Henson DA, McAnulty SR, Gross SJ, Lind RH (2005) Muscle damage is linked to cytokine changes following a 160-km race. Brain Behav Immun 19:398-403
29. Nishimoto N, Kishimoto T (2006) Interleukin 6: From bench to bedside. Nat Clin Pract Rheumatol 2:619-626
30. Okada Y, Tanaka K, Sato E, Okajima H (2006) Kinetic and mechanistic studies of allicin as an antioxidant. Org Biomol Chem 4:4113-4117
31. Peake JM, Suzuki K, Hordern M, Wilson G, Nosaka K, Coombes JS (2005a) Plasma cytokine changes in relation to exercise intensity and muscle damage. Eur J Appl Physiol 95:514-521
32. Peake J, Nosaka K, Suzuki K (2005b) Characterization of inflammatory responses to eccentric exercise in humans. Exerc Immunol Rev 11:64-85
33. Pedersen BK, Steensberg A, Fischer C, Keller C, Keller P, Plomgaard P, Febbraio M, Saltin B (2003) Searching for the exercise factor: Is IL-6 a candidate? J Muscle Res Cell Motil 24:113-119
34. Pedersen BK, Fischer CP (2007) Physiological roles of muscle-derived interleukin-6 in response to exercise. Curr Opin Clin Nutr Metab Care 10:265-271
35. Petersen EW, Ostrowski K, Ibfelt T, Richelle M, Offord E, Halkjaer-Kristensen J, Pedersen BK (2001) Effect of vitamin supplementation on cytokine response and on muscle damage after strenuous exercise. Am J Physiol Cell Physiol 280:C1570-1575
36. Pizza FX, Cavender D, Stockard A, Baylies H, Beighle A (1999) Anti-inflammatory doses of ibuprofen: Effect on neutrophils and exercise-induced muscle injury. Int J Sports Med 20:98-102
37. Prasad K, Laxdal VA, Yu M, Raney BL (1995) Antioxidant activity of allicin, an active principle in garlic. Mol Cell Biochem 148:183-189
38. Proske U, Morgan DL (2001) Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications. J Physiol 537:333-345
39. Rivlin RS (2001) Historical perspective on the use of garlic. J Nutr 131:951S-954S
40. Rodenburg JB, de Boer RW, Schiereck P, van Echteld CJ, Bär PR (1994) Changes in phosphorus compounds and water content in skeletal muscle due to eccentric exercise. Eur J Appl Physiol Occup Physiol 68:205-213
41. Savage KJ, Clarkson PM (2002) Oral contraceptive use and exercise-induced muscle damage and recovery. Contraception 66:67-71
42. Sela U, Ganor S, Hecht I, Brill A, Miron T, Rabinkov A, Wilchek M, Mirelman D, Lider O, Hershkoviz R (2004) Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression. Immunology 111:391-399
43. Sjödin B, Hellsten Westing Y, Apple FS (1990) Biochemical mechanisms for oxygen free radical formation during exercise. Sports Med 10:236-254
44. Sobenin IA, Nedosugova LV, Filatova LV, Balabolkin MI, Gorchakova TV, Orekhov AN (2007). Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: The results of double-blinded placebo-controlled study. Acta Diabetol 45(1):1-6, (Epub ahead of print)
45. Son EW, Mo SJ, Rhee DK, Pyo S (2006) Inhibition of ICAM-1 expression by garlic component, allicin, in gamma-irradiated human vascular endothelial cells via downregulation of the JNK signaling pathway. Int Immunopharmacol 6:1788-1795
46. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, Klarlund Pedersen B (2000) Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529(Pt 1):237-242
47. Stouthard JM, Romijn JA, Van der Poll T, Endert E, Klein S, Bakker PJ, Veenhof CH, Sauerwein HP (1995) Endocrinologic and metabolic effects of interleukin-6 in humans. Am J Physiol 268(5 Pt 1):E813-819
48. Tokmakidis SP, Kokkinidis EA, Smilios I, Douda H (2003) The effects of ibuprofen on delayed muscle soreness and muscular performance after eccentric exercise. J Strength Cond Res 17:53-59
49. Uchiyama S, Tsukamoto H, Yoshimura S, Tamaki T (2006) Relationship between oxidative stress in muscle tissue and weight-lifting-induced muscle damage. Pflugers Arch 452:109-116
50. van de Stolpe A, van der Saag PT (1996) Intercellular adhesion molecule-1. J Mol Med 74:13-33
51. Volfinger L, Lassourd V, Michaux JM, Braun JP, Toutain PL (1994) Kinetic evaluation of muscle damage during exercise by calculation of amount of creatine kinase released. Am J Physiol 266:R434-441
52. Woodward PW (1996) Garlic and friends. The history, growth and use of edible alliums. Hyland House, Melbourne, pp 2-22
53. Xiao H, Parkin KL (2002) Antioxidant functions of selected allium thiosulfinates and S-alk(en)yl-L-cysteine sulfoxides. J Agric Food Chem 50:2488-2493
54. Zhang XH, Lowe D, Giles P, Fell S, Connock MJ, Maslin DJ (2001) Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. J Nutr 131:1471-1478