-
3
-
-
0141733073
-
2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2
-
2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. J Biol Chem. 2003;278:37937-37947.
-
(2003)
J Biol Chem.
, vol.278
, pp. 37937-37947
-
-
Murakami, M.1
Nakashima, K.2
Kamei, D.3
-
4
-
-
0034692689
-
2 synthase that acts in concert with cyclooxygenase-2
-
2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem. 2000;275:32783-32792.
-
(2000)
J Biol Chem.
, vol.275
, pp. 32783-32792
-
-
Murakami, M.1
Naraba, H.2
Tanioka, T.3
-
5
-
-
0242584866
-
2 production in the rat adjuvant-induced arthritis model
-
2 production in the rat adjuvant-induced arthritis model. J Immunol. 2003;170:4738-4744.
-
(2003)
J Immunol.
, vol.170
, pp. 4738-4744
-
-
Claveau, D.1
Sirinyan, M.2
Guay, J.3
-
7
-
-
0031809716
-
Thromboxanes: Synthase and receptors
-
Shen RF, Tai HH. Thromboxanes: synthase and receptors. J Biomed Sci. 1998;5:153-172.
-
(1998)
J Biomed Sci.
, vol.5
, pp. 153-172
-
-
Shen, R.F.1
Tai, H.H.2
-
8
-
-
0034077475
-
Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase
-
Kanaoka Y, Fujimori K, Kikuno R, et al. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. Eur J Biochem. 2000;267: 3315-3322.
-
(2000)
Eur J Biochem.
, vol.267
, pp. 3315-3322
-
-
Kanaoka, Y.1
Fujimori, K.2
Kikuno, R.3
-
9
-
-
0034684216
-
Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase
-
Urade Y, Hayaishi O. Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase. Biochim Biophys Acta. 2000;1482:259-271.
-
(2000)
Biochim Biophys Acta.
, vol.1482
, pp. 259-271
-
-
Urade, Y.1
Hayaishi, O.2
-
11
-
-
33646007357
-
Implications of the molecular basis of prostacyclin biosynthesis and signaling in pharmaceutical designs
-
Ruan KH, Dogne JM. Implications of the molecular basis of prostacyclin biosynthesis and signaling in pharmaceutical designs. Curr Pharm Des. 2006;12:925-941.
-
(2006)
Curr Pharm Des.
, vol.12
, pp. 925-941
-
-
Ruan, K.H.1
Dogne, J.M.2
-
12
-
-
0036092565
-
2 system
-
Hayaishi O. Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D2 system. J Appl Physiol. 2002;92:863-868.
-
(2002)
J Appl Physiol.
, vol.92
, pp. 863-868
-
-
Hayaishi, O.1
-
13
-
-
0036007458
-
2 in sleep-wake regulation: Recent progress and perspectives
-
2 in sleep-wake regulation: recent progress and perspectives. Neuroscientist. 2002;8:12-15.
-
(2002)
Neuroscientist.
, vol.8
, pp. 12-15
-
-
Hayaishi, O.1
Urade, Y.2
-
14
-
-
0025696564
-
2 is selectively elevated in cerebrospinal fluid of advanced sleeping sickness patients
-
2 is selectively elevated in cerebrospinal fluid of advanced sleeping sickness patients. Trans R Soc Trop Med Hyg. 1990;84:795-799.
-
(1990)
Trans R Soc Trop Med Hyg.
, vol.84
, pp. 795-799
-
-
Pentreath, V.W.1
Rees, K.2
Owolabi, O.A.3
-
15
-
-
4444306832
-
2 for induction of human articular chondrocyte apoptosis in arthritis
-
2 for induction of human articular chondrocyte apoptosis in arthritis. J Biol Chem. 2004;279:37939-37950.
-
(2004)
J Biol Chem.
, vol.279
, pp. 37939-37950
-
-
Shan, Z.Z.1
Masuko-Hongo, K.2
Dai, S.M.3
-
16
-
-
84988482483
-
Differential expression of brain PGD2 synthase in OA cartilage: Role and mechanism of action of PGD2 in eicosanoid metabolism
-
Attur M, Dave M, Leung M, et al. Differential expression of brain PGD2 synthase in OA cartilage: role and mechanism of action of PGD2 in eicosanoid metabolism. Arthritis Rheum. 2003;48:430.
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 430
-
-
Attur, M.1
Dave, M.2
Leung, M.3
-
17
-
-
0031913845
-
Characterization of the recombinant human prostanoid DP receptor and identification of L-644, 698, A novel selective DP agonist
-
Wright DH, Metters KM, Abramovitz M, et al. Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998;123:1317-1324.
-
(1998)
Br J Pharmacol.
, vol.123
, pp. 1317-1324
-
-
Wright, D.H.1
Metters, K.M.2
Abramovitz, M.3
-
18
-
-
0035862329
-
2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
-
2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med. 2001;193: 255-261.
-
(2001)
J Exp Med.
, vol.193
, pp. 255-261
-
-
Hirai, H.1
Tanaka, K.2
Yoshie, O.3
-
19
-
-
0020501863
-
2. Identification of products formed in vitro
-
Fitzpatrick FA, Wynalda MA. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. J Biol Chem. 1983;258:11713-11718.
-
(1983)
J Biol Chem.
, vol.258
, pp. 11713-11718
-
-
Fitzpatrick, F.A.1
Wynalda, M.A.2
-
20
-
-
0037155868
-
2 metabolite generated during inflammatory processes
-
2 metabolite generated during inflammatory processes. J Biol Chem. 2002;277:10459-10466.
-
(2002)
J Biol Chem.
, vol.277
, pp. 10459-10466
-
-
Shibata, T.1
Kondo, M.2
Osawa, T.3
-
22
-
-
0034610759
-
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
-
Rossi A, Kapahi P, Natoli G, et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature. 2000;403:103-108.
-
(2000)
Nature
, vol.403
, pp. 103-108
-
-
Rossi, A.1
Kapahi, P.2
Natoli, G.3
-
24
-
-
0031886864
-
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
-
Ricote M, Li AC, Willson TM, et al. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature. 1998;391:79-82.
-
(1998)
Nature
, vol.391
, pp. 79-82
-
-
Ricote, M.1
Li, A.C.2
Willson, T.M.3
-
25
-
-
0031888958
-
PPAR-F agonists inhibit production of monocyte inflammatory cytokines
-
Jiang C, Ting AT, Seed B. PPAR-F agonists inhibit production of monocyte inflammatory cytokines. Nature. 1998;391:82-86.
-
(1998)
Nature
, vol.391
, pp. 82-86
-
-
Jiang, C.1
Ting, A.T.2
Seed, B.3
-
27
-
-
0142195899
-
Activation of nuclear receptors by prostaglandins
-
Ide T, Egan K, Bell-Parikh LC, et al. Activation of nuclear receptors by prostaglandins. Thrombosis research. 2003;110:311-315.
-
(2003)
Thrombosis Research
, vol.110
, pp. 311-315
-
-
Ide, T.1
Egan, K.2
Bell-Parikh, L.C.3
-
30
-
-
0034805226
-
A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPAR-F
-
Wilmer WA, Dixon C, Lu L, et al. A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPAR-F. Biochem Biophys Res Commun. 2001;281:57-62.
-
(2001)
Biochem Biophys Res Commun.
, vol.281
, pp. 57-62
-
-
Wilmer, W.A.1
Dixon, C.2
Lu, L.3
-
31
-
-
1642457242
-
Nuclear receptor signaling in macrophages
-
Valledor AF, Ricote M. Nuclear receptor signaling in macrophages. Biochem Pharmacol. 2004;67:201-212.
-
(2004)
Biochem Pharmacol.
, vol.67
, pp. 201-212
-
-
Valledor, A.F.1
Ricote, M.2
-
32
-
-
0034809335
-
2 inhibits IL-10 and IL-12 production by macrophages
-
Azuma Y, Shinohara M, Wang PL, et al. 15-Deoxy-delta(12,14)-prostaglandin J2 inhibits IL-10 and IL-12production by macrophages. Biochem Biophys Res Commun. 2001;283:344-346.
-
(2001)
Biochem Biophys Res Commun.
, vol.283
, pp. 344-346
-
-
Azuma, Y.1
Shinohara, M.2
Wang, P.L.3
-
33
-
-
0037233828
-
Rapid induction of peroxisome proliferator-activated receptor gamma expression in human monocytes by monosodium urate monohydrate crystals
-
Akahoshi T, Namai R, Murakami Y, et al. Rapid induction of peroxisome proliferator-activated receptor gamma expression in human monocytes by monosodium urate monohydrate crystals. Arthritis Rheum. 2003;48:231-39.
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 231-239
-
-
Akahoshi, T.1
Namai, R.2
Murakami, Y.3
-
34
-
-
0034660182
-
Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-γ-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells
-
Marx N, Mach F, Sauty A, et al. Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-F-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. J Immunol. 2000;164:6503-6508.
-
(2000)
J Immunol.
, vol.164
, pp. 6503-6508
-
-
Marx, N.1
Mach, F.2
Sauty, A.3
-
35
-
-
0034805606
-
Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium
-
Chen NG, Han X. Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium. Biochem Biophys Res Commun. 2001;282:717-722.
-
(2001)
Biochem Biophys Res Commun.
, vol.282
, pp. 717-722
-
-
Chen, N.G.1
Han, X.2
-
36
-
-
0033925031
-
2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats
-
2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J Clin Invest. 2000;106:189-197.
-
(2000)
J Clin Invest.
, vol.106
, pp. 189-197
-
-
Kawahito, Y.1
Kondo, M.2
Tsubouchi, Y.3
-
37
-
-
0142135636
-
Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase
-
Murakami Y, Akahoshi T, Hayashi I, et al. Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase. Arthritis Rheum. 2003;48:2931-2941.
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 2931-2941
-
-
Murakami, Y.1
Akahoshi, T.2
Hayashi, I.3
-
39
-
-
0033000906
-
Inducible cyclooxygenase may have anti-inflammatory properties
-
Gilroy DW, Colville-Nash PR,Willis D, et al. Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med. 1999;5:698-701.
-
(1999)
Nat Med.
, vol.5
, pp. 698-701
-
-
Gilroy, D.W.1
Colville-Nash, P.R.2
Willis, D.3
-
40
-
-
33845390748
-
2α by selective cyclooxygenase 2 inhibitors accounts for reduced rat leukocyte migration
-
2α by selective cyclooxygenase 2 inhibitors accounts for reduced rat leukocyte migration. Inflammation. 2005;29:163-169.
-
(2005)
Inflammation
, vol.29
, pp. 163-169
-
-
De Menezes, G.B.1
Dos Reis, W.G.2
Santos, J.M.3
-
41
-
-
27744605174
-
2α produced by inducible cyclooxygenase may contribute to the resolution of inflammation
-
discussion 477-480
-
2α produced by inducible cyclooxygenase may contribute to the resolution of inflammation. Inflammopharmacology. 2005;12:473-476; discussion 477-480.
-
(2005)
Inflammopharmacology
, vol.12
, pp. 473-476
-
-
Colville-Nash, P.R.1
Gilroy, D.W.2
Willis, D.3
-
42
-
-
0017550650
-
1 treatment of NZB/NZW F1 hybrid mice. II. Prevention of glomerulonephritis
-
1 treatment of NZB/NZW F1 hybrid mice. II. Prevention of glomerulonephritis. Arthritis Rheum. 1977;20:1449-1456.
-
(1977)
Arthritis Rheum.
, vol.20
, pp. 1449-1456
-
-
Zurier, R.B.1
Damjanov, I.2
Sayadoff, D.M.3
-
46
-
-
2942722569
-
2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP
-
2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP. J Immunol. 2004;173:559-565.
-
(2004)
J Immunol.
, vol.173
, pp. 559-565
-
-
Aronoff, D.M.1
Canetti, C.2
Peters-Golden, M.3
-
48
-
-
18844430825
-
The fibroblast-like synovial cell in rheumatoid arthritis: A key player in inflammation and joint destruction
-
Mor A, Abramson SB, Pillinger MH. The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destruction. Clin Immunol. 2005;115:118-128.
-
(2005)
Clin Immunol.
, vol.115
, pp. 118-128
-
-
Mor, A.1
Abramson, S.B.2
Pillinger, M.H.3
-
49
-
-
3843092892
-
Regulation of metalloproteinases and NF-κB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: Contrasting effects of nabumetone and 6MNA
-
Pillinger MH, Dinsell V, Apsel B, et al. Regulation of metalloproteinases and NF-κB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA. Br J Pharmacol. 2004;142:973-982.
-
(2004)
Br J Pharmacol.
, vol.142
, pp. 973-982
-
-
Pillinger, M.H.1
Dinsell, V.2
Apsel, B.3
-
50
-
-
0344153852
-
Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation
-
Pillinger MH, Rosenthal PB, Tolani SN, et al. Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation. J Immunol. 2003;171:6080-6089.
-
(2003)
J Immunol.
, vol.171
, pp. 6080-6089
-
-
Pillinger, M.H.1
Rosenthal, P.B.2
Tolani, S.N.3
-
51
-
-
0036802356
-
The role of NF-κB in the regulation of cell stress responses
-
Wang T, Zhang X, Li JJ. The role of NF-κB in the regulation of cell stress responses. Int Immunopharmacol. 2002;2:1509-1520.
-
(2002)
Int Immunopharmacol.
, vol.2
, pp. 1509-1520
-
-
Wang, T.1
Zhang, X.2
Li, J.J.3
-
52
-
-
27744552036
-
2 dissociates nuclear trafficking of individual NF-κB subunits (p65, p50) in stimulated rheumatoid synovial fibroblasts
-
2 dissociates nuclear trafficking of individual NF-κB subunits (p65, p50) in stimulated rheumatoid synovial fibroblasts. J Immunol. 2005;175:6924-6930.
-
(2005)
J Immunol.
, vol.175
, pp. 6924-6930
-
-
Gomez, P.F.1
Pillinger, M.H.2
Attur, M.3
-
53
-
-
20144376215
-
Matrix metalloproteinase secretion by gastric epithelial cells is regulated by E prostaglandins and MAPKs
-
Pillinger MH, Marjanovic N, Kim SY, et al. Matrix metalloproteinase secretion by gastric epithelial cells is regulated by E prostaglandins and MAPKs. J Biol Chem. 2005;280:9973-9979.
-
(2005)
J Biol Chem.
, vol.280
, pp. 9973-9979
-
-
Pillinger, M.H.1
Marjanovic, N.2
Kim, S.Y.3
-
54
-
-
34648814090
-
2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: This involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, A gene linked to chondrocyte hypertrophy
-
Tchetina EV, Di Battista JA, Zukor DJ, et al. Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy. Arthritis Res Ther. 2007;9:R75.
-
(2007)
Arthritis Res Ther.
, vol.9
-
-
Tchetina, E.V.1
Di Battista, J.A.2
Zukor, D.J.3
-
55
-
-
35248867156
-
2 and ciglitazone, in reperfusion injury: Role of nuclear factor-κB, heat shock factor 1, and Akt
-
2 and ciglitazone, in reperfusion injury: role of nuclear factor-κB, heat shock factor 1, and Akt. Shock. 2007;28:554-563.
-
(2007)
Shock
, vol.28
, pp. 554-563
-
-
Zingarelli, B.1
Hake, P.W.2
Mangeshkar, P.3
-
56
-
-
33847188169
-
Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: A possible mechanism for increased cardiovascular risk
-
Chan ES, Zhang H, Fernandez P, et al. Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk. Arthritis Res Ther. 2007;9:R4.
-
(2007)
Arthritis Res Ther.
, vol.9
-
-
Chan, E.S.1
Zhang, H.2
Fernandez, P.3
-
57
-
-
31044441042
-
Biological basis for the cardiovascular consequences of COX-2 inhibition: Therapeutic challenges and opportunities
-
Grosser T, Fries S, FitzGerald GA. Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest. 2006;116:4-15.
-
(2006)
J Clin Invest.
, vol.116
, pp. 4-15
-
-
Grosser, T.1
Fries, S.2
FitzGerald, G.A.3
-
58
-
-
3042853037
-
Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans
-
Cipollone F, Fazia M, Iezzi A, et al. Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans. Arterioscler Thromb Vasc Biol. 2004;24: 1259-1265.
-
(2004)
Arterioscler Thromb Vasc Biol.
, vol.24
, pp. 1259-1265
-
-
Cipollone, F.1
Fazia, M.2
Iezzi, A.3
-
59
-
-
0028167846
-
Inhibition of NF-κB by sodium salicylate and aspirin
-
Kopp E, Ghosh S. Inhibition of NF-κB by sodium salicylate and aspirin. Science. 1994;265:956-959.
-
(1994)
Science
, vol.265
, pp. 956-959
-
-
Kopp, E.1
Ghosh, S.2
-
60
-
-
0032564358
-
Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion
-
Pillinger MH, Capodici C, Rosenthal P, et al. Modes of action of aspirin-like drugs: salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion. Proc Natl Acad Sci U S A. 1998;95:14540-14545.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 14540-14545
-
-
Pillinger, M.H.1
Capodici, C.2
Rosenthal, P.3
-
61
-
-
0015237292
-
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
-
Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971;231:232-235.
-
(1971)
Nat New Biol.
, vol.231
, pp. 232-235
-
-
Vane, J.R.1
-
62
-
-
24344510350
-
Anti-inflammatory circuitry: Lipoxin, aspirin-triggered lipoxins and their receptor ALX
-
Chiang N, Arita M, Serhan CN. Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX. Prostaglandins Leukot Essent Fatty Acids. 2005;73:163-177.
-
(2005)
Prostaglandins Leukot Essent Fatty Acids
, vol.73
, pp. 163-177
-
-
Chiang, N.1
Arita, M.2
Serhan, C.N.3
-
63
-
-
24344469200
-
Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution
-
Serhan CN. Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins Leukot Essent Fatty Acids. 2005;73:141-162.
-
(2005)
Prostaglandins Leukot Essent Fatty Acids
, vol.73
, pp. 141-162
-
-
Serhan, C.N.1
|