메뉴 건너뛰기




Volumn 2, Issue 3, 2009, Pages 140-148

Polyunsaturated fatty acids and cardiovascular disease: Implications for nutrigenetics

Author keywords

5 Lipoxygenase; Cardiovascular disease; Fatty acids; Genes; Leukotriene

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; LEUKOTRIENE; LINOLEIC ACID; LINOLENIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID;

EID: 70349258116     PISSN: 16616499     EISSN: 16616758     Source Type: Journal    
DOI: 10.1159/000235562     Document Type: Short Survey
Times cited : (58)

References (69)
  • 1
    • 0034648768 scopus 로고    scopus 로고
    • Atherosclerosis
    • Lusis AJ: Atherosclerosis. Nature 2000; 407: 233-241.
    • (2000) Nature , vol.407 , pp. 233-241
    • Lusis, A.J.1
  • 3
    • 58049217860 scopus 로고    scopus 로고
    • National Human Genome Research Institute (NHGRI). accessed 17 August
    • National Human Genome Research Institute (NHGRI): A catalog of published genomewide association studies. www.genome.gov/ gwastudies (accessed 17 August 2009).
    • (2009) A Catalog of Published Genomewide Association Studies
  • 4
    • 0028707020 scopus 로고
    • The metabolism and availability of essential fatty acids in animal and human tissues
    • Bezard J, Blond JP, Bernard A, Clouet P: The metabolism and availability of essential fatty acids in animal and human tissues. Reprod Nutr Dev 1994; 34: 539-568.
    • (1994) Reprod Nutr Dev , vol.34 , pp. 539-568
    • Bezard, J.1    Blond, J.P.2    Bernard, A.3    Clouet, P.4
  • 5
    • 46449123205 scopus 로고    scopus 로고
    • The importance of the omega- 6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases
    • (Maywood)
    • Simopoulos AP: The importance of the omega- 6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood) 2008; 233: 674-688.
    • (2008) Exp Biol Med , vol.233 , pp. 674-688
    • Simopoulos, A.P.1
  • 6
    • 3142753961 scopus 로고    scopus 로고
    • Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases
    • Nakamura MT, Nara TY: Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 2004; 24: 345-376.
    • (2004) Annu Rev Nutr , vol.24 , pp. 345-376
    • Nakamura, M.T.1    Nara, T.Y.2
  • 7
    • 0036517387 scopus 로고    scopus 로고
    • Efficiency of conversion of alphalinolenic acid to long chain n-3 fatty acids in man
    • Brenna JT: Efficiency of conversion of alphalinolenic acid to long chain n-3 fatty acids in man. Curr Opin Clin Nutr Metab Care 2002; 5: 127-132.
    • (2002) Curr Opin Clin Nutr Metab Care , vol.5 , pp. 127-132
    • Brenna, J.T.1
  • 8
    • 3142753943 scopus 로고    scopus 로고
    • Dietary n-6 and n-3 fatty acid balance and cardiovascular health
    • Wijendran V, Hayes KC: Dietary n-6 and n-3 fatty acid balance and cardiovascular health. Annu Rev Nutr 2004; 24: 597-615.
    • (2004) Annu Rev Nutr , vol.24 , pp. 597-615
    • Wijendran, V.1    Hayes, K.C.2
  • 9
    • 23844549859 scopus 로고    scopus 로고
    • Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses
    • Goyens PL, Spilker ME, Zock PL, Katan MB, Mensink RP: Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. J Lipid Res 2005; 46: 1474-1483.
    • (2005) J Lipid Res , vol.46 , pp. 1474-1483
    • Goyens, P.L.1    Spilker, M.E.2    Zock, P.L.3    Katan, M.B.4    Mensink, R.P.5
  • 10
    • 0037088677 scopus 로고    scopus 로고
    • The biochemistry of n-3 polyunsaturated fatty acids
    • Jump DB: The biochemistry of n-3 polyunsaturated fatty acids. J Biol Chem 2002; 277: 8755-8758.
    • (2002) J Biol Chem , vol.277 , pp. 8755-8758
    • Jump, D.B.1
  • 11
    • 43249091138 scopus 로고    scopus 로고
    • Fish oil fatty acids as cardiovascular drugs
    • Leaf A, Kang JX, Xiao YF: Fish oil fatty acids as cardiovascular drugs. Curr Vasc Pharmacol 2008; 6: 1-12.
    • (2008) Curr Vasc Pharmacol , vol.6 , pp. 1-12
    • Leaf, A.1    Kang, J.X.2    Xiao, Y.F.3
  • 13
    • 39649111988 scopus 로고    scopus 로고
    • Omega-3 fatty acids and coronary heart disease risk: Clinical and mechanistic perspectives
    • Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ: Omega-3 fatty acids and coronary heart disease risk: Clinical and mechanistic perspectives. Atherosclerosis 2008; 197: 12-24.
    • (2008) Atherosclerosis , vol.197 , pp. 12-24
    • Harris, W.S.1    Miller, M.2    Tighe, A.P.3    Davidson, M.H.4    Schaefer, E.J.5
  • 15
    • 3042517241 scopus 로고    scopus 로고
    • Cyclooxygenase and 5-lipoxygenase pathways in the vessel wall: Role in atherosclerosis
    • Vila L: Cyclooxygenase and 5-lipoxygenase pathways in the vessel wall: Role in atherosclerosis. Med Res Rev 2004; 24: 399-424.
    • (2004) Med Res Rev , vol.24 , pp. 399-424
    • Vila, L.1
  • 16
    • 9744242678 scopus 로고    scopus 로고
    • Omega-3 fatty acids and inflammation
    • Mori TA, Beilin LJ: Omega-3 fatty acids and inflammation. Curr Atheroscler Rep 2004; 6: 461-467.
    • (2004) Curr Atheroscler Rep , vol.6 , pp. 461-467
    • Mori, T.A.1    Beilin, L.J.2
  • 17
    • 33746830525 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases
    • Calder PC: N-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 2006; 83: 1505S-1519S.
    • (2006) Am J Clin Nutr , vol.83
    • Calder, P.C.1
  • 18
    • 0034014271 scopus 로고    scopus 로고
    • Intracellular compartmentalization of leukotriene biosynthesis
    • Peters-Golden M, Brock TG: Intracellular compartmentalization of leukotriene biosynthesis. Am J Respir Crit Care Med 2000; 161:S36-S40.
    • (2000) Am J Respir Crit Care Med , vol.161
    • Peters-Golden, M.1    Brock, T.G.2
  • 20
    • 33751113286 scopus 로고    scopus 로고
    • Leukotriene receptors in atherosclerosis
    • Back M, Hansson GK: Leukotriene receptors in atherosclerosis. Ann Med 2006; 38: 493-502.
    • (2006) Ann Med , vol.38 , pp. 493-502
    • Back, M.1    Hansson, G.K.2
  • 21
    • 34247548667 scopus 로고    scopus 로고
    • 5-lipoxygenase: Regulation and possible involvement in atherosclerosis
    • Radmark O, Samuelsson B: 5-lipoxygenase: Regulation and possible involvement in atherosclerosis. Prostaglandins Other Lipid Mediat 2007; 83: 162-174.
    • (2007) Prostaglandins Other Lipid Mediat , vol.83 , pp. 162-174
    • Radmark, O.1    Samuelsson, B.2
  • 22
    • 42649113385 scopus 로고    scopus 로고
    • Thromboxane A2: Physiology/ pathophysiology, cellular signal transduction and pharmacology
    • Nakahata N: Thromboxane A2: Physiology/ pathophysiology, cellular signal transduction and pharmacology. Pharmacol Ther 2008; 118: 18-35.
    • (2008) Pharmacol Ther , vol.118 , pp. 18-35
    • Nakahata, N.1
  • 23
    • 0023604658 scopus 로고
    • Prophylaxis of atherosclerosis with marine omega-3 fatty acids A comprehensive strategy
    • von Schacky C: Prophylaxis of atherosclerosis with marine omega-3 fatty acids. A comprehensive strategy. Ann Intern Med 1987; 107: 890-899.
    • (1987) Ann Intern Med , vol.107 , pp. 890-899
    • Von Schacky, C.1
  • 24
    • 0021252756 scopus 로고
    • Biosynthesis and biological activity of leukotriene B5
    • Terano T, Salmon JA, Moncada S: Biosynthesis and biological activity of leukotriene B5. Prostaglandins 1984; 27: 217-232.
    • (1984) Prostaglandins , vol.27 , pp. 217-232
    • Terano, T.1    Salmon, J.A.2    Moncada, S.3
  • 25
    • 0142093151 scopus 로고    scopus 로고
    • 5-Lipoxygenase and atherosclerosis
    • Mehrabian M, Allayee H: 5-Lipoxygenase and atherosclerosis. Curr Opin Lipidol 2003; 14: 447-457.
    • (2003) Curr Opin Lipidol , vol.14 , pp. 447-457
    • Mehrabian, M.1    Allayee, H.2
  • 27
    • 0035920262 scopus 로고    scopus 로고
    • Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia
    • Mehrabian M, Wong J, Wang X, et al: Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia. Circ Res 2001; 89: 125-130.
    • (2001) Circ Res , vol.89 , pp. 125-130
    • Mehrabian, M.1    Wong, J.2    Wang, X.3
  • 28
    • 0037178728 scopus 로고    scopus 로고
    • Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice
    • Mehrabian M, Allayee H, Wong J, et al: Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res 2002; 91: 120-126.
    • (2002) Circ Res , vol.91 , pp. 120-126
    • Mehrabian, M.1    Allayee, H.2    Wong, J.3
  • 29
    • 4644301666 scopus 로고    scopus 로고
    • The 5- lipoxygenase pathway promotes pathogenesis of hyperlipidemia- dependent aortic aneurysm
    • Zhao L, Moos MP, Grabner R, et al: The 5- lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med 2004; 10: 966-973.
    • (2004) Nat Med , vol.10 , pp. 966-973
    • Zhao, L.1    Moos, M.P.2    Grabner, R.3
  • 30
    • 68949116297 scopus 로고    scopus 로고
    • Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice
    • Poeckel D, Zemski Berry KA, Murphy RC, Funk CD: Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice. J Biol Chem 2009; 284: 21077-21089.
    • (2009) J Biol Chem , vol.284 , pp. 21077-21089
    • Poeckel, D.1    Zemski Berry, K.A.2    Murphy, R.C.3    Funk, C.D.4
  • 31
    • 62649157212 scopus 로고    scopus 로고
    • Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice
    • Cao RY, St Amand T, Grabner R, Habenicht AJ, Funk CD: Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice. Atherosclerosis 2009; 203: 395-400.
    • (2009) Atherosclerosis , vol.203 , pp. 395-400
    • Cao, R.Y.1    St Amand, T.2    Grabner, R.3    Habenicht, A.J.4    Funk, C.D.5
  • 32
    • 27644549928 scopus 로고    scopus 로고
    • Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits
    • Mehrabian M, Allayee H, Stockton J, et al: Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet 2005; 37: 1224-1233.
    • (2005) Nat Genet , vol.37 , pp. 1224-1233
    • Mehrabian, M.1    Allayee, H.2    Stockton, J.3
  • 33
    • 43049088783 scopus 로고    scopus 로고
    • Identification of ALOX5 as a gene regulating adiposity and pancreatic function
    • Mehrabian M, Schulthess FT, Nebohacova M, et al: Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia 2008; 51: 978-988.
    • (2008) Diabetologia , vol.51 , pp. 978-988
    • Mehrabian, M.1    Schulthess, F.T.2    Nebohacova, M.3
  • 34
    • 0037417973 scopus 로고    scopus 로고
    • Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis
    • Spanbroek R, Grabner R, Lotzer K, et al: Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc Natl Acad Sci USA 2003; 100: 1238-1243.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1238-1243
    • Spanbroek, R.1    Grabner, R.2    Lotzer, K.3
  • 35
    • 33744497551 scopus 로고    scopus 로고
    • Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
    • Qiu H, Gabrielsen A, Agardh HE, et al: Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proc Natl Acad Sci USA 2006; 103: 8161-8166.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8161-8166
    • Qiu, H.1    Gabrielsen, A.2    Agardh, H.E.3
  • 36
    • 57749205363 scopus 로고    scopus 로고
    • Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis
    • Sanchez-Galan E, Gomez-Hernandez A, Vidal C, et al: Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis. Cardiovasc Res 2009; 81: 216-225.
    • (2009) Cardiovasc Res , vol.81 , pp. 216-225
    • Sanchez-Galan, E.1    Gomez-Hernandez, A.2    Vidal, C.3
  • 37
    • 64949177776 scopus 로고    scopus 로고
    • Correlation of peripheral-blood gene expression with the extent of coronary artery stenosis
    • Wingrove JA, Daniels SE, Sehnert AJ, et al: Correlation of peripheral-blood gene expression with the extent of coronary artery stenosis. Circ Cardiovasc Genet 2008; 1: 31-38.
    • (2008) Circ Cardiovasc Genet , vol.1 , pp. 31-38
    • Wingrove, J.A.1    Daniels, S.E.2    Sehnert, A.J.3
  • 38
    • 0347418277 scopus 로고    scopus 로고
    • Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis
    • Dwyer JH, Allayee H, Dwyer KM, et al: Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med 2004; 350: 29-37.
    • (2004) N Engl J Med , vol.350 , pp. 29-37
    • Dwyer, J.H.1    Allayee, H.2    Dwyer, K.M.3
  • 39
    • 53849103285 scopus 로고    scopus 로고
    • Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction
    • Allayee H, Baylin A, Hartiala J, et al: Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction. Am J Clin Nutr 2008; 88: 934-940.
    • (2008) Am J Clin Nutr , vol.88 , pp. 934-940
    • Allayee, H.1    Baylin, A.2    Hartiala, J.3
  • 40
    • 33947250836 scopus 로고    scopus 로고
    • A functional Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene is not associated with myocardial infarction
    • Gonzalez P, Reguero JR, Lozano I, Moris C, Coto E: A functional Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene is not associated with myocardial infarction. Int J Immunogenet 2007; 34: 127-130.
    • (2007) Int J Immunogenet , vol.34 , pp. 127-130
    • Gonzalez, P.1    Reguero, J.R.2    Lozano, I.3    Moris, C.4    Coto, E.5
  • 41
    • 45649085560 scopus 로고    scopus 로고
    • Arachidonate 5-lipoxygenase (5-LO) promoter genotype and risk of myocardial infarction: A case-control study
    • Maznyczka A, Braund P, Mangino M, Samani NJ: Arachidonate 5-lipoxygenase (5-LO) promoter genotype and risk of myocardial infarction: A case-control study. Atherosclerosis 2008; 199: 328-332.
    • (2008) Atherosclerosis , vol.199 , pp. 328-332
    • Maznyczka, A.1    Braund, P.2    Mangino, M.3    Samani, N.J.4
  • 42
    • 0037381586 scopus 로고    scopus 로고
    • Adipose tissue α-linolenic acid and nonfatal acute myocardial infarction in Costa Rica
    • DOI 10.1161/01.CIR.0000058165.81208.C6
    • Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H: Adipose tissue alphalinolenic acid and nonfatal acute myocardial infarction in Costa Rica. Circulation 2003; 107: 1586-1591. (Pubitemid 36397325)
    • (2003) Circulation , vol.107 , Issue.12 , pp. 1586-1591
    • Baylin, A.1    Kabagambe, E.K.2    Ascherio, A.3    Spiegelman, D.4    Campos, H.5
  • 43
    • 33947241740 scopus 로고    scopus 로고
    • Tag- SNP evaluation for the association of 42 inflammation loci and vascular disease: Evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects
    • Carlson CS, Heagerty PJ, Nord AS, et al: Tag- SNP evaluation for the association of 42 inflammation loci and vascular disease: Evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects. Hum Genet 2007; 121: 65-75.
    • (2007) Hum Genet , vol.121 , pp. 65-75
    • Carlson, C.S.1    Heagerty, P.J.2    Nord, A.S.3
  • 44
    • 60549085208 scopus 로고    scopus 로고
    • Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis
    • Crosslin DR, Shah SH, Nelson SC, et al: Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis. Hum Genet 2009; 125: 217-229.
    • (2009) Hum Genet , vol.125 , pp. 217-229
    • Crosslin, D.R.1    Shah, S.H.2    Nelson, S.C.3
  • 45
    • 10744220794 scopus 로고    scopus 로고
    • The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
    • Helgadottir A, Manolescu A, Thorleifsson G, et al: The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 2004; 36: 233-239.
    • (2004) Nat Genet , vol.36 , pp. 233-239
    • Helgadottir, A.1    Manolescu, A.2    Thorleifsson, G.3
  • 46
    • 13844289142 scopus 로고    scopus 로고
    • Association between the gene encoding 5- lipoxygenase-activating protein and stroke replicated in a Scottish population
    • Helgadottir A, Gretarsdottir S, St Clair D, et al: Association between the gene encoding 5- lipoxygenase-activating protein and stroke replicated in a Scottish population. Am J Hum Genet 2005; 76: 505-509.
    • (2005) Am J Hum Genet , vol.76 , pp. 505-509
    • Helgadottir, A.1    Gretarsdottir, S.2    St Clair, D.3
  • 47
    • 34548157531 scopus 로고    scopus 로고
    • ALOX5AP gene variants and risk of coronary artery disease: An angiography-based study
    • Girelli D, Martinelli N, Trabetti E, et al: ALOX5AP gene variants and risk of coronary artery disease: An angiography-based study. Eur J Hum Genet 2007; 15: 959-966.
    • (2007) Eur J Hum Genet , vol.15 , pp. 959-966
    • Girelli, D.1    Martinelli, N.2    Trabetti, E.3
  • 48
    • 58149166487 scopus 로고    scopus 로고
    • Genetic variation in the arachidonate 5-lipoxygenase- activating protein (ALOX5AP) is associated with myocardial infarction in the German population
    • (Lond)
    • Linsel-Nitschke P, Gotz A, Medack A, et al: Genetic variation in the arachidonate 5-lipoxygenase- activating protein (ALOX5AP) is associated with myocardial infarction in the German population. Clin Sci (Lond) 2008; 115: 309-315.
    • (2008) Clin Sci , vol.115 , pp. 309-315
    • Linsel-Nitschke, P.1    Gotz, A.2    Medack, A.3
  • 49
    • 62649140865 scopus 로고    scopus 로고
    • Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia
    • van der Net JB, Versmissen J, Oosterveer DM, et al: Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. Atherosclerosis 2009; 203: 472-478.
    • (2009) Atherosclerosis , vol.203 , pp. 472-478
    • Van Der Net, J.B.1    Versmissen, J.2    Oosterveer, D.M.3
  • 50
    • 29444444748 scopus 로고    scopus 로고
    • A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
    • Helgadottir A, Manolescu A, Helgason A, et al: A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet 2006; 38: 68-74.
    • (2006) Nat Genet , vol.38 , pp. 68-74
    • Helgadottir, A.1    Manolescu, A.2    Helgason, A.3
  • 51
    • 33747183983 scopus 로고    scopus 로고
    • Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: A nested case-control approach
    • Zee RY, Cheng S, Hegener HH, Erlich HA, Ridker PM: Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: A nested case-control approach. Stroke 2006; 37: 2007-2011.
    • (2006) Stroke , vol.37 , pp. 2007-2011
    • Zee, R.Y.1    Cheng, S.2    Hegener, H.H.3    Erlich, H.A.4    Ridker, P.M.5
  • 52
    • 33847072582 scopus 로고    scopus 로고
    • No association of polymorphisms in the gene encoding 5-lipoxygenase- activating protein and myocardial infarction in a large central European population
    • Koch W, Hoppmann P, Mueller JC, Schomig A, Kastrati A: No association of polymorphisms in the gene encoding 5-lipoxygenase- activating protein and myocardial infarction in a large central European population. Genet Med 2007; 9: 123-129.
    • (2007) Genet Med , vol.9 , pp. 123-129
    • Koch, W.1    Hoppmann, P.2    Mueller, J.C.3    Schomig, A.4    Kastrati, A.5
  • 53
    • 42149181753 scopus 로고    scopus 로고
    • Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease
    • Assimes TL, Knowles JW, Priest JR, et al: Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. Hum Genet 2008; 123: 399-408.
    • (2008) Hum Genet , vol.123 , pp. 399-408
    • Assimes, T.L.1    Knowles, J.W.2    Priest, J.R.3
  • 54
    • 18244403498 scopus 로고    scopus 로고
    • Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: A randomized trial
    • Hakonarson H, Thorvaldsson S, Helgadottir A, et al: Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: A randomized trial. JAMA 2005; 293: 2245-2256.
    • (2005) JAMA , vol.293 , pp. 2245-2256
    • Hakonarson, H.1    Thorvaldsson, S.2    Helgadottir, A.3
  • 55
    • 33644749435 scopus 로고    scopus 로고
    • Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice
    • Jawien J, Gajda M, Rudling M, et al: Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice. Eur J Clin Invest 2006; 36: 141-146.
    • (2006) Eur J Clin Invest , vol.36 , pp. 141-146
    • Jawien, J.1    Gajda, M.2    Rudling, M.3
  • 57
    • 1042268024 scopus 로고    scopus 로고
    • Role of leukotriene B4 receptors in the development of atherosclerosis: Potential mechanisms
    • Subbarao K, Jala VR, Mathis S, et al: Role of leukotriene B4 receptors in the development of atherosclerosis: Potential mechanisms. Arterioscler Thromb Vasc Biol 2004; 24: 369-375.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 369-375
    • Subbarao, K.1    Jala, V.R.2    Mathis, S.3
  • 58
    • 5344263063 scopus 로고    scopus 로고
    • Leukotriene B4 strongly increases monocyte chemoattractant protein-1 in human monocytes
    • Huang L, Zhao A, Wong F, et al: Leukotriene B4 strongly increases monocyte chemoattractant protein-1 in human monocytes. Arterioscler Thromb Vasc Biol 2004; 24: 1783-1788.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1783-1788
    • Huang, L.1    Zhao, A.2    Wong, F.3
  • 59
    • 23044443692 scopus 로고    scopus 로고
    • Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment
    • Heller EA, Liu E, Tager AM, et al: Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation 2005; 112: 578-586.
    • (2005) Circulation , vol.112 , pp. 578-586
    • Heller, E.A.1    Liu, E.2    Tager, A.M.3
  • 60
    • 33846545108 scopus 로고    scopus 로고
    • Association between a leukotriene C4 synthase gene promoter polymorphism and coronary artery calcium in young women: The muscatine study
    • Iovannisci DM, Lammer EJ, Steiner L, et al: Association between a leukotriene C4 synthase gene promoter polymorphism and coronary artery calcium in young women: The Muscatine Study. Arterioscler Thromb Vasc Biol 2007; 27: 394-399.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 394-399
    • Iovannisci, D.M.1    Lammer, E.J.2    Steiner, L.3
  • 61
    • 61749085692 scopus 로고    scopus 로고
    • Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals
    • Freiberg JJ, Dahl M, Tybjaerg-Hansen A, Grande P, Nordestgaard BG: Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. J Mol Cell Cardiol 2009; 46: 579-586.
    • (2009) J Mol Cell Cardiol , vol.46 , pp. 579-586
    • Freiberg, J.J.1    Dahl, M.2    Tybjaerg-Hansen, A.3    Grande, P.4    Nordestgaard, B.G.5
  • 62
    • 41149089320 scopus 로고    scopus 로고
    • Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: A replication study in two independent populations
    • Bevan S, Dichgans M, Wiechmann HE, Gschwendtner A, Meitinger T, Markus HS: Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: A replication study in two independent populations. Stroke 2008; 39: 1109-1114.
    • (2008) Stroke , vol.39 , pp. 1109-1114
    • Bevan, S.1    Dichgans, M.2    Wiechmann, H.E.3    Gschwendtner, A.4    Meitinger, T.5    Markus, H.S.6
  • 63
    • 35448968676 scopus 로고    scopus 로고
    • The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics
    • Allayee H, Hartiala J, Lee W, et al: The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics. Chest 2007; 132: 868-874.
    • (2007) Chest , vol.132 , pp. 868-874
    • Allayee, H.1    Hartiala, J.2    Lee, W.3
  • 65
    • 36649010249 scopus 로고    scopus 로고
    • Fat-1 transgenic mice: A new model for omega-3 research
    • Kang JX: Fat-1 transgenic mice: A new model for omega-3 research. Prostaglandins Leukot Essent Fatty Acids 2007; 77: 263-267.
    • (2007) Prostaglandins Leukot Essent Fatty Acids , vol.77 , pp. 263-267
    • Kang, J.X.1
  • 66
    • 33746625086 scopus 로고    scopus 로고
    • Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis
    • Hudert CA, Weylandt KH, Lu Y, et al: Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc Natl Acad Sci USA 2006; 103: 11276-11281.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11276-11281
    • Hudert, C.A.1    Weylandt, K.H.2    Lu, Y.3
  • 67
    • 34447119437 scopus 로고    scopus 로고
    • Increased dietary intake of omega-3- polyunsaturated fatty acids reduces pathological retinal angiogenesis
    • Connor KM, SanGiovanni JP, Lofqvist C, et al: Increased dietary intake of omega-3- polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med 2007; 13: 868-873.
    • (2007) Nat Med , vol.13 , pp. 868-873
    • Connor, K.M.1    Sangiovanni, J.P.2    Lofqvist, C.3
  • 68
    • 34447121230 scopus 로고    scopus 로고
    • Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
    • Berquin IM, Min Y, Wu R, et al: Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest 2007; 117: 1866-1875.
    • (2007) J Clin Invest , vol.117 , pp. 1866-1875
    • Berquin, I.M.1    Min, Y.2    Wu, R.3
  • 69
    • 63249102365 scopus 로고    scopus 로고
    • Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids
    • Mayer K, Kiessling A, Ott J, et al: Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids. Am J Respir Crit Care Med 2009; 179: 474-483.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 474-483
    • Mayer, K.1    Kiessling, A.2    Ott, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.