Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria

European Journal of Clinical Pharmacology

Volumn 65, Issue 10, 2009, Pages 977-987

  Miller, Ann K ^a   Bandyopadhyay, Nibedita ^a,b   Wootton, Daniel G ^c   Duparc, Stephan ^d,e   Kirby, Paula L ^d   Winstanley, Peter A ^f   Ward, Stephen A ^g  

^a GLAXOSMITHKLINE   (United States)

^b JOHNSON AND JOHNSON   (United States)

^c ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

^e Medicines for Malaria Venture   (Switzerland)

^f UNIVERSITY OF LIVERPOOL   (United Kingdom)

^g LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Antimalarial combination therapy; Artesunate; Chlorproguanil dapsone; Malaria; Pharmacokinetics

Indexed keywords

ACETYLDAPSONE; ARTESUNATE; CHLORCYCLOGUANIL; CHLORPROGUANIL; CHLORPROGUANIL PLUS DAPSONE; DAPSONE; DIHYDROARTEMISININ; DRUG METABOLITE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EFFICACY; DRUG STABILITY; FEMALE; GAMBIA; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALAWI; MALE; MAXIMUM PLASMA CONCENTRATION; PHARMACOLOGICAL PARAMETERS; PHASE 2 CLINICAL TRIAL; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TABLET FORMULATION; TREATMENT DURATION;

ADULT; ANTIMALARIALS; AREA UNDER CURVE; ARTEMISININS; CHLOROGUANIDE; DAPSONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; GAMBIA; HUMANS; MALARIA, FALCIPARUM; MALAWI; MALE; MIDDLE AGED; PARASITIC SENSITIVITY TESTS; TIME FACTORS;

EID: 70349229344     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-009-0672-1     Document Type: Article

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