Absence of time-dependent artesunate pharmacokinetics in healthy subjects during 5-day oral administration

European Journal of Clinical Pharmacology

Volumn 64, Issue 10, 2008, Pages 993-998

  Diem Thuy, L T ^a   Ngoc Hung, L ^b   Danh, P T ^b   Na Bangchang, K ^a  

^a THAMMASAT UNIVERSITY   (Thailand)

^b CHO RAY HOSPITAL   (Viet Nam)

Author keywords

Artesunate; Dihydroartemisinin; Enzyme induction; Malaria; Pharmacokinetics

Indexed keywords

ARTESUNATE; CYTOCHROME P450 2B6; DIHYDROARTEMISININ;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; ENZYME INDUCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ADULT; ANTIMALARIALS; AREA UNDER CURVE; ARTEMISININS; DRUG ADMINISTRATION SCHEDULE; HALF-LIFE; HUMANS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; TIME; VIETNAM; YOUNG ADULT;

EID: 53249144071     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-008-0506-6     Document Type: Article

References (21)

1. GQ Li XB Guo LC Fu HX Jian XH Wang 1994 Clinical trials of artemisinin and its derivatives in the treatment of malaria in China Trans R Soc Trop Med Hyg 88 Suppl 1 S5 S6
2. M Ashton TN Hai ND Sy DX Huong N Van Huong NT Niêu LD Công 1998 Artemisinin pharmacokinetics is time-dependent during repeated oral administration in healthy male adults Drug Metab Dispos 26 25 27
3. M Ashton T Gordi NH Trinh VH Nguyen DS Nguyen TN Nguyen XH Dinh M Johansson DC Le 1998 Artemisinin pharmacokinetics in healthy adults after 250, 500 and 1000 mg single oral doses Biopharm Drug Dispos 19 245 250
4. M Ashton DS Nguyen VH Nguyen T Gordi NH Trinh XH Dinh TN Nguyen DC Le 1998 Artemisinin kinetics and dynamics during oral and rectal treatment of uncomplicated malaria Clin Pharmacol Ther 63 482 493
5. MH Alin M Ashton CM Kihamia GJ Mtey A Björkman 1996 Clinical efficacy and pharmacokinetics of artemisinin monotherapy and in combination with mefloquine in patients with falciparum malaria Br J Clin Pharmacol 4 587 592
6. M Hassan Alin M Ashton CM Kihamia GJ Mtey A Björkman 1996 Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients Trans R Soc Trop Med Hyg 90 61 65
7. NX Khanh PJ de Vries LD Ha CJ van Boxtel R Koopmans PA Kager 1999 Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for falciparum malaria Antimicrob Agents Chemother 43 690 692
8. DA Elsherbiny SA Asimus MO Karlsson M Ashton US Simonsson 2008 A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens J Pharmacokinet Pharmacodyn 10928 9084 9096
9. Diem Thuy LT, Ngoc Hung L, Danh PT, Na-Bangchang K (2008) Pharmacokinetics of a five-day oral dihydroartemisinin monotherapy regimen in patients with uncomplicated falciparum malaria. Drug Met Pharmacokinet (in press)
10. Diem Thuy LT, Ngoc Hung L, Danh PT, Na-Bangchang K (2008) Development and validation of a liquid chromatography-mass spectrometry method for the simultaneous quantification of artesunate and dihydroartemisininin human plasma (submitted)
11. d' Argenio DZ, Schumitzky A (2003) ADAPT II, release 4: pharmacokinetic/pharmacodynamic system analysis software. http://bmsr.usc.edu/ Software/ADAPT/ADAPT.html. Accessed 14 May 2008
12. K Na-Bangchang S Krudsood U Silachamroon P Molunto O Tasanor K Chalermrut O Tangpukdee S Kano S Looareesuwan 2004 The pharmacokinetics of oral dihydroartemisinin and artesunate in healthy Thai volunteers Southeast Asian J Trop Med Pub Health 35 575 580
13. KT Batty M Ashton KF Ilett G Edwards TM Davis 1998 The pharmacokinetics of artemisinin (ART) and artesunate (ARTS) in healthy volunteers Am J Trop Med Hyg 58 125 126
14. ME Molyneux S Looareesuwan IS Menzies SL Grainger RE Phillips Y Wattanagoon RP Thompson DA Warrell 1989 Reduced hepatic blood flow and intestinal malabsorption in severe falciparum malaria Am J Trop Med Hyg 40 470 476
15. KF Ilett BT Ethell JL Maggs TM Davis KT Batty B Burchell TQ Binh TA Thu le NC Hung M Pirmohamed BK Park G Edwards 2002 Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP- glucuronosyltransferases Drug Metab Dispos 30 1005 1012
16. US Svensson M Ashton NH Trinh L Bertilsson XH Dinh VH Nguyen TN Nguyen DS Nguyen J Lykkesfeldt DC Le 1998 Artemisinin induces omeprazole metabolism in human beings Clin Pharmacol Ther 64 160 167
17. US Svensson M Ashton 1999 Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin Br J Clin Pharmacol 48 528 535
18. PL Olliaro NK Nair K Sathasivam SM Mansor V Navaratnam 2002 Pharmacokinetics of artesunate after single oral administration to rats BMC Pharmacol 1 12 15
19. JM Grace AJ Aguilar KM Trotman JO Peggins TG Brewer 1998 Metabolism of beta-arteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P450 Drug Metab Dispos 26 313 317
20. T Shimada H Yamazaki M Mimura Y Inui FP Guengerich 1994 Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians J Pharmacol Exp Ther 270 414 423
21. TK Mutabingwa 2005 Artemisinin-based combination therapies (ACTs): best hope for malaria treatment but inaccessible to the needy! Acta Trop 95 305 315