Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria

Tropical Medicine and International Health

Volumn 6, Issue 11, 2001, Pages 952-954

  Winstanley, Peter ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Drug development; Falciparum malaria; LAPDAP

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; CHLORPROGUANIL DAPSONE; CHLORPROGUANIL DAPSONE ARTESUNATE; FANSIDAR; UNCLASSIFIED DRUG;

DISEASE TREATMENT; MALARIA; PUBLIC HEALTH;

ARTICLE; DRUG ELIMINATION; HEALTH CARE POLICY; HUMAN; INFECTION; MALARIA FALCIPARUM; ORGANIZATION; PUBLIC HEALTH; SCIENCE;

ANTIMALARIALS; ARTEMISININS; CHLOROGUANIDE; CLINICAL TRIALS, PHASE III; DAPSONE; DRUG APPROVAL; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; HEALTH SERVICES ACCESSIBILITY; HUMANS; MALARIA, FALCIPARUM; SESQUITERPENES;

AFRICA;

ARTESUNATE; ILEX COOKII; PROTOZOA;

EID: 0034775612     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3156.2001.00751.x     Document Type: Article

References (10)

1. Chlorproguanil-dapsone: An effective treatment for uncomplicated falciparum malaria
2. Drug resistant falciparum malaria in Tanzania: Chlorproguanil-dapsone is effective treatment for infections resistant to pyrimethamine-sulfadoxine
3. Molecular evidence of greater selective pressure for drug resistance exerted by the long acting antifolate pyrimethamine/sulfadoxine compared with the shorter acting chlorproguanil-dapsone on Kenyan Plasmodium falciparum
4. Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: The genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites
5. The efficacy of antifolate combinations in Africa: A predictive model based on pharmacodynamic and pharmacokinetic analyses
6. Treatment of Plasmodium falciparum malaria with pyrimethamine and sulphadoxine: A selective pressure for resistance in a function of long elimination half-life
7. Preventing antimalarial drug resistance through combinations
8. Chemotherapy for falciparum malaria: The armoury, the problems and the prospects
9. The in vitro activity of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte colony-forming-units
10. Chlorproguanil-dapsone for uncomplicated falciparum malaria in young children: Pharmacokinetics and therapeutic range