Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 876, Issue 1, 2008, Pages 54-60

  Lindegardh, N ^a,b   Hanpithakpong, W ^a   Kamanikom, B ^a   Singhasivanon, P ^a   Socheat, D ^c   Yi, P ^c   Dondorp, A M ^a,b   McGready, R ^d   Nosten, F ^d   White, N J ^a,b   Day, N P J ^a,b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c National Center for Parasitology Entomology and Malaria Control   (Cambodia)

^d SHOKLO MALARIA RESEARCH UNIT   (Thailand)

Author keywords

Antimalarial; Artesunate; Degradation; Dihydroartemisinin; Liquid chromatography tandem mass spectrometry (LC MS MS); Pitfalls; Protein precipitation; Solid phase extraction; Stable isotope labeled (SIL) internal standard

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; CONCENTRATION (PROCESS); DATA STORAGE EQUIPMENT; DEGRADATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; ORGANIC COMPOUNDS; ORGANIC SOLVENTS; PHARMACOKINETICS; PLASMAS; SOLVENT EXTRACTION; SOLVENTS;

ANTIMALARIAL; ARTESUNATE; DIHYDROARTEMISININ; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY (LC/MS/MS); PITFALLS; PROTEIN PRECIPITATION; SOLID PHASE EXTRACTION; STABLE ISOTOPE LABELED (SIL) INTERNAL STANDARD;

EXTRACTION;

ARTESUNATE; DIHYDROARTEMISININ; MEFLOQUINE; ORGANIC SOLVENT;

ANALYSIS OF VARIANCE; ANALYTIC METHOD; ARTICLE; CLINICAL ARTICLE; CLINICAL STUDY; CONCENTRATION (PARAMETERS); DEGRADATION; DRUG BLOOD LEVEL; FEMALE; FOOD AND DRUG ADMINISTRATION; HEMOLYSIS; HUMAN; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MALARIA; MASS SPECTROMETRY; MEASUREMENT; PLASMA; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; UNITED STATES;

ANTICOAGULANTS; ANTIMALARIALS; ARTEMISININS; FEMALE; HEMOLYSIS; HUMANS; MALARIA, FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TEMPERATURE;

ARTESUNATE;

EID: 56249094488     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.10.021     Document Type: Article

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