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Volumn 5, Issue 6, 2009, Pages 871-888

Systemic therapy of kidney cancer: Tyrosine kinase inhibitors antiagiogenesis or IL-2?

Author keywords

Angiogenesis inhibitors; Bevacizumab; Interleukin 2; Mammalian target of rapamycin; Multikinase inhibitors; Renal cell carcinoma; Sorafenib; Sunitinib; Targeted therapy; VEGF

Indexed keywords

ANGIOGENESIS INHIBITOR; HYPOXIA INDUCIBLE FACTOR; INTERLEUKIN 2; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN TYROSINE KINASE INHIBITOR; SUNITINIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VON HIPPEL LINDAU PROTEIN;

EID: 70349209358     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.09.51     Document Type: Review
Times cited : (5)

References (94)
  • 2
    • 7144255510 scopus 로고    scopus 로고
    • Interferon γ-1b compared with placebo in metastatic renal cell carcinoma
    • Gleave ME, Elhilali M, Fradet Y et al.: Interferon γ-1b compared with placebo in metastatic renal cell carcinoma. N. Engl. J. Med. 338, 1265-1271 (1998).
    • (1998) N. Engl. J. Med , vol.338 , pp. 1265-1271
    • Gleave, M.E.1    Elhilali, M.2    Fradet, Y.3
  • 3
    • 0030853434 scopus 로고    scopus 로고
    • Classification of renal cell carcinoma: Workgroup no. 1. Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC)
    • Störkel S, Eble JN, Adlakha K et al.: Classification of renal cell carcinoma: Workgroup no. 1. Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC), Cancer 80, 987-989 (1997).
    • (1997) Cancer , vol.80 , pp. 987-989
    • Störkel, S.1    Eble, J.N.2    Adlakha, K.3
  • 4
    • 4644335916 scopus 로고    scopus 로고
    • Update on the role of interleukin 2 and other cytokines in the treatment of patients with stage IV renal carcinoma
    • Atkins MB, Regan M, McDermott D: Update on the role of interleukin 2 and other cytokines in the treatment of patients with stage IV renal carcinoma. Clin. Cancer Res. 10(18 Part 2), S6342-S6346 (2004).
    • (2004) Clin. Cancer Res , vol.10 , Issue.18 PART 2
    • Atkins, M.B.1    Regan, M.2    McDermott, D.3
  • 6
    • 33749451610 scopus 로고    scopus 로고
    • Molecular pathways in renal cell carcinoma - rationale for targeted treatment
    • Kim WY, Kaelin WG: Molecular pathways in renal cell carcinoma - rationale for targeted treatment. Semin. Oncol. 33, 588-595 (2006).
    • (2006) Semin. Oncol , vol.33 , pp. 588-595
    • Kim, W.Y.1    Kaelin, W.G.2
  • 7
    • 0027954044 scopus 로고
    • Mutations of the VHL tumor suppressor gene in renal carcinoma
    • Gnarra JR, Tory K, Weng Y et al.: Mutations of the VHL tumor suppressor gene in renal carcinoma. Nat. Genet. 7(1), 85-90 (1994).
    • (1994) Nat. Genet , vol.7 , Issue.1 , pp. 85-90
    • Gnarra, J.R.1    Tory, K.2    Weng, Y.3
  • 8
    • 0033602089 scopus 로고    scopus 로고
    • Alternate choice of initiation codon procedures a biologically active product of the von Hippel Lindau gene with tumor suppressor activity
    • Blakenship C, Naglich JG, Whalet et al.: Alternate choice of initiation codon procedures a biologically active product of the von Hippel Lindau gene with tumor suppressor activity. Oncogene 18, 1529-1535 (1999).
    • (1999) Oncogene , vol.18 , pp. 1529-1535
    • Blakenship, C.1    Naglich, J.G.2    Whalet3
  • 9
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • Kaelin WG: Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer 2, 673-682 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 673-682
    • Kaelin, W.G.1
  • 10
    • 0035313697 scopus 로고    scopus 로고
    • HIF-1 and mechanisms of hypoxia sensing
    • Semenza GL: HIF-1 and mechanisms of hypoxia sensing. Curr. Opin. Cell Biol. 13, 167-171 (2001).
    • (2001) Curr. Opin. Cell Biol , vol.13 , pp. 167-171
    • Semenza, G.L.1
  • 12
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL: Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721-732 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 13
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - a key regulatory factor in tumor growth
    • Harris AL: Hypoxia - a key regulatory factor in tumor growth. Nat. Rev. Cancer 2, 38-47 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 14
    • 0037204026 scopus 로고    scopus 로고
    • Serial analysis of gene expression in renal carcinoma cells reveals VHL-dependent sensitivity to TNF-α cytotoxicity
    • Caldwell MC, Hough C, Furer S et al.: Serial analysis of gene expression in renal carcinoma cells reveals VHL-dependent sensitivity to TNF-α cytotoxicity. Oncogene 21, 929-936 (2002).
    • (2002) Oncogene , vol.21 , pp. 929-936
    • Caldwell, M.C.1    Hough, C.2    Furer, S.3
  • 15
    • 39049162107 scopus 로고    scopus 로고
    • Targeting vasculature in Urologic tumors: Mechanistic and therapeutic significance
    • Sakamato S, Ryan AJ, Kyprianu N: Targeting vasculature in Urologic tumors: mechanistic and therapeutic significance. J. Cell. Biochem. 103, 691-708 (2008).
    • (2008) J. Cell. Biochem , vol.103 , pp. 691-708
    • Sakamato, S.1    Ryan, A.J.2    Kyprianu, N.3
  • 16
    • 84975525035 scopus 로고
    • Clinical applications of research on angiogenesis
    • Folkman J: Clinical applications of research on angiogenesis. N. Engl. J. Med. 333, 1757-1763 (1995).
    • (1995) N. Engl. J. Med , vol.333 , pp. 1757-1763
    • Folkman, J.1
  • 17
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase a receptor for vascular endothelial growth factor
    • de Vries C, Escobedo JS, Ueno H, Houck K, Ferrara N, Williams LT: The fms-like tyrosine kinase a receptor for vascular endothelial growth factor. Science 255, 989-991 (1992).
    • (1992) Science , vol.255 , pp. 989-991
    • de Vries, C.1    Escobedo, J.S.2    Ueno, H.3    Houck, K.4    Ferrara, N.5    Williams, L.T.6
  • 18
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggests flk-I as a major regulator of vasculogenesis and angiogenesis
    • Millauer B, Wizigmann-Voos S, Schnurch H et al.: High affinity VEGF binding and developmental expression suggests flk-I as a major regulator of vasculogenesis and angiogenesis. Cell 72, 835-846 (1993).
    • (1993) Cell , vol.72 , pp. 835-846
    • Millauer, B.1    Wizigmann-Voos, S.2    Schnurch, H.3
  • 19
    • 33846866035 scopus 로고    scopus 로고
    • The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer
    • Cho D, Signoretti S, Regan M et al.: The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer. Clin. Cancer Res. 13, S758-S763 (2007).
    • (2007) Clin. Cancer Res , vol.13
    • Cho, D.1    Signoretti, S.2    Regan, M.3
  • 20
    • 53849125004 scopus 로고    scopus 로고
    • mTORC1 inhibitors: Is temsirolimus in renal cancer telling us how they really work?
    • Le Tourneau C, Faivre S, Raymond E: mTORC1 inhibitors: is temsirolimus in renal cancer telling us how they really work? Br. J. Cancer 99, 1197-1203 (2008).
    • (2008) Br. J. Cancer , vol.99 , pp. 1197-1203
    • Le Tourneau, C.1    Faivre, S.2    Raymond, E.3
  • 21
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kraeme G, Ramond E: Current development of mTOR inhibitors as anticancer agents. Nat. Rev. Drug Discov. 5, 671-688 (2006).
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1    Kraeme, G.2    Ramond, E.3
  • 23
    • 24344446438 scopus 로고    scopus 로고
    • The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
    • Hamada K, Sasaki T, Koni PA et al.: The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev. 19, 2054-2065 (2005).
    • (2005) Genes Dev , vol.19 , pp. 2054-2065
    • Hamada, K.1    Sasaki, T.2    Koni, P.A.3
  • 24
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by anti-angiogenesis involvement of vascular endothelial growth factor
    • Gaba M, von Breitenbuch P, Steinbauer M et al.: Rapamycin inhibits primary and metastatic tumor growth by anti-angiogenesis involvement of vascular endothelial growth factor. Nat. Med. 8, 128-135 (2002).
    • (2002) Nat. Med , vol.8 , pp. 128-135
    • Gaba, M.1    von Breitenbuch, P.2    Steinbauer, M.3
  • 25
    • 0037177867 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/ Akt signaling is neither required for hypoxic stabilization of HIF-1 α nor sufficient for HIF-1 dependent target gene transcription
    • Arsham AM, Plas DR, Thompson CB, Simon MC: Phosphatidylinositol 3-kinase/ Akt signaling is neither required for hypoxic stabilization of HIF-1 α nor sufficient for HIF-1 dependent target gene transcription. J. Biol. Chem. 277(17), 15162-15170 (2002).
    • (2002) J. Biol. Chem , vol.277 , Issue.17 , pp. 15162-15170
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 26
    • 33947504730 scopus 로고    scopus 로고
    • Sunitinib from rational design to clinical efficacy
    • Chow LQ, Eckhardt SG: Sunitinib from rational design to clinical efficacy. J. Clin. Oncol. 25, 884-896 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 884-896
    • Chow, L.Q.1    Eckhardt, S.G.2
  • 27
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • Faivre S, Delbaldo, Vera K et al.: Safety, pharmacokinetic and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J. Clin. Oncol. 24, 25-25 (2007).
    • (2007) J. Clin. Oncol , vol.24 , pp. 25-25
    • Faivre, S.1    Delbaldo, V.K.2
  • 28
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor in patients with metastatic renal cell carcinoma
    • Motzer RJ, Michaelson MD, Redman BG et al.: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 24, 16-24 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 29
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer RJ, Rini BI, Bukowski RM et al.: Sunitinib in patients with metastatic renal cell carcinoma. JAMA 295, 2516-2524 (2006).
    • (2006) JAMA , vol.295 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 30
    • 0032772880 scopus 로고    scopus 로고
    • Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
    • Motzer RJ, Mazumdar M, Bacik J et al.: Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J. Clin. Oncol. 17, 2530-2540 (1999).
    • (1999) J. Clin. Oncol , vol.17 , pp. 2530-2540
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, J.3
  • 31
    • 35148857486 scopus 로고    scopus 로고
    • Sunitinib efficacy against advanced renal cell carcinoma
    • Motzer RJ, Michaelson MD, Rosenberg J et al.: Sunitinib efficacy against advanced renal cell carcinoma. J. Urol. 178, 1883-1887 (2007).
    • (2007) J. Urol , vol.178 , pp. 1883-1887
    • Motzer, R.J.1    Michaelson, M.D.2    Rosenberg, J.3
  • 32
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon α in metastatic renal cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P et al.: Sunitinib versus interferon α in metastatic renal cell carcinoma. N. Engl. J. Med. 356, 115-124 (2007).
    • (2007) N. Engl. J. Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 33
    • 48649094719 scopus 로고    scopus 로고
    • Overall survival with sunitinib versus interferon (IFN) α as first line treatment of metastatic renal-cell carcinoma (mRCC, 26(Suppl, S256 , Abstract 5024
    • Figlin TA, Hutson TE, Tomczak P et al.: Overall survival with sunitinib versus interferon (IFN) α as first line treatment of metastatic renal-cell carcinoma (mRCC). J. Clin. Oncol. 26(Suppl.), S256 (2008) (Abstract 5024).
    • (2008) J. Clin. Oncol
    • Figlin, T.A.1    Hutson, T.E.2    Tomczak, P.3
  • 34
    • 41149156160 scopus 로고    scopus 로고
    • Sunitinib in metastatic renal cell carcinoma (mRCC): Preliminary assessment of safety and efficacy in an expanded access trial with subpopulation analysis
    • Abstract 4503
    • Gore M, Szczylik C, Porta C et al.: Sunitinib in metastatic renal cell carcinoma (mRCC): preliminary assessment of safety and efficacy in an expanded access trial with subpopulation analysis. Eur. J. Cancer 5 (Suppl.), 299 (2007) (Abstract 4503).
    • (2007) Eur. J. Cancer , vol.5 , Issue.SUPPL. , pp. 299
    • Gore, M.1    Szczylik, C.2    Porta, C.3
  • 35
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L et al.: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64, 7099-7109 (2004).
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 36
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • Ratain MJ, Eisen T, Stadler WM et al.: Phase II placebo controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 24, 2505-2512 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3
  • 37
    • 33746501603 scopus 로고    scopus 로고
    • Randomized Phase II trial of the multikinase inhibitor sorafenib versus interferon (IFN) in treatment naïve patients with metastatic renal cell carcinoma (mRCC)
    • Escudier B, Szcylik C, Demkov T et al.: Randomized Phase II trial of the multikinase inhibitor sorafenib versus interferon (IFN) in treatment naïve patients with metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. 24(Suppl. 18), 4501 (2006).
    • (2006) J. Clin. Oncol , vol.24 , Issue.SUPPL. 18 , pp. 4501
    • Escudier, B.1    Szcylik, C.2    Demkov, T.3
  • 38
    • 33846148701 scopus 로고    scopus 로고
    • TARGET Study Group: Sorafenib in advanced clear cell renal carcinoma
    • Escudier B, Eisen T, Stadler WM et al.; TARGET Study Group: sorafenib in advanced clear cell renal carcinoma. N. Engl. J. Med. 356, 125-134 (2007).
    • (2007) N. Engl. J. Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 39
    • 34548315347 scopus 로고    scopus 로고
    • Final results of the randomized Phase III trial of sorafenib in advanced renal cell carcinoma: Survival and biomarker analysis
    • Bukowski RM, Eisen T, Szcylik C et al.: Final results of the randomized Phase III trial of sorafenib in advanced renal cell carcinoma: survival and biomarker analysis. J. Clin. Oncol. 25(Suppl.), 5023 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.SUPPL. , pp. 5023
    • Bukowski, R.M.1    Eisen, T.2    Szcylik, C.3
  • 40
    • 70349212140 scopus 로고    scopus 로고
    • Beck J, Procopio E, Verzoni S et al, Large open label non-comparative clinical experience trial of the multi-targeted kinase inhibitor salraftnib in-European pati.ents with advanced RCC. J. Clin. Oncol. 26Suppl, 2008, Abstract 1621
    • Beck J, Procopio E, Verzoni S et al.: Large open label non-comparative clinical experience trial of the multi-targeted kinase inhibitor salraftnib in-European pati.ents with advanced RCC. J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 1621).
  • 41
    • 65549155468 scopus 로고    scopus 로고
    • A multicenter prospective trial of sorafenib in patients with metastatic clear cell renal cell carcinoma refractory to prior sunitinib or bevacizumab
    • Abstract 5123
    • Shepard DR, Rini BI, Garcia A et al.: A multicenter prospective trial of sorafenib in patients with metastatic clear cell renal cell carcinoma refractory to prior sunitinib or bevacizumab. J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 5123).
    • (2008) J. Clin. Oncol , Issue.SUPPL. , pp. 26
    • Shepard, D.R.1    Rini, B.I.2    Garcia, A.3
  • 42
    • 35548931472 scopus 로고    scopus 로고
    • Randomized Phase II trial of first line treatment with sorafenib versus IFN in patients with advanced renal cell carcinoma: Final results
    • Abstract 5025
    • Szczylik C, Demkow T, Staehler M et al.: Randomized Phase II trial of first line treatment with sorafenib versus IFN in patients with advanced renal cell carcinoma: final results. J. Clin. Oncol. 25 (Suppl.) (2007) (Abstract 5025).
    • (2007) J. Clin. Oncol , Issue.SUPPL. , pp. 25
    • Szczylik, C.1    Demkow, T.2    Staehler, M.3
  • 43
    • 1542398693 scopus 로고    scopus 로고
    • Randomized Phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins MB, Hidalgo M, Stadler WM et al.: Randomized Phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J. Clin. Oncol. 22, 909-918 (2004).
    • (2004) J. Clin. Oncol , vol.22 , pp. 909-918
    • Atkins, M.B.1    Hidalgo, M.2    Stadler, W.M.3
  • 44
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon α or both for advanced renal cell carcinoma
    • Hudes G, Carducci M, Tomczak P et al.: Temsirolimus, interferon α or both for advanced renal cell carcinoma. N. Engl. J. Med. 356, 2271-2281 (2007).
    • (2007) N. Engl. J. Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 45
    • 49149091251 scopus 로고    scopus 로고
    • Sunitinib versus interferon-α as first line treatment of metastatic renal cell carcinoma: Updated efficacy and safety results and further analysis of prognostic factors
    • Abstract 301
    • Motzer RJ, Michaelson MD, Hutson TE: Sunitinib versus interferon-α as first line treatment of metastatic renal cell carcinoma: updated efficacy and safety results and further analysis of prognostic factors. Eur. J. Cancer 5(Suppl.) (2007) (Abstract 301).
    • (2007) Eur. J. Cancer , vol.5 , Issue.SUPPL.
    • Motzer, R.J.1    Michaelson, M.D.2    Hutson, T.E.3
  • 46
    • 35548977012 scopus 로고    scopus 로고
    • A Phase II trial of RAD001 in patients with metastatic renal cell carcinoma (mRCC)
    • Abstract 5107
    • Jac J, Giessinger S, Khan M et al.: A Phase II trial of RAD001 in patients with metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. 25(Suppl.) (2007) (Abstract 5107).
    • (2007) J. Clin. Oncol , Issue.SUPPL. , pp. 25
    • Jac, J.1    Giessinger, S.2    Khan, M.3
  • 47
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double blind, randomized, placebo-controlled Phase II trial
    • Motzer RJ, Escudier B, Ouard S et al.: Efficacy of everolimus in advanced renal cell carcinoma: a double blind, randomized, placebo-controlled Phase II trial. Lancet 372, 449-456 (2008).
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Ouard, S.3
  • 48
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab an anti-vascular endothelial growth factor antibody for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM et al.: A randomized trial of bevacizumab an anti-vascular endothelial growth factor antibody for metastatic renal cancer. N. Engl. J. Med. 349, 427-434 (2003).
    • (2003) N. Engl. J. Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 49
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plusIFN α-2a for treatment of metastatic renal cell carcinoma: A randomised, double blind Phase III trial
    • Escudier B, Pluzanska A, Koralewski P et al.: Bevacizumab plusIFN α-2a for treatment of metastatic renal cell carcinoma: a randomised, double blind Phase III trial. Lancet 370, 2103-2111 (2007).
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 50
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon α compared with interferon α monotherapy in patients with metastatic renal cell carcinoma: CALGB
    • Rini BI, Halabi S, Rosenberg JE et al.: Bevacizumab plus interferon α compared with interferon α monotherapy in patients with metastatic renal cell carcinoma: CALGB. J. Clin. Oncol. 26, 5422-5428 (2008).
    • (2008) J. Clin. Oncol , vol.26 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 51
    • 37849001813 scopus 로고    scopus 로고
    • Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma
    • Choueiri TK, Plantade A, Elson P et al.: Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. J. Clin. Oncol. 26, 171-131 (2008).
    • (2008) J. Clin. Oncol , vol.26 , pp. 171-131
    • Choueiri, T.K.1    Plantade, A.2    Elson, P.3
  • 52
    • 67651056360 scopus 로고    scopus 로고
    • Effect of remsirolimus versus interferon-α on survival of patients with advanced renal cell carcinoma of different rumor histologies
    • Dutcher J, de Souza P, McDermott DR et al.: Effect of remsirolimus versus interferon-α on survival of patients with advanced renal cell carcinoma of different rumor histologies. Med. Oncol. 26(2), 202-209 (2009).
    • (2009) Med. Oncol , vol.26 , Issue.2 , pp. 202-209
    • Dutcher, J.1    de Souza, P.2    McDermott, D.R.3
  • 53
    • 43049132543 scopus 로고    scopus 로고
    • Metastatic non-clear cell renal cell carcinoma: Current therapeutic options
    • Schrader AJ, Olbert PJ, Hegele A, Varga Z, Hofmann R: Metastatic non-clear cell renal cell carcinoma: current therapeutic options. BJU Int. 101, 1343-1345 (2008).
    • (2008) BJU Int , vol.101 , pp. 1343-1345
    • Schrader, A.J.1    Olbert, P.J.2    Hegele, A.3    Varga, Z.4    Hofmann, R.5
  • 54
    • 0036136548 scopus 로고    scopus 로고
    • Prognostic factors and survival of patients with sarcomatoid renal cell carcinoma
    • Mian BM, Bhadkamkar N, Slaton JW et al.: Prognostic factors and survival of patients with sarcomatoid renal cell carcinoma. J. Urol. 167, 65-70 (2002).
    • (2002) J. Urol , vol.167 , pp. 65-70
    • Mian, B.M.1    Bhadkamkar, N.2    Slaton, J.W.3
  • 55
    • 41149106110 scopus 로고    scopus 로고
    • Large open label, non-comparative, Phase III study of the multi-targeied kinase inhibitor sorafenib in European patients with advanced renal cell carcinoma
    • Abstract 4506
    • Beck J, Bajetta E, Escudier B et al.: Large open label, non-comparative, Phase III study of the multi-targeied kinase inhibitor sorafenib in European patients with advanced renal cell carcinoma. Eur. J. Cancer 5 (Suppl.), 300 (2007) (Abstract 4506).
    • (2007) Eur. J. Cancer , vol.5 , Issue.SUPPL. , pp. 300
    • Beck, J.1    Bajetta, E.2    Escudier, B.3
  • 56
    • 52949136961 scopus 로고    scopus 로고
    • Metastatic renal cell carcinoma (mRCC) patients with sarcomatoid features treated with VEGF-targeted therapy
    • Abstract 5102
    • Golshayan AR, George S, Heng DY et al.: Metastatic renal cell carcinoma (mRCC) patients with sarcomatoid features treated with VEGF-targeted therapy. J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 5102).
    • (2008) J. Clin. Oncol , Issue.SUPPL. , pp. 26
    • Golshayan, A.R.1    George, S.2    Heng, D.Y.3
  • 57
    • 50849108567 scopus 로고    scopus 로고
    • Phase II study of bevacizumab and everolimus (RAD001) in the treatment of advanced renal cell carcinoma (RCC)
    • Abstract 5010
    • Whorf JD, Hainsworth DR, Spigel DA et al.: Phase II study of bevacizumab and everolimus (RAD001) in the treatment of advanced renal cell carcinoma (RCC). J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 5010).
    • (2008) J. Clin. Oncol , Issue.SUPPL. , pp. 26
    • Whorf, J.D.1    Hainsworth, D.R.2    Spigel, D.A.3
  • 59
    • 35648938219 scopus 로고    scopus 로고
    • Randomized Phase II study of erlotinib combined with bevacizumab compared with bevaczumab alone in metastatic renal cell cancer
    • Bukowski RM, Kabbinavar FF, Figlin RA et al.: Randomized Phase II study of erlotinib combined with bevacizumab compared with bevaczumab alone in metastatic renal cell cancer. J. Clin. Oncol. 29, 4536-4541 (2007).
    • (2007) J. Clin. Oncol , vol.29 , pp. 4536-4541
    • Bukowski, R.M.1    Kabbinavar, F.F.2    Figlin, R.A.3
  • 60
    • 70349218487 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in bevacizumab refractory metastatic renal cell cancer: Updated results and analysis of circulating biomarkers
    • Abstract 5035
    • George-DJ, Michaelson MD, Rosenberg JE et al.: Phase II trial of sunitinib in bevacizumab refractory metastatic renal cell cancer: updated results and analysis of circulating biomarkers. J. Clin. Oncol. 25(Suppl.) (2007) (Abstract 5035).
    • (2007) J. Clin. Oncol , Issue.SUPPL. , pp. 25
    • DJ, G.1    Michaelson, M.D.2    Rosenberg, J.E.3
  • 61
    • 35448934762 scopus 로고    scopus 로고
    • Axitinib treatment in patients with cytokine refractory metastatic renal cell cancer: A Phase II study
    • Rixe O, Bukowski RM, Michaelson MD et al.: Axitinib treatment in patients with cytokine refractory metastatic renal cell cancer: a Phase II study. Lancet Oncol. 8(11), 975-984 (2007).
    • (2007) Lancet Oncol , vol.8 , Issue.11 , pp. 975-984
    • Rixe, O.1    Bukowski, R.M.2    Michaelson, M.D.3
  • 62
    • 35549007093 scopus 로고    scopus 로고
    • Axitinib AG-013736; AG, patients with metastatic renal cell cancer refractory to sorafenib
    • Rini B, Wilding GT, Hudes G et al.: Axitinib (AG-013736; AG) in patients with metastatic renal cell cancer refractory to sorafenib. J. Clin. Oncol. 25(18S), 5032 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.18 S , pp. 5032
    • Rini, B.1    Wilding, G.T.2    Hudes, G.3
  • 63
    • 33847405376 scopus 로고    scopus 로고
    • Pazopanib: A novel multitargeted tyrosine kinase inhibitor
    • Sonpavde G, Hutson TE: Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr. Oncol. Rep. 9(2), 115-119 (2007).
    • (2007) Curr. Oncol. Rep , vol.9 , Issue.2 , pp. 115-119
    • Sonpavde, G.1    Hutson, T.E.2
  • 64
    • 35548997095 scopus 로고    scopus 로고
    • Pazopanib (GW786034) is active in metastatic renal cell carcinoma. Interim results of a Phase II randomized discontinuation trial
    • Hutson TE, Davis ID, Machiels JP et al.: Pazopanib (GW786034) is active in metastatic renal cell carcinoma. Interim results of a Phase II randomized discontinuation trial. J. Clin. Oncol. 25(Suppl.), 5031 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.SUPPL. , pp. 5031
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.P.3
  • 66
    • 38549180269 scopus 로고    scopus 로고
    • The oncolgist's view: Targeted therapies in advanced renal cell carcinoma
    • Bellmunt J: The oncolgist's view: targeted therapies in advanced renal cell carcinoma. Eur. Urol. 7(Suppl. 2), 55-62 (2008).
    • (2008) Eur. Urol , vol.7 , Issue.SUPPL. 2 , pp. 55-62
    • Bellmunt, J.1
  • 67
    • 55049136730 scopus 로고    scopus 로고
    • Targeted therapies for metastatic renal cell carcinoma: An overview of toxicity and dosing strategies
    • Hutson TE, Figlin RA, Kuhn JG, Motzer RJ: Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. Oncologist 13, 1084-1096 (2008).
    • (2008) Oncologist , vol.13 , pp. 1084-1096
    • Hutson, T.E.1    Figlin, R.A.2    Kuhn, J.G.3    Motzer, R.J.4
  • 68
    • 53149144282 scopus 로고    scopus 로고
    • Sunitinib induced macrocytosis in patients with metastatic renal cell carcinoma
    • Rini BI, Choueiri TK, Elson P et al.: Sunitinib induced macrocytosis in patients with metastatic renal cell carcinoma. Cancer 113, 1309-1314 (2008).
    • (2008) Cancer , vol.113 , pp. 1309-1314
    • Rini, B.I.1    Choueiri, T.K.2    Elson, P.3
  • 69
    • 0035818877 scopus 로고    scopus 로고
    • Nephrectomy followed by interferon α-2b compared with interferon α-2b alone for metastatic renal cell cancer
    • Flanigan RC, Salmon SE, Blumenstein BA et al.: Nephrectomy followed by interferon α-2b compared with interferon α-2b alone for metastatic renal cell cancer. N. Engl. J. Med. 345, 1655-1659 (2001).
    • (2001) N. Engl. J. Med , vol.345 , pp. 1655-1659
    • Flanigan, R.C.1    Salmon, S.E.2    Blumenstein, B.A.3
  • 70
    • 0025360452 scopus 로고
    • Antiproliferative and antitumor effects of α interferon in renal cell carcinomas: Correlation with the expression of a kidney associated differentiation glycoprotein
    • Nanus DM, Pfeffer LM, Bander NH, Bahri S, Albino AP: Antiproliferative and antitumor effects of α interferon in renal cell carcinomas: correlation with the expression of a kidney associated differentiation glycoprotein. Cancer Res. 50, 4190-4194 (1990).
    • (1990) Cancer Res , vol.50 , pp. 4190-4194
    • Nanus, D.M.1    Pfeffer, L.M.2    Bander, N.H.3    Bahri, S.4    Albino, A.P.5
  • 71
    • 18944385751 scopus 로고    scopus 로고
    • Coppin C, Porzsolt F, Awa A et al.: Immunotherapy for advanced renal cell cancer. Cochrane Database Syst. Rev. 1, CD01425 (2005).
    • Coppin C, Porzsolt F, Awa A et al.: Immunotherapy for advanced renal cell cancer. Cochrane Database Syst. Rev. 1, CD01425 (2005).
  • 72
    • 0035902080 scopus 로고    scopus 로고
    • Progress in human tumor immunology and immunotherapy
    • Rosenberg SA: Progress in human tumor immunology and immunotherapy. Nature 411, 380-384 (2001).
    • (2001) Nature , vol.411 , pp. 380-384
    • Rosenberg, S.A.1
  • 74
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high dose recombinant interleukin therapy
    • Fyfe G, Fisher RI, Rosenberg SA, Sznol M, Parkinson DR, Louie AC: Results of treatment of 255 patients with metastatic renal cell carcinoma who received high dose recombinant interleukin therapy. J. Clin. Oncol. 13, 688-696 (1995).
    • (1995) J. Clin. Oncol , vol.13 , pp. 688-696
    • Fyfe, G.1    Fisher, R.I.2    Rosenberg, S.A.3    Sznol, M.4    Parkinson, D.R.5    Louie, A.C.6
  • 75
    • 0033847587 scopus 로고    scopus 로고
    • Long term survival update for high dose recombinant interleukin-2 in patients with renal cell carcinoma
    • Fisher RI, Rosenberg SA, Fyfe G: Long term survival update for high dose recombinant interleukin-2 in patients with renal cell carcinoma. Cancer J. Sci. Am. 6(Suppl. 1), S55-S57 (2000).
    • (2000) Cancer J. Sci. Am , vol.6 , Issue.SUPPL. 1
    • Fisher, R.I.1    Rosenberg, S.A.2    Fyfe, G.3
  • 76
    • 16644401873 scopus 로고    scopus 로고
    • Randomized Phase III trial of high dose interleukin-2 and interferon in patients with metastatic renal cell carcinoma
    • McDermott DF, Regan M, Clack JI et al.: Randomized Phase III trial of high dose interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 23, 133-141 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 133-141
    • McDermott, D.F.1    Regan, M.2    Clack, J.I.3
  • 77
    • 0042914703 scopus 로고    scopus 로고
    • Randomized study of high dose and low dose interleukin-2 in patients with metastatic renal cell cancer
    • Yang JC, Sherry RM, Steinberg SM et al.: Randomized study of high dose and low dose interleukin-2 in patients with metastatic renal cell cancer. J. Clin. Oncol. 16, 3127-3132 (2003).
    • (2003) J. Clin. Oncol , vol.16 , pp. 3127-3132
    • Yang, J.C.1    Sherry, R.M.2    Steinberg, S.M.3
  • 79
    • 2142695181 scopus 로고    scopus 로고
    • Interleukin-2 and interferon α-2a based immunotherapy in advanced renal cell carcinoma: A prospectively randomized trial of the German Cooperative Renal, Carcinoma Chemoimmunotherapy Group (DGCIN)
    • Atzpodien J, Kirchner H, Jonas U et al.: Interleukin-2 and interferon α-2a based immunotherapy in advanced renal cell carcinoma: a prospectively randomized trial of the German Cooperative Renal, Carcinoma Chemoimmunotherapy Group (DGCIN). J. Clin. Oncol. 22, 1188-1194 (2004).
    • (2004) J. Clin. Oncol , vol.22 , pp. 1188-1194
    • Atzpodien, J.1    Kirchner, H.2    Jonas, U.3
  • 80
    • 0031674558 scopus 로고    scopus 로고
    • Interleukin-2, interferon-a and interleukin-2 plus interferon-a in renal cell carcinoma. A randomized Phase II trial
    • Boccardo, F, Rubagotti A, Canabbia L et al.: Interleukin-2, interferon-a and interleukin-2 plus interferon-a in renal cell carcinoma. A randomized Phase II trial. Tumori 84, 534-539 (1998).
    • (1998) Tumori , vol.84 , pp. 534-539
    • Boccardo, F.1    Rubagotti, A.2    Canabbia, L.3
  • 81
    • 0031935841 scopus 로고    scopus 로고
    • Survival in renal cell carcinoma: A randomized evaluation of tamoxifen vs interleukin-2, α-interferon and tamoxifen
    • Henriksson R, Nilsson S, Colleen S et al.: Survival in renal cell carcinoma: a randomized evaluation of tamoxifen vs interleukin-2, α-interferon and tamoxifen. Br. J. Cancer 77, 1311-1317 (1998).
    • (1998) Br. J. Cancer , vol.77 , pp. 1311-1317
    • Henriksson, R.1    Nilsson, S.2    Colleen, S.3
  • 82
    • 7144227930 scopus 로고    scopus 로고
    • Recombinant human interleukin-2, recombinant human interferon α-2a, or both in metastatic renal cell carcinoma. Grouppe François d'Immunotherapie
    • Negrier S, Escudier B, Lasset C et al.: Recombinant human interleukin-2, recombinant human interferon α-2a, or both in metastatic renal cell carcinoma. Grouppe François d'Immunotherapie. N. Engl. J. Med. 338, 1272-1278 (1998).
    • (1998) N. Engl. J. Med , vol.338 , pp. 1272-1278
    • Negrier, S.1    Escudier, B.2    Lasset, C.3
  • 83
    • 70349221329 scopus 로고    scopus 로고
    • Long term outcome of interleukin-2 based immunotherapy for the treatment of metastatic renal cell carcinoma
    • Abstract 5119
    • Klatte T, de Martino M, Shuch B et al.: Long term outcome of interleukin-2 based immunotherapy for the treatment of metastatic renal cell carcinoma. J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 5119).
    • (2008) J. Clin. Oncol , Issue.SUPPL. , pp. 26
    • Klatte, T.1    de Martino, M.2    Shuch, B.3
  • 84
    • 0037314709 scopus 로고    scopus 로고
    • Carbonic anhyrase IX is an independent predictor of survival in advanced renal cell carcinoma: Implications for prognosis and therapy
    • Bui MHT, Seligson D, Han K et al.: Carbonic anhyrase IX is an independent predictor of survival in advanced renal cell carcinoma: implications for prognosis and therapy. Clin. Cancer Res. 9, 802-811 (2003).
    • (2003) Clin. Cancer Res , vol.9 , pp. 802-811
    • Bui, M.H.T.1    Seligson, D.2    Han, K.3
  • 85
    • 21044442672 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression predicts outcome of interleukin-2 therapy for renal cancer
    • Atkins M, Regan M, McDermott D et al.: Carbonic anhydrase IX expression predicts outcome of interleukin-2 therapy for renal cancer. Clin. Cancer Res. 11, 3714-3721 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 3714-3721
    • Atkins, M.1    Regan, M.2    McDermott, D.3
  • 86
    • 57849117384 scopus 로고    scopus 로고
    • Eisenhauer EA, Therasse P, Bogaerts J et al.: New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228-247 (2009).
    • Eisenhauer EA, Therasse P, Bogaerts J et al.: New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228-247 (2009).
  • 87
    • 48649094719 scopus 로고    scopus 로고
    • Overall survival with sunitinib versus interferon (IFN) - α as first line treatment of metastatic renal cell carcinoma (mRCC)
    • Abstract 5024
    • Figlin RA, Hutson TE, Tomczak P et al.: Overall survival with sunitinib versus interferon (IFN) - α as first line treatment of metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 5024).
    • (2008) J. Clin. Oncol , Issue.SUPPL. , pp. 26
    • Figlin, R.A.1    Hutson, T.E.2    Tomczak, P.3
  • 88
  • 89
    • 0036138580 scopus 로고    scopus 로고
    • Interferon α as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon α as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J. Clin. Oncol. 20, 289-296 (2002).
    • (2002) J. Clin. Oncol , vol.20 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3    Russo, P.4    Mazumdar, M.5
  • 90
    • 35548931472 scopus 로고    scopus 로고
    • Randomized Phase II trial of first line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: Final results
    • Abstract 5025
    • Szczylik C, Demkov T, Staehler M, Rolland F, Negrier S. Randomized Phase II trial of first line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results. J. Clin. Oncol. 25(Suppl.) (2007) (Abstract 5025).
    • (2007) J. Clin. Oncol , Issue.SUPPL. , pp. 25
    • Szczylik, C.1    Demkov, T.2    Staehler, M.3    Rolland, F.4    Negrier, S.5
  • 91
    • 60549104635 scopus 로고    scopus 로고
    • Metastatic renal cell cancer treatments: An indirect meta-analysis
    • Mills EJ, Rachlis B. O'Regan C, Thabane L, Perri D: Metastatic renal cell cancer treatments: an indirect meta-analysis. BMC Cancer 9, 34-42 (2009).
    • (2009) BMC Cancer , vol.9 , pp. 34-42
    • Mills, E.J.1    Rachlis, B.2    O'Regan, C.3    Thabane, L.4    Perri, D.5
  • 92
    • 58149181329 scopus 로고    scopus 로고
    • Response of the primary tumor to neoadjuvant sunitinib in patients with advanced renal cell carcinoma
    • Thomas AA, Rini BI, Lane BR et al.: Response of the primary tumor to neoadjuvant sunitinib in patients with advanced renal cell carcinoma. J. Urol. 181, 518-523 (2009)
    • (2009) J. Urol , vol.181 , pp. 518-523
    • Thomas, A.A.1    Rini, B.I.2    Lane, B.R.3
  • 93
    • 55349114392 scopus 로고    scopus 로고
    • Adjuvant and neoadjuvant therapy in renal cell carcinoma
    • Jonasch E, Tannir N: Adjuvant and neoadjuvant therapy in renal cell carcinoma. Cancer J. 14, 315-319 (2008).
    • (2008) Cancer J , vol.14 , pp. 315-319
    • Jonasch, E.1    Tannir, N.2
  • 94
    • 57649235319 scopus 로고    scopus 로고
    • Editorial Comment on: Prognostic value of renal vein and inferior vena cava involvement in renal cell carcinoma
    • Kirkali Z: Editorial Comment on: prognostic value of renal vein and inferior vena cava involvement in renal cell carcinoma. Eur Urol. 55(2), 460 (2009).
    • (2009) Eur Urol , vol.55 , Issue.2 , pp. 460
    • Kirkali, Z.1


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