-
1
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin DM, Bray F, Ferlay J, Pisani P: Global cancer statistics, 2002. CA Cancer J. Clin. 55, 74-108 (2005).
-
(2005)
CA Cancer J. Clin
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
2
-
-
7144255510
-
Interferon γ-1b compared with placebo in metastatic renal cell carcinoma
-
Gleave ME, Elhilali M, Fradet Y et al.: Interferon γ-1b compared with placebo in metastatic renal cell carcinoma. N. Engl. J. Med. 338, 1265-1271 (1998).
-
(1998)
N. Engl. J. Med
, vol.338
, pp. 1265-1271
-
-
Gleave, M.E.1
Elhilali, M.2
Fradet, Y.3
-
3
-
-
0030853434
-
Classification of renal cell carcinoma: Workgroup no. 1. Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC)
-
Störkel S, Eble JN, Adlakha K et al.: Classification of renal cell carcinoma: Workgroup no. 1. Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC), Cancer 80, 987-989 (1997).
-
(1997)
Cancer
, vol.80
, pp. 987-989
-
-
Störkel, S.1
Eble, J.N.2
Adlakha, K.3
-
4
-
-
4644335916
-
Update on the role of interleukin 2 and other cytokines in the treatment of patients with stage IV renal carcinoma
-
Atkins MB, Regan M, McDermott D: Update on the role of interleukin 2 and other cytokines in the treatment of patients with stage IV renal carcinoma. Clin. Cancer Res. 10(18 Part 2), S6342-S6346 (2004).
-
(2004)
Clin. Cancer Res
, vol.10
, Issue.18 PART 2
-
-
Atkins, M.B.1
Regan, M.2
McDermott, D.3
-
6
-
-
33749451610
-
Molecular pathways in renal cell carcinoma - rationale for targeted treatment
-
Kim WY, Kaelin WG: Molecular pathways in renal cell carcinoma - rationale for targeted treatment. Semin. Oncol. 33, 588-595 (2006).
-
(2006)
Semin. Oncol
, vol.33
, pp. 588-595
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
7
-
-
0027954044
-
Mutations of the VHL tumor suppressor gene in renal carcinoma
-
Gnarra JR, Tory K, Weng Y et al.: Mutations of the VHL tumor suppressor gene in renal carcinoma. Nat. Genet. 7(1), 85-90 (1994).
-
(1994)
Nat. Genet
, vol.7
, Issue.1
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
-
8
-
-
0033602089
-
Alternate choice of initiation codon procedures a biologically active product of the von Hippel Lindau gene with tumor suppressor activity
-
Blakenship C, Naglich JG, Whalet et al.: Alternate choice of initiation codon procedures a biologically active product of the von Hippel Lindau gene with tumor suppressor activity. Oncogene 18, 1529-1535 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 1529-1535
-
-
Blakenship, C.1
Naglich, J.G.2
Whalet3
-
9
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin WG: Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer 2, 673-682 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 673-682
-
-
Kaelin, W.G.1
-
10
-
-
0035313697
-
HIF-1 and mechanisms of hypoxia sensing
-
Semenza GL: HIF-1 and mechanisms of hypoxia sensing. Curr. Opin. Cell Biol. 13, 167-171 (2001).
-
(2001)
Curr. Opin. Cell Biol
, vol.13
, pp. 167-171
-
-
Semenza, G.L.1
-
12
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL: Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721-732 (2003).
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
13
-
-
0036359548
-
Hypoxia - a key regulatory factor in tumor growth
-
Harris AL: Hypoxia - a key regulatory factor in tumor growth. Nat. Rev. Cancer 2, 38-47 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
14
-
-
0037204026
-
Serial analysis of gene expression in renal carcinoma cells reveals VHL-dependent sensitivity to TNF-α cytotoxicity
-
Caldwell MC, Hough C, Furer S et al.: Serial analysis of gene expression in renal carcinoma cells reveals VHL-dependent sensitivity to TNF-α cytotoxicity. Oncogene 21, 929-936 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 929-936
-
-
Caldwell, M.C.1
Hough, C.2
Furer, S.3
-
15
-
-
39049162107
-
Targeting vasculature in Urologic tumors: Mechanistic and therapeutic significance
-
Sakamato S, Ryan AJ, Kyprianu N: Targeting vasculature in Urologic tumors: mechanistic and therapeutic significance. J. Cell. Biochem. 103, 691-708 (2008).
-
(2008)
J. Cell. Biochem
, vol.103
, pp. 691-708
-
-
Sakamato, S.1
Ryan, A.J.2
Kyprianu, N.3
-
16
-
-
84975525035
-
Clinical applications of research on angiogenesis
-
Folkman J: Clinical applications of research on angiogenesis. N. Engl. J. Med. 333, 1757-1763 (1995).
-
(1995)
N. Engl. J. Med
, vol.333
, pp. 1757-1763
-
-
Folkman, J.1
-
17
-
-
0026572345
-
The fms-like tyrosine kinase a receptor for vascular endothelial growth factor
-
de Vries C, Escobedo JS, Ueno H, Houck K, Ferrara N, Williams LT: The fms-like tyrosine kinase a receptor for vascular endothelial growth factor. Science 255, 989-991 (1992).
-
(1992)
Science
, vol.255
, pp. 989-991
-
-
de Vries, C.1
Escobedo, J.S.2
Ueno, H.3
Houck, K.4
Ferrara, N.5
Williams, L.T.6
-
18
-
-
0027466849
-
High affinity VEGF binding and developmental expression suggests flk-I as a major regulator of vasculogenesis and angiogenesis
-
Millauer B, Wizigmann-Voos S, Schnurch H et al.: High affinity VEGF binding and developmental expression suggests flk-I as a major regulator of vasculogenesis and angiogenesis. Cell 72, 835-846 (1993).
-
(1993)
Cell
, vol.72
, pp. 835-846
-
-
Millauer, B.1
Wizigmann-Voos, S.2
Schnurch, H.3
-
19
-
-
33846866035
-
The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer
-
Cho D, Signoretti S, Regan M et al.: The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer. Clin. Cancer Res. 13, S758-S763 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
-
-
Cho, D.1
Signoretti, S.2
Regan, M.3
-
20
-
-
53849125004
-
mTORC1 inhibitors: Is temsirolimus in renal cancer telling us how they really work?
-
Le Tourneau C, Faivre S, Raymond E: mTORC1 inhibitors: is temsirolimus in renal cancer telling us how they really work? Br. J. Cancer 99, 1197-1203 (2008).
-
(2008)
Br. J. Cancer
, vol.99
, pp. 1197-1203
-
-
Le Tourneau, C.1
Faivre, S.2
Raymond, E.3
-
21
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre S, Kraeme G, Ramond E: Current development of mTOR inhibitors as anticancer agents. Nat. Rev. Drug Discov. 5, 671-688 (2006).
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kraeme, G.2
Ramond, E.3
-
22
-
-
0036568448
-
Loss of tumor suppressor protein PTEN during renal angiogenesis
-
Brenner W, Farber G, Herget T, Lehr HA, Heggstler JG, Thuroff W: Loss of tumor suppressor protein PTEN during renal angiogenesis. Int. J. Cancer 99, 53-57 (2002).
-
(2002)
Int. J. Cancer
, vol.99
, pp. 53-57
-
-
Brenner, W.1
Farber, G.2
Herget, T.3
Lehr, H.A.4
Heggstler, J.G.5
Thuroff, W.6
-
23
-
-
24344446438
-
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
-
Hamada K, Sasaki T, Koni PA et al.: The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev. 19, 2054-2065 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 2054-2065
-
-
Hamada, K.1
Sasaki, T.2
Koni, P.A.3
-
24
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by anti-angiogenesis involvement of vascular endothelial growth factor
-
Gaba M, von Breitenbuch P, Steinbauer M et al.: Rapamycin inhibits primary and metastatic tumor growth by anti-angiogenesis involvement of vascular endothelial growth factor. Nat. Med. 8, 128-135 (2002).
-
(2002)
Nat. Med
, vol.8
, pp. 128-135
-
-
Gaba, M.1
von Breitenbuch, P.2
Steinbauer, M.3
-
25
-
-
0037177867
-
Phosphatidylinositol 3-kinase/ Akt signaling is neither required for hypoxic stabilization of HIF-1 α nor sufficient for HIF-1 dependent target gene transcription
-
Arsham AM, Plas DR, Thompson CB, Simon MC: Phosphatidylinositol 3-kinase/ Akt signaling is neither required for hypoxic stabilization of HIF-1 α nor sufficient for HIF-1 dependent target gene transcription. J. Biol. Chem. 277(17), 15162-15170 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, Issue.17
, pp. 15162-15170
-
-
Arsham, A.M.1
Plas, D.R.2
Thompson, C.B.3
Simon, M.C.4
-
26
-
-
33947504730
-
Sunitinib from rational design to clinical efficacy
-
Chow LQ, Eckhardt SG: Sunitinib from rational design to clinical efficacy. J. Clin. Oncol. 25, 884-896 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 884-896
-
-
Chow, L.Q.1
Eckhardt, S.G.2
-
27
-
-
33644847440
-
Safety, pharmacokinetic and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
-
Faivre S, Delbaldo, Vera K et al.: Safety, pharmacokinetic and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J. Clin. Oncol. 24, 25-25 (2007).
-
(2007)
J. Clin. Oncol
, vol.24
, pp. 25-25
-
-
Faivre, S.1
Delbaldo, V.K.2
-
28
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor in patients with metastatic renal cell carcinoma
-
Motzer RJ, Michaelson MD, Redman BG et al.: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 24, 16-24 (2006).
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
-
29
-
-
33744954585
-
Sunitinib in patients with metastatic renal cell carcinoma
-
Motzer RJ, Rini BI, Bukowski RM et al.: Sunitinib in patients with metastatic renal cell carcinoma. JAMA 295, 2516-2524 (2006).
-
(2006)
JAMA
, vol.295
, pp. 2516-2524
-
-
Motzer, R.J.1
Rini, B.I.2
Bukowski, R.M.3
-
30
-
-
0032772880
-
Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
-
Motzer RJ, Mazumdar M, Bacik J et al.: Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J. Clin. Oncol. 17, 2530-2540 (1999).
-
(1999)
J. Clin. Oncol
, vol.17
, pp. 2530-2540
-
-
Motzer, R.J.1
Mazumdar, M.2
Bacik, J.3
-
31
-
-
35148857486
-
Sunitinib efficacy against advanced renal cell carcinoma
-
Motzer RJ, Michaelson MD, Rosenberg J et al.: Sunitinib efficacy against advanced renal cell carcinoma. J. Urol. 178, 1883-1887 (2007).
-
(2007)
J. Urol
, vol.178
, pp. 1883-1887
-
-
Motzer, R.J.1
Michaelson, M.D.2
Rosenberg, J.3
-
32
-
-
33846181370
-
Sunitinib versus interferon α in metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P et al.: Sunitinib versus interferon α in metastatic renal cell carcinoma. N. Engl. J. Med. 356, 115-124 (2007).
-
(2007)
N. Engl. J. Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
33
-
-
48649094719
-
-
Overall survival with sunitinib versus interferon (IFN) α as first line treatment of metastatic renal-cell carcinoma (mRCC, 26(Suppl, S256 , Abstract 5024
-
Figlin TA, Hutson TE, Tomczak P et al.: Overall survival with sunitinib versus interferon (IFN) α as first line treatment of metastatic renal-cell carcinoma (mRCC). J. Clin. Oncol. 26(Suppl.), S256 (2008) (Abstract 5024).
-
(2008)
J. Clin. Oncol
-
-
Figlin, T.A.1
Hutson, T.E.2
Tomczak, P.3
-
34
-
-
41149156160
-
Sunitinib in metastatic renal cell carcinoma (mRCC): Preliminary assessment of safety and efficacy in an expanded access trial with subpopulation analysis
-
Abstract 4503
-
Gore M, Szczylik C, Porta C et al.: Sunitinib in metastatic renal cell carcinoma (mRCC): preliminary assessment of safety and efficacy in an expanded access trial with subpopulation analysis. Eur. J. Cancer 5 (Suppl.), 299 (2007) (Abstract 4503).
-
(2007)
Eur. J. Cancer
, vol.5
, Issue.SUPPL.
, pp. 299
-
-
Gore, M.1
Szczylik, C.2
Porta, C.3
-
35
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L et al.: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64, 7099-7109 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
36
-
-
33744984843
-
Phase II placebo controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
-
Ratain MJ, Eisen T, Stadler WM et al.: Phase II placebo controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 24, 2505-2512 (2006).
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 2505-2512
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
-
37
-
-
33746501603
-
Randomized Phase II trial of the multikinase inhibitor sorafenib versus interferon (IFN) in treatment naïve patients with metastatic renal cell carcinoma (mRCC)
-
Escudier B, Szcylik C, Demkov T et al.: Randomized Phase II trial of the multikinase inhibitor sorafenib versus interferon (IFN) in treatment naïve patients with metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. 24(Suppl. 18), 4501 (2006).
-
(2006)
J. Clin. Oncol
, vol.24
, Issue.SUPPL. 18
, pp. 4501
-
-
Escudier, B.1
Szcylik, C.2
Demkov, T.3
-
38
-
-
33846148701
-
TARGET Study Group: Sorafenib in advanced clear cell renal carcinoma
-
Escudier B, Eisen T, Stadler WM et al.; TARGET Study Group: sorafenib in advanced clear cell renal carcinoma. N. Engl. J. Med. 356, 125-134 (2007).
-
(2007)
N. Engl. J. Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
39
-
-
34548315347
-
Final results of the randomized Phase III trial of sorafenib in advanced renal cell carcinoma: Survival and biomarker analysis
-
Bukowski RM, Eisen T, Szcylik C et al.: Final results of the randomized Phase III trial of sorafenib in advanced renal cell carcinoma: survival and biomarker analysis. J. Clin. Oncol. 25(Suppl.), 5023 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.SUPPL.
, pp. 5023
-
-
Bukowski, R.M.1
Eisen, T.2
Szcylik, C.3
-
40
-
-
70349212140
-
-
Beck J, Procopio E, Verzoni S et al, Large open label non-comparative clinical experience trial of the multi-targeted kinase inhibitor salraftnib in-European pati.ents with advanced RCC. J. Clin. Oncol. 26Suppl, 2008, Abstract 1621
-
Beck J, Procopio E, Verzoni S et al.: Large open label non-comparative clinical experience trial of the multi-targeted kinase inhibitor salraftnib in-European pati.ents with advanced RCC. J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 1621).
-
-
-
-
41
-
-
65549155468
-
A multicenter prospective trial of sorafenib in patients with metastatic clear cell renal cell carcinoma refractory to prior sunitinib or bevacizumab
-
Abstract 5123
-
Shepard DR, Rini BI, Garcia A et al.: A multicenter prospective trial of sorafenib in patients with metastatic clear cell renal cell carcinoma refractory to prior sunitinib or bevacizumab. J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 5123).
-
(2008)
J. Clin. Oncol
, Issue.SUPPL.
, pp. 26
-
-
Shepard, D.R.1
Rini, B.I.2
Garcia, A.3
-
42
-
-
35548931472
-
Randomized Phase II trial of first line treatment with sorafenib versus IFN in patients with advanced renal cell carcinoma: Final results
-
Abstract 5025
-
Szczylik C, Demkow T, Staehler M et al.: Randomized Phase II trial of first line treatment with sorafenib versus IFN in patients with advanced renal cell carcinoma: final results. J. Clin. Oncol. 25 (Suppl.) (2007) (Abstract 5025).
-
(2007)
J. Clin. Oncol
, Issue.SUPPL.
, pp. 25
-
-
Szczylik, C.1
Demkow, T.2
Staehler, M.3
-
43
-
-
1542398693
-
Randomized Phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
Atkins MB, Hidalgo M, Stadler WM et al.: Randomized Phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J. Clin. Oncol. 22, 909-918 (2004).
-
(2004)
J. Clin. Oncol
, vol.22
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
-
44
-
-
34249779568
-
Temsirolimus, interferon α or both for advanced renal cell carcinoma
-
Hudes G, Carducci M, Tomczak P et al.: Temsirolimus, interferon α or both for advanced renal cell carcinoma. N. Engl. J. Med. 356, 2271-2281 (2007).
-
(2007)
N. Engl. J. Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
45
-
-
49149091251
-
Sunitinib versus interferon-α as first line treatment of metastatic renal cell carcinoma: Updated efficacy and safety results and further analysis of prognostic factors
-
Abstract 301
-
Motzer RJ, Michaelson MD, Hutson TE: Sunitinib versus interferon-α as first line treatment of metastatic renal cell carcinoma: updated efficacy and safety results and further analysis of prognostic factors. Eur. J. Cancer 5(Suppl.) (2007) (Abstract 301).
-
(2007)
Eur. J. Cancer
, vol.5
, Issue.SUPPL.
-
-
Motzer, R.J.1
Michaelson, M.D.2
Hutson, T.E.3
-
46
-
-
35548977012
-
A Phase II trial of RAD001 in patients with metastatic renal cell carcinoma (mRCC)
-
Abstract 5107
-
Jac J, Giessinger S, Khan M et al.: A Phase II trial of RAD001 in patients with metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. 25(Suppl.) (2007) (Abstract 5107).
-
(2007)
J. Clin. Oncol
, Issue.SUPPL.
, pp. 25
-
-
Jac, J.1
Giessinger, S.2
Khan, M.3
-
47
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double blind, randomized, placebo-controlled Phase II trial
-
Motzer RJ, Escudier B, Ouard S et al.: Efficacy of everolimus in advanced renal cell carcinoma: a double blind, randomized, placebo-controlled Phase II trial. Lancet 372, 449-456 (2008).
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Ouard, S.3
-
48
-
-
0042343801
-
A randomized trial of bevacizumab an anti-vascular endothelial growth factor antibody for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM et al.: A randomized trial of bevacizumab an anti-vascular endothelial growth factor antibody for metastatic renal cancer. N. Engl. J. Med. 349, 427-434 (2003).
-
(2003)
N. Engl. J. Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
49
-
-
37349080670
-
Bevacizumab plusIFN α-2a for treatment of metastatic renal cell carcinoma: A randomised, double blind Phase III trial
-
Escudier B, Pluzanska A, Koralewski P et al.: Bevacizumab plusIFN α-2a for treatment of metastatic renal cell carcinoma: a randomised, double blind Phase III trial. Lancet 370, 2103-2111 (2007).
-
(2007)
Lancet
, vol.370
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
-
50
-
-
56749161699
-
Bevacizumab plus interferon α compared with interferon α monotherapy in patients with metastatic renal cell carcinoma: CALGB
-
Rini BI, Halabi S, Rosenberg JE et al.: Bevacizumab plus interferon α compared with interferon α monotherapy in patients with metastatic renal cell carcinoma: CALGB. J. Clin. Oncol. 26, 5422-5428 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 5422-5428
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
51
-
-
37849001813
-
Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma
-
Choueiri TK, Plantade A, Elson P et al.: Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. J. Clin. Oncol. 26, 171-131 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 171-131
-
-
Choueiri, T.K.1
Plantade, A.2
Elson, P.3
-
52
-
-
67651056360
-
Effect of remsirolimus versus interferon-α on survival of patients with advanced renal cell carcinoma of different rumor histologies
-
Dutcher J, de Souza P, McDermott DR et al.: Effect of remsirolimus versus interferon-α on survival of patients with advanced renal cell carcinoma of different rumor histologies. Med. Oncol. 26(2), 202-209 (2009).
-
(2009)
Med. Oncol
, vol.26
, Issue.2
, pp. 202-209
-
-
Dutcher, J.1
de Souza, P.2
McDermott, D.R.3
-
53
-
-
43049132543
-
Metastatic non-clear cell renal cell carcinoma: Current therapeutic options
-
Schrader AJ, Olbert PJ, Hegele A, Varga Z, Hofmann R: Metastatic non-clear cell renal cell carcinoma: current therapeutic options. BJU Int. 101, 1343-1345 (2008).
-
(2008)
BJU Int
, vol.101
, pp. 1343-1345
-
-
Schrader, A.J.1
Olbert, P.J.2
Hegele, A.3
Varga, Z.4
Hofmann, R.5
-
54
-
-
0036136548
-
Prognostic factors and survival of patients with sarcomatoid renal cell carcinoma
-
Mian BM, Bhadkamkar N, Slaton JW et al.: Prognostic factors and survival of patients with sarcomatoid renal cell carcinoma. J. Urol. 167, 65-70 (2002).
-
(2002)
J. Urol
, vol.167
, pp. 65-70
-
-
Mian, B.M.1
Bhadkamkar, N.2
Slaton, J.W.3
-
55
-
-
41149106110
-
Large open label, non-comparative, Phase III study of the multi-targeied kinase inhibitor sorafenib in European patients with advanced renal cell carcinoma
-
Abstract 4506
-
Beck J, Bajetta E, Escudier B et al.: Large open label, non-comparative, Phase III study of the multi-targeied kinase inhibitor sorafenib in European patients with advanced renal cell carcinoma. Eur. J. Cancer 5 (Suppl.), 300 (2007) (Abstract 4506).
-
(2007)
Eur. J. Cancer
, vol.5
, Issue.SUPPL.
, pp. 300
-
-
Beck, J.1
Bajetta, E.2
Escudier, B.3
-
56
-
-
52949136961
-
Metastatic renal cell carcinoma (mRCC) patients with sarcomatoid features treated with VEGF-targeted therapy
-
Abstract 5102
-
Golshayan AR, George S, Heng DY et al.: Metastatic renal cell carcinoma (mRCC) patients with sarcomatoid features treated with VEGF-targeted therapy. J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 5102).
-
(2008)
J. Clin. Oncol
, Issue.SUPPL.
, pp. 26
-
-
Golshayan, A.R.1
George, S.2
Heng, D.Y.3
-
57
-
-
50849108567
-
Phase II study of bevacizumab and everolimus (RAD001) in the treatment of advanced renal cell carcinoma (RCC)
-
Abstract 5010
-
Whorf JD, Hainsworth DR, Spigel DA et al.: Phase II study of bevacizumab and everolimus (RAD001) in the treatment of advanced renal cell carcinoma (RCC). J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 5010).
-
(2008)
J. Clin. Oncol
, Issue.SUPPL.
, pp. 26
-
-
Whorf, J.D.1
Hainsworth, D.R.2
Spigel, D.A.3
-
58
-
-
30944452354
-
Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib
-
Hainsworth JD, Sosman JA, Spigel DR, Edwards DL, Baughman C, Greco A: Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib. J. Clin. Oncol. 23, 7889-7896 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 7889-7896
-
-
Hainsworth, J.D.1
Sosman, J.A.2
Spigel, D.R.3
Edwards, D.L.4
Baughman, C.5
Greco, A.6
-
59
-
-
35648938219
-
Randomized Phase II study of erlotinib combined with bevacizumab compared with bevaczumab alone in metastatic renal cell cancer
-
Bukowski RM, Kabbinavar FF, Figlin RA et al.: Randomized Phase II study of erlotinib combined with bevacizumab compared with bevaczumab alone in metastatic renal cell cancer. J. Clin. Oncol. 29, 4536-4541 (2007).
-
(2007)
J. Clin. Oncol
, vol.29
, pp. 4536-4541
-
-
Bukowski, R.M.1
Kabbinavar, F.F.2
Figlin, R.A.3
-
60
-
-
70349218487
-
Phase II trial of sunitinib in bevacizumab refractory metastatic renal cell cancer: Updated results and analysis of circulating biomarkers
-
Abstract 5035
-
George-DJ, Michaelson MD, Rosenberg JE et al.: Phase II trial of sunitinib in bevacizumab refractory metastatic renal cell cancer: updated results and analysis of circulating biomarkers. J. Clin. Oncol. 25(Suppl.) (2007) (Abstract 5035).
-
(2007)
J. Clin. Oncol
, Issue.SUPPL.
, pp. 25
-
-
DJ, G.1
Michaelson, M.D.2
Rosenberg, J.E.3
-
61
-
-
35448934762
-
Axitinib treatment in patients with cytokine refractory metastatic renal cell cancer: A Phase II study
-
Rixe O, Bukowski RM, Michaelson MD et al.: Axitinib treatment in patients with cytokine refractory metastatic renal cell cancer: a Phase II study. Lancet Oncol. 8(11), 975-984 (2007).
-
(2007)
Lancet Oncol
, vol.8
, Issue.11
, pp. 975-984
-
-
Rixe, O.1
Bukowski, R.M.2
Michaelson, M.D.3
-
62
-
-
35549007093
-
-
Axitinib AG-013736; AG, patients with metastatic renal cell cancer refractory to sorafenib
-
Rini B, Wilding GT, Hudes G et al.: Axitinib (AG-013736; AG) in patients with metastatic renal cell cancer refractory to sorafenib. J. Clin. Oncol. 25(18S), 5032 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.18 S
, pp. 5032
-
-
Rini, B.1
Wilding, G.T.2
Hudes, G.3
-
63
-
-
33847405376
-
Pazopanib: A novel multitargeted tyrosine kinase inhibitor
-
Sonpavde G, Hutson TE: Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr. Oncol. Rep. 9(2), 115-119 (2007).
-
(2007)
Curr. Oncol. Rep
, vol.9
, Issue.2
, pp. 115-119
-
-
Sonpavde, G.1
Hutson, T.E.2
-
64
-
-
35548997095
-
Pazopanib (GW786034) is active in metastatic renal cell carcinoma. Interim results of a Phase II randomized discontinuation trial
-
Hutson TE, Davis ID, Machiels JP et al.: Pazopanib (GW786034) is active in metastatic renal cell carcinoma. Interim results of a Phase II randomized discontinuation trial. J. Clin. Oncol. 25(Suppl.), 5031 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.SUPPL.
, pp. 5031
-
-
Hutson, T.E.1
Davis, I.D.2
Machiels, J.P.3
-
65
-
-
70349218486
-
Activity and safety of AV-951, a potent and selective VEGFR1, 2 and 3 kinase inhibitor
-
February, Abstract 283
-
Bhargava P, Esteves O, Liparov ON et al.: Activity and safety of AV-951, a potent and selective VEGFR1, 2 and 3 kinase inhibitor, in patients with renal cell carcinoma: interim results of a Phase II randomized discontinuation trial. Presented at: ASCO Genitourinary Cancers Symposium. Orlando, FL, USA. 26-28 February 2009 (Abstract 283).
-
(2009)
patients with renal cell carcinoma: Interim results of a Phase II randomized discontinuation trial. Presented at: ASCO Genitourinary Cancers Symposium. Orlando, FL, USA. 26-28
-
-
Bhargava, P.1
Esteves, O.2
Liparov, O.N.3
-
66
-
-
38549180269
-
The oncolgist's view: Targeted therapies in advanced renal cell carcinoma
-
Bellmunt J: The oncolgist's view: targeted therapies in advanced renal cell carcinoma. Eur. Urol. 7(Suppl. 2), 55-62 (2008).
-
(2008)
Eur. Urol
, vol.7
, Issue.SUPPL. 2
, pp. 55-62
-
-
Bellmunt, J.1
-
67
-
-
55049136730
-
Targeted therapies for metastatic renal cell carcinoma: An overview of toxicity and dosing strategies
-
Hutson TE, Figlin RA, Kuhn JG, Motzer RJ: Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. Oncologist 13, 1084-1096 (2008).
-
(2008)
Oncologist
, vol.13
, pp. 1084-1096
-
-
Hutson, T.E.1
Figlin, R.A.2
Kuhn, J.G.3
Motzer, R.J.4
-
68
-
-
53149144282
-
Sunitinib induced macrocytosis in patients with metastatic renal cell carcinoma
-
Rini BI, Choueiri TK, Elson P et al.: Sunitinib induced macrocytosis in patients with metastatic renal cell carcinoma. Cancer 113, 1309-1314 (2008).
-
(2008)
Cancer
, vol.113
, pp. 1309-1314
-
-
Rini, B.I.1
Choueiri, T.K.2
Elson, P.3
-
69
-
-
0035818877
-
Nephrectomy followed by interferon α-2b compared with interferon α-2b alone for metastatic renal cell cancer
-
Flanigan RC, Salmon SE, Blumenstein BA et al.: Nephrectomy followed by interferon α-2b compared with interferon α-2b alone for metastatic renal cell cancer. N. Engl. J. Med. 345, 1655-1659 (2001).
-
(2001)
N. Engl. J. Med
, vol.345
, pp. 1655-1659
-
-
Flanigan, R.C.1
Salmon, S.E.2
Blumenstein, B.A.3
-
70
-
-
0025360452
-
Antiproliferative and antitumor effects of α interferon in renal cell carcinomas: Correlation with the expression of a kidney associated differentiation glycoprotein
-
Nanus DM, Pfeffer LM, Bander NH, Bahri S, Albino AP: Antiproliferative and antitumor effects of α interferon in renal cell carcinomas: correlation with the expression of a kidney associated differentiation glycoprotein. Cancer Res. 50, 4190-4194 (1990).
-
(1990)
Cancer Res
, vol.50
, pp. 4190-4194
-
-
Nanus, D.M.1
Pfeffer, L.M.2
Bander, N.H.3
Bahri, S.4
Albino, A.P.5
-
71
-
-
18944385751
-
-
Coppin C, Porzsolt F, Awa A et al.: Immunotherapy for advanced renal cell cancer. Cochrane Database Syst. Rev. 1, CD01425 (2005).
-
Coppin C, Porzsolt F, Awa A et al.: Immunotherapy for advanced renal cell cancer. Cochrane Database Syst. Rev. 1, CD01425 (2005).
-
-
-
-
72
-
-
0035902080
-
Progress in human tumor immunology and immunotherapy
-
Rosenberg SA: Progress in human tumor immunology and immunotherapy. Nature 411, 380-384 (2001).
-
(2001)
Nature
, vol.411
, pp. 380-384
-
-
Rosenberg, S.A.1
-
74
-
-
0028929682
-
Results of treatment of 255 patients with metastatic renal cell carcinoma who received high dose recombinant interleukin therapy
-
Fyfe G, Fisher RI, Rosenberg SA, Sznol M, Parkinson DR, Louie AC: Results of treatment of 255 patients with metastatic renal cell carcinoma who received high dose recombinant interleukin therapy. J. Clin. Oncol. 13, 688-696 (1995).
-
(1995)
J. Clin. Oncol
, vol.13
, pp. 688-696
-
-
Fyfe, G.1
Fisher, R.I.2
Rosenberg, S.A.3
Sznol, M.4
Parkinson, D.R.5
Louie, A.C.6
-
75
-
-
0033847587
-
Long term survival update for high dose recombinant interleukin-2 in patients with renal cell carcinoma
-
Fisher RI, Rosenberg SA, Fyfe G: Long term survival update for high dose recombinant interleukin-2 in patients with renal cell carcinoma. Cancer J. Sci. Am. 6(Suppl. 1), S55-S57 (2000).
-
(2000)
Cancer J. Sci. Am
, vol.6
, Issue.SUPPL. 1
-
-
Fisher, R.I.1
Rosenberg, S.A.2
Fyfe, G.3
-
76
-
-
16644401873
-
Randomized Phase III trial of high dose interleukin-2 and interferon in patients with metastatic renal cell carcinoma
-
McDermott DF, Regan M, Clack JI et al.: Randomized Phase III trial of high dose interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 23, 133-141 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 133-141
-
-
McDermott, D.F.1
Regan, M.2
Clack, J.I.3
-
77
-
-
0042914703
-
Randomized study of high dose and low dose interleukin-2 in patients with metastatic renal cell cancer
-
Yang JC, Sherry RM, Steinberg SM et al.: Randomized study of high dose and low dose interleukin-2 in patients with metastatic renal cell cancer. J. Clin. Oncol. 16, 3127-3132 (2003).
-
(2003)
J. Clin. Oncol
, vol.16
, pp. 3127-3132
-
-
Yang, J.C.1
Sherry, R.M.2
Steinberg, S.M.3
-
79
-
-
2142695181
-
Interleukin-2 and interferon α-2a based immunotherapy in advanced renal cell carcinoma: A prospectively randomized trial of the German Cooperative Renal, Carcinoma Chemoimmunotherapy Group (DGCIN)
-
Atzpodien J, Kirchner H, Jonas U et al.: Interleukin-2 and interferon α-2a based immunotherapy in advanced renal cell carcinoma: a prospectively randomized trial of the German Cooperative Renal, Carcinoma Chemoimmunotherapy Group (DGCIN). J. Clin. Oncol. 22, 1188-1194 (2004).
-
(2004)
J. Clin. Oncol
, vol.22
, pp. 1188-1194
-
-
Atzpodien, J.1
Kirchner, H.2
Jonas, U.3
-
80
-
-
0031674558
-
Interleukin-2, interferon-a and interleukin-2 plus interferon-a in renal cell carcinoma. A randomized Phase II trial
-
Boccardo, F, Rubagotti A, Canabbia L et al.: Interleukin-2, interferon-a and interleukin-2 plus interferon-a in renal cell carcinoma. A randomized Phase II trial. Tumori 84, 534-539 (1998).
-
(1998)
Tumori
, vol.84
, pp. 534-539
-
-
Boccardo, F.1
Rubagotti, A.2
Canabbia, L.3
-
81
-
-
0031935841
-
Survival in renal cell carcinoma: A randomized evaluation of tamoxifen vs interleukin-2, α-interferon and tamoxifen
-
Henriksson R, Nilsson S, Colleen S et al.: Survival in renal cell carcinoma: a randomized evaluation of tamoxifen vs interleukin-2, α-interferon and tamoxifen. Br. J. Cancer 77, 1311-1317 (1998).
-
(1998)
Br. J. Cancer
, vol.77
, pp. 1311-1317
-
-
Henriksson, R.1
Nilsson, S.2
Colleen, S.3
-
82
-
-
7144227930
-
Recombinant human interleukin-2, recombinant human interferon α-2a, or both in metastatic renal cell carcinoma. Grouppe François d'Immunotherapie
-
Negrier S, Escudier B, Lasset C et al.: Recombinant human interleukin-2, recombinant human interferon α-2a, or both in metastatic renal cell carcinoma. Grouppe François d'Immunotherapie. N. Engl. J. Med. 338, 1272-1278 (1998).
-
(1998)
N. Engl. J. Med
, vol.338
, pp. 1272-1278
-
-
Negrier, S.1
Escudier, B.2
Lasset, C.3
-
83
-
-
70349221329
-
Long term outcome of interleukin-2 based immunotherapy for the treatment of metastatic renal cell carcinoma
-
Abstract 5119
-
Klatte T, de Martino M, Shuch B et al.: Long term outcome of interleukin-2 based immunotherapy for the treatment of metastatic renal cell carcinoma. J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 5119).
-
(2008)
J. Clin. Oncol
, Issue.SUPPL.
, pp. 26
-
-
Klatte, T.1
de Martino, M.2
Shuch, B.3
-
84
-
-
0037314709
-
Carbonic anhyrase IX is an independent predictor of survival in advanced renal cell carcinoma: Implications for prognosis and therapy
-
Bui MHT, Seligson D, Han K et al.: Carbonic anhyrase IX is an independent predictor of survival in advanced renal cell carcinoma: implications for prognosis and therapy. Clin. Cancer Res. 9, 802-811 (2003).
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 802-811
-
-
Bui, M.H.T.1
Seligson, D.2
Han, K.3
-
85
-
-
21044442672
-
Carbonic anhydrase IX expression predicts outcome of interleukin-2 therapy for renal cancer
-
Atkins M, Regan M, McDermott D et al.: Carbonic anhydrase IX expression predicts outcome of interleukin-2 therapy for renal cancer. Clin. Cancer Res. 11, 3714-3721 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 3714-3721
-
-
Atkins, M.1
Regan, M.2
McDermott, D.3
-
86
-
-
57849117384
-
-
Eisenhauer EA, Therasse P, Bogaerts J et al.: New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228-247 (2009).
-
Eisenhauer EA, Therasse P, Bogaerts J et al.: New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228-247 (2009).
-
-
-
-
87
-
-
48649094719
-
Overall survival with sunitinib versus interferon (IFN) - α as first line treatment of metastatic renal cell carcinoma (mRCC)
-
Abstract 5024
-
Figlin RA, Hutson TE, Tomczak P et al.: Overall survival with sunitinib versus interferon (IFN) - α as first line treatment of metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 5024).
-
(2008)
J. Clin. Oncol
, Issue.SUPPL.
, pp. 26
-
-
Figlin, R.A.1
Hutson, T.E.2
Tomczak, P.3
-
89
-
-
0036138580
-
Interferon α as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
-
Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon α as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J. Clin. Oncol. 20, 289-296 (2002).
-
(2002)
J. Clin. Oncol
, vol.20
, pp. 289-296
-
-
Motzer, R.J.1
Bacik, J.2
Murphy, B.A.3
Russo, P.4
Mazumdar, M.5
-
90
-
-
35548931472
-
Randomized Phase II trial of first line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: Final results
-
Abstract 5025
-
Szczylik C, Demkov T, Staehler M, Rolland F, Negrier S. Randomized Phase II trial of first line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results. J. Clin. Oncol. 25(Suppl.) (2007) (Abstract 5025).
-
(2007)
J. Clin. Oncol
, Issue.SUPPL.
, pp. 25
-
-
Szczylik, C.1
Demkov, T.2
Staehler, M.3
Rolland, F.4
Negrier, S.5
-
91
-
-
60549104635
-
Metastatic renal cell cancer treatments: An indirect meta-analysis
-
Mills EJ, Rachlis B. O'Regan C, Thabane L, Perri D: Metastatic renal cell cancer treatments: an indirect meta-analysis. BMC Cancer 9, 34-42 (2009).
-
(2009)
BMC Cancer
, vol.9
, pp. 34-42
-
-
Mills, E.J.1
Rachlis, B.2
O'Regan, C.3
Thabane, L.4
Perri, D.5
-
92
-
-
58149181329
-
Response of the primary tumor to neoadjuvant sunitinib in patients with advanced renal cell carcinoma
-
Thomas AA, Rini BI, Lane BR et al.: Response of the primary tumor to neoadjuvant sunitinib in patients with advanced renal cell carcinoma. J. Urol. 181, 518-523 (2009)
-
(2009)
J. Urol
, vol.181
, pp. 518-523
-
-
Thomas, A.A.1
Rini, B.I.2
Lane, B.R.3
-
93
-
-
55349114392
-
Adjuvant and neoadjuvant therapy in renal cell carcinoma
-
Jonasch E, Tannir N: Adjuvant and neoadjuvant therapy in renal cell carcinoma. Cancer J. 14, 315-319 (2008).
-
(2008)
Cancer J
, vol.14
, pp. 315-319
-
-
Jonasch, E.1
Tannir, N.2
-
94
-
-
57649235319
-
Editorial Comment on: Prognostic value of renal vein and inferior vena cava involvement in renal cell carcinoma
-
Kirkali Z: Editorial Comment on: prognostic value of renal vein and inferior vena cava involvement in renal cell carcinoma. Eur Urol. 55(2), 460 (2009).
-
(2009)
Eur Urol
, vol.55
, Issue.2
, pp. 460
-
-
Kirkali, Z.1
|