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Volumn 2, Issue 3, 2008, Pages 121-127

Naltrexone in the Treatment of Alcohol Dependence

Author keywords

Alcoholism; Dopamine; Ethanol; Naltrexone; Opioid peptides; Opioid receptors; Reward circuitry; Treatment

Indexed keywords


EID: 70349197973     PISSN: 19320620     EISSN: 19353227     Source Type: Journal    
DOI: 10.1097/ADM.0b013e318182b20f     Document Type: Review
Times cited : (11)

References (99)
  • 1
    • 0018822216 scopus 로고
    • Alteration of ethanol self-administration by naltrexone
    • Altshuler HL, Phillips PE, Feinhandler DA. Alteration of ethanol self-administration by naltrexone. Life Sci. 1980;26:679-688.
    • (1980) Life Sci. , vol.26 , pp. 679-688
    • Altshuler, H.L.1    Phillips, P.E.2    Feinhandler, D.A.3
  • 2
    • 0022846287 scopus 로고
    • Antagonism by naltrexone of voluntary alcohol selection in the chronically drinking macaque monkey
    • Myers RD, Borg S, Mossberg R. Antagonism by naltrexone of voluntary alcohol selection in the chronically drinking macaque monkey. Alcohol. 1986;3:383-388.
    • (1986) Alcohol , vol.3 , pp. 383-388
    • Myers, R.D.1    Borg, S.2    Mossberg, R.3
  • 3
    • 0021253151 scopus 로고
    • Decrease in ethanol consumption by naloxone in naïve and dependent rats
    • Marfaing-Jallat P, Miceli D, Le Magnen J. Decrease in ethanol consumption by naloxone in naïve and dependent rats. Pharmacol Biochem Behav. 1983;18:537-539.
    • (1983) Pharmacol Biochem Behav. , vol.18 , pp. 537-539
    • Marfaing-Jallat, P.1    Miceli, D.2    Le Magnen, J.3
  • 4
    • 0021945692 scopus 로고
    • Oral ethanol self-administration in the rat: Effect of naloxone
    • Samson HH, Doyle TF. Oral ethanol self-administration in the rat: effect of naloxone. Pharmacol Biochem Behav. 1985;22:91-99.
    • (1985) Pharmacol Biochem Behav. , vol.22 , pp. 91-99
    • Samson, H.H.1    Doyle, T.F.2
  • 5
    • 0025171961 scopus 로고
    • Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference
    • Froehlich JC, Hars J, Lumeng L, et al. Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference. Pharmacol Biochem Behav. 1990;35:385-390.
    • (1990) Pharmacol Biochem Behav. , vol.35 , pp. 385-390
    • Froehlich, J.C.1    Hars, J.2    Lumeng, L.3
  • 6
    • 0026498986 scopus 로고
    • Naltrexone and coping skills therapy for alcohol dependence: A controlled study
    • O'Malley SS, Jaffe AJ, Chang G, et al. Naltrexone and coping skills therapy for alcohol dependence: a controlled study. Arch Gen Psychiatry. 1992;49:881-887.
    • (1992) Arch Gen Psychiatry. , vol.49 , pp. 881-887
    • O'Malley, S.S.1    Jaffe, A.J.2    Chang, G.3
  • 8
    • 0033667730 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse
    • Chick J, Anton R, Checinski K, et al. A multicenter, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse. Alcohol Alcohol. 2000;35:587-593.
    • (2000) Alcohol Alcohol. , vol.35 , pp. 587-593
    • Chick, J.1    Anton, R.2    Checinski, K.3
  • 9
    • 0035139865 scopus 로고    scopus 로고
    • Posttreatment results of combining naltrexone with cognitive-behavior therapy for the treatment of alcoholism
    • Anton RF, Moak DH, Latham PK, et al. Posttreatment results of combining naltrexone with cognitive-behavior therapy for the treatment of alcoholism. J Clin Psychopharmacol. 2001;21:72-77.
    • (2001) J Clin Psychopharmacol. , vol.21 , pp. 72-77
    • Anton, R.F.1    Moak, D.H.2    Latham, P.K.3
  • 10
    • 0035164126 scopus 로고    scopus 로고
    • Naltrexone for alcohol dependence: A randomized controlled trial
    • Morris PL, Hopwood M, Whelan G, et al. Naltrexone for alcohol dependence: a randomized controlled trial. Addiction. 2001;96:1565-1573.
    • (2001) Addiction , vol.96 , pp. 1565-1573
    • Morris, P.L.1    Hopwood, M.2    Whelan, G.3
  • 11
    • 0036897358 scopus 로고    scopus 로고
    • Lack of efficacy of naltrexone in the prevention of alcohol relapse: Results from a German multicenter study
    • Gastpar M, Bonnet U, Boning J, et al. Lack of efficacy of naltrexone in the prevention of alcohol relapse: results from a German multicenter study. J Clin Psychopharmacol. 2002;22:592-598.
    • (2002) J Clin Psychopharmacol , vol.22 , pp. 592-598
    • Gastpar, M.1    Bonnet, U.2    Boning, J.3
  • 12
    • 0035857147 scopus 로고    scopus 로고
    • Naltrexone in the treatment of alcohol dependence
    • Krystal JH, Cramer JA, Krol WF, et al. Naltrexone in the treatment of alcohol dependence. New Engl J Med. 2001;345:1734-1739.
    • (2001) New Engl J Med. , vol.345 , pp. 1734-1739
    • Krystal, J.H.1    Cramer, J.A.2    Krol, W.F.3
  • 13
    • 33745476469 scopus 로고    scopus 로고
    • A synopsis of the pharmacological rationale, properties and therapeutic effects of depot preparations of naltrexone for treating alcohol dependence
    • Johnson BA. A synopsis of the pharmacological rationale, properties and therapeutic effects of depot preparations of naltrexone for treating alcohol dependence. Expert Opin Pharmacother. 2006;7:1065-1073.
    • (2006) Expert Opin Pharmacother , vol.7 , pp. 1065-1073
    • Johnson, B.A.1
  • 14
    • 0029609445 scopus 로고
    • Molecular pharmacology of the opioid receptors
    • Satoh M, Minami M. Molecular pharmacology of the opioid receptors. Pharmacol Ther. 1995;68:343-364.
    • (1995) Pharmacol Ther. , vol.68 , pp. 343-364
    • Satoh, M.1    Minami, M.2
  • 15
    • 0028887626 scopus 로고
    • Opioid-receptor mRNA expression in the rat CNS: Anatomical and functional implications
    • Mansour A, Fox CA, Akil H, et al. Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci. 1995;18:22-29.
    • (1995) Trends Neurosci , vol.18 , pp. 22-29
    • Mansour, A.1    Fox, C.A.2    Akil, H.3
  • 16
    • 4644374022 scopus 로고    scopus 로고
    • Secrets of the opium poppy revealed
    • Evans CJ. Secrets of the opium poppy revealed. Neuropharmacology. 2004;47(suppl 1):293-299.
    • (2004) Neuropharmacology , vol.47 SUPPL 1 , pp. 293-299
    • Evans, C.J.1
  • 17
    • 0017623919 scopus 로고
    • Enkephalin may mediate euphoria and drive-reduction reward
    • Belluzzi DJ, Stein L. Enkephalin may mediate euphoria and drive-reduction reward. Nature. 1977;266:556-558.
    • (1977) Nature , vol.266 , pp. 556-558
    • Belluzzi, D.J.1    Stein, L.2
  • 18
    • 0018715152 scopus 로고
    • Brain endorphins: Possible role in reward and memory formation
    • Belluzzi DJ, Stein L. Brain endorphins: possible role in reward and memory formation. Fed Proc. 1979;38:2468-2472.
    • (1979) Fed Proc. , vol.38 , pp. 2468-2472
    • Belluzzi, D.J.1    Stein, L.2
  • 19
    • 0028006303 scopus 로고
    • Pharmacological characterization of the cloned kappa-, delta- and mu-opioid receptors
    • Raynor K, Kong H, Chen Y, et al. Pharmacological characterization of the cloned kappa-, delta- and mu-opioid receptors. Mol Pharmacol. 1994;45:330-334.
    • (1994) Mol Pharmacol , vol.45 , pp. 330-334
    • Raynor, K.1    Kong, H.2    Chen, Y.3
  • 20
    • 0024459590 scopus 로고
    • Multiple opioid receptors: Ligand selectivity profiles and binding site signatures
    • Goldstein A, Naidu A. Multiple opioid receptors: ligand selectivity profiles and binding site signatures. Mol Pharmacol. 1989;36:265-272.
    • (1989) Mol Pharmacol , vol.36 , pp. 265-272
    • Goldstein, A.1    Naidu, A.2
  • 21
    • 34247584466 scopus 로고    scopus 로고
    • Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors
    • Peng X, Knapp BI, Bidlack JM, et al. Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors. J Med Chem. 2007;50:2254-2258.
    • (2007) J Med Chem. , vol.50 , pp. 2254-2258
    • Peng, X.1    Knapp, B.I.2    Bidlack, J.M.3
  • 22
    • 38149139307 scopus 로고    scopus 로고
    • Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects
    • Weerts EM, Kin YK, Wand GS, et al. Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. Neuropsychopharmacology. 2008;33:653-665.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 653-665
    • Weerts, E.M.1    Kin, Y.K.2    Wand, G.S.3
  • 23
    • 0022930865 scopus 로고
    • Endogenous opioid peptides and hypothalamopituitary function
    • Howlett TA, Rees LH. Endogenous opioid peptides and hypothalamopituitary function. Annu Rev Physiol. 1986;48:527-536
    • (1986) Annu Rev Physiol , vol.48 , pp. 527-536
    • Howlett, T.A.1    Rees, L.H.2
  • 24
    • 0020463792 scopus 로고
    • Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment
    • Tempel A, Zukin RS, Gardner EL. Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment. Life Sci. 1982;31:1401-1404.
    • (1982) Life Sci. , vol.31 , pp. 1401-1404
    • Tempel, A.1    Zukin, R.S.2    Gardner, E.L.3
  • 25
    • 0031949981 scopus 로고    scopus 로고
    • Quantitative immuno-localization of mu opioid receptors: Regulation by naltrexone
    • Unterwald EM, Anton B, To T, et al. Quantitative immuno-localization of mu opioid receptors: regulation by naltrexone. Neuroscience. 1998;85:897-905.
    • (1998) Neuroscience , vol.85 , pp. 897-905
    • Unterwald, E.M.1    Anton, B.2    To, T.3
  • 26
    • 0023742942 scopus 로고
    • Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DADLE
    • Yoburn BC, Kuke MC, Pasternak GW, et al. Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DADLE. Life Sci. 1988;43:1319-1324.
    • (1988) Life Sci. , vol.43 , pp. 1319-1324
    • Yoburn, B.C.1    Kuke, M.C.2    Pasternak, G.W.3
  • 27
    • 0026507628 scopus 로고
    • Drugs of abuse: Anatomy, pharmacology and function of reward pathways
    • Koob GF. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci. 1992;13:177-184.
    • (1992) Trends Pharmacol Sci. , vol.13 , pp. 177-184
    • Koob, G.F.1
  • 28
    • 0025091887 scopus 로고
    • Involvement of central mu and delta opioid receptors in mediating the reinforcing effects of β-endorphin in the rat
    • Bals-Kubik R, Shippenberg TS, Herz A. Involvement of central mu and delta opioid receptors in mediating the reinforcing effects of β-endorphin in the rat. Eur J Pharmacol. 1990;175:63-69.
    • (1990) Eur J Pharmacol , vol.175 , pp. 63-69
    • Bals-Kubik, R.1    Shippenberg, T.S.2    Herz, A.3
  • 29
    • 0021876216 scopus 로고
    • Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning
    • Mucha RF, Herz A. Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning. Psychopharmacology. 1985;86:274-280.
    • (1985) Psychopharmacology , vol.86 , pp. 274-280
    • Mucha, R.F.1    Herz, A.2
  • 30
    • 0027374753 scopus 로고
    • Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats
    • Bals-Kubik R, Ableitner A, Herz A, et al. Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats. J Pharmacol Exp Ther. 1993;264:489-495.
    • (1993) J Pharmacol Exp Ther. , vol.264 , pp. 489-495
    • Bals-Kubik, R.1    Ableitner, A.2    Herz, A.3
  • 31
    • 0028274559 scopus 로고
    • Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats
    • Devine DP, Wise RA. Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats. J Neurosci. 1994;14:1978-1984.
    • (1994) J Neurosci , vol.14 , pp. 1978-1984
    • Devine, D.P.1    Wise, R.A.2
  • 32
    • 0026559951 scopus 로고
    • Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway
    • Spanagel R, Herz A, Shippenberg TS. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc Natl Acad Sci USA. 1992;89:2046-2050.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2046-2050
    • Spanagel, R.1    Herz, A.2    Shippenberg, T.S.3
  • 33
    • 0027847675 scopus 로고
    • Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: In vivo microdialysis studies
    • Devine DP, Leone P, Pocock D, et al. Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies. J Pharmacol Exp Ther. 1993;266:1236-1246.
    • (1993) J Pharmacol Exp Ther. , vol.266 , pp. 1236-1246
    • Devine, D.P.1    Leone, P.2    Pocock, D.3
  • 34
    • 0028914467 scopus 로고    scopus 로고
    • Molecular mechanisms of drug reinforcement and addiction
    • Self DWL, Nestler EJ. Molecular mechanisms of drug reinforcement and addiction. Annu Rev Neurosci. 1996;18:463-495.
    • (1996) Annu Rev Neurosci , vol.18 , pp. 463-495
    • Dwl, S.1    Nestler, E.J.2
  • 35
    • 0030756351 scopus 로고    scopus 로고
    • Drug abuse: Hedonic homeostatic dysregulation
    • Koob GF, Le Moal M. Drug abuse: hedonic homeostatic dysregulation. Science. 1997;278:52-58.
    • (1997) Science , vol.278 , pp. 52-58
    • Koob, G.F.1    Le Moal, M.2
  • 36
    • 0019359655 scopus 로고
    • Aversive effects of naltrexone in subjects not dependent on opiates
    • Hollister LE, Johnson K, Boukhabza D, et al. Aversive effects of naltrexone in subjects not dependent on opiates. Drug Alcohol Depend. 1981;8:37-41.
    • (1981) Drug Alcohol Depend , vol.8 , pp. 37-41
    • Hollister, L.E.1    Johnson, K.2    Boukhabza, D.3
  • 37
    • 0023277101 scopus 로고
    • Naltrexone and dysphoria: A double-blind placebo controlled trial
    • Malcolm R, O'Neil PM, Von JM, et al. Naltrexone and dysphoria: a double-blind placebo controlled trial. Biol Psychiatry. 1987;22:710-716.
    • (1987) Biol Psychiatry , vol.22 , pp. 710-716
    • Malcolm, R.1    Jm Von O.Pm2
  • 38
    • 0036114390 scopus 로고    scopus 로고
    • Naltrexone and dysphoria: Fact or myth?
    • Miotto K, McCann M, Basch J, et al. Naltrexone and dysphoria: fact or myth? Am J Addict. 2002;11:151-160.
    • (2002) Am J Addict , vol.11 , pp. 151-160
    • Miotto, K.1    McCann, M.2    Basch, J.3
  • 39
    • 22044457008 scopus 로고    scopus 로고
    • Naltrexone-induced conditioned place aversion following a single dose of morphine in the rat
    • White DA, Hwang ML, Holtzman SG. Naltrexone-induced conditioned place aversion following a single dose of morphine in the rat. Pharmacol Biochem Behav. 2005;81:451-458.
    • (2005) Pharmacol Biochem Behav. , vol.81 , pp. 451-458
    • White, D.A.1    Hwang, M.L.2    Holtzman, S.G.3
  • 40
    • 1642387528 scopus 로고    scopus 로고
    • Central administration of nociceptin/orphanin FQ blocks the acquisition of conditioned place preference to morphine and cocaine, but not conditioned place aversion to naloxone in mice
    • Sakoori K, Murphy NP. Central administration of nociceptin/orphanin FQ blocks the acquisition of conditioned place preference to morphine and cocaine, but not conditioned place aversion to naloxone in mice. Psychopharmacology. 2004;172:129-136.
    • (2004) Psychopharmacology , vol.172 , pp. 129-136
    • Sakoori, K.1    Murphy, N.P.2
  • 41
    • 0026719935 scopus 로고
    • Analgesic and aversive effects of naloxone in BALB/C mice
    • Vaccarino AL, Plamondon H, Melzack R. Analgesic and aversive effects of naloxone in BALB/C mice. Exp Neurol. 1992;117:216-218.
    • (1992) Exp Neurol. , vol.117 , pp. 216-218
    • Vaccarino, A.L.1    Plamondon, H.2    Melzack, R.3
  • 42
    • 0035980463 scopus 로고    scopus 로고
    • Naloxone fails to produced conditioned place aversion in mu-opioid receptor knock-out mice
    • Skoubis PD, Matthew HW, Walwyn WM, et al. Naloxone fails to produced conditioned place aversion in mu-opioid receptor knock-out mice. Neuroscience. 2001;106:757-763.
    • (2001) Neuroscience , vol.106 , pp. 757-763
    • Skoubis, P.D.1    Matthew, H.W.2    Walwyn, W.M.3
  • 43
    • 17144418417 scopus 로고    scopus 로고
    • Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice
    • Skoubis PD, Lam HA, Shoblock J, et al. Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice. Eur J Neurosci. 2005;21:1379-1384.
    • (2005) Eur J Neurosci , vol.21 , pp. 1379-1384
    • Skoubis, P.D.1    Lam, H.A.2    Shoblock, J.3
  • 44
    • 0034972443 scopus 로고    scopus 로고
    • Inverse agonists and neutral antagonists at mu opioid receptor (MOR): Possible role of basal receptor signaling in narcotic dependence
    • Wang D, Raehal KM, Bilsky EJ, et al. Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. J Neurochem. 2001;77:1590-1600.
    • (2001) J Neurochem , vol.77 , pp. 1590-1600
    • Wang, D.1    Raehal, K.M.2    Bilsky, E.J.3
  • 45
    • 32844470518 scopus 로고    scopus 로고
    • Constitutively active mu opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice
    • Shoblock JR, Maidment NT. Constitutively active mu opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice. Neuropsychopharmacology. 2006;31:171-177.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 171-177
    • Shoblock, J.R.1    Maidment, N.T.2
  • 46
    • 0033056475 scopus 로고    scopus 로고
    • Discriminative stimulus effects of naltrexone after a single dose of morphine in the rat
    • Easterling KW, Holtzman SG. Discriminative stimulus effects of naltrexone after a single dose of morphine in the rat. J Pharmacol Exp Ther. 1999;288:1269-1277.
    • (1999) J Pharmacol Exp Ther. , vol.288 , pp. 1269-1277
    • Easterling, K.W.1    Holtzman, S.G.2
  • 47
    • 0345708156 scopus 로고    scopus 로고
    • Repeated experience with naloxone facilitates acute morphine withdrawal: Potential role for conditioning processes in acute opioid dependence
    • Schulteis G, Morse AC, Liu J. Repeated experience with naloxone facilitates acute morphine withdrawal: potential role for conditioning processes in acute opioid dependence. Pharmacol Biochem Behav. 2003;76:493-503.
    • (2003) Pharmacol Biochem Behav. , vol.76 , pp. 493-503
    • Schulteis, G.1    Morse, A.C.2    Liu, J.3
  • 48
    • 0025302671 scopus 로고
    • Acute opioid physical dependence in humans: Effe of naloxone at 6 and 24 ours postmorphine
    • Heishman SJ, Stitzer ML, Bigelow GE, et al. Acute opioid physical dependence in humans: effe of naloxone at 6 and 24 ours postmorphine. Pharmacol Biochem Behav. 1990;36:393-399.
    • (1990) Pharmacol Biochem Behav. , vol.36 , pp. 393-399
    • Heishman, S.J.1    Stitzer, M.L.2    Bigelow, G.E.3
  • 49
    • 0031885242 scopus 로고    scopus 로고
    • Neurocircuitry of targets of ethanol reward and dependence
    • Koob GF, Roberts AJ, Schulteis G, et al. Neurocircuitry of targets of ethanol reward and dependence. Alcohol Clin Exp Res. 1998;22:3-9.
    • (1998) Alcohol Clin Exp Res. , vol.22 , pp. 3-9
    • Koob, G.F.1    Roberts, A.J.2    Schulteis, G.3
  • 50
    • 38849099417 scopus 로고    scopus 로고
    • Acamprosate in alcohol dependence: Implications of a unique mechanism of action
    • Littleton JM. Acamprosate in alcohol dependence: implications of a unique mechanism of action. J Addict Med. 2007;1:115-125.
    • (2007) J Addict Med. , vol.1 , pp. 115-125
    • Littleton, J.M.1
  • 51
    • 34447644753 scopus 로고    scopus 로고
    • A key role for corticotropin-releasing factor in alcohol dependence
    • Heilig M, Koob GF. A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci. 2007;30:399-406.
    • (2007) Trends Neurosci , vol.30 , pp. 399-406
    • Heilig, M.1    Koob, G.F.2
  • 52
    • 0022899199 scopus 로고
    • Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol
    • Imperato A, Di Chiara G. Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther. 1986;239:221-229.
    • (1986) J Pharmacol Exp Ther. , vol.239 , pp. 221-229
    • Imperato, A.1    Di Chiara, G.2
  • 53
    • 0026485324 scopus 로고
    • Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens
    • Rassnick S, Pulvirenti L, Koob GF. Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens. Psychopharmacology. 1992;109:92-98.
    • (1992) Psychopharmacology , vol.109 , pp. 92-98
    • Rassnick, S.1    Pulvirenti, L.2    Koob, G.F.3
  • 54
    • 0027434656 scopus 로고
    • Effect of dopamine agonists and antagonists on ethanol reinforced behavior: The involvement of the nucleus accumbens
    • Samsom HH, Hodge CW, Tolliver GA, et al. Effect of dopamine agonists and antagonists on ethanol reinforced behavior: the involvement of the nucleus accumbens. Brain Res Bull. 1993;30:133-141.
    • (1993) Brain Res Bull. , vol.30 , pp. 133-141
    • Samsom, H.H.1    Hodge, C.W.2    Tolliver, G.A.3
  • 55
    • 0026545188 scopus 로고
    • Influence of dopaminergic and serotonergic neurons on intravenous ethanol self-administration in the rat
    • Lyness WH, Smith FL. Influence of dopaminergic and serotonergic neurons on intravenous ethanol self-administration in the rat. Pharmacol Biochem Behav. 1992;42:187-192.
    • (1992) Pharmacol Biochem Behav. , vol.42 , pp. 187-192
    • Lyness, W.H.1    Smith, F.L.2
  • 56
    • 0027220050 scopus 로고
    • The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat
    • Rassnick S, Stinus L, Koob GF. The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat. Brain Res. 1993;623:16-24.
    • (1993) Brain Res. , vol.623 , pp. 16-24
    • Rassnick, S.1    Stinus, L.2    Koob, G.F.3
  • 57
    • 0029983167 scopus 로고    scopus 로고
    • Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism
    • Gianoulakis C, Krishnan B, Thavundayil J. Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism. Arch Gen Psychiatry. 1996;53:250-257.
    • (1996) Arch Gen Psychiatry , vol.53 , pp. 250-257
    • Gianoulakis, C.1    Krishnan, B.2    Thavundayil, J.3
  • 58
    • 0029129250 scopus 로고
    • Genetic factors in alcohol self-administration
    • Froehlich JC. Genetic factors in alcohol self-administration. J Clin Psychiatry. 1995;56:15-23.
    • (1995) J Clin Psychiatry , vol.56 , pp. 15-23
    • Froehlich, J.C.1
  • 59
    • 0028984364 scopus 로고
    • Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking
    • Krishnan-Sarin S, Wand GS, Li X-W, et al. Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking. Pharmacol Biochem Behav. 1995;52:153-159.
    • (1995) Pharmacol Biochem Behav. , vol.52 , pp. 153-159
    • Krishnan-Sarin, S.1    Wand, G.S.2    Li, X.-W.3
  • 60
    • 0031024621 scopus 로고    scopus 로고
    • Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence
    • King AC, Volpicelli JR, Frazer A, et al. Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence. Psychopharmacology. 1997;129:15-22.
    • (1997) Psychopharmacology , vol.129 , pp. 15-22
    • King, A.C.1    Volpicelli, J.R.2    Frazer, A.3
  • 61
    • 0028922703 scopus 로고
    • Effect of naltrexone on alcohol 'high' in alcoholics
    • Volpicelli JR, Watson NT, King AC, et al. Effect of naltrexone on alcohol 'high' in alcoholics. Am J Psychiatry. 1995;152:613-615.
    • (1995) Am J Psychiatry , vol.152 , pp. 613-615
    • Volpicelli, J.R.1    Watson, N.T.2    King, A.C.3
  • 62
    • 0034126517 scopus 로고    scopus 로고
    • Mu opioid receptor knockout mice do not self-administer alcohol
    • Roberts AJ, McDonald JS, Heyser CJ, et al. Mu opioid receptor knockout mice do not self-administer alcohol. J Pharmacol Exp Ther. 2000;293:1002-1008.
    • (2000) J Pharmacol Exp Ther. , vol.293 , pp. 1002-1008
    • Roberts, A.J.1    McDonald, J.S.2    Heyser, C.J.3
  • 63
    • 0031949311 scopus 로고    scopus 로고
    • A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol comsumption in the rat
    • Stromberg MF, Casale M, Volpicelli L, et al. A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol comsumption in the rat. Alcohol. 1998;15:281-289.
    • (1998) Alcohol , vol.15 , pp. 281-289
    • Stromberg, M.F.1    Casale, M.2    Volpicelli, L.3
  • 64
    • 0026027048 scopus 로고
    • Importance of delta opioid receptors in maintaining high alcohol drinking
    • Froehlich JC, Zweifel M, Harts J, et al. Importance of delta opioid receptors in maintaining high alcohol drinking. Psychopharmacology. 1991;103:467-472.
    • (1991) Psychopharmacology , vol.103 , pp. 467-472
    • Froehlich, J.C.1    Zweifel, M.2    Harts, J.3
  • 65
    • 0030896873 scopus 로고    scopus 로고
    • Differential sensitivity of c-Fos expression in hippocampus and other brain regions to moderate and low doses of alcohol
    • Ryabinin AE, Criado JR, Henriksen SJ, et al. Differential sensitivity of c-Fos expression in hippocampus and other brain regions to moderate and low doses of alcohol. Mol Psychiatry. 1997;2:32-43.
    • (1997) Mol Psychiatry , vol.2 , pp. 32-43
    • Ryabinin, A.E.1    Criado, J.R.2    Henriksen, S.J.3
  • 66
    • 0031615310 scopus 로고    scopus 로고
    • Brain imaging. Functional consequences of ethanol in the central nervous system
    • Lyons D, Whitlow CT, Smith HR, et al. Brain imaging. Functional consequences of ethanol in the central nervous system. Recent Dev Alcohol. 1998;14:253-284.
    • (1998) Recent Dev Alcohol , vol.14 , pp. 253-284
    • Lyons, D.1    Whitlow, C.T.2    Smith, H.R.3
  • 67
    • 0028981524 scopus 로고
    • GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats
    • Hyytia P, Koob GF. GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol. 1995;283:151-159.
    • (1995) Eur J Pharmacol , vol.283 , pp. 151-159
    • Hyytia, P.1    Koob, G.F.2
  • 68
    • 0029910859 scopus 로고    scopus 로고
    • Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats
    • Roberts AJ, Cole M, Koob GF. Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats. Alcohol Clin Exp Res. 1996;20:1289-1298.
    • (1996) Alcohol Clin Exp Res. , vol.20 , pp. 1289-1298
    • Roberts, A.J.1    Cole, M.2    Koob, G.F.3
  • 69
    • 0343488556 scopus 로고    scopus 로고
    • Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions
    • Moller C, Wiklund L, Sommer W, et al. Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions. Brain Res. 1997;760:94-101.
    • (1997) Brain Res. , vol.760 , pp. 94-101
    • Moller, C.1    Wiklund, L.2    Sommer, W.3
  • 70
    • 0021366487 scopus 로고
    • Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats
    • Mereu G, Fadda F, Gessa GL. Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats. Brain Res. 1984;292:63-69.
    • (1984) Brain Res. , vol.292 , pp. 63-69
    • Mereu, G.1    Fadda, F.2    Gessa, G.L.3
  • 71
    • 0027482405 scopus 로고
    • Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: Genetic and motivational determinants
    • Weiss F, Lorang MT, Bloom FE, et al. Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther. 1993;267:250-258.
    • (1993) J Pharmacol Exp Ther. , vol.267 , pp. 250-258
    • Weiss, F.1    Lorang, M.T.2    Bloom, F.E.3
  • 72
    • 0032859353 scopus 로고    scopus 로고
    • Central administration of an opiate antagonist decreases oral ethanol self-administration in rats
    • Heyser CJ, Roberts AJ, Schulteis G, et al. Central administration of an opiate antagonist decreases oral ethanol self-administration in rats. Alcohol Clin Exp Res. 1999;23:1468-1476.
    • (1999) Alcohol Clin Exp Res. , vol.23 , pp. 1468-1476
    • Heyser, C.J.1    Roberts, A.J.2    Schulteis, G.3
  • 73
    • 0842308151 scopus 로고    scopus 로고
    • GABAA and opioid receptors of the central nucleus of the amygdala selectively regulate ethanol-maintained behaviors
    • Foster KL, McKay PF, Seyoum R, et al. GABAA and opioid receptors of the central nucleus of the amygdala selectively regulate ethanol-maintained behaviors. Neuropsychopharmacology. 2004;29:269-284.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 269-284
    • Foster, K.L.1    McKay, P.F.2    Seyoum, R.3
  • 74
    • 0035125031 scopus 로고    scopus 로고
    • Suppression of ethanol responding by centrally administered CTOP and naltrindole in AA and Wistar rats
    • Hyytia P, Kiianmaa K. Suppression of ethanol responding by centrally administered CTOP and naltrindole in AA and Wistar rats. Alcohol Clin Exp Res. 2001;25:25-33.
    • (2001) Alcohol Clin Exp Res. , vol.25 , pp. 25-33
    • Hyytia, P.1    Kiianmaa, K.2
  • 75
    • 35748931731 scopus 로고    scopus 로고
    • Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice
    • Lasek AW, Janak PH, He L, et al. Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice. Genes Brain Behav. 2007;6:728-735.
    • (2007) Genes Brain Behav. , vol.6 , pp. 728-735
    • Lasek, A.W.1    Janak, P.H.2    He, L.3
  • 76
    • 0031451427 scopus 로고    scopus 로고
    • The development of a conditioned place preference to morphine: Effects of microinjections into various CNS sites
    • Olmstead MC, Franklin KB. The development of a conditioned place preference to morphine: effects of microinjections into various CNS sites. Behav Neurosci. 1997;111:1324-1334.
    • (1997) Behav Neurosci , vol.111 , pp. 1324-1334
    • Olmstead, M.C.1    Franklin, K.B.2
  • 77
    • 45849137099 scopus 로고    scopus 로고
    • Cocaine reward and hyperactivity in the rat: Sites of mu opioid receptor modulation
    • Soderman AS, Unterwald EM. Cocaine reward and hyperactivity in the rat: sites of mu opioid receptor modulation. Neuroscience. 2008;154:1506-1516.
    • (2008) Neuroscience , vol.154 , pp. 1506-1516
    • Soderman, A.S.1    Unterwald, E.M.2
  • 78
    • 0023697444 scopus 로고
    • New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata
    • Alheid GF, Heimer L. New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: the striatopallidal, amygdaloid, and corticopetal components of substantia innominata. Neuroscience. 1988;27:1-39.
    • (1988) Neuroscience , vol.27 , pp. 1-39
    • Alheid, G.F.1    Heimer, L.2
  • 79
    • 0028156034 scopus 로고
    • Distribution of dopamine fibers in the central division of the extended amygdala of the rat
    • Freedman LJ, Cassell MD. Distribution of dopamine fibers in the central division of the extended amygdala of the rat. Brain Res. 1994;633:234-252.
    • (1994) Brain Res. , vol.633 , pp. 234-252
    • Freedman, L.J.1    Cassell, M.D.2
  • 80
    • 0026652547 scopus 로고
    • Regulation of somatodendritic dopamine release in the ventral tegmental area by opioids and GABA: An in vivo microdialysis study
    • Klitenick MA, DeWitte P, Kalivas PW. Regulation of somatodendritic dopamine release in the ventral tegmental area by opioids and GABA: an in vivo microdialysis study. J Neurosci. 1992;12:2623-2632.
    • (1992) J Neurosci , vol.12 , pp. 2623-2632
    • Ma, K.1    Dewitte, P.2    Kalivas, P.W.3
  • 81
    • 0026592638 scopus 로고
    • Opioids excite dopamine neurons by hyperpolarization of local interneurons
    • Johnson SW, North RA. Opioids excite dopamine neurons by hyperpolarization of local interneurons. J Neurosci. 1992;12:483-489.
    • (1992) J Neurosci , vol.12 , pp. 483-489
    • Johnson, S.W.1    North, R.A.2
  • 82
    • 0033535772 scopus 로고    scopus 로고
    • Localization of mu-opioid receptors on amygdaloid projection neurons in the parabrachial nucleus of the rat
    • Chamberlin NL, Mansour A, Watson SJ, et al. Localization of mu-opioid receptors on amygdaloid projection neurons in the parabrachial nucleus of the rat. Brain Res. 1999;827:198-204.
    • (1999) Brain Res. , vol.827 , pp. 198-204
    • Chamberlin, N.L.1    Mansour, A.2    Watson, S.J.3
  • 83
    • 33745891772 scopus 로고    scopus 로고
    • Characterization of neurons in the rat central nucleus of the amygdala: Cellular physiology, morphology, and opioid sensitivity
    • Chieng BC, Christie MJ, Osborne PB. Characterization of neurons in the rat central nucleus of the amygdala: cellular physiology, morphology, and opioid sensitivity. J Comp Neurol. 2006;297:910-927
    • (2006) J Comp Neurol , vol.297 , pp. 910-927
    • Chieng, B.C.1    Christie, M.J.2    Osborne, P.B.3
  • 84
    • 36649031015 scopus 로고    scopus 로고
    • Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area
    • Rodaros D, Caruana DA, Amir S, et al. Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area. Neuroscience. 2007;150:8-13.
    • (2007) Neuroscience , vol.150 , pp. 8-13
    • Rodaros, D.1    Caruana, D.A.2    Amir, S.3
  • 85
    • 0033037311 scopus 로고    scopus 로고
    • Direct comparison of projections from the central amygdaloid region and nucleus accumbens shell
    • Zahm DS, Jensen SL, Williams ES, et al. Direct comparison of projections from the central amygdaloid region and nucleus accumbens shell. Eur J Neurosci. 1999;11:1119-1126.
    • (1999) Eur J Neurosci , vol.11 , pp. 1119-1126
    • Zahm, D.S.1    Jensen, S.L.2    Williams, E.S.3
  • 86
    • 18844455279 scopus 로고    scopus 로고
    • Mu-opioid-mediated inhibition of glutamate synaptic transmission in rat central amygdala neurons
    • Zhu W, Pan ZZ. Mu-opioid-mediated inhibition of glutamate synaptic transmission in rat central amygdala neurons. Neuroscience. 2005;133:97-103.
    • (2005) Neuroscience , vol.133 , pp. 97-103
    • Zhu, W.1    Pan, Z.Z.2
  • 87
    • 0034821702 scopus 로고    scopus 로고
    • Efficacy of naltrexone and acamprosate for alcoholism treatment: A meta-analysis
    • Kranzler HR, Van Kirk J. Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. Alcohol Clin Exp Res. 2001;25:1335-1341.
    • (2001) Alcohol Clin Exp Res. , vol.25 , pp. 1335-1341
    • Kranzler, H.R.1    Van Kirk, J.2
  • 88
    • 0029802286 scopus 로고    scopus 로고
    • Naltrexone, relapse prevention, and supportive therapy with alcoholics: An analysis of patient treatment matching
    • Jaffe AJ, Rounsaville B, Chang G, et al. Naltrexone, relapse prevention, and supportive therapy with alcoholics: an analysis of patient treatment matching. J Consul Clin Psychol. 1996;64:1044-1053.
    • (1996) J Consul Clin Psychol , vol.64 , pp. 1044-1053
    • Jaffe, A.J.1    Rounsaville, B.2    Chang, G.3
  • 89
    • 0041383898 scopus 로고    scopus 로고
    • A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    • Oslin DW, Berrettini W, Kranzler HR, et al. A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology. 2003;28:1546-1552.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1546-1552
    • Oslin, D.W.1    Berrettini, W.2    Kranzler, H.R.3
  • 90
    • 34548458513 scopus 로고    scopus 로고
    • Effects of naltrexone on alcohol sensitivity and genetics moderators of medication response
    • Ray LA, Hutchinson KE. Effects of naltrexone on alcohol sensitivity and genetics moderators of medication response. Arch Gen Psychiatry. 2007;9:1069-1077.
    • (2007) Arch Gen Psychiatry , vol.9 , pp. 1069-1077
    • Ray, L.A.1    Hutchinson, K.E.2
  • 91
    • 33947289675 scopus 로고    scopus 로고
    • Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: Results from the VA Cooperative Study
    • Gelernter J, Gueorguieva R, Kranzler HR, et al. Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. Alcohol Clin Exp Res. 2007;31:555-563.
    • (2007) Alcohol Clin Exp Res. , vol.31 , pp. 555-563
    • Gelernter, J.1    Gueorguieva, R.2    Kranzler, H.R.3
  • 92
    • 13144261678 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction
    • Bond C, LaForge KS, Tian M, et al. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci USA. 1998;95:9608-9613.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9608-9613
    • Bond, C.1    Laforge, K.S.2    Tian, M.3
  • 93
    • 0036149110 scopus 로고    scopus 로고
    • The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade
    • Wand GS, McCaul M, Yang X, et al. The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade. Neuropsychopharmacology. 2002;26:106-114.
    • (2002) Neuropsychopharmacology , vol.26 , pp. 106-114
    • Wand, G.S.1    McCaul, M.2    Yang, X.3
  • 94
    • 0038755197 scopus 로고    scopus 로고
    • Et al. association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (ORPM1
    • Hernandez-Avila C, Wand G, Luo X, et al. association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (ORPM1). Am J Med Genet. 2003;118B:60-65.
    • (2003) Am J Med Genet , vol.118 B , pp. 60-65
    • Hernandez-Avila, C.1    Wand, G.2    Luo, X.3
  • 95
    • 0033001527 scopus 로고    scopus 로고
    • Mu-opioid receptor variants and dopaminergic sensitivity in alcohol withdrawal
    • Smolka M, Sander T, Schmidt L, et al. Mu-opioid receptor variants and dopaminergic sensitivity in alcohol withdrawal. Psychoneuroendocrinology. 1999;24:629-638.
    • (1999) Psychoneuroendocrinology , vol.24 , pp. 629-638
    • Smolka, M.1    Sander, T.2    Schmidt, L.3
  • 96
    • 0035177988 scopus 로고    scopus 로고
    • Naltrexone, a relapse prevention maintenance treatment of alcohol dependence: A meta-analysis of randomized controlled trials
    • Streeton C, Whelan G. Naltrexone, a relapse prevention maintenance treatment of alcohol dependence: a meta-analysis of randomized controlled trials. Alcohol Alcohol. 2001;36:544-552.
    • (2001) Alcohol Alcohol , vol.36 , pp. 544-552
    • Streeton, C.1    Whelan, G.2
  • 97
    • 0032535299 scopus 로고    scopus 로고
    • Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens
    • Gonzales RA, Weiss F. Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens. J Neurosci. 1998;18:10663-10671.
    • (1998) J Neurosci , vol.18 , pp. 10663-10671
    • Gonzales, R.A.1    Weiss, F.2
  • 98
    • 0037107155 scopus 로고    scopus 로고
    • Additive effect of stress and drug cues on reinstatement of ethanol seeking: Exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms
    • Liu X, Weiss F. Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms. J Neurosci. 2002;22:7856-7861.
    • (2002) J Neurosci , vol.22 , pp. 7856-7861
    • Liu, X.1    Weiss, F.2
  • 99
    • 33646150204 scopus 로고    scopus 로고
    • The ethanol self-administration context as a reinstatement cue: Acute effects of naltrexone
    • Burattini C, Gill TM, Aicardi G, et al. The ethanol self-administration context as a reinstatement cue: acute effects of naltrexone. Neuroscience. 2006;139:877-887.
    • (2006) Neuroscience , vol.139 , pp. 877-887
    • Burattini, C.1    Gill, T.M.2    Aicardi, G.3


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