Lipoic acid increases glutathione production and enhances the effect of mercury in human cell lines

Toxicology

Volumn 175, Issue 1-3, 2002, Pages 103-110

  Hultberg, Björn ^a   Andersson, Anders ^a   Isaksson, Anders ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Lipoic acid; Cell culture; Dithiothreitol; Glutathione; Human cell lines; Mercury; N acetylcysteine; Thiols

Indexed keywords

ACETYLCYSTEINE; DIHYDROLIPOATE; DITHIOTHREITOL; GLUTATHIONE; HOMOCYSTEINE; MERCURY; THIOCTIC ACID; THIOL DERIVATIVE;

ARTICLE; CELL LEVEL; CHEMICAL INTERACTION; CONTROLLED STUDY; CYTOTOXICITY; HELA CELL; HEPATOMA CELL; HUMAN; HUMAN CELL; METABOLISM; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; TOXICITY TESTING;

ACETYLCYSTEINE; ANTIOXIDANTS; DITHIOTHREITOL; DRUG SYNERGISM; GLUTATHIONE; HELA CELLS; HEPATOCYTES; HOMOCYSTEINE; HUMANS; MERCURY; THIOCTIC ACID;

EID: 0037076855     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00060-4     Document Type: Article

References (20)

1. Homocysteine and other thiols determined in plasma by HPLC and thiol-specific postcolumn derivatization
2. Dose-proportionality of oral thioctic acid - Coincidence of assessments via pooled plasma and individual data
3. Thiol-based antioxidants
4. Regulation of cellular glutathione
5. Glutathione, albumin, cysteine and cysteinylglycine effects on toxicity and accumulation of mercuric chloride in LLC-PK1 cells
6. Copper ions differ from other metal ions in their effects on the concentration and redox status of thiols in HeLa cell cultures
7. The cell-damaging effects of low amounts of homocysteine and copper ions in human cell line cultures are caused by oxidative stress
8. Interaction of metals and thiols in cell damage and glutathione distribution: Potentiation of mercury toxicity by dithiolthreitol
9. Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine
10. Protein measurement with Folin phenol reagent
11. Specificity and directionality of thiol effects on sinusoidal glutathione transport in rat liver
12. Glutathione metabolism and its selective modification
13. Glutathione, ascorbate, and cellular protection
14. Glutathione
15. Cystine uptake and glutathione levels in endothelial cells exposed to oxidative stress
16. Toxic metals
17. Glutathione homeostasis in response to exercise training and nutritional supplements
18. Cellular thiols and redox-regulated signal transduction
19. Gamma-glutamyltranspeptidase and L-cysteine regulate methylmercury uptake by HepG2 cells, a human hepatoma cell line