Methyl balance and transmethylation fluxes in humans

American Journal of Clinical Nutrition

Volumn 85, Issue 1, 2007, Pages 19-25

  Mudd, S Harvey ^a   Brosnan, John T ^b   Brosnan, Margaret E ^b   Jacobs, René L ^c   Stabler, Sally P ^d   Allen, Robert H ^d   Vance, Dennis E ^c   Wagner, Conrad ^e  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^c CANADIAN INSTITUTES OF HEALTH RESEARCH   (Canada)

^d UNIVERSITY OF COLORADO   (United States)

^e VANDERBILT UNIVERSITY   (United States)

Author keywords

Creatine; Labile methyl balance; Phosphatidylcholine; Sarcosine; Transmethylation

Indexed keywords

CREATINE; GLYCINE METHYLTRANSFERASE; GUANIDINOACETATE METHYLTRANSFERASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; S ADENOSYLMETHIONINE; SARCOSINE;

DIETARY INTAKE; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME DEFICIENCY; HUMAN; METHYLATION; NONHUMAN; REVIEW;

ANIMALIA; MAMMALIA; MUS;

EID: 33846035428     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/85.1.19     Document Type: Review

References (42)

1. Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL. Is it time to reevaluate methyl balance in humans? Am J Clin Nutr 2006;83:5-10.
2. Mudd SH, Poole JR. Labile methyl balances for normal humans on various dietary regimens. Metabolism 1975;24:721-35.
3. Katz JE, Dlakic M, Clarke S. Automated identification of putative methyltransferases from genomic open reading frames. Mol Cell Proteom 2003;2:525-40.
4. Rosenblatt DS, Fenton WA. Inherited disorders of folate and cobalamin transport and metabolism. In: Scriver CR, Beaudet AL, Valle D et al, eds. The metabolic and molecular bases of inherited disease. New York, NY: McGraw-Hill, 2001:3897-933.
5. Barber JR, Morimoto BH, Brunauer LS, Clarke S. Metabolism of S-adenosyl-L-methionine in intact human erythrocytes. Biochim Biophys Acta 1986;886:361-72.
6. Mudd SH, Ebert MH, Scriver CR. Labile methyl group balances in the human: the role of sarcosine. Metabolism 1980;29:707-20.
7. Harris RC, Söderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci 1992;83:367-74.
8. Harris RC, Nevill M, Harris DB, Fallowfield JL, Bogdanis GC, Wise JA. Absorption of creatine supplied as a drink, in meat or in solid form. J Sports Sci 2002;20:147-51.
9. 3. J Chromatogr B 2005;827:210-5.
10. 13C]methionine. Am J Physiol Endocrinol Metab 1988;255:E322-31.
11. Fukagawa NK, Martin JM, Wurthmann A, Prue AH, Ebenstein D, O'Rourke B. Sex-related differences in methionine metabolism and plasma homocysteine concentrations. Am J Clin Nutr 2000;72:22-9.
12. MacCoss MJ, Fukagawa NK, Matthews DE. Measurement of intracellular sulfur amino acid metabolism in humans. Am J Physiol Endocrinol Metab 2001;280:E947-55.
13. Davis SR, Stacpoole PW, Williamson J, et al. Tracer-derived total and folate-dependent homocysteine methylation and synthesis rates in humans indicate that serine is the main one-carbon donor. AmJ Physiol Endocrinol Metab 2004;286:E272-9.
14. Mercier S, Breuillé D, Buffière C, et al. Methionine kinetics are altered in the elderly both in the basal state and after vaccination. Am J Clin Nutr 2006;83:291-8.
15. Noga AA, Stead LM, Zhao Y, Brosnan ME, Brosnan JT, Vance DE. Plasma homocysteine is regulated by phospholipid methylation. J Biol Chem 2003;279:5952-5.
16. Shields DJ, Lingrell S, Agellon LB, Brosnan JT, Vance DE. Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase. J Biol Chem 2005;280:27339-44.
17. Jacobs RL, Stead LM, Devlin C, et al. Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J Biol Chem 2005;280:28299-305.
18. 13C NMR spectroscopy. Biochim Biophys Acta 2002;1580:171-88.
19. Loo G, Goodman PJ, Hill KA, Smith JT. Creatine metabolism in the pyridoxine-deficient rat. J Nutr 1986;116:2403-8.
20. Rendeli C, Ausili E, Castorina M, Antuzzi D, Tabacco F, Caldarelli M. Homocysteine, folate, lipid profile and MTHFR genotype and disability in children with myelomeningocele. Childs Nerv Syst 2006;22:1316-21. Epub 2000 April 7.
21. Martos R, Valle M, Morales R, Canete R, Gavilan MI, Sánchez- Margalet V. Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal children. Metab Clin Exp 2006;55:72-7.
22. Capdevila A, Wagner C. Measurement of plasma S-adenosylmethionine and S-adenosylhomocysteine as their fluorescent isoindoles. Anal Biochem 1998;264:180-4.
23. Allen RH, Stabler SP, Lindenbaum J. Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism 1993;42:1448-60.
24. Stabler SP, Marcell PD, Podell ER, Allen RH. Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem 1987;162:185-96.
25. Stabler SP, Lindenbaum J, Savage DG, Allen RH. Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency. Blood 1993;81:3404-13.
26. Svardal A, Refsum H, Ueland PM. Determination of in vivo protein binding of homocysteine and its relation to free homocysteine in the liver and other tissues of the rat. J Biol Chem 1986;261:3156-63.
27. Mudd SH, Cerone R, Schiaffino MC, et al. Glycine N- methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninemia. J Inherit Metab Dis 2001;24:448-64.
28. Augoustides-Savvopoulou P, Luka Z, Karyda S, et al. Glycine N-methyltransferase deficiency: a new patient with a novel mutation. J Inherit Metab Dis 2003;26:745-59.
29. Luka Z, Capdevila A, Mato JM, Wagner C. A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme. Transgenic Res 2006;15:393-7.
30. Thomas N-E, Cooper S-M, Williams SRP, Baker JS, Davies B. Fibrinogen, homocysteine, and C-reactive protein concentrations relative to sex and socioeconomic status in British young people. Am J Hum Biol 2005;17:809-13.
31. von Figura K, Hanefeld F, Isbrandt D, Stöckler-Ipsiroglu S. Guanidino-acetate methyltransferase deficiency. In: Scriver CR, Beaudet AL, Sly WS, et al, eds. The metabolic and molecular bases of inherited disease. New York, NY: McGraw-Hill, 2001:1897-908.
32. Guthmiller P, Van Pilsum JF, Boen JR, McGuire DM. Cloning and sequencing of rat kidney L-arginine:glycine amidinotransferase. J Biol Chem 1994;269:17556-60.
33. Stead LM, Au KP, Jacobs RL, Brosnan ME, Brosnan JT. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am J Physiol Endocrinol Metab 2001;281:E1095-100.
34. Korzun WJ. Oral creatine supplements lower plasma homocysteine concentrations in humans. Clin Lab Sci 2004;17:102-6.
35. Steenge GR, Verhoef P, Greenhaff PL. The effect of creatine and resistance training on plasma homocysteine concentrations in healthy volunteers. Arch Intern Med 2001;161:1455-6.
36. Datko AH, Aksamit RR, Mudd SH. Phosphatidylcholine synthesis in the rat: the substrate for methylation and regulation by choline. Lipids 1990;25:135-42.
37. Shields DJ, Lehner R, Agellon LB, Vance DE. Membrane topography of human phosphatidylethanolamine N-methytransferase. J Biol Chem 2003;278:2956-62.
38. Sehayek E, Wang R, Ono JG, et al. Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol. J Lipid Res 2004;44:1605-13.
39. Shields DJ, Altarejos JY, Wang X, Agellon LB, Vance DE. Molecular dissection of the S-adenosylmethionine-binding site of phosphatidylethanolamine N-methyltransferase. J Biol Chem 2003;278:35826-36.
40. Craig SAS. Betaine in human nutrition. Am J Clin Nutr 2004;80:539-49.
41. Slow S, Donaggio M, Cressey PJ, Lever M, George PM, Chambers ST. The betaine content of New Zealand foods and estimated intake in the New Zealand diet. J Food Comp Anal 2005;18:473-85.
42. Cho E, Zeisel SH, Jacques P, Selhub J, Dougherty L, Colditz GA. Dietary choline and betaine assessed by food-frequency questionaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr 2006;83:905-11.