Lipoic acid supplementation prevents angiotensin II-induced renal injury

Kidney International

Volumn 64, Issue 2, 2003, Pages 501-508

  Mervaala, Eero ^a   Finckenberg, Piet ^b   Lapatto, Risto ^b   Müller, Dominik N ^b   Park, Joon Keun ^b   Dechend, Ralf ^b   Ganten, Detlev ^b   Vapaatalo, Heikki ^b   Luft, Friedrich C ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NONE

Author keywords

Cysteine; Glutathione; Inflammation; Oxidative stress; Transcription factor AP 1; Transcription factor NF B

Indexed keywords

ANGIOTENSIN; ANGIOTENSINOGEN; ANTIOXIDANT; CYSTEINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RENIN; SUPEROXIDE; THIOCTIC ACID; THIOL; TRANSCRIPTION FACTOR AP 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL WALL; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; GEL MOBILITY SHIFT ASSAY; GENE; GLOMERULUS; HEMOSTASIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATION; KIDNEY BLOOD VESSEL; KIDNEY INJURY; LIVER; MALE; MICROSCOPY; NONHUMAN; NORTHERN BLOTTING; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN EXPRESSION; RAT; RAT STRAIN; SUPPLEMENTATION;

EID: 0038458764     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2003.00108.x     Document Type: Article

References (44)

1. KUNSCH C, MEDFORD RM: Oxidative stress as a regulator of gene expression in the vasculature. Circ Res 85:753-766, 1999
2. GRIENDLING KK, SORESCU D, LASSÈGUE B, USHIO-FUKAI M: Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol 20:2175-2183, 2000
3. IRANI K: Oxidant signalling in vascular cell growth, death, and survival. A review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signalling. Circ Res 87:179-183, 2000
4. ROMERO JC, RECKELHOFF JF: Role of angiotensin and oxidative stress in essential hypertension. Hypertension 34:943-949, 1999
5. GRIENDLING KK, SORESCU D, USHIO-FUKAI M: NAD(P)H oxidase. Role in cardiovascular biology and disease. Circ Res 86:494-501, 2000
6. MEISTER A, ANDERSON ME: Glutathione. Annu Rev Biochem 52:711-760, 1983
7. MEISTER A: Glutathione metabolism Methods Enzymol 251:3-7, 1995
8. ANDERSON ME: Glutathione and glutathione delivery compounds. Adv Pharmacol 38:65-78, 1997
9. PACKER L, ROY S, SEN CK: Alpha-lipoic acid: A metabolic antioxidant and potential redox modulator of transcription. Adv Pharmacol 38:79-101, 1997
10. PACKER L, WITT EC, TRITSCHLER HJ: Alpha-lipoic acid as a biological antioxidant. Free Rad Biol Med 19:227-250, 1995
11. CARREAU JP: Biosynthesis of lipoic acid via unsaturated fatty acids. Methods Enzymol 62:152-158, 1979
12. MOINI H, PACKER L, SARIS NE: Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol 182:84-90, 2002
13. MORIKAWA T, YASUNO R, WADA H: DO mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in the mitochondria. FEBS Lett 498:16-21, 2001
14. SEN CK, PACKER L: Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr 72(Suppl 2):6538-6598, 2000
15. SEN CK, PACKER L: Antioxidant and redox regulation of gene transcription. FASEB J 10:709-720, 1996
16. CLARK WM, RINKER LG, LESSOV NS, et al: Efficacy of antioxidant therapies in transient focal ischemia in mice. Stroke 32:1000-1004, 2001
17. COOMBES JS, POWERS SK, HAMILTON KL, et al: Improved cardiac performance after ischemia in aged rats supplemented with vitamin E and α-lipoic acid. Am J Physiol Regul Integr Comp Physiol 279:R2149-R2155, 2000
18. HAGEN TM, INGERSOLL RT, LYKKESFELDT J, et al: (R)-α-Lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J 13:411-418, 1999
19. SUH JH, SHIGENO ET, MORROW JD, et al: Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-α-lipoic acid. FASEB J 15:700-706, 2001
20. KOCAK G, AKTAN F, CANBOLAT O, et al: Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessels already damaged by streptozotocin-diabetes. Diabetes Nutr Metab 13:308-318, 2000
21. MELHEM MF, CRAVEN PA, LIACHENKO J, DERUBERTIS FR: Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol 13:108-116, 2000
22. EL MIDAOUI A, DE CHAMPLAIN J: Prevention of hypertension, insulin resistance, and oxidative stress by alpha-lipoic acid Hypertension 39:303-307, 2002
23. TAKAOKA M, KOBAYASHI Y, YUBA M, et al: Effects of alpha-lipoic acid on deoxycorticosterone acetate-salt-induced hypertension in rats. Eur J Pharmacol 424:121-129, 2001
24. LUFT FC, MERVAALA EMA, MULLER DN, et al: Hypertension-induced end-organ damage. A new transgenic approach to an old problem. Hypertension 33:212-218, 1999
25. MERVAALA EMA, MULLER DN, PARK J-K, et al: Monocyte infiltration and adhesion molecules in a rat model of high human renin hypertension. Hypertension 33:389-395, 1999
26. MERVAALA EMA, MULLER DN, SCHMIDT F, et al: Blood pressure-independent effects in rats with human renin and angiotensinogen genes. Hypertension 35:587-594, 2000
27. MÜLLER DN, DECHEND R, MERVAALA EMA, et al: NF-kappaB inhibition ameliorates angiotensin II-induced inflammatory damage in rats. Hypertension 35:193-201, 2000
28. MERVAALA EMA, CHENG ZJ, TIKKANEN I, et al: Endothelial dysfunction and xanthine oxidoreductase activity in rats with human renin and angiotensinogen genes. Hypertension 37:414-418, 2001
29. GANTEN D, WAGNER J, ZEH K, et al: Species specificity of renin kinetics in transgenic rats harboring human renin and angiotensinogen genes. Proc Natl Acad Sci USA 89:7806-7810, 1992
30. BOHLENDER J, FUKAMIZU A, LIPPOLDT A, et al: High human renin hypertension in transgenic rats. Hypertension 29:428-434, 1997
31. LYKKESFELDT J, HAGEN TM, VINARSKY V, AMES BN: Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes - Reversal with (R)-α-lipoic acid supplementation. FASEB J 12:1183-1189, 1998
32. PERE A-K, LINDGREN L, TUOMAINEN P, et al: Dietary potassium and magnesium supplementations in cyclosporine-induced hypertension and nephrotoxicity, Kidney Int 58:2462-2472, 2000
33. FINCKENBERG P, LASSILA M, INKINEN K, et al: Cyclosporine A induces myocardial connective tissue growth factor in spontaneously hypertensive rats on high sodium diet. Transplantation 71: 951-958. 2001
34. MULLER DN, DECHEND R, MERVAALA EMA, et al: NF-kappaB inhibition ameliorates angiotensin II-induced inflammatory damage in rats. Hypertension 35:193-201, 2000
35. LEVONEN AL, LAAKSO J, VASKONEN T, et al: Down-regulation of renal glutathione synthesis by systemic nitric oxide synthesis inhibition in spontaneously hypertensive rats. Biochem Pharmacol 59: 441-443, 2000
36. LEVONEN AL, LAPATTO R, SAKSELA M, RAIVIO KO: Expression of gamma-glutamylcysteine synthetase during development. Pediatr Res 47:266-270, 2000
37. BIEWENGA GP, HAENEN GR, BAST A: The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29:315-331, 1997
38. SEN CK, PACKER L: Antioxidant and redox regulation of gene transcription FASEB J 10:709-720, 1996
39. SEN CK: Redox signaling and the emerging therapeutic potential of thiol antioxidants. Biochem Pharmacol 55:1747-1758, 1998
40. MULLER DN, MERVAALA EMA, SCHMIDT F, et al: Effect of bosentan on NF-kB, inflammation, and tissue factor in angiotensin II-induced end-organ damage. Hypertension 36:282-290, 2000
41. VASDEV S, FORD CA, PARAI S, et al: Dietary α-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive rats. J Hypertens 18:567-573, 2000
42. LAURSEN JB, RAJAGOPALAN S, GALLS Z, et al: Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation 95:588-593, 1997
43. 1 receptor blockade modify pressure-natriuresis by different mechanisms in rats with human renin and angiotensinogen genes. J Am Soc Nephrol 10:1669-1680, 1999
44. DZAU V: Tissue angiotensin and pathobiology of vascular disease. A unifying hypothesis. Hypertension 37:1047-1052, 2001