-
2
-
-
66849124975
-
Osthole: a promising lead compound for drug discovery from a traditional Chinese medicine (TCM)
-
You L., Feng S., An R., and Wang X. Osthole: a promising lead compound for drug discovery from a traditional Chinese medicine (TCM). Nat. Prod. Commun. 4 (2009) 297-302
-
(2009)
Nat. Prod. Commun.
, vol.4
, pp. 297-302
-
-
You, L.1
Feng, S.2
An, R.3
Wang, X.4
-
3
-
-
0036597076
-
Effects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiol
-
Li X.X., Hara I., and Matsumiya T. Effects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiol. Biol. Pharm. Bull. 25 (2002) 738-742
-
(2002)
Biol. Pharm. Bull.
, vol.25
, pp. 738-742
-
-
Li, X.X.1
Hara, I.2
Matsumiya, T.3
-
4
-
-
23944463238
-
Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells
-
Kuo P.L., Hsu Y.L., Chang C.H., and Chang J.K. Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells. J. Pharmacol. Exp. Ther. 314 (2005) 1290-1299
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.314
, pp. 1290-1299
-
-
Kuo, P.L.1
Hsu, Y.L.2
Chang, C.H.3
Chang, J.K.4
-
5
-
-
33847794096
-
Coumarins from Cnidium monnieri and their antiosteoporotic activity
-
Zhang Q., Qin L., He W., Van Puyvelde L., Maes D., Adams A., Zheng H., and De Kimpe N. Coumarins from Cnidium monnieri and their antiosteoporotic activity. Planta Med. 73 (2007) 13-19
-
(2007)
Planta Med.
, vol.73
, pp. 13-19
-
-
Zhang, Q.1
Qin, L.2
He, W.3
Van Puyvelde, L.4
Maes, D.5
Adams, A.6
Zheng, H.7
De Kimpe, N.8
-
6
-
-
0029793826
-
Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro
-
Huang R.L., Chen C.C., Huang Y.L., Hsieh D.J., Hu C.P., Chen C.F., and Chang C. Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro. Hepatology 24 (1996) 508-515
-
(1996)
Hepatology
, vol.24
, pp. 508-515
-
-
Huang, R.L.1
Chen, C.C.2
Huang, Y.L.3
Hsieh, D.J.4
Hu, C.P.5
Chen, C.F.6
Chang, C.7
-
7
-
-
0037441385
-
Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway
-
Okamoto T., Kawasaki T., and Hino O. Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway. Biochem. Pharmacol. 65 (2003) 677-681
-
(2003)
Biochem. Pharmacol.
, vol.65
, pp. 677-681
-
-
Okamoto, T.1
Kawasaki, T.2
Hino, O.3
-
8
-
-
33846073130
-
Synthetic derivatives of osthole for the prevention of hepatitis
-
Okamoto T., Kobayashi T., and Yoshida S. Synthetic derivatives of osthole for the prevention of hepatitis. Med. Chem. 3 (2007) 35-44
-
(2007)
Med. Chem.
, vol.3
, pp. 35-44
-
-
Okamoto, T.1
Kobayashi, T.2
Yoshida, S.3
-
9
-
-
0036595830
-
Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol
-
Matsuda H., Tomohiro N., Ido Y., and Kubo M. Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. Biol. Pharm. Bull. 25 (2002) 809-812
-
(2002)
Biol. Pharm. Bull.
, vol.25
, pp. 809-812
-
-
Matsuda, H.1
Tomohiro, N.2
Ido, Y.3
Kubo, M.4
-
10
-
-
56849097369
-
Effect of the Chinese herb extract osthol on IL-4-induced eotaxin expression in BEAS-2B cells
-
Chiu P.R., Lee W.T., Chu Y.T., Lee M.S., Jong Y.J., and Hung C.H. Effect of the Chinese herb extract osthol on IL-4-induced eotaxin expression in BEAS-2B cells. Pediatr. Neonatol. 49 (2008) 135-140
-
(2008)
Pediatr. Neonatol.
, vol.49
, pp. 135-140
-
-
Chiu, P.R.1
Lee, W.T.2
Chu, Y.T.3
Lee, M.S.4
Jong, Y.J.5
Hung, C.H.6
-
11
-
-
62149147196
-
Osthole suppresses seizures in the mouse maximal electroshock seizure model
-
Luszczki J.J., Andres-Mach M., Cisowski W., Mazol I., Glowniak K., and Czuczwar S.J. Osthole suppresses seizures in the mouse maximal electroshock seizure model. Eur. J. Pharmacol. 607 (2009) 107-109
-
(2009)
Eur. J. Pharmacol.
, vol.607
, pp. 107-109
-
-
Luszczki, J.J.1
Andres-Mach, M.2
Cisowski, W.3
Mazol, I.4
Glowniak, K.5
Czuczwar, S.J.6
-
12
-
-
0029879647
-
Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens
-
Guh J.H., Yu S.M., Ko F.N., Wu T.S., and Teng C.M. Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens. Eur. J. Pharmacol. 298 (1996) 191-197
-
(1996)
Eur. J. Pharmacol.
, vol.298
, pp. 191-197
-
-
Guh, J.H.1
Yu, S.M.2
Ko, F.N.3
Wu, T.S.4
Teng, C.M.5
-
13
-
-
33947581715
-
Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study
-
Chou S.Y., Hsu C.S., Wang K.T., Wang M.C., and Wang C.C. Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study. Phytother. Res. 21 (2007) 226-230
-
(2007)
Phytother. Res.
, vol.21
, pp. 226-230
-
-
Chou, S.Y.1
Hsu, C.S.2
Wang, K.T.3
Wang, M.C.4
Wang, C.C.5
-
14
-
-
34247889815
-
Effects of osthole on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats
-
Ogawa H., Sasai N., Kamisako T., and Baba K. Effects of osthole on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats. J. Ethnopharmacol. 112 (2007) 26-31
-
(2007)
J. Ethnopharmacol.
, vol.112
, pp. 26-31
-
-
Ogawa, H.1
Sasai, N.2
Kamisako, T.3
Baba, K.4
-
15
-
-
34547813175
-
Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression
-
Zhang Y., Xie M., Xue J., and Gu Z. Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression. Planta Med. 73 (2007) 718-724
-
(2007)
Planta Med.
, vol.73
, pp. 718-724
-
-
Zhang, Y.1
Xie, M.2
Xue, J.3
Gu, Z.4
-
16
-
-
33847206106
-
Therapeutic effect of osthole on hyperlipidemic fatty liver in rats
-
Zhang Y., Xie M.L., Zhu L.J., and Gu Z.L. Therapeutic effect of osthole on hyperlipidemic fatty liver in rats. Acta Pharmacol. Sin. 28 (2007) 398-403
-
(2007)
Acta Pharmacol. Sin.
, vol.28
, pp. 398-403
-
-
Zhang, Y.1
Xie, M.L.2
Zhu, L.J.3
Gu, Z.L.4
-
17
-
-
56149122623
-
Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats
-
Zhang Y., Xie M.L., Xue J., and Gu Z.L. Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats. J. Asian Nat. Prod. Res. 10 (2008) 807-812
-
(2008)
J. Asian Nat. Prod. Res.
, vol.10
, pp. 807-812
-
-
Zhang, Y.1
Xie, M.L.2
Xue, J.3
Gu, Z.L.4
-
18
-
-
58149161248
-
Inhibitory effect of osthole on alcohol-induced fatty liver in mice
-
Sun F., Xie M.L., Zhu L.J., Xue J., and Gu Z.L. Inhibitory effect of osthole on alcohol-induced fatty liver in mice. Dig. Liver Dis. 41 (2009) 127-133
-
(2009)
Dig. Liver Dis.
, vol.41
, pp. 127-133
-
-
Sun, F.1
Xie, M.L.2
Zhu, L.J.3
Xue, J.4
Gu, Z.L.5
-
19
-
-
34547438382
-
Dipeptidyl peptidase IV inhibitors and the incretin system in type 2 diabetes mellitus
-
Langley A.K., Suffoletta T.J., and Jennings H.R. Dipeptidyl peptidase IV inhibitors and the incretin system in type 2 diabetes mellitus. Pharmacotherapy 27 (2007) 1163-1180
-
(2007)
Pharmacotherapy
, vol.27
, pp. 1163-1180
-
-
Langley, A.K.1
Suffoletta, T.J.2
Jennings, H.R.3
-
20
-
-
33749479230
-
AMP-activated protein kinase: role in metabolism and therapeutic implications
-
Schimmack G., Defronzo R.A., and Musi N. AMP-activated protein kinase: role in metabolism and therapeutic implications. Diabetes Obes. Metab. 8 (2006) 591-602
-
(2006)
Diabetes Obes. Metab.
, vol.8
, pp. 591-602
-
-
Schimmack, G.1
Defronzo, R.A.2
Musi, N.3
-
21
-
-
56449117024
-
AMPK: a metabolic gauge regulating whole-body energy homeostasis
-
Lage R., Diéguez C., Vidal-Puig A., and López M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol. Med. 14 (2008) 539-549
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 539-549
-
-
Lage, R.1
Diéguez, C.2
Vidal-Puig, A.3
López, M.4
-
22
-
-
50549100488
-
Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease
-
Hutchinson D.S., Summers R.J., and Bengtsson T. Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease. Pharmacol. Ther. 119 (2008) 291-310
-
(2008)
Pharmacol. Ther.
, vol.119
, pp. 291-310
-
-
Hutchinson, D.S.1
Summers, R.J.2
Bengtsson, T.3
-
23
-
-
0026785388
-
Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids
-
Schmidt A., Endo N., Rutledge S.J., Vogel R., Shinar D., and Rodan G.A. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol. Endocrinol. 6 (1992) 1634-1641
-
(1992)
Mol. Endocrinol.
, vol.6
, pp. 1634-1641
-
-
Schmidt, A.1
Endo, N.2
Rutledge, S.J.3
Vogel, R.4
Shinar, D.5
Rodan, G.A.6
-
24
-
-
47949117951
-
Taiwanofungus camphoratus activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats
-
Suk F.M., Lin S.Y., Chen C.H., Yen S.J., Su C.H., Liu D.Z., Hou W.C., Hung L.F., Lin P.J., and Liang Y.C. Taiwanofungus camphoratus activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats. Biosci. Biotechnol. Biochem. 72 (2008) 1704-1713
-
(2008)
Biosci. Biotechnol. Biochem.
, vol.72
, pp. 1704-1713
-
-
Suk, F.M.1
Lin, S.Y.2
Chen, C.H.3
Yen, S.J.4
Su, C.H.5
Liu, D.Z.6
Hou, W.C.7
Hung, L.F.8
Lin, P.J.9
Liang, Y.C.10
-
25
-
-
34249682802
-
Switch activation of PI-PLC downstream signals in activated macrophages with wortmannin
-
Liu D.Z., Liang H.J., Chen C.H., Lin S.Y., Zhong W.B., Ho F.M., Hou W.C., Lo J.L., Ho Y.S., Lin P.J., Hung L.F., and Liang Y.C. Switch activation of PI-PLC downstream signals in activated macrophages with wortmannin. Biochim. Biophys. Acta 1773 (2007) 869-879
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 869-879
-
-
Liu, D.Z.1
Liang, H.J.2
Chen, C.H.3
Lin, S.Y.4
Zhong, W.B.5
Ho, F.M.6
Hou, W.C.7
Lo, J.L.8
Ho, Y.S.9
Lin, P.J.10
Hung, L.F.11
Liang, Y.C.12
-
26
-
-
0031886864
-
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
-
Ricote M., Li A.C., Willson T.M., Kelly C.J., and Glass C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391 (1998) 79-82
-
(1998)
Nature
, vol.391
, pp. 79-82
-
-
Ricote, M.1
Li, A.C.2
Willson, T.M.3
Kelly, C.J.4
Glass, C.K.5
-
27
-
-
50649097541
-
Fat and beyond: the diverse biology of PPARgamma
-
Tontonoz P., and Spiegelman B.M. Fat and beyond: the diverse biology of PPARgamma. Annu. Rev. Biochem. 77 (2008) 289-312
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 289-312
-
-
Tontonoz, P.1
Spiegelman, B.M.2
-
28
-
-
0027191040
-
cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor
-
Sher T., Yi H.F., McBride O.W., and Gonzalez F.J. cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32 (1993) 5598-5604
-
(1993)
Biochemistry
, vol.32
, pp. 5598-5604
-
-
Sher, T.1
Yi, H.F.2
McBride, O.W.3
Gonzalez, F.J.4
-
29
-
-
42949089310
-
Peroxisome proliferator-activated receptors and the metabolic syndrome
-
Bragt M.C., and Popeijusm H.E. Peroxisome proliferator-activated receptors and the metabolic syndrome. Physiol. Behav. 94 (2008) 187-197
-
(2008)
Physiol. Behav.
, vol.94
, pp. 187-197
-
-
Bragt, M.C.1
Popeijusm, H.E.2
-
30
-
-
0034668205
-
Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis
-
Neve B.P., Fruchart J.C., and Staels B. Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis. Biochem. Pharmacol. 60 (2000) 1245-1250
-
(2000)
Biochem. Pharmacol.
, vol.60
, pp. 1245-1250
-
-
Neve, B.P.1
Fruchart, J.C.2
Staels, B.3
-
31
-
-
34247155688
-
Peroxisome proliferator-activated receptor (PPAR) in metabolic syndrome and type 2 diabetes mellitus
-
Jay M.A., and Ren J. Peroxisome proliferator-activated receptor (PPAR) in metabolic syndrome and type 2 diabetes mellitus. Curr. Diabetes Rev. 3 (2007) 33-39
-
(2007)
Curr. Diabetes Rev.
, vol.3
, pp. 33-39
-
-
Jay, M.A.1
Ren, J.2
-
32
-
-
10744221639
-
Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association
-
Nesto R.W., Bell D., Bonow R.O., Fonseca V., Grundy S.M., Horton E.S., Le Winter M., Porte D., Semenkovich C.F., Smith S., Young L.H., and Kahn R. Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care 27 (2004) 256-263
-
(2004)
Diabetes Care
, vol.27
, pp. 256-263
-
-
Nesto, R.W.1
Bell, D.2
Bonow, R.O.3
Fonseca, V.4
Grundy, S.M.5
Horton, E.S.6
Le Winter, M.7
Porte, D.8
Semenkovich, C.F.9
Smith, S.10
Young, L.H.11
Kahn, R.12
-
33
-
-
28144451163
-
Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus
-
Nissen S.E., Wolski K., and Topol E.J. Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus. J. Am. Med. Assoc. 294 (2005) 2581-2586
-
(2005)
J. Am. Med. Assoc.
, vol.294
, pp. 2581-2586
-
-
Nissen, S.E.1
Wolski, K.2
Topol, E.J.3
-
35
-
-
33750580948
-
Halofenate is a selective peroxisome proliferator-activated receptor gamma modulator with antidiabetic activity
-
Allen T., Zhang F., Moodie S.A., Clemens L.E., Smith A., Gregoire F., Bell A., Muscat G.E., and Gustafson T.A. Halofenate is a selective peroxisome proliferator-activated receptor gamma modulator with antidiabetic activity. Diabetes 55 (2006) 2523-2533
-
(2006)
Diabetes
, vol.55
, pp. 2523-2533
-
-
Allen, T.1
Zhang, F.2
Moodie, S.A.3
Clemens, L.E.4
Smith, A.5
Gregoire, F.6
Bell, A.7
Muscat, G.E.8
Gustafson, T.A.9
-
36
-
-
33645394377
-
A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro
-
Burgermeister E., Schnoebelen A., Flament A., Benz J., Stihle M., Gsell B., Rufer A., Ruf A., Kuhn B., Märki H.P., Mizrahi J., Sebokova E., Niesor E., and Meyer M. A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro. Mol. Endocrinol. 20 (2006) 809-830
-
(2006)
Mol. Endocrinol.
, vol.20
, pp. 809-830
-
-
Burgermeister, E.1
Schnoebelen, A.2
Flament, A.3
Benz, J.4
Stihle, M.5
Gsell, B.6
Rufer, A.7
Ruf, A.8
Kuhn, B.9
Märki, H.P.10
Mizrahi, J.11
Sebokova, E.12
Niesor, E.13
Meyer, M.14
-
37
-
-
29844443744
-
Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes
-
Han K.L., Jung M.H., Sohn J.H., and Hwang J.K. Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes. Biol. Pharm. Bull. 29 (2006) 110-113
-
(2006)
Biol. Pharm. Bull.
, vol.29
, pp. 110-113
-
-
Han, K.L.1
Jung, M.H.2
Sohn, J.H.3
Hwang, J.K.4
-
38
-
-
33745685683
-
Momordica charantia constituents and antidiabetic screening of the isolated major compounds
-
Harinantenaina L., Tanaka M., Takaoka S., Oda M., Mogami O., Uchida M., and Asakawa Y. Momordica charantia constituents and antidiabetic screening of the isolated major compounds. Chem. Pharm. Bull. (Tokyo) 54 (2006) 1017-1021
-
(2006)
Chem. Pharm. Bull. (Tokyo)
, vol.54
, pp. 1017-1021
-
-
Harinantenaina, L.1
Tanaka, M.2
Takaoka, S.3
Oda, M.4
Mogami, O.5
Uchida, M.6
Asakawa, Y.7
-
39
-
-
33746386763
-
Bitter gourd (Momordica Charantia): a dietary approach to hyperglycemia
-
Krawinkel M.B., and Keding G.B. Bitter gourd (Momordica Charantia): a dietary approach to hyperglycemia. Nutr. Rev. 64 (2006) 331-337
-
(2006)
Nutr. Rev.
, vol.64
, pp. 331-337
-
-
Krawinkel, M.B.1
Keding, G.B.2
-
40
-
-
34547589477
-
Modulation of PPAR activity via phosphorylation
-
Burns K.A., and Vanden Heuvel J.P. Modulation of PPAR activity via phosphorylation. Biochim. Biophys. Acta 1771 (2007) 952-960
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 952-960
-
-
Burns, K.A.1
Vanden Heuvel, J.P.2
-
41
-
-
0037329494
-
AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins
-
Leff T. AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins. Biochem. Soc. Trans. 31 (2003) 224-227
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 224-227
-
-
Leff, T.1
-
42
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., Wu M., Ventre J., Doebber T., Fujii N., Musi N., Hirshman M.F., Goodyear L.J., and Moller D.E. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108 (2001) 1167-1174
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
Wu, M.7
Ventre, J.8
Doebber, T.9
Fujii, N.10
Musi, N.11
Hirshman, M.F.12
Goodyear, L.J.13
Moller, D.E.14
-
43
-
-
33746929932
-
Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals
-
Song F., Xie M.L., Zhu L.J., Zhang K.P., Xue J., and Gu Z.L. Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals. World J. Gastroenterol. 12 (2006) 4359-4363
-
(2006)
World J. Gastroenterol.
, vol.12
, pp. 4359-4363
-
-
Song, F.1
Xie, M.L.2
Zhu, L.J.3
Zhang, K.P.4
Xue, J.5
Gu, Z.L.6
|