Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens

European Journal of Pharmacology

Volumn 298, Issue 2, 1996, Pages 191-197

  Guh, Jih Hwa ^a   Yu, Sheu Meei ^b   Ko, Feng Nien ^a   Wu, Tian Shung ^c   Teng, Che Ming ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Angelica pubescens; Cell cycle; DNA synthesis; Osthole; Rat; Smooth muscle cell; Vascular

Indexed keywords

8 BROMO CYCLIC AMP; 8 BROMO CYCLIC GMP; ANGELICA PUBESCENS EXTRACT; CYCLIC AMP; CYCLIC GMP; FORSKOLIN; IONOMYCIN; ISOBUTYLMETHYLXANTHINE; MITOGENIC AGENT; NITROPRUSSIDE SODIUM; OSTHOLE; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL DIBUTYRATE; PLANT EXTRACT; PLATELET DERIVED GROWTH FACTOR; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENTIATION; FETAL CALF SERUM; FLOW CYTOMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; THORACIC AORTA; VASCULAR SMOOTH MUSCLE;

EID: 0029879647     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00812-8     Document Type: Article

References (28)

1. Alexander, R.W., T.A. Brock, M.A. Gimbrone and S.E. Rittenhouse, 1985, Angiotensin increases inositol trisphosphate and calcium in vascular smooth muscle, Hypertension 7, 447.
2. Alexander, S.P.H., D.A. Kendall and S.J. Hill, 1989, Differences in the adenosine receptors modulating inositol phosphates and cyclic AMP accumulation in mammalian cerebral cortex, Br. J. Pharmacol. 98, 1241.
3. 2+ mobilization, by cyclic AMP and GMP in rabbit aortic smooth-muscle cells, Biochem. J. 288, 527.
4. Berk, B.C., T.A. Brock, R.C. Webb, M.B. Taubman, W.J. Atkinson, M.A. Gimbrone and R.W. Alexander, 1985, Epidermal growth factor, a vascular smooth muscle mitogen, induces rat aortic contraction, J. Clin. Invest. 75, 1083.
5. Berk, B.C., R.W. Alexander, T.A. Brock, M.A. Gimbrone and B.C. Webb, 1986, Vasoconstriction: a new activity for platelet-derived growth factor, Science 232, 87.
6. Bobik, A., A. Grooms, J.A. Millar, A. Mitchell and S. Grinpukel, 1990, Growth factor activity of endothelin on vascular smooth muscle, Am. J. Physiol. 258, C408.
7. Brock, T.A., R.W. Alexander, L.S. Ekstein, W.J. Atkinson and M.A. Gimbrone, 1985, Angiotensin increases cytosolic free calcium in cultured vascular smooth muscle cells, Hypertension 7, 1105.
8. Campbell, G.R. and J.H. Campbell, 1985, Smooth muscle phenotypic changes in arterial wall homeostasis: Implications for the pathogenesis of atherosclerosis, Exp. Mol. Pathol. 42, 139.
9. Collins, M. and E. Rozengurt, 1982, Binding of phorbol esters to high affinity sites on murine fibroblastic cells elicits a motogenic response, J. Cell. Physiol. 112, 42.
10. Daemen, M.J.A.P., D.M. Lombardi, F.T. Bosman and S.M. Schwartz, 1991, Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall, Circ. Res. 68, 450.
11. Dicker, P. and E. Rozengurt, 1980, Phorbol esters and vasopressin stimulate DNA synthesis by a common mechanism, Nature 87, 607.
12. Friedman, D.L., 1976, Role of cyclic nucleotides in cell growth and differentiation, Physiol. Rev. 56, 652.
13. Garg, U.C. and A. Hassid, 1989, Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells, J. Clin. Invest. 83, 1774.
14. Ip, J.H., V. Fuster, L. Badimon, J. Badimon, M.B. Taubman and J.H. Chesebro, 1990, Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation, J. Am. Coll. Cardiol. 15, 1667.
15. Jackson, C.L., R.C. Bush and D.E. Bowyer, 1988, Inhibitory effect of calcium antagonists on balloon catheter-induced arterial smooth muscle cell proliferation and lesion size, Atherosclerosis 69, 115.
16. Kawahara, Y., K. Kariya, S. Aracki, H. Fukuzaki and Y. Takai, 1988. Platelet-derived growth factor (PDGF)-induced phospholipase C-mediated hydrolysis of phosphoinositides in vascular smooth muscle cells - different sensitivity of PDGF and angiotensin II-induced phospholipase C reactions by protein kinase C-activating phorbol esters, Biochem. Biophys. Res. Commun. 156, 846.
17. Ko, F.N., T.S. Wu, M.J. Liou, T.F. Huang and C.M. Teng, 1992, Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens, Eur. J. Pharmacol. 219, 29.
18. Naftilan, A.J., R.E. Pratt and V.T. Dzau, 1989, Induction of platelet-derived growth factor A chain and c-myc gene expression by angiotensin II in cultured rat vascular smooth muscle cells, J. Clin. Invest. 83, 1419.
19. Newby, A.C. and S.J. George, 1993, Proposed roles for growth factors in mediating smooth muscle proliferation in vascular pathologies, Cardiovasc. Res. 27, 1173.
20. Ross, R., 1986, The pathogenesis of atherosclerosis-an update, New Engl. J. Med. 314, 488.
21. Scott-Burden, T. and F.R. Buhler, 1988, Regulation of smooth muscle proliferative phenotype by heparinoid-matrix interactions, Trends Pharmacol. Sci. 9, 94.
22. Scott-Burden, T. and P.M. Vanhoutte, 1993, The endothelium as a regulator of vascular smooth muscle proliferation, Circulation 87 (Suppl. V), V51.
23. Smith, J.B., 1986, Angiotensin-receptor signaling in cultured vascular smooth muscle cells, Am. J. Physiol. 250, F759.
24. Taubman, M.B., B.C. Berk, S. Izumo, T. Tsuda, R.W. Alexander and B. Nadal-Ginard, 1989, Angiotensin II induces c-fos mRNA in aortic smooth muscle, J. Biol. Chem. 264, 526.
25. Teng, C.M., C.H. Lin, F.N. Ko, T.S. Wu and T.F. Huang, 1994, The relaxant action of osthole isolated from Angelica pubescens in guinea-pig trachea, Naunyn-Schmied. Arch. Pharmacol. 349, 202.
26. Uehara, Y., T. Nagata, H. Matsuoka, A. Numabe, S. Takada and T. Ishimitsu, 1991, Antiproliferative effects of serotonin type 2 receptor antagonist, ketanserin, on smooth muscle cell growth in rats, J. Cardiovasc. Pharmacol. 17 (Suppl. 2), S154.
27. Wang, D., N. Huang and L.A. Happel, 1992, Extracellular ATP and ADP stimulate proliferation of porcine aortic smooth muscle cells, J. Cell. Physiol. 153, 221.
28. Wu, T.S., M.J. Liou, F.N. Ko and C.M. Teng, 1990, Osthole, an antiplatelet aggregation principle from the root of Angelica pubescens, Chin. Pharm. J. 42, 317.