Pifithrin-α decreases the radioprotective efficacy of a Podophyllum hexandrum (Himalayan mayapple) fraction (REC-2006) in HepG2 cells

Biotechnology and Applied Biochemistry

Volumn 54, Issue 1, 2009, Pages 53-64

  Singh, Pankaj Kumar ^a   Kumar, Raj ^a   Sharma, Ashok ^a   Arora, Rajesh ^a   Jain, Swatantra Kumar ^b   Sharma, Rakesh Kumar ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^b Department of Biotechnology ^*  (India)

Author keywords

Apoptosis; HepG2 cell; Pifithrin ; Podophyllum hexandrum (Himalayan mayapple); Radioprotection; Ras GTPase activating protein

Indexed keywords

APOPTOSIS; HEPG2 CELL; PODOPHYLLUM HEXANDRUM (HIMALAYAN MAYAPPLE); RADIOPROTECTION; RAS-GTPASE-ACTIVATING PROTEIN;

CELL CULTURE; CELL DEATH; DNA; DRUG PRODUCTS; ENZYME INHIBITION; GENES; IRRADIATION; NUCLEIC ACIDS; PROTEINS; TUMORS;

CELL MEMBRANES;

CASPASE 3; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; PIFITHRIN ALPHA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P53; RADIOPROTECTIVE AGENT; REC 2006; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BENZOTHIAZOLE DERIVATIVE; CELL CYCLE PROTEIN; DNA; DNA BINDING PROTEIN; DRUG DERIVATIVE; HEAT SHOCK TRANSCRIPTION FACTOR; MDM2 PROTEIN, HUMAN; PIFITHRIN; PLANT EXTRACT; TOLUENE; TP53 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; HUMAN; HUMAN CELL; IRRADIATION; PODOPHYLLUM HEXANDRUM; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION PROTECTION; UPREGULATION; BIOSYNTHESIS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; METABOLISM; PODOPHYLLUM; RADIATION EXPOSURE; TUMOR CELL LINE;

MURINAE; SINOPODOPHYLLUM HEXANDRUM;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZOTHIAZOLES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA, NEOPLASM; DNA-BINDING PROTEINS; DRUG INTERACTIONS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; PLANT EXTRACTS; PODOPHYLLUM; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MDM2; RADIATION-PROTECTIVE AGENTS; RAS GTPASE-ACTIVATING PROTEINS; TOLUENE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 70149123087     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20080250     Document Type: Article

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