Effect of chronic hypoxia on proliferation, apoptosis, and HSP70 expression in mouse bronchiolar epithelial cells

Physiological Research

Volumn 55, Issue 4, 2006, Pages 405-411

  Kim, E K ^a   Park, J D ^a,b   Shim, S Y ^a   Kim, H S ^a   Kim, B I ^a   Choi, J H ^a   Kim, J E ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

Apoptosis; Bronchiolar epithelium; Chronic hypoxia; HSP70; Proliferation

Indexed keywords

HEAT SHOCK PROTEIN 70; KI 67 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRONCHIOLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; EXPERIMENTAL MODEL; HYPOXIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; ANOXIA; APOPTOSIS; BLOTTING, WESTERN; BRONCHI; CELL DIVISION; CHRONIC DISEASE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HSP70 HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RESPIRATORY MUCOSA;

EID: 33747892751     PISSN: 08628408     EISSN: 08628408     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. BEN-SASSON SA, SHERMAN Y, GAVRIELI Y: Identification of dying cells - in situ staining. Methods Cell Biol 46: 29-39, 1995.
2. DI CARLO A, WHITE N, GUO F, GARRETT P, LITOVITZ T: Chronic electromagnetic field exposure decreases HSP70 levels and lowers cytoprotection. J Cell Biochem 84: 447-454, 2002.
3. 2+]i. J Investig Med 44: 144-153, 1996.
4. FILIPOVIC D, GAVRILOVIC L, DRONJAK S, RADOJCIC MB: Brain glucocoid receptor and heat shock protein 70 levels in rats exposed to acute, chronic or combined stress. Neuropsychobiology 51: 107-114, 2005.
5. JÄÄTTELÄ M: Overexpression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells. Int J Cancer 60: 689-693, 1995.
6. JÄÄTTELÄ M, WISSING D, BAUER PA, LI GC: Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity. EMBO J 11: 3507-3512, 1992.
7. JÄÄTTELÄ M, WISSING D, KOKHOLM K, KALLUNKI T, EGEBLAD M: Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J 17: 6124-6134, 1998.
8. JOHNSON D, OPPERMANN H, JACKSON J, LEVINSON W: Induction of four proteins in chick embryo cells by sodium arsenite. J Biol Chem 255: 6975-6980, 1980.
9. KELLEY PM, SCHLESINGER MJ: The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts. Cell 15: 1277-1286, 1978.
10. KIANG JG, TSOKOS GC: Heat shock protein 70 kDa molecular biology, biochemistry, and physiology. Pharmacol Ther 80: 183-201, 1998.
11. KIANG JG, WANG XD, DING XZ, GIST ID, SMALLRIDGE RC: Heat shock inhibits the hypoxia-induced effects on iodide uptake and signal transduction and enhances cell survival in rat thyroid FTRL-5 cells. Thyroid 6: 475-483, 1996.
12. LEVINSON W, OPPERMANN H, JACKSON J: Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells. Biochem Biophys Acta 606: 170-180, 1980.
13. LI CY, LEE JS, KO YG, KIM JI, SEO JS: Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation. J Biol Chem 276: 25665-25671, 2000.
14. 3H-thymidine by cells of the rat pulmonary arteries and alveolar wall. Am J Pathol 96: 51-70, 1979.
15. MOSSER DD, CARON AW, BOURGET L, DENIS-LAROSE C, MASSIE B: Role of human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol 17: 5317-5327, 1997.
16. NADZIEJKO CE, LOUD AV, KIKKAWA Y: Effect of alveolar hypoxia on pulmonary mast cells in vivo. Am Rev Respir Dis 140: 743-748, 1989.
17. NOLLEN EA, BRUNSTING JF, ROELOFSEN H, WEBER LA, KAMPINGA HH: In vivo chaperone activity of heat shock protein 70 and thermotolerance. Mol Cell Biol 11: 2069-2079, 1999.
18. POUYSSEGUR J, SHIU PC, PASTAN I: Induction of two-transformation- sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation. Cell 11: 941-947, 1977.
19. RAVAGNAN L, GURBUXANI S, SUSIN SA, MAISSE C, DAUGAS E, ZAMZAMI N, MAK T, JÄÄTTELÄ M, PENNINGER JM, GARRIDO C, KROEMER G: Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 3: 839-843, 2001.
20. RILEY DJ, THAKKER-VARIA S, WILSON FJ, POIANI GJ, TOZZI CA: Role of proteolysis and apoptosis in regression of pulmonary vascular remodeling. Physiol Res 49: 577-585, 2000.
21. SCHOLZEN T, GERDES J: The Ki-67 protein: from the known and the unknown. J Cell Physiol 182: 311-322, 2000.
22. STORCH TG, TALLEY GD: Oxygen concentration regulates the proliferative response of human fibroblasts to serum and growth factors. Exp Cell Res 175: 317-325, 1988.
23. SUZUKI K, WATANABE M: Modulation of cell growth and mutation induction by introduction of the expression vector of human HSP70 gene. Exp Cell Res 215: 75-81, 1994.
24. WEI Y, ZHAO X, KARIYA Y, TESHIGAWARA K, UCHIDA A: Inhibition of proliferation and induction of apoptosis by abrogation of HSP70 expression in tumor cells. Cancer Immunol Immunother 40: 73-78, 1995.
25. WEISS YG, MALOYAN A, TAZELAAR J, RAJ N, DEUTSCHMAN CS: Adenoviral transfer of HSP70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. J Clin Invest 110: 801-806, 2002.