Expression of α1-adrenoceptors on thymic cells and their role in fine tuning of thymopoiesis

Journal of Neuroimmunology

Volumn 214, Issue 1-2, 2009, Pages 55-66

  Pesic V ^a   Kosec, D ^b   Radojevic K ^b   Pilipovic I ^b   Perisic M ^b   Vidic Dankovic B ^b   Leposavic G ^a,b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b Institute of Virology Vaccines and Sera Torlak   (Serbia)

Author keywords

1 adrenoceptors; Rat thymus; T cell differentiation

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; CD161 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; T LYMPHOCYTE RECEPTOR BETA CHAIN; URAPIDIL; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY B; PIPERAZINE DERIVATIVE; THY 1 ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EFFECTOR CELL; EPITHELIUM CELL; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY T LYMPHOCYTE; THYMOCYTE; ANIMAL; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; T LYMPHOCYTE; THYMUS; WISTAR RAT;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTIGENS, CD4; ANTIGENS, THY-1; APOPTOSIS; CELL PROLIFERATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY B; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, BETA; T-LYMPHOCYTES; THYMUS GLAND;

EID: 70049096992     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2009.06.018     Document Type: Article

References (66)

1. Agus D.B., Surh C.D., and Sprent J. Reentry of T cells to the adult thymus is restricted to activated T cells. J. Exp. Med. 173 (1991) 1039-1046
2. Anger C., van Aken H., Feldhaus P., Wusten R., Konig H., Krahling K.H., and Lawin P. Permeation of the blood-brain barrier by urapidil and its influence on intracranial pressure in man in the presence of compromised intracranial dynamics. J. Hypertens. Suppl. 6 (1988) S63-64
3. Baglole C.J., Sigalet D.L., Martin G.R., Yao S., and Meddings J.B. Acute denervation alters the epithelial response to adrenoceptor activation through an increase in alpha1-adrenoceptor expression on villus enterocytes. Br. J. Pharmacol. 147 (2006) 101-108
4. Baglole C.J., Sigalet D.L., and Meddings J.B. Alpha1-adrenoceptors down-regulate ClC-2 chloride channels in epithelial cells from the acutely denervated jejunum. Eur. J. Pharmacol. 565 (2007) 202-206
5. Bao J.Y., Huang Y., Wang F., Peng Y.P., and Qiu Y.H. Expression of alpha-AR subtypes in T lymphocytes and role of the alpha-ARs in mediating modulation of T cell function. Neuroimmunomodulation 14 (2007) 344-353
6. Bellinger D.L., Millar B.A., Perez S., Carter J., Wood C., Thyagarajan S., Molinaro C., Lubahn C., and Lorton D. Sympathetic modulation of immunity: relevance to disease. Cell. Immunol. 252 (2008) 27-56
7. Berzins S.P., Uldrich A.P., Pellicci D.G., McNab F., Hayakawa Y., Smyth M.J., and Godfrey D.I. Parallels and distinctions between T and NKT cell development in the thymus. Immunol. Cell Biol. 82 (2004) 269-275
8. Blalock J.E., and Smith E.M. Conceptual development of the immune system as a sixth sense. Brain Behav. Immun. 21 (2007) 23-33
9. Botham C.A., Jones G.V., and Kendall M.D. Immuno-characterisation of neuroendocrine cells of the rat thymus gland in vitro and in vivo. Cell Tissue Res. 303 (2001) 381-389
10. Castor G., and Schmidt U. Urapidil permeates the intact blood-brain barrier. Intensive Care Med. 20 (1994) 278-281
11. Cavallotti C., Artico M., and Cavallotti D. Occurrence of adrenergic nerve fibers and of noradrenaline in thymus gland of juvenile and aged rats. Immunol. Lett. 70 (1999) 53-62
12. Chu Y.W., Schmitz S., Choudhury B., Telford W., Kapoor V., Garfield S., Howe D., and Gress R.E. Exogenous insulin-like growth factor 1 enhances thymopoiesis predominantly through thymic epithelial cell expansion. Blood 112 (2008) 2836-2846
13. Cohen J.J. Programmed cell death in the immune system. Adv. Immunol. 50 (1991) 55-85
14. Cook-Mills J.M., Cohen R.L., Perlman R.L., and Chambers D.A. Inhibition of lymphocyte activation by catecholamines: evidence for a non-classical mechanism of catecholamine action. Immunology 85 (1995) 544-549
15. Csaba G., and Pallinger E. In vitro effect of hormones on the hormone content of rat peritoneal and thymic cells. Is there an endocrine network inside the immune system?. Inflamm. Res. 56 (2007) 447-451
16. Csaba G., Kovacs P., and Pallinger E. In vitro effect of biogenic amines on the hormone content of immune cells of the peritoneal fluid and thymus. Is there a hormonal network inside the immune system?. Cell Biol. Int. 31 (2007) 224-228
17. Dijkstra C.D., Dopp E.A., Joling P., and Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 54 (1985) 589-599
18. Elenkov I.J., Wilder R.L., Chrousos G.P., and Vizi E.S. The sympathetic nerve-an integrative interface between two supersystems: the brain and the immune system. Pharmacol. Rev. 52 (2000) 595-638
19. Felten D.L., Felten S.Y., Carlson S.L., Olschowka J.A., and Livnat S. Noradrenergic and peptidergic innervation of lymphoid tissue. J. Immunol. 135 (1985) 755s-765s
20. Friedman E., and Irwin M. Modulation of immune cell function by autonomic nervous system. Pharmacol. Ther. (1997) 27-38
21. Gosain A., Muthu K., Gamelli R.L., and DiPietro L.A. Norepinephrine suppresses wound macrophage phagocytic efficiency through alpha- and beta-adrenoreceptor dependent pathways. Surgery 142 (2007) 170-179
22. Harbuz M. Neuroendocrinology of autoimmunity. Int. Rev. Neurobiol. 52 (2002) 133-161
23. Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
24. -/- mice show augmented TCR signaling and impaired differentiation. Curr. Biol. 7 (1997) 705-708
25. Kamath A.B., Nagarkatti P.S., and Nagarkatti M. Characterization of phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its effect on apoptosis. Toxicol. Appl. Pharmacol. 150 (1998) 117-124
26. Kavelaars A. Regulated expression of alpha-1 adrenergic receptors in the immune system. Brain Behav. Immun. 16 (2002) 799-807
27. Kranz A., Kendall M.D., and von Gaudecker B. Studies on rat and human thymus to demonstrate immunoreactivity of calcitonin gene-related peptide, tyrosine hydroxylase and neuropeptide Y. J. Anat. 191 Pt 3 (1997) 441-450
28. Leposavić G., Mićić M., Ugrešić N., Bogojević M., and Isaković K. Components of sympathetic innervation of the rat thymus during late fetal and postnatal development: histofluorescence and biochemical study. Thymus 19 (1992) 77-87
29. Leposavić G., Arsenović-Ranin N., Radojević K., Kosec D., Pešić V., Vidić-Danković B., Plećaš-Solarović B., and Pilipović I. Characterization of thymocyte phenotypic alterations induced by long-lasting beta-adrenoceptor blockade in vivo and its effects on thymocyte proliferation and apoptosis. Mol. Cell. Biochem. 285 (2006) 87-99
30. Leposavić G., Pilipović I., Radojević K., Pešić V., Perišić M., and Kosec D. Catecholamines as immunomodulators: a role for adrenoceptor-mediated mechanisms in fine tuning of T-cell development. Auton. Neurosci. 144 (2008) 1-12
31. Lomasney J.W., Cotecchia S., Lefkowitz R.J., and Caron M.G. Molecular biology of alpha-adrenergic receptors: implications for receptor classification and for structure-function relationships. Biochim. Biophys. Acta 1095 (1991) 127-139
32. Madden K.S., and Felten D.L. Beta-adrenoceptor blockade alters thymocyte differentiation in aged mice. Cell. Mol. Biol. (Noisy-le-grand) 47 (2001) 189-196
33. Maestroni G.J., and Conti A. Noradrenergic modulation of lymphohematopoiesis. Int. J. Immunopharmacol. 16 (1994) 117-122
34. Miosge L., and Zamoyska R. Signalling in T-cell development: is it all location, location, location?. Curr. Opin. Immunol. 19 (2007) 194-199
35. Mojcik C.F., Greiner D.L., and Goldschneider I. Characterization of RT6-bearing rat lymphocytes. II. Developmental relationships of RT6- and RT6+ T cells. Dev. Immunol. 1 (1991) 191-201
36. Mower Jr. D.A., Peckham D.W., Illera V.A., Fishbaugh J.K., Stunz L.L., and Ashman R.F. Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature mouse B cell apoptosis. J. Immunol. 152 (1994) 4832-4842
37. Muthu K., Iyer S., He L.K., Szilagyi A., Gamelli R.L., Shankar R., and Jones S.B. Murine hematopoietic stem cells and progenitors express adrenergic receptors. J. Neuroimmunol. 186 (2007) 27-36
38. Novotny G.E., Sommerfeld H., and Zirbes T. Thymic innervation in the rat: a light and electron microscopical study. J. Comp. Neurol. 302 (1990) 552-561
39. Pallinger E., and Csaba G. Presence and distribution of biogenic amines (histamine, serotonin and epinephrine) in immunophenotyped human immune cells. Inflamm. Res. 57 (2008) 530-534
40. Pešić V., Plećaš-Solarović B., Radojević K., Kosec D., Pilipović I., Perišić M., and Leposavić G. Long-term beta-adrenergic receptor blockade increases levels of the most mature thymocyte subsets in aged rats. Int. Immunopharmacol. 7 (2007) 674-686
41. Pilipović I., Vidić-Danković B., Perišić M., Radojevi K., Čolić M., Todorović V., and Leposavić G. Sexual dimorphism in the catecholamine-containing thymus microenvironment: a role for gonadal hormones. J. Neuroimmunol. 195 (2008) 7-20
42. 1-adrenoceptor blockade produces age-dependent changes in rat thymus structure and thymocyte differentiation. Histol. Histopathol. 20 (2005) 833-841
43. Popovik E., and Haynes L.W. Survival and mitogenesis of neuroepithelial cells are influenced by noradrenergic but not cholinergic innervation in cultured embryonic rat neopallium. Brain Res. 853 (2000) 227-235
44. Price D.T., Lefkowitz R.J., Caron M.G., Berkowitz D., and Schwinn D.A. Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology. Mol. Pharmacol. 45 (1994) 171-175
45. Qiu Y.H., Peng Y.P., Jiang J.M., and Wang J.J. Expression of tyrosine hydroxylase in lymphocytes and effect of endogenous catecholamines on lymphocyte function. Neuroimmunomodulation 11 (2004) 75-83
46. Ray D.E., and Cramer J.E. The action of decamethrin (a synthetic pyrethroid) on the rat. Pest. Biochem. Physiol. 10 (1979) 333-340
47. Roupe van der Voort C., Heijnen C.J., Wulffraat N., Kuis W., and Kavelaars A. Stress induces increases in IL-6 production by leucocytes of patients with the chronic inflammatory disease juvenile rheumatoid arthritis: a putative role for alpha(1)-adrenergic receptors. J. Neuroimmunol. 110 (2000) 223-229
48. Rouppe van der Voort C., Kavelaars A., van de Pol M., and Heijnen C.J. Noradrenaline induces phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of alpha(1)-adrenergic receptors. J. Neuroimmunol. 108 (2000) 82-91
49. Sanders K.H., and Jurna I. Effects of urapidil, clonidine, prazosin and propranolol on autonomic nerve activity, blood pressure and heart rate in anaesthetized rats and cats. Eur. J. Pharmacol. 110 (1985) 181-190
50. Scollay R., and Godfrey D.I. Thymic emigration: conveyor belts or lucky dips?. Immunol. Today 16 (1995) 268-273 discussion 273-264
51. Seddon B., and Mason D. The third function of the thymus. Immunol. Today 21 (2000) 95-99
52. Shortman K., Vremec D., and Egerton M. The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells. J. Exp. Med. 173 (1991) 323-332
53. 3- exchanger in immortalized SHR proximal tubular epithelial cells. Br. J. Pharmacol. 153 (2008) 1445-1455
54. Singh U. Effect of sympathectomy on the maturation of fetal thymocytes grown within the anterior eye chambers in mice. Adv. Exp. Med. Biol. 186 (1985) 349-356
55. Singh U. Lymphopoiesis in the nude fetal thymus following sympathectomy. Cell. Immunol. 93 (1985) 222-228
56. Stevenson J.R., Westermann J., Liebmann P.M., Hortner M., Rinner I., Felsner P., Wolfler A., and Schauenstein K. Prolonged alpha-adrenergic stimulation causes changes in leukocyte distribution and lymphocyte apoptosis in the rat. J. Neuroimmunol. 120 (2001) 50-57
57. Takahama Y. Journey through the thymus: stromal guides for T-cell development and selection. Nat. Rev. Immunol. 6 (2006) 127-135
58. Takeya M., Hsiao L., Shimokawa Y., and Takahashi K. Heterogeneity of rat macrophages recognized by monoclonal antibodies: an immunohistochemical and immunoelectron microscopic study. J. Histochem. Cytochem. 37 (1989) 635-641
59. Tsuchida M., Konishi M., Jojima K., Naito K., Fujikura Y., and Fukumoto T. Analysis of cell surface antigens on glucocorticoid-treated rat thymocytes with monoclonal antibodies. Immunol. Lett. 39 (1994) 209-217
60. van Zwieten P.A. Pharmacology of centrally acting hypotensive drugs. Br. J. Clin. Pharmacol. 10 Suppl 1 (1980) 13S-20S
61. Vicente A., Varas A., Moreno J., Sacedon R., Jimenez E., and Zapata A.G. Ontogeny of rat thymic macrophages. Phenotypic characterization and possible relationships between different cell subsets. Immunology 85 (1995) 99-105
62. Vizi E.S., Orso E., Osipenko O.N., Hasko G., and Elenkov I.J. Neurochemical, electrophysiological and immunocytochemical evidence for a noradrenergic link between the sympathetic nervous system and thymocytes. Neuroscience 68 (1995) 1263-1276
63. von Boehmer H. Selection of the T-cell repertoire: receptor controlled checkpoints in T cell development. Adv. Immunol. 84 (2004) 201-238
64. Wajeman-Chao S.A., Lancaster S.A., Graf Jr. L.H., and Chambers D.A. Mechanism of catecholamine-mediated destabilization of messenger RNA encoding Thy-1 protein in T-lineage cells. J. Immunol. 161 (1998) 4825-4833
65. Weigent D.A., and Blalock J.E. Production of peptide hormones and neurotransmitters by the immune system. In: Blalock J.E. (Ed). Neuroimmunoendocrinology. Chemical Immunology Vol. 69 (1997), Karger, Basel 1-30
66. Xi H., Schwartz R., Engel I., Murre C., and Kersh G.J. Interplay between RORgammat, Egr3, and E proteins controls proliferation in response to pre-TCR signals. Immunity 24 (2006) 813-826