Studies on rat and human thymus to demonstrate immunoreactivity of calcitonin gene-related peptide, tyrosine hydroxylase and neuropeptide Y

Journal of Anatomy

Volumn 191, Issue 3, 1997, Pages 441-450

  Kranz, Andrea ^a   Kendall, Marion D ^b   Von Gaudecker, Brita ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Epithelial cells; Peptidergic and noradrenergic innervation

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; DOPAMINE; NEUROPEPTIDE Y; NORADRENALIN; TYROSINE 3 MONOOXYGENASE;

AGING; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CHILD; ELECTRON MICROSCOPY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROSCOPY; NONHUMAN; NORADRENERGIC SYSTEM; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; THYMUS;

AGING; ANIMALS; ANIMALS, NEWBORN; CALCITONIN GENE-RELATED PEPTIDE; CHILD; CHILD, PRESCHOOL; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; MICROSCOPY, IMMUNOELECTRON; NEUROPEPTIDE Y; RATS; RATS, INBRED LEW; THYMUS GLAND; TYROSINE 3-MONOOXYGENASE;

EID: 0030671132     PISSN: 00218782     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0021878297002677     Document Type: Article

References (48)

1. ACKERMAN KD, BELLINGER DL, FELTEN SY, FELTEN DL (1991) Ontogeny and senescence of noradrenergic innervation of the rodent thymus and spleen. In Psychoneuroimmunology (ed. Ader R, Felten DL, Cohen N) 2nd edn, pp. 72-112.
2. AL-ASAM HS, KENDALL MD (1996) Preliminary studies on neural profiles and ganglion cells in the rat thymus. Journal of Anatomy 188, 221-222.
3. AL-SHAWAF AA, KENDALL MD, COHEN T (1991) Identification of neural profiles containing vasoactive intestinal polypeptide, acetylcholinesterase and catecholamines in the rat thymus. Journal of Anatomy 174, 131-143.
4. BATANERO E, LEEUW F-E DE, JANSEN GH, WICHEN DF VAN, HUBER J, SCHUURMAN H-J (1992) The neural and neuro-endocrine component of the human thymus II. Hormone immunoreactivity. Brain, Behavior, and Immunity 6, 249-264.
5. BELLINGER DL, FELTEN SY, FELTEN DL (1988) Maintenance of noradrenergic sympathetic innervation in the involuted thymus of the aged Fischer 344 rat. Brain, Behavior, and Immunity 2, 133-150.
6. BULLOCH K (1985) Neuroanatomy of lymphoid tissue: A review. In Neural Modulation of Immunity (ed. Guillemin R, Cohn M, Melnechuk T), pp. 111-141. New York: Raven Press.
7. BULLOCH K, HAUSMAN J, RADOJCIC T, SHORT S (1991) Calcitonin gene-related peptide in the developing and aging thymus. An immunocytochemical study. Annals of the New York Academy of Sciences 621, 218-228.
8. BULLOCH K, MCEWEN BS, DIWA A, RADOJCIC T, HAUSMAN J, BAIRD S (1994) The role of calcitonin gene-related peptide in the mouse thymus revisited. Annals of the New York Academy of Sciences 741, 129-136.
9. DARDENNE M, SAVINO W (1994) Control of thymus physiology by peptidergic hormones and neuropeptides. Immunology Today 15, 518-523.
10. DE LEEUW F-E, JANSEN GH, BATANERO E, WICHEN VAN DF, HUBER J, SCHUURMAN H-J (1992) The neural and neuro-endocrine component of the human thymus I. Nerve-like structures. Brain, Behavior, and Immunity 6, 234-248.
11. ERICSSON A, GEENEN V, ROBERT F, LEGROS J-J, VRINDTS-GEVAERT Y, FRANCHIMONT P et al. (1990) Expression of preprotachykinin-A and neuropeptide Y messenger RNA in the thymus. Molecular Endocrinology 4, 1211-1218.
12. FELTEN DL (1993) Direct innervation of lymphoid organs: substrate for neurotransmitter signaling of cells of the immune system. Neuropsychobiology 28, 110-112.
13. FELTEN DL, FELTEN SY (1989) Innervation of the thymus. Thymus Update 2, 73-88.
14. FELTEN SY, FELTEN DL (1991) Innervation of the lymphoid tissue. In Psychoneuroimmunology (ed. Ader R, Felten DL, Cohen N), 2nd edn, pp. 28-53. San Diego: Academic Press.
15. FELTEN DL, FELTEN SY, CARLSON SL, OLSCHOWKA JA, LIVNAT S (1985) Noradrenergic and peptidergic innervation in lymphoid tissue. Journal of Immunology 135, 755S-765S.
16. GEPPETTI P, MAGGI CA, ZECCHI-ORLANDINI S, SANTICIOLI P, MELI A, FRILLI S et al. (1987) Substance P-like immunoreactivity in capsiacin-sensitive structures in the rat thymus. Regulatory Peptides 18, 321-329.
17. GOMARIZ RP, LORENZO MJ, CACICEDO L, VICENTE A, ZAPATA A (1990) Demonstration of immuno-reactive vasoactive intestinal peptide (ir-VIP) and somatostatin (ir-SOM) in rat thymus. Brain, Behavior, and Immunity 4, 151-161.
18. HEAD GM, MENTLEIN R, PATAY B VON, DOWNING JEG, KENDALL MD (1997) Neuropeptides exert direct effects on rat thymic epithelial cells in culture. Developmental Immunology, in press.
19. HEAD GM, KENDALL MD (1996) Neuropeptides alter dye coupling of cultured thymic rat epithelial cells. 12th International Conference on Germinal Centres in Immune Reactions, 1-5th July, Graz, Austria, Ab 10.8, p. 27.
20. KENDALL MD (1989) The morphology of the perivascular spaces in the thymus. Thymus 13, 157-164.
21. KENDALL MD (1991) Functional anatomy of the thymic microenvironment. Journal of Anatomy 177, 1-29.
22. KENDALL MD, AL-SHAWAF AA (1991) Innervation of the rat thymus gland. Brain, Behavior, and Immunity 5, 9-28.
23. KENDALL MD, ATKINSON BA, MUNOZ FJ, DE LA RIVA C, CLARKE AG, VON GAUDECKER B (1994) The noradrenergic innervation of the rat thymus during pregnancy and in the post partum period. Journal of Anatomy 185, 617-625.
24. KENDALL MD, BOTHAM K, CLARKE AG, JONES G, HEAD GM (1997) Immunohistochemistry of neural crest cells of the rat thymus. Journal of Anatomy 191, 133.
25. KRANZ A (1994) Vergleichende Untersuchungen zum Vorkommen bioaktiver Peptide im Thymus von Ratte und Mensch. Thesis, University of Kiel, Germany.
26. KURZ B, GAUDECKER VON B, KRANZ A, KRISCH B, MENTLEIN R (1995) Calcitonin gene-related peptide and its receptor in the thymus. Peptides 16, 1497-1503.
27. KURZ B, FEINDT J, GAUDECKER VON B, KRANZ A, LOPPNOW H, MENTLEIN R (1997) β-adrenoceptor-mediated effects in rat cultured thymic epithelial cells. British Journal of Pharmacology 120, 1401-1408.
28. LEPOSAVIC G, MICIC M, UGRESIC N, BOGOJEVIC M, ISAKOVIC K (1992) Components of sympathetic innervation of the rat thymus during late fetal and postnatal development: histofluorescence and biochemical study. Thymus 19, 77-87.
29. LINDVALL UO, BJÖRKLUND A, FALK B (1981) Fluorescence microscopy of biogenic amines. In Methods in Neurobiology 2, (ed. Lahne R), pp. 365-431, New York, London: Plenum Press.
30. LORTON D, BELLINGER DL, FELTEN SY, FELTEN DL (1990) Substance P innervation of the rat thymus. Peptides 22, 1269-1275.
31. MAGNI F, BRUSCHI F, KASTI M (1987) The afferent innervation of the thymus gland in the rat. Brain Research 424, 379-385.
32. MICEVYCH PE, KRUGER L (1992) The status of calcitonin gene-related peptide as an effector peptide. Annals of the New York Academy of Sciences 657, 379-396.
33. MICIC M, LEPOSAVIC G, UGRESIC N (1994) Relationships between monoaminergic and cholinergic innervation of the rat thymus during aging. Journal of Neuroimmunology 49, 205-212.
34. MÜLLER S, WEIHE E (1991) Interrelation of peptidergic innervation with mast cells and ED1-positive cells in rat thymus. Brain, Behavior, and Immunity 5, 55-72.
35. NABARRA B, ANDRIANARISON I (1995) Thymic reticulum of mice. III. The connective compartment (innervation, vascularisation, fibrous tissues and myoid cells). Tissue & Cell 27, 249-261.
36. NOVOTNY GEK, SOMMERFELD H, ZIRBES T (1990) Thymic innervation in the rat: a light and electron microscopical study. Journal of Comparative Neurology 302, 552-561.
37. PIANTELLI M, MAGGIANO N, LAROCCA LM, RICCI R, RANELLETTI FO, LAURIOLA L et al. (1990) Neuropeptide-immunoreactive cells in human thymus. Brain, Behavior, and Immunity 4, 189-197.
38. REN T, SAGAR SM (1992) Induction of c-fos immunostaining in the rat brain after the systemic administration of nicotine. Brain Research Bulletin 29, 589-597.
39. SAVINO W, DARDENNE M (1995) Immune-neuroendocrine interactions. Immunology Today 16, 318-321.
40. STEEL JH, GON G, GIAID A, O'HALLORAN DJ, EMSON MA, NOORDEN VAN S et al. (1992) Localization of calcitonin gene-related peptide in the rat and human pituitary gland using immunocytochemistry and in situ hybridization. Annals of the New York Academy of Science 657, 135-154.
41. SUNDLER F, HAKANSON R, EKBLAND E, UDDMAN R, WAHLESTEDT C (1986) Neuropeptide Y (NPY) in the peripheral adrenergic and enteric nervous systems. International Review of Cytology 102, 234-269.
42. TORRE JC DE LA, SURGEON JW (1976) A methodological approach to rapid and sensitive monoamine histofluorescence using a modified glyoxylic acid technique: the SPG method. Histochemistry 49, 81-93.
43. UMEDA Y (1992) Inhibition of immune responses by calcitonin gene-related peptide. Annals of the New York Academy of Science 657, 552-554.
44. VON GAUDECKER B, KENDALL MD, RITTER MA (1997) Immunoelectron microscopy of the thymic epithelial microenvironment. Microscopy Research and Technique 38, 237-249.
45. WANG F, MILLET I, BOTTOMLY K, VIGNERY A (1992) Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes. Journal of Biological Chemistry 267, 21052-21057.
46. WHARTON J, POLAK JM (1990) Neuropeptide tyrosine in the cardiovascular system. Annals of the New York Academy of Science 611, 133-144.
47. WEIHE E, MÜLLER S, FINK T, ZENTEL HJ (1989) Tachykinins, calcitonin gene-related peptide and neuropeptide Y in nerves of the mammalian thymus: interactions with mast cells in autonomic and sensory neuroimmunomodulation? Neuroscience Letters 100, 77-82.
48. WIJNGAERT VAN DE FP, KENDALL MD, SCHUURMAN H-J, RADEMAKERS LHPM, KATER L (1984) Heterogeneity of epithelial cells in the human thymus. Cell and Tissue Research 237, 227-237.