Characterization of thymocyte phenotypic alterations induced by long-lasting β-adrenoceptor blockade in vivo and its effects on thymocyte proliferation and apoptosis

Molecular and Cellular Biochemistry

Volumn 285, Issue 1-2, 2006, Pages 87-99

  Leposavić, Gordana ^a,b   Arsenovic Ranin N ^a   Radojevic K ^b   Kosec, D ^b   Pesic V ^a   Vidic Dankovic B ^b   Plecas Solarovic B ^a   Pilipovic I ^b  

^a Department of Immunology and Microbiology   (Serbia)

^b Immunology Research Center Belgrade   (Yugoslavia)

Author keywords

CD90 expression; Con A; T cell differentiation; Thymocyte apoptosis; Thymocyte proliferation; adrenoceptor blockade

Indexed keywords

BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; CONCANAVALIN A; PROPRANOLOL; SODIUM CHLORIDE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; THY 1 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CATECHOLAMINE RELEASE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC SELECTION; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; MALE; NONHUMAN; PHENOTYPE; RAT; RAT STRAIN; RECEPTOR DENSITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE; THYMUS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 33646152757     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-005-9059-5     Document Type: Article

References (72)

1. Jameson SC, Hogquist KA, Bevan MJ: Positive selection of thymocytes. Annu Rev Immunol 13: 93-126, 1995
2. Guidos CJ: Positive selection of CD4+ and CD8+ cells. Curr Opin Immunol 8: 225-232, 1996
3. Ellmeier W, Sawada S, Littman DR: The regulation of CD4 and CD8 coreceptor gene expression during T cell development. Annu Rev Immunol 17: 523-554, 1999
4. Cantrell DA: Transgenic analysis of thymocyte signal transduction. Nature Rev Immunol 2: 20-27, 2002
5. Chan SH, Cosgrove D, Waltzinger C, Benoist C, Mathis D: Another view of the selective model of thymocyte selection. Cell 73: 225-236, 1993
6. Seddon B, Mason D: The third function of the thymus. Immunol Today 21: 95-99, 2000
7. Shevach EM: CD4+CD25+ suMpressor T cells: more questions than answers. Nature Rev Immunol 2: 389-400, 2002
8. Williams JM, Felten DL: Sympathetic innervation of murine thymus and spleen: A comparative histofluorescence and biochemical study. Anat Res 199: 531-542, 1981
9. Madden KS, Felten DL: Experimental basis for neural-immune interactions. Physiol Rev 75: 77-106, 1995
10. Friedman EM, Irwin MR: Modulation of immune cell function by autonomic nervous system. Pharmacol Therapeut 74: 27-38, 1997 27-38, 1997
11. Nance MD, Hopkins HD, Bieger D: Re-investigation of the innervation of the thymus gland in mice and rats. Brain Behav Immun 1: 134-147, 1987.
12. Leposavić G. Mićić M. Ugreŝić N. Bogojević M. Isaković K. Components of sympathetic innervation of the rat thymus during late fetal and postnatal development: Histofluorescence and biochemical study. Thymus 19: 77-87, 1992
13. Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES: The sympathetic nerve - an integrative interface between two supersystems: The brain and immune system. Pharmacol Rev 52: 595-638, 2000
14. Novotny GEK, SommerfeAd H, Zirbes T: Thymic innervation of rat: a light and electron microscopical study. Comp Neurology 302: 552-556, 1990
15. Vizi ES, Orso E, Osipenko ON, Hasko G, Elenkov IJ: Neurochemical, electrophysiological and immunocytochemical evidence for a noradrenergic link between the sympathetic nervous system and thymocytes. Neurosci 68: 1263-1276, 1995
16. Singh U: Effects of catecholamines in lymphopoesis in fetal mouse thymic explants. J Anat 129: 279-285, 1979
17. Marchetti B, Morale MC, Paradis P, Bouvier M: Characterization, expression, and hormonal control of a thymic beta(2)-adrenergic receptor. Am J Physiol 267: E18-31, 1994
18. Börne HR, Lichtenstein TM, Mean KL: Pharmacological control of allergic histamine release in vitro: Evidence for an inhibitory role of 3′,5′-adenine monophosphate in human leukocytes. J Immunol 142: 695-705, 1989
19. Kurz B, Feindt J, von Gaudecker B, Kranz A, Loppnow H, Mentlein R: β-Adrenoceptor-mediated effects in rat cultured thymic epithelial cells. B J Pharmacol 120: 1401-1408, 1997
20. Sanders VM, Kasprowicz JD, Swanson-Mungerson MA, Podojil JR, Kohm PA: Adaptive immunity in mice lacking the β2-adrenergic receptors. Brain Behav Immun 17: 55-67, 2003
21. Pochet R, Delespresse G: Beta-adrenoceptors display different efficiency on lymphocyte subpopulations. Biochem Pharmacol 32: 1651-1655, 1983
22. van de Griend RJ, Astraldi A, Wijermans P, van Doorn R, Ross D: Low beta-adrenergic receptor concentration on human thymocytes. Clin Exp Immunol 51: 55-63, 1983
23. Singh U, Owen JJ: Studies on the maturation of thymus stem cell. The effects of catecholamines, histamine and peptide hormones on the expression of T cell alloantigens. Eur J Immunol 6: 59-62, 1976
24. Leposavić G, Plecaŝ-Solarović B, Kosec D: Differential effects of chronic propranolol treatment on the phenotypic profile of thymocytes from immature and adult rats. Immunopharmacol 46: 79-87, 2000
25. Madden KS: Catecholamines, sympathetic innervation, and immunity. Brain Behav Immun 17: S5-S10, 2003
26. Sanders VM, Straub RH: Norepinephrine, the β-adrenergic receptor, and immunity. Brain Behav Immun 16: 290-333, 2002
27. Karp JD, Szczytkawski JL, Gentile CF: Noradrenergic responses of peripheral organs to cyclophosphamide in mice. Life Sci 75: 2077-2089, 2004
28. Aldridge WN: An assessment of the toxicological properties of pyrethroids and their neurotoxicity. CRC Crit Rev Toxicol 21: 89-104, 1990
29. Ray DE, Cramer JE: The action of decamethrin (a synthetic pyrethroid) on the rat. Pestic Bioch Physiol 10: 33-340, 1979
30. Desi I, Varga L, Dobrony I, Saklenerik GY: Immunotoxicological investigations of the effect of pesticide cypermethrin. Arch Toxicol 8 (Suppl.): 300-304, 1985
31. Madsen C, Claesson MH, Ropke C: Immunotoxicity of the pyrethroid insecticides deltametrin and α-cypermetrin. Toxicology 107: 219-227, 1996
32. Santoni G, Cantalamessa F, Cavagna R, Romagnoli S, Spreghini E, Piccoli M: Cypermethrin-induced alteration of thymocyte distribution and functions in perinatally-exposed rats. Toxicology 125: 67-68, 1998
33. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB: Changes in thymic function with age and during the treatment of HIV infection. Nature 396: 690-695, 1998
34. McFarland RD, Douek DC, Koup RA, Picker LJ: Identification of a human recent thymic emigrant phenotype. Proc Natl Acad Sci USA 97: 4215-4220, 2000
35. Wajeman-Chao SA, Lancaster SA, Graf LH Jr, Chambers D: Mechanism of catecholamine-mediated destabilization of messenger RNA encoding Thy-1 protein in T-lineage cells. J Immunol 161: 4825-4833, 1998
36. Killeen N: Thy-1-hiding in full view. Curr Biol 7: R774-R777, 1997
37. Harbuz, M: Neuroendocrinology of autoimmunity. Inter Rev Neurobiol 52: 133-161, 2002
38. Rauki A. Kosec D. Vidić-Danković B, Radojević K, Plećaŝ-Solarović B: Thymopoiesis following chronic blockade of beta-adrenoceptors. Immunopharm Immunotoxicol 25: 515-528, 2003
39. Kamath AB, Nagarkatti PS, Nagarkatti M: Characterization of phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its effect on apoptosis. Toxicol Appl Pharmacol 150: 117-124, 1998
40. Okasha SA, Ryu S, Do Y, McKallip RJ, Nagarkatti M, Nagarkatti PS: Evidence for estradiol-induced apoptosis and dysregulated T cell maturation in the thymus. Toxicology 163: 49-62, 2001
41. Brown DG, Sun X-M, Cohen G: Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation. J Biol Chem 268: 3037-3039, 1993
42. Mower DA Jr, Peckham DW, Illera VA, Fishbaugh JK, Stunz LL, Ashman RF: Decreased membrane phospholipid packing and decreased size precede DNA cleavage in mature mouse B cell apoptosis. J Immunol 152: 4832-4842, 1994
43. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C: A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Meth 184: 39-51, 1995
44. Eray M, Matto M, Kaartinen M, Andersson L, Pelkonen J: Flow cytometric analysis of apoptotic subpopulations with a combination of annexin V-FITC, propidium iodide, and SYTO 17. Cytometry 43: 134-142, 2001
45. Reid S, Cross R, Snow ER: Combined Hoechst 33342 and merocyanine 540 staining to examine murine B cell cycle stage, viability and apoptosis. J Immunol Method 192: 43-54, 1996
46. Lecoeur H, Prevost MC, Gougeon ML: Oncosis is associated with exposure of phosphatidylserine residues on the outside layer of the plasma membrane: A reconsideration of the specificity of the annexin V/ propidium iodide assay. Cytometry 44, 65-72, 2001
47. McConkey DJ, Orrenius S, Okret S, Jondal M: Cyclic AMP potentiates glucocorticoid-induced endogenous endonuclease activation in thymocytes. FASEB J 7: 580-585, 1993
48. Josefsson E, Bergquist R, Ekman R, Tarakowski A: Catecholamines are synthesized by mouse lymphocytes and regulate function of these cells by induction of apoptosis. Immunology 88: 140-146, 1996
49. Vidić-Danković B, Radojević K, Leposavić G: Orchidectomy affects the monoamine content in rat thymocytes. J Neuroimmunol 154: 132, 2004
50. Hünig T, Wallny HJ, Hartley JK, Lawetzky A, Tiefenthaler G: A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. J Exp Med 169: 73-86, 1989
51. Tsuchida M, Konishi M, Jojima K, Naito K, Fujikura Y, Fukumoto T: Analysis of cell surface antigens on glucocorticoid-treated rat thymocytes with monoclonal antibodies. Immunol Lett 39: 209-217, 1994
52. Stephens LA, Mason D: CD25 is a marker for CD4 thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD251 and CD252 subpopulations. J Immunol 65: 3105-3110, 2000
53. Madden KS, Felten DL: β-Adrenoceptor blockade alters thymocyte differentiation in aged mice. Cell Mol Biol 47: 189-196, 2001
54. Komura H, Iwaki M: Pharmacokinetics and metabolism of metoprolol and propranolol in the female DA and female Wistar rat: The female DA rat is not always an animal model for poor metabolizers of CYP2D6. J Pharmaceutical Sci 94: 397-408, 2005
55. TsaoC-W, Cheng J-T, Shen C-L, Lin Y-S: 6-Hydroxydopamine induces thymocyte apoptosis in mice. J Neuroimmunol 65: 91-95, 1995
56. Hueber AO, Roposo G, Pierres M, He HT: Thy-1 triggers mouse thymocyte apoptosis through a bcl-2 resistant mechanism. J Exp Med 179: 785-792, 1994
57. Cook-Milles MJ, Cohen RL, Perlan RL, Chambers DA: Inhibition of lymphocyte activation by catecholamines: Evidence for non-classical mechanisms of catecholamine action. Immunology 85: 544-549, 1995
58. Cremer JE, Seville MP: Comparative effects of two pyrethroids deltamethrin and cismethrin on plasma catecholamines and on blood glucose and lactate. Toxicol Appl Pharmacol 66: 124-133, 1982
59. Al-Shawaf AA, Kendal DM, Cowen T: Identification of neural profiles containing vasoactive intestinal polypeptide, acetylcholinesterase and catecholamines in the rat thymus. J Anat 174: 131-143, 1991
60. Petrie HT, Hugo P, Scollay R, Shortman K: Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4 and CD8 acquisition in vivo and in vitro. J Exp Med 172: 1583-1588, 1990
61. Pongracz J, Parnell S, Anderson G, Jaffrezou J-P, Jenkinson E: Con A activates an Akt/PKB dependent survival mechanism to modulate TCR induced cell death in double positive thymocytes. Mol Immunol 39: 1013-1023, 2003
62. Hueber AO, Bernard AM, Battari CL, Marguet D, Massol P, Foa C, Brun, N, Garsia S, Steward C, Pierres M, He HT: Thymocytes in Thy-1-/- mice show augmented TCR signaling and impaired differentiation. Curr Biol 7: 705-708, 1997
63. Westermann J, Smith T, Peters U, Tschernig T, Pabst R, Steinhoff G, Sparshott SM, Bell EB: Both activated and non-activated leukocytes from the periphery continuously enter the thymic medulla of adult rats: phenotypes, source and magnitude of traffic. Eur J Immunol 26: 1866-1874, 1996
64. Bensinger SJ, Bandeira A, Jordan MS, Caton AJ, Laufer TM: Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J Exp Med 194: 427-438, 2001
65. von Patay B, Loppnow H, Feindt J, Kurz B, Mentlein R: Catecholamines and lipopolysaccharide synergistically induce the release of interleukin-6 from thymic epithelial cells. J Neuroimmunol 86: 182-189, 1998
66. von Patay B, Kurz B, Mentlein R: Effects of transmitters and co-transmitters of the sympathetic nervous system on interleukin-6 synthesis in thymic epithelial cells. Neuroimmunomodulation 6: 45-50, 1999
67. Neil-Dwyer G, Bartlett J, McAinsh J, Cruickshank JM: β-Adrenoceptor blockers and the blood-brain barrier. Br J Clin Pharmacol 11: 549-553, 1981
68. Oberbeck R, Schürmeyer T, Jacobs R, Benschop RJ, Sommer B, Schmidt RE, Schedlowski M: Effects of beta-adrenoceptor-blockade on stress-induced adrenocorticotrophin release in humans. Neuroendocrinology 69: 309-315, 1999
69. Cheolyoung P, Inmyung Y, Jeongtaek W, Sungwoon K, Jinwoo K, Youngseol K, Seungjoon P: Acute hyperglycemia and activation of the beta-adrenergic system exhibit synergistic inhibitory actions on growth hormone (GH) releasing hormone-induced GH release. Eur J Endocrinol 148: 635-640, 2003
70. Daftary SS, Boudaba C, Tasker JG: Noradrenergic regulation of parvocellular neurons in the rat hypothalamic paraventricular nucleus. Neurosci 96: 743-51, 2000
71. Blalock JE: A molecular basis for communication berween immune and neuroendocrine system. Physiol Rev 69: 1-32, 1989
72. Savino W, Dardenne M: Neuroendocrine control of t hymus physiology. Endocrine Rev 21: 412-443, 2000