Lessons in rational drug design for protein kinases

Science

Volumn 308, Issue 5726, 2005, Pages 1266-1267

  Ahn, Natalie G ^a   Resing, Katheryn A ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ADENOSINE TRIPHOSPHATE; CHLORINE DERIVATIVE; CHLOROMETHYL KETONE; CYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUORINE DERIVATIVE; FLUOROMETHYL KETONE; GEFITINIB; IMATINIB; KETONE DERIVATIVE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; S6 KINASE; S6 KINASE 1; S6 KINASE 2; UNCLASSIFIED DRUG; ENZYME INHIBITOR;

DRUG DEVELOPMENT;

AMINO ACID SEQUENCE; BINDING SITE; BIOINFORMATICS; DRUG DESIGN; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; FOOD AND DRUG ADMINISTRATION; HYDROPHOBICITY; MOLECULAR RECOGNITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION; ALKYLATION; BIOLOGY; CHEMICAL MODEL; CHEMISTRY; DRUG ANTAGONISM; DRUG RESISTANCE; GENETICS; METABOLISM; MUTATION; NOTE;

ADENOSINE TRIPHOSPHATE; ALKYLATION; BINDING SITES; COMPUTATIONAL BIOLOGY; CYSTEINE; DRUG DESIGN; DRUG RESISTANCE; ENZYME INHIBITORS; HYDROPHOBICITY; MODELS, CHEMICAL; MUTATION; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20144376030     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1113707     Document Type: Review

References (8)

1. W. Pao, V. A. Miller, J. Clin. Oncol. 23, 2556 (2005).
2. M. Deininger, E. Buchdunger, B. J. Druker, Blood 105, 2640 (2005).
3. M. S. Cohen, C. Zhang, K. M. Shokat, J. Taunton, Science 308, 1318 (2005).
4. Y. Liu et al. Chem. Biol. 6, 671 (1999).
5. A. J. Bridges, Curr. Med. Chem. 6, 825 (1999).
6. S. Kobayashi et al., N. Engl. J. Med. 352, 786 (2005).
7. W. Pao et al., PLoS Med. 2, e73 (2005).
8. M. E. Gorre et al., Science 293, 876 (2001).