Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 688-692

  Smil, David V ^a   Manku, Sukhdev ^a   Chantigny, Yves A ^a   Leit, Silvana ^a   Wahhab, Amal ^a   Yan, Theresa P ^b   Fournel, Marielle ^b   Maroun, Christiane ^b   Li, Zuomei ^b   Lemieux, Anne Marie ^b   Nicolescu, Alina ^b   Rahil, Jubrail ^b   Lefebvre, Sylvain ^b   Panetta, Anthony ^b   Besterman, Jeffrey M ^b   Déziel, Robert ^a  

^a METHYLGENE INC   (Canada)

^b Department of Molecular Biology ^*  (Canada)

Author keywords

3,4 Dihydroquinoxalin 2(1H) ones; Aryl hydroxamic acids; HDAC inhibitors; HDAC6; Histone acetylation; Piperazine 2,5 diones; Tubulin acetylation

Indexed keywords

3,4 DIHYDROQUINOXALIN 2(1H) ONE DERIVATIVE; ALPHA TUBULIN; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE IIA; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; HYDROXAMIC ACID DERIVATIVE; ISOENZYME; PIPERAZINE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50;

ACETYLATION; CATALYTIC DOMAIN; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HISTONES; HUMANS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; PIPERAZINES; PROTEIN ISOFORMS; TUBULIN;

EID: 58549085379     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.045     Document Type: Article

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