Altered immunogenicity of isoaspartate containing proteins

Autoimmunity

Volumn 40, Issue 2, 2007, Pages 131-137

  Doyle, Hester A ^a   Gee, Renelle J ^a   Mamula, Mark J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen processing; Capthesin D; Isoaspartyl; T cells; Tolerance

Indexed keywords

CATHEPSIN D; CYTOCHROME C; ISOASPARTIC ACID; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; AUTOIMMUNITY; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; PIGEONS AND DOVES; PROTEIN PROCESSING; T LYMPHOCYTE; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; AUTOIMMUNITY; CATHEPSIN D; CELL PROLIFERATION; COLUMBIDAE; CYTOCHROMES C; IMMUNE TOLERANCE; ISOASPARTIC ACID; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 34250354402     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930601165180     Document Type: Article

References (26)

1. Chan OTM, Madaio MP, Shlomchik MJ. The central and multiple roles of B cells in lupus pathogenesis. Immunol Rev 1999;169:107-121 (Pubitemid 29338727)
2. Craft J, Peng S, Fujii R, Okada M, Fatenejad S. Autoreactive T cells in murine lupus: Origins and roles in autoantibody production. Immunol Res 1999;19:245-257 (Pubitemid 29401381)
3. Tan EM. Antinuclear antibodies: Diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 1989;44:93-151 (Pubitemid 19090837)
4. Sercarz EE, Lehmann PV, Ametani A, Benichou G, Miller A, Moudgil K. Dominance and crypticity of T cell antigenic determinants. Annu Rev Immunol 1993;11:729-766 (Pubitemid 23115022)
5. Doyle HA, Mamula MJ. Post-translational protein modifications in antigen recognition and autoimmunity. Trends Immunol 2001;22:443-449 (Pubitemid 32709979)
6. Mamula MJ, Gee RJ, Elliot JI, Sette A, Southwood S, Jones P, Blier PR. Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins. J Biol Chem 1999;274:22321-22327
7. Clarke S, Stephenson RC, Lowenson JD. Liability of asparagine and aspartic acid residues in proteins and peptides. In: Aher TJ, Manning MC, Aher TJ, Manning MCs, editors. Stability of protein pharmaceuticals, part A: Chemical and physical pathways of protein degradation. New York: Plenum Press; 1992
8. Lowenson J, Clarke S. Does the chemical instability of aspartyl and asparaginyl residues in proteins contribute to erythrocyte aging? The role of protein carboxyl methylation reactions. Blood Cells 1988;14:103-118
9. Teshima G, Porter J, Yim K, Ling V, Guzzetta A. Deamidiation of soluble CD4 at asparagine-52 results in reduced binding capacity for the HIV-1 envelope glycoprotein gp120. Biochemistry 1991;30:3916-3922
10. Clarke S. Protein carboxyl methyltransferases: Two distinct classes of enzymes. Annu Rev Biochem 1985;54:479-506 (Pubitemid 15073655)
11. Kim E, Lowenson JD, MacLauren DC, Clarke S, Young SG. Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice. Proc Natl Acad Sci USA 1997;94: 6132-6137 (Pubitemid 27270649)
12. +T cells from lupus-prone mice are hyper-responsive to TCR engagement with low and high affinity peptide antigens: A model to explain spontaneous T cell activation in lupus. J Exp Med 2001; 193:329-337 (Pubitemid 32524516)
13. Zamvil SS, Mitchell DJ, Moore AC, Kitamura K, Steinman L, Rothbard JB. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 1986;324: 258-260 (Pubitemid 17180453)
14. Meadows L,WangW, de Haan JMM, Blokland E, Reinhardus C, Drijfhout JW, Shabanowitz J, Pierce R, Agulnik AI, Bishop CE, Hunt DF, Goulmy E, Engelhard VH. The HLA-A 0201-restricted H-Yantigen contains a posttranslationally modified cysteine that significantly affects T cell recognition. Immunity 1997;6:273-281 (Pubitemid 27148594)
15. Glithero A, Tormo J, Haurum JS, Arsequell G, Valencia G, Edwards J, Springer S, Townsend AR, Pao YL,Wormald MR, Swek RA, Jones EY, Elliot T. Crytstal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity. Immunity 1999;10
16. Manoury B, Mazzeo D, Fugger L, Viner N, Ponsford M, Streeter H, Mazza G, Wraith DC, Watts C. Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP. Nat Immunol 2002; 3:169-174 (Pubitemid 34141447)
17. Anderton SM, Viner MJ, Matharu P, Lowrey PA, Wraith DC. Influence of a dominant cryptic epitope on auotimmune T cell tolerance. Nat Immunol 2002;3:175-181 (Pubitemid 34141448)
18. Gahring LC, Carlson NG, Meyer EL, Rogers SW. Granzyme B proteolysis of a neruonal glutamate receptor generates an autoantigen and is modulated by glycosylation. J Immunol 2001;166:1433-1438 (Pubitemid 32114618)
19. Johnson BA, Aswad DW. Fragmentation of isoaspartyl peptides and proteins by carboxypeptidase Y: Release of isoaspartyl dipeptides as a result of internal and external cleavage. Biochemistry 1990;29:4373-4380 (Pubitemid 20153639)
20. Moss CX, Matthews SP, Lamont DJ, Watts C. Asparagine deamidation perturbs antigen presentation on class II major histocompatibility complex molecules. J Biol Chem 2005;280:18498-18503 (Pubitemid 41389099)
21. Pritzker LB, Joshi S, Gowan JJ, Harauz G, Moscarello MA. Deimination of myelin basic protein. 1. Effect of deimination of arginyl residues of myelin basic protein on its structure and susceptibility to digestion by cathepsin D. Biochemistry 2000;39:5374-5381 (Pubitemid 30257077)
22. Schwartz RH, Fox BS, Fraga E, Chen C, Singh B. The T lymphocyte response to cytochrome c. V. Determination of the minimal peptide size required for stimulation of T cell clones and assessment of the contribution of each residue beyond this size to antigenic potency. J Immunol 1985;135:2598-2608 (Pubitemid 16215856)
23. Andrade F, Casciola-Rosen L, Rosen A. Apoptosis in systemic lupus erythematosus. Clinical implications. Rheum Dis Clin North Am 2000;26:215-227 (Pubitemid 30198757)
24. Casciola-Rosen L, Andrade F, Ulanet D,Wong WB, Rosen A. Cleavage by granzyme B is strongly predictive of autoantigen status: Implications for initiation of autoimmunity. J Exp Med 1999;190:815-826
25. Watts C. Immunology. Antigen presentation-losing its shine in the absence of GILT. Science 2001;294:1294-1295 (Pubitemid 33063085)
26. Maric M, Arunachalam B, Phan UT, Dong C, Garrett WS, Cannon KS, Alfonso C, Karlsson L, Flavell RA, Cresswell P. Defective antigen processing in GILT-free mice. Science 2001; 294:1361-1365. (Pubitemid 33063106)