Comparative oxidation studies of methionine residues reflect a structural effect on chemical kinetics in rhG-CSF

Biochemistry

Volumn 45, Issue 51, 2006, Pages 15430-15443

  Pan, Bin ^a   Abel, Jeff ^b   Ricci, Margaret S ^b   Brems, David N ^b   Wang, Daniel I C ^a   Trout, Bernhardt L ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FREE ENERGY; HYDROGEN PEROXIDE; OXIDATION; PROTEINS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

CHEMICAL DEGRADATION KINETICS; CHEMICALLY SYNTHESIZED PEPTIDES; EQUILIBRIUM DENATURATION; METHIONINE RESIDUES;

AMINES;

HYDROGEN PEROXIDE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ARTICLE; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; FLUORESCENCE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATHEMATICAL MODEL; OXIDATION; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN TERTIARY STRUCTURE; REACTION TIME; SHELF LIFE; TANDEM MASS SPECTROMETRY; TEMPERATURE DEPENDENCE;

GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; HUMANS; KINETICS; METHIONINE; MODELS, CHEMICAL; OXIDATION-REDUCTION; PEPTIDES; PROTEIN DENATURATION; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE; THERMODYNAMICS; TRYPTOPHAN;

EID: 33845960288     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061855c     Document Type: Article

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