The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects

Journal of Neurochemistry

Volumn 75, Issue 4, 2000, Pages 1520-1527

  Skaper, Stephen D ^a,b   Kee, Wai Jing ^a,b   Facci, Laura ^a,b   Macdonald, Gregor ^a,b   Doherty, Patrick ^a,b   Walsh, Frank S ^a,b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Fibroblast growth factor; Mitogen activated protein kinase; Neuritogenesis; Receptor inhibition; Signal transduction; Survival

Indexed keywords

3 [4 METHYL 2 (2 OXO 3 INDOLINYLMETHYLIDENYL) 3 PYRROLYL]PROPIONIC ACID; CILIARY NEUROTROPHIC FACTOR; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PD 173074; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVATION; GRANULE CELL; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SPINAL GANGLION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; CELLS, CULTURED; CHICK EMBRYO; CILIARY NEUROTROPHIC FACTOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; INSULIN-LIKE GROWTH FACTOR I; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTOR; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURITES; NEURONS; PC12 CELLS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PYRIMIDINES; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTORS, FIBROBLAST GROWTH FACTOR; SENSITIVITY AND SPECIFICITY;

ANIMALIA;

EID: 0033817222     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751520.x     Document Type: Article

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