Leishmania donovani: A glycosyl dihydropyridine analogue induces apoptosis like cell death via targeting pteridine reductase 1 in promastigotes

Experimental Parasitology

Volumn 123, Issue 3, 2009, Pages 258-264

  Kaur, Jaspreet ^a   Singh, Biswajit Kumar ^a   Tripathi, Rama Pati ^a   Singh, Prashant ^b   Singh, Neeloo ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b DAV PG College   (India)

Author keywords

Antifolate chemotherapy; Cell cycle arrest; Flow cytometry; Leishmania donovani; Pteridine reductase 1 (EC 1.5.1.33)

Indexed keywords

2,6 DIMETHYL 4 (3 O BENZYL 1,2 O ISOPROPYLIDENE BETA THREOPENTOFURANOS 4 YL) 1 PHENYL 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLIC ACID DIETHYL ESTER; DIHYDROPYRIDINE DERIVATIVE; OXIDOREDUCTASE; PHOSPHATIDYLSERINE; PTERIDINE REDUCTASE 1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG TARGETING; FLOW CYTOMETRY; LEISHMANIA DONOVANI; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMASTIGOTE;

ANIMALS; ANTIPROTOZOAL AGENTS; APOPTOSIS; DIHYDROPYRIDINES; DNA FRAGMENTATION; DNA, PROTOZOAN; FLOW CYTOMETRY; GLYCOSIDES; LEISHMANIA DONOVANI; MEMBRANE POTENTIALS; MITOCHONDRIA; OXIDOREDUCTASES; REACTIVE OXYGEN SPECIES;

LEISHMANIA DONOVANI;

EID: 69449106463     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2009.07.009     Document Type: Article

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