On the evolution of programmed cell death: Apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization

Cell Death and Differentiation

Volumn 9, Issue 1, 2002, Pages 65-81

  Arnoult, D ^a   Akarid, K ^a,b   Grodet, A ^c   Petit, P X ^d   Estaquier, J ^a   Ameisen, J C ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b FACULTÉ DES SCIENCES   (Morocco)

^c INSERM   (France)

^d INSTITUT COCHIN   (France)

Author keywords

(cytochrome c; Bax; evolution; unicellular eukaryote); Apoptosis; Cell death; Cysteine proteinase; DNA fragmentation; Leishmania major; Mitochondria

Indexed keywords

CELL EXTRACT; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; CYTOCHROME C; DNA; PHOSPHATIDYLSERINE; PROTEIN BAX; RECOMBINANT PROTEIN; SAPONIN; STAUROSPORINE;

APOPTOSIS; ARTICLE; BIOASSAY; CELL MEMBRANE; CELL NUCLEUS; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOPLASM; DNA DEGRADATION; DYING; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME RELEASE; ENZYME SUBSTRATE; EUKARYOTE; EVOLUTION; EXPOSURE; FLAGELLATE; GENE DELETION; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; INCUBATION TIME; LEISHMANIA MAJOR; MAMMAL CELL; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PHENOTYPE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CARRIER PROTEINS; CELL NUCLEUS; CHROMATIN; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROME C GROUP; DNA FRAGMENTATION; ENZYME ACTIVATION; EVOLUTION; GLYCOPROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; LEISHMANIA MAJOR; MITOCHONDRIA; PERMEABILITY; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; STAUROSPORINE;

EUKARYOTA; INSERTION SEQUENCES; KINETOPLASTIDA; LEISHMANIA MAJOR; MAMMALIA; MASTIGOPHORA (FLAGELLATES); PROTISTA; PROTOZOA;

EID: 0036142979     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400951     Document Type: Article

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