Leishmania donovani pteridine reductase 1: Biochemical properties and structure-modeling studies

Experimental Parasitology

Volumn 120, Issue 1, 2008, Pages 73-79

  Kumar, Pranav ^a   Kumar, Ashutosh ^a   Verma, Shyam Sundar ^a   Dwivedi, Namrata ^a   Singh, Nasib ^a   Siddiqi, Mohammad Imran ^a   Tripathi, Rama Pati ^a   Dube, Anuradha ^a   Singh, Neeloo ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antileishmanial drug screening; Antileishmanial screening; Clinical isolate; DHFR TS, dihydrofolate reductase thymidylate synthase; DHPR, dihydropteridine reductase; Flow cytometry; GFP, green fluorescence protein; Leishmania donovani; MTX, methotrexate; pABA, para aminobenzoic acid; Pteridine reductase 1; PTR1, pteridine reductase 1; Recombinant protein; SAG, sodium antimony gluconate; Structural modeling

Indexed keywords

(4 FLUORO PHENYL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDRO PYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; CARBOXYLIC ACID; OXIDOREDUCTASE; OXIDOREDUCTASE INHIBITOR; PTERIDINE REDUCTASE 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME SPECIFICITY; LEISHMANIA DONOVANI; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ANTIPROTOZOAL AGENTS; BIOPTERIN; ENZYME INHIBITORS; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; LEISHMANIA DONOVANI; METHOTREXATE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDOREDUCTASES; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

LEISHMANIA DONOVANI; PROTOZOA;

EID: 48849097750     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2008.05.005     Document Type: Article

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