Biomarkers of DHA status

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 81, Issue 2-3, 2009, Pages 111-118

  Kuratko, Connye N ^a   Salem Jr , Norman ^a  

^a Martek Biosciences Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DOCOSAHEXAENOIC ACID; OMEGA 3 FATTY ACID; PHOSPHOLIPID;

ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; BRAIN LEVEL; CENTRAL NERVOUS SYSTEM; ERYTHROCYTE LEVEL; FATTY ACID ANALYSIS; FOOD INTAKE; GAS CHROMATOGRAPHY; HUMAN; LIPID ANALYSIS; NUTRITIONAL REQUIREMENT; OBSERVATIONAL STUDY; PRIORITY JOURNAL; TISSUE LEVEL;

ADULT; ANIMALS; BIOLOGICAL MARKERS; DIETARY FATS; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS, OMEGA-3; FEMALE; HUMANS; MALE; MIDDLE AGED;

EID: 69449099083     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2009.05.007     Document Type: Article

References (85)

1. Salem N. Omega-3 Fatty Acids: Molecular and Biochemical Aspects. New Protective Roles for Selected Nutrients (1989), Alan R. Liss, Inc. pp. 109-228
2. Kim H.-Y. Novel metabolism of docosahexaenoic acid in neural cells. J. Biol. Chem. 282 26 (2007) 18661-18665
3. Lauritzen L., Hansen H.S., Jorgensen M.H., and Michaelsen K.F. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog. Lipid Res. 40 1-2 (2001) 1-94
4. Salem Jr. N., Litman B., Kim H.Y., and Gawrisch K. Mechanisms of action of docosahexaenoic acid in the nervous system. Lipids 36 9 (2001) 945-959
5. Feller S.E., and Gawrisch K. Properties of docosahexaenoic-acid-containing lipids and their influence on the function of rhodopsin. Curr. Opin. Struct. Biol. 15 (2005) 416-422
6. Niu S.L., Mitchell D.C., Lim S.Y., et al. Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to N-3 fatty acid deficiency. J. Biol. Chem. 279 30 (2004) 31098-31104
7. Feller S.E. Acyl chain conformations in phospholipid bilayers: a comparative study of docosahexaenoic acid and saturated fatty acids. Chem. Phys. Lipids 153 1 (2008) 76-80
8. Rapoport S.I., Rao J.S., and Igarashi M. Regulation by diet and liver of brain metabolism of nutritionally essential polyunsatruated fatty acids. Brain Physiology and Metabolism Section. NIH (2007) 216-223
9. Mori T.A., and Woodman R.J. The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans. Curr. Opin. Clin. Nutr. Metab. Care 9 2 (2006) 95-104
10. Katan M.B., Deslypere J.P., van Birgelen A.P., Penders M., and Zegwaard M. Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. J. Lipid Res. 38 10 (1997) 2012-2022
11. National Cancer Institute. 〈http://riskfactor.cancer.gov/areas/biomarkers/〉 Accessed April 15 2009.
12. Maruvada P., and Srivastava S. Biomarkers for cancer diagnosis: implications for nutritional research. J. Nutr. 134 6 Suppl (2004) 1640S-1645S discussion 64S-66S, 67S-72S
13. Potischman N., and Freudenheim J.L. Biomarkers of nutritional exposure and nutritional status: an overview. J. Nutr. 133 Suppl 3 (2003) 873S-874S
14. Arab L. Biomarkers of fat and fatty acid intake. J. Nutr. 133 Suppl 3 (2003) 925S-932S
15. Folch J., Lees M., and Sloane Stanley G. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226 1 (1957) 497-509
16. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37 (1954) 911-917
17. AOCS. Official method. Direct methylation of lipids for the determination of total fat, saturated, cis-monounsaturated, cis-polyunsaturated, and trans fatty acids by chromatography. Revised 2007.
18. Arterburn L.M., Oken H.A., Bailey Hall E., Hamersley J., Kuratko C.N., and Hoffman J.P. Algal-oil capsules and cooked salmon: nutritionally equivalent sources of docosahexaenoic acid. J. Am. Diet Assoc. 108 7 (2008) 1204-1209
19. Arterburn L.M., Oken H.A., Hoffman J.P., et al. Bioequivalence of Docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food. Lipids 42 11 (2007) 1011-1024
20. Masood A., Stark K.D., and Salem Jr. N. A simplified and efficient method for the analysis of fatty acid methyl esters suitable for large clinical studies. J. Lipid Res. 46 10 (2005) 2299-2305
21. Masood M.A., and Salem Jr. N. High-throughput analysis of plasma fatty acid methyl esters employing robotic transesterification and fast gas chromatography. Lipids 43 2 (2008) 171-180
22. Sarri K.O., Linardakis M., Tzanakis N., and Kafatos A.G. Adipose DHA inversely associated with depression as measured by the Beck Depression Inventory. Prostaglandins Leukot. Essent. Fatty Acids 78 2 (2008) 117-122
23. Koletzko B., Knoppke B., von Schenck U., Demmelmair H., and Damli A. Noninvasive assessment of essential fatty acid status in preterm infants by buccal mucosal cell phospholipid analysis. J. Pediatr. Gastroenterol. Nutr. 29 4 (1999) 467-474
24. Connor S.L., Zhu N., Anderson G.J., et al. Cheek cell phospholipids in human infants: a marker of docosahexaenoic and arachidonic acids in the diet, plasma, and red blood cells. Am. J. Clin. Nutr. 71 1 (2000) 21-27
25. Hoffman D.R., Birch E.E., Birch D.G., and Uauy R. Fatty acid profile of buccal cheek cell phospholipids as an index for dietary intake of docosahexaenoic acid in preterm infants. Lipids 34 4 (1999) 337-342
26. Gulaya N.M., Margitich V.M., Govseeva N.M., Klimashevsky V.M., Gorpynchenko II, and Boyko M.I. Phospholipid composition of human sperm and seminal plasma in relation to sperm fertility. Arch. Androl. 46 3 (2001) 169-175
27. Li D., Yu X.M., Xie H.B., et al. Platelet phospholipid n-3 PUFA negatively associated with plasma homocysteine in middle-aged and geriatric hyperlipaemia patients. Prostaglandins Leukot. Essent. Fatty Acids 76 5 (2007) 293-297
28. Vedin I., Cederholm T., Freund Levi Y., et al. Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study. Am. J. Clin. Nutr. 87 6 (2008) 1616-1622
29. Polozova A., and Salem N. Role of liver and plasma lipoproteins in selective transport of n-3 fatty acids to tissues: a comparative study of 14C-DHA and 3H-Oleic acid tracers. J. Mol. Neurosci. 33 1 (2007) 56-66
30. Spector A. Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. J. Mol. Neurosci. 16 (2001) 159-165
31. Rapoport S.I., Chang M.C., and Spector A.A. Delivery and turnover of plasma-derived essential PUFAs in mammalian brain. J. Lipid Res. 42 5 (2001) 678-685
32. Lagarde M., Bernoud N., Brossard N., et al. Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain. J. Mol. Neurosci. 16 2-3 (2001) 201-204 discussion 15-21
33. Marangoni F., Angeli M.T., Colli S., et al. Changes of n-3 and n-6 fatty acids in plasma and circulating cells of normal subjects, after prolonged administration of 20:5 (EPA) and 22:6 (DHA) ethyl esters and prolonged washout. Biochim. Biophys. Acta 1210 1 (1993) 55-62
34. Brown A.J., Pang E., and Roberts D.C. Erythrocyte eicosapentaenoic acid versus docosahexaenoic acid as a marker for fish and fish oil consumption. Prostaglandins Leukot. Essent. Fatty Acids 44 2 (1991) 103-106
35. Brown A.J., Pang E., and Roberts D.C. Persistent changes in the fatty acid composition of erythrocyte membranes after moderate intake of n-3 polyunsaturated fatty acids: study design implications. Am. J. Clin. Nutr. 54 4 (1991) 668-673
36. Skeaff C.M., Hodson L., and McKenzie J.E. Dietary-induced changes in fatty acid composition of human plasma, platelet, and erythrocyte lipids follow a similar time course. J. Nutr. 136 3 (2006) 565-569
37. Staufenbiel M. Ankyrin-bound fatty acid turns over rapidly at the erythrocyte plasma membrane. Mol. Cell Biol. 7 8 (1987) 2981-2984
38. Stark K.D. The percentage of n-3 highly unsaturated fatty acids in total HUFA as a biomarker for omega-3 fatty acid status in tissues. Lipids 43 1 (2008) 45-53
39. Andersen L.F., Solvoll K., Johansson L.R., Salminen I., Aro A., and Drevon C.A. Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. Am. J. Epidemiol. 150 1 (1999) 75-87
40. Kobayashi M., Sasaki S., Kawabata T., Hasegawa K., Akabane M., and Tsugane S. Single measurement of serum phospholipid fatty acid as a biomarker of specific fatty acid intake in middle-aged Japanese men. Eur. J. Clin. Nutr. 55 8 (2001) 643-650
41. Kuriki K., Nagaya T., Tokudome Y., et al. Plasma concentrations of (n-3) highly unsaturated fatty Acids are good biomarkers of relative dietary fatty acid intakes: a cross-sectional study. J. Nutr. 133 11 (2003) 3643-3650
42. Lucas M., Asselin G., Merette C., Poulin M.J., and Dodin S. Validation of an FFQ for evaluation of EPA and DHA intake. Public Health Nutr. 23 (2008) 1-8 [Epub ahead of print]
43. Milte C.M., Coates A.M., Buckley J.D., Hill A.M., and Howe P.R. Dose-dependent effects of docosahexaenoic acid-rich fish oil on erythrocyte docosahexaenoic acid and blood lipid levels. Br. J. Nutr. 99 5 (2008) 1083-1088
44. Ma J., Folsom A.R., Shahar E., and Eckfeldt J.H. Plasma fatty acid composition as an indicator of habitual dietary fat intake in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Am. J. Clin. Nutr. 62 3 (1995) 564-571
45. Norrish A.E., Skeaff C.M., Arribas G.L., Sharpe S.J., and Jackson R.T. Prostate cancer risk and consumption of fish oils: a dietary biomarker- based case-control study. Br. J. Cancer 81 7 (1999) 1238-1242
46. Poppitt S.D., Kilmartin P., Butler P., and Keogh G.F. Assessment of erythrocyte phospholipid fatty acid composition as a biomarker for dietary MUFA, PUFA or saturated fatty acid intake in a controlled cross-over intervention trial. Lipids Health Dis. 4 (2005) 30
47. Sullivan B.L., Williams P.G., and Meyer B.J. Biomarker validation of a long-chain omega-3 polyunsaturated fatty acid food frequency questionnaire. Lipids 41 9 (2006) 845-850
48. Sun Q., Ma J., Campos H., Hankinson S.E., and Hu F.B. Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women. Am. J. Clin. Nutr. 86 1 (2007) 74-81
49. Barcelo-Coblijn G., Murphy E.J., Othman R., Moghadasian M.H., Kashour T., and Friel J.K. Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acid. Am. J. Clin. Nutr. 88 3 (2008) 801-809
50. Cao J., Schwichtenberg K.A., Hanson N.Q., and Tsai M.Y. Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin. Chem. 52 12 (2006) 2265-2272
51. Conquer J.A., and Holub B.J. Effect of supplementation with different doses of DHA on the levels of circulating DHA as non-esterified fatty acid in subjects of Asian Indian background. J. Lipid Res. 39 2 (1998) 286-292
52. Geppert J., Kraft V., Demmelmair H., and Koletzko B. Docosahexaenoic acid supplementation in vegetarians effectively increases omega-3 index: a randomized trial. Lipids 40 8 (2005) 807-814
53. Vidgren H.M., Agren J.J., Schwab U., Rissanen T., Hanninen O., and Uusitupa M.I. Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men. Lipids 32 7 (1997) 697-705
54. Brenna J.T., Salem Jr. N., Sinclair A.J., and Cunnane S.C. alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukot. Essent. Fatty Acids 80 2-3 (2009) 85-91
55. Arterburn L.M., Hall E.B., and Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am. J. Clin. Nutr. 83 6 Suppl (2006) 1467S-1476S
56. USDA. What's in the food you eat. 〈http://199.133.10.140/codesearchwebapp/(cxea2n450tmhhcfosubkd4v1)/codesearch.aspx〉 Accessed April 15, 2009.
57. Beblo S., Stark K.D., Murthy M., et al. Effects of alcohol intake during pregnancy on docosahexaenoic acid and arachidonic acid in umbilical cord vessels of black women. Pediatrics 115 2 (2005) e194-e203
58. Pawlosky R.J., Bacher J., and Salem Jr. N. Ethanol consumption alters electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus monkeys: nutritional consequences of a low n-3 fatty acid diet. Alcohol Clin. Exp. Res. 25 12 (2001) 1758-1765
59. Larque E., Zamora S., and Gil A. Dietary trans fatty acids in early life: a review. Early Hum. Dev. 65 Suppl 2 (2001) S31-S41
60. Agostoni C., Galli C., Riva E., Colombo C., Giovannini M., and Marangoni F. Reduced docosahexaenoic acid synthesis may contribute to growth restriction in infants born to mothers who smoke. J. Pediatr. 147 6 (2005) 854-856
61. Xie L., and Innis S.M. Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. J. Nutr. 138 11 (2008) 2222-2228
62. Calon F., and Cole G. Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. Prostaglandins Leukot. Essent. Fatty Acids 77 5-6 (2007) 287-293
63. Morris M.C., Evans D.A., Tangney C.C., Bienias J.L., and Wilson R.S. Fish consumption and cognitive decline with age in a large community study. Arch. Neurol. 62 12 (2005) 1849-1853
64. Schaefer E.J., Bongard V., Beiser A.S., et al. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch. Neurol. 63 11 (2006) 1545-1550
65. Hibbeln J.R., Davis J.M., Steer C., et al. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet 369 9561 (2007) 578-585
66. Hibbeln J.R. Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J. Affect. Disord. 69 1-3 (2002) 15-29
67. Sarkadi-Nagy E., Wijendran V., Diau G.Y., et al. Formula feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm baboon neonates. J Lipid Res. 45 1 (2004) 71-80
68. Pawlosky R.J., Denkins Y., Ward G., and Salem Jr. N. Retinal and brain accretion of long-chain polyunsaturated fatty acids in developing felines: the effects of corn oil-based maternal diets. Am. J. Clin. Nutr. 65 2 (1997) 465-472
69. Pawlosky R., Hibbelin J.R., Novotny J.A., and Salem Jr. N. Physiological compartmental analysis of α-linolenic acid metabolism in adult humans. J. Lipid Res. 42 (2001) 1257-1265
70. Soderberg M., Edlund C., Alafuzoff I., Kristensson K., and Dallner G. Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type. J. Neurochem. 59 5 (1992) 1646-1653
71. Morris M.C., Evans D.A., Bienias J.L., et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch. Neurol. 60 7 (2003) 940-946
72. Lim G.P., Calon F., Morihara T., et al. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J. Neurosci. 25 12 (2005) 3032-3040
73. Whalley L.J., Fox H.C., Wahle K.W., Starr J.M., and Deary I.J. Cognitive aging, childhood intelligence, and the use of food supplements: possible involvement of n-3 fatty acids. Am. J. Clin. Nutr. 80 6 (2004) 1650-1657
74. Harris W.S., Assaad B., and Poston W.C. Tissue omega-6/omega-3 fatty acid ratio and risk for coronary artery disease. Am. J. Cardiol. 98 4S1 (2006) 19-26
75. Metcalf R.G., James M.J., Gibson R.A., et al. Effects of fish-oil supplementation on myocardial fatty acids in humans. Am. J. Clin. Nutr. 85 5 (2007) 1222-1228
76. Courville A.B., Keplinger M.R., Judge M.P., and Lammi-Keefe C.J. Plasma or red blood cell phospholipids can be used to assess docosahexaenoic acid status in women during pregnancy. Nutr. Res. 29 3 (2009) 151-155
77. Lands W.E., Libelt B., Morris A., et al. Maintenance of lower proportions of (n-6) eicosanoid precursors in phospholipids of human plasma in response to added dietary (n-3) fatty acids. Biochim. Biophys. Acta 118 2 (1992) 147-162
78. Lands W.E. Stories about acyl chains. Biochim. Biophys. Acta 1483 1 (2000) 1-14
79. Albert C.M. Dietary n-3 fatty acid intake and risk of sudden death and coronary artery disease. Curr. Treat Options Cardiovasc. Med. 9 1 (2007) 71-77
80. Harris W.S., Poston W.C., and Haddock C.K. Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events. Atherosclerosis 193 1 (2007) 1-10 [Epub]
81. Harris W.S., Sands S.A., Windsor S.L., et al. Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation. Circulation 110 12 (2004) 1645-1649
82. Stark K.D. The percentage of n-3 highly unsaturated fatty acids in total HUFA as a biomarker for omega-3 fatty acid status in tissues. Lipids (2007)
83. Lands W.E. Long-term fat intake and biomarkers. Am. J. Clin. Nutr. 61 3 Suppl (1995) 721S-725S
84. Stark K.D., Beblo S., Murthy M., et al. Comparison of bloodstream fatty acid composition from African-American women at gestation, delivery, and postpartum. J. Lipid Res. 46 3 (2005) 516-525
85. O'Brien D.M., Kristal A.R., Jeannet M.A., Wilkinson M.J., Bersamin A., and Luick B. Red blood cell delta15N: a novel biomarker of dietary eicosapentaenoic acid and docosahexaenoic acid intake. Am. J. Clin. Nutr. 89 3 (2009) 913-919