Cellular cardiomyoplasty: What have we learned?

Asian Cardiovascular and Thoracic Annals

Volumn 17, Issue 1, 2009, Pages 89-101

  Kao, Race L ^a   Browder, William ^a   Li, Chuanfu ^a  

^a East Tennessee State University   (United States)

Author keywords

Adult stem cells; Cardiac; Heart failure; Myocardial infarction; Myocytes

Indexed keywords

TOLL LIKE RECEPTOR 4;

ACUTE HEART INFARCTION; ANTIINFLAMMATORY ACTIVITY; CARDIOMYOPLASTY; CELL CARDIOMYOPLASTY; CELL COUNT; CELL DIFFERENTIATION; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; ENGRAFTMENT; HEALING; HEART INFARCTION SIZE; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE; HEART TRANSPLANTATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HOSPITAL READMISSION; HUMAN; IMMUNOMODULATION; MUSCLE REGENERATION; MYOBLAST; NONHUMAN; REVIEW; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME; ADULT; ADULT STEM CELL; HEART FAILURE; HEART INFARCTION; MESENCHYMAL STEM CELL TRANSPLANTATION; METHODOLOGY; REGENERATION; TRANSPLANTATION;

ADULT; ADULT STEM CELLS; CARDIOMYOPLASTY; HEART FAILURE; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MYOCARDIAL INFARCTION; REGENERATION;

EID: 69449095075     PISSN: 02184923     EISSN: None     Source Type: Journal    
DOI: 10.1177/0218492309104144     Document Type: Review

References (177)

1. Kao RL, Ganote CE, Pennington DG, Browder IW. Myocardial regeneration, tissue engineering and therapy. In: Prakash S, editor. Artificial cells, cell engineering and therapy, 1st ed. Woodhead Publishing Ltd., Cambridge, England, 2007:349-365
2. Olson EN, Schneider MD. Sizing up the heart: development redux in disease. Genes Dev 2003;17:1937-1956
3. Pasumarthi KB, Field LJ. Cardiomyocyte cell cycle regulation [Review]. Circ Res 2002;90:1044-1054 (Pubitemid 34627902)
4. Anversa P, Leri A, Kajstura J, Nadal-Ginard B. Myocyte growth and cardiac repair [Review]. J Mol Cell Cardiol 2002; 34:91-105. (Pubitemid 35222821)
5. Li F, Wang X, Capasso JM, Gerdes AM. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol 1996;28:1737-1746 (Pubitemid 26300573)
6. Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, et al. Heart disease and stroke statistics - 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008;117:e25-146.
7. Kao RL, Chua R-J. Cellular cardiomyoplasty: myocardial repair with cell implantation. Landes, Austin, TX, 1997.
8. Kao RL. Transplantation of satellite cells for myocardial regeneration. In: Kipshidae NN, Serruys PW, editors. Handbook of cardiovascular cell transplantation, 1st ed. Martin Dunitz, London, England, 2004:91-105.
9. Jolicoeur EM, Granger CB, Fakunding JL, Mockrin SC, Grant SM, Ellis SG, et al. Bringing cardiovascular cell-based therapy to clinical application: perspectives based on a National Heart, Lung, and Blood institute Cell Therapy Working Group meeting. Am Heart J 2007;153:732-742
10. Menasché P. Skeletal myoblasts as a therapeutic agent. Prog Cardiovasc Dis 2007;50:7-17.
11. Pelacho B, Luttun A, Aranguren XL, Verfaillie CM, Prosper F. Therapeutic potential of adult progenitor cells in cardiovascular disease [Review]. Expert Opin Biol Ther 2007;7:1153-1165 (Pubitemid 47307262)
12. Gulati R, Simari RD. Cell therapy for acute myocardial infarction [Review]. Med Clin North Am 2007;91:769-785 (Pubitemid 47058138)
13. Liao R, Pfister O, Jain M, Mouquet F. The bone marrow-cardiac axis of myocardial regeneration [Review]. Prog Cardiovasc Dis 2007;50:18-30. (Pubitemid 47049720)
14. Schuleri KH, Boyle AJ, Hare JM. Mesenchymal stem cells for cardiac regenerative therapy [Review]. Handb Exp Pharmacol 2007;180:195-218.
15. Zenovich AG, Davis BH, Taylor DA. Comparison of intracardiac cell transplantation: autologous skeletal myoblasts versus bone marrow cells [Review]. Handb Exp Pharmacol 2007;180:117-165
16. Christoforou N, Gearhart JD. Stem cells and their potential in cell-based cardiac therapies [Review]. Prog Cardiovasc Dis 2007; 49:396-413. (Pubitemid 46693944)
17. Collins SD, Baffour R, Waksman R. Cell therapy in myocardial infarction [Review]. Cardiovasc Revasc Med 2007;8:43-51. (Pubitemid 46216181)
18. Segers VF, Lee RT. Stem-cell therapy for cardiac disease [Review]. Nature 2008;451:937-942
19. Leri A, Kajstura J, Anversa P, Frishman WH. Myocardial regeneration and stem cell repair [Review]. Curr Probl Cardiol 2008;33:91-153. (Pubitemid 351163350)
20. Leri A, Anversa P, Frishman W, editors. Cardiovascular regeneration and stem cell therapy. Hoboken, NJ: Wiley- Blackwell Publishing, 2007.
21. Ahuja P, Sdek P, MacLellan WR. Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev 2007;87:521-544 (Pubitemid 47086282)
22. Pasumarthi KB, Nakajima H, Nakajima HO, Soonpaa MH, Field LJ. Targeted expression of cyclin D2 results in cardiomyo-cyte DNA synthesis and infarct regression in transgenic mice. Circ Res 2005;96:110-118 (Pubitemid 40095760)
23. Hassink RJ, Pasumarthi KB, Nakajima H, Rubart M, Soonpaa MH, de la Rivière AB, et al. Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction. Cardiovasc Res 2008;78:18-25.
24. Engel FB, Schebesta M, Duong MT, Lu G, Ren S, Madwed JB, et al. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev 2005;19:1175-1187 (Pubitemid 40696184)
25. Engel FB, Hsieh PC, Lee RT, Keating MT. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc Natl Acad Sci U S A 2006;103:15546-15551
26. Chaudhry HW, Dashoush NH, Tang H, Zhang L, Wang X, Wu EX, et al. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem 2004;279:35858-35866
27. Cheng RK, Asai T, Tang H, Dashoush NH, Kara RJ, Costa KD, et al. Cyclin A2 induces cardiac regeneration after myocardial infarction and prevents heart failure. Circ Res 2007; 100:1741-1748 (Pubitemid 46987866)
28. Warejcka DJ, Harvey R, Taylor BJ, Young HE, Lucas PA. A population of cells isolated from rat heart capable of differentiating into several mesodermal phenotypes. J Surg Res 1996;62:233-242 (Pubitemid 26142417)
29. Hierlihy AM, Seale P, Lobe CG, Rudnicki MA, Megeney LA. The post-natal heart contains a myocardial stem cell population. FEBS Lett 2002;530:239-243 (Pubitemid 35248218)
30. Gelman AE, LaRosa DF, Zhang J, Walsh PT, Choi Y, Sunyer JO, et al. The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide- mediated costimulation. Immunity 2006;25:783-793 (Pubitemid 46107281)
31. Oyama T, Nagai T, Wada H, Naito AT, Matsuura K, Iwanaga K, et al. Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol 2007;176:329-341 (Pubitemid 46184884)
32. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003;114:763-776 (Pubitemid 37186770)
33. Bearzi C, Rota M, Hosoda T, Tillmanns J, Nascimbene A, De Angelis A, et al. Human cardiac stem cells. Proc Natl Acad Sci U S A 2007;104:14068-14073
34. Oh H, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y, et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A 2003;100:12313-12318
35. Matsuura K, Nagai T, Nishigaki N, Oyama T, Nishi J, Wada H, et al. Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem 2004;279: 11384-11391
36. Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, et al. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 2005;433: 647-653
37. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, et al. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 2006;127:1151-1165 (Pubitemid 44895618)
38. Laugwitz KL, Moretti A, Caron L, Nakano A, Chien KR. Islet1 cardiovascular progenitors: a single source for heart lineages [Review]? Development 2008;135:193-205. (Pubitemid 351228412)
39. Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F, et al. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res 2004;95:911-921 (Pubitemid 39435006)
40. Steele A, Jones OY, Gok F, Marikar Y, Steele P, Chamizo W, et al. Stem-like cells traffic from heart ex vivo, expand in vitro, and can be transplanted in vivo. J Heart Lung Transplant 2005;24:1930-1939 (Pubitemid 41641871)
41. Tang YL, Shen L, Qian K, Phillips MI. A novel two-step procedure to expand cardiac Sca-1+ cells clonally. Biochem Biophys Res Commun 2007;359:877-883 (Pubitemid 46946901)
42. Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, et al. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation 2007;115:896-908. (Pubitemid 46294730)
43. Anversa P, Kajstura J, Leri A, Bolli R. Life and death of cardiac stem cells: a paradigm shift in cardiac biology. Circulation 2006;113:1451-1463 (Pubitemid 43739442)
44. Steele A, Steele P. Stem cells for repair of the heart [Review]. Curr Opin Pediatr 2006;18:518-523 (Pubitemid 44403696)
45. Lyngbaek S, Schneider M, Hansen JL, Sheikh SP. Cardiac regeneration by resident stem and progenitor cells in the adult heart. Basic Res Cardiol 2007;102:101-114 (Pubitemid 46193950)
46. Anversa P, Leri A, Rota M, Anversa P, Leri A, Rota M. Concise review: stem cells, myocardial regeneration, and methodological artifacts [Review]. Stem Cells 2007;25:589-601. (Pubitemid 46354217)
47. Guan K, Hasenfuss G. Do stem cells in the heart truly differentiate into cardiomyocytes [Review]?. J Mol Cell Cardiol 2007;43: 377-387 (Pubitemid 47451429)
48. Barile L, Messina E, Giacomello A, Marban E. Endogenous cardiac stem cells [Review]. Prog Cardiovasc Dis 2007;50:31-48. (Pubitemid 47042841)
49. Wagers AJ, Weissman IL. Plasticity of adult stem cells [Review]. Cell 2004;116:639-648 (Pubitemid 38326723)
50. Lakshmipathy U, Verfaillie C. Stem cell plasticity [Review]. Blood Rev 2005;19:29-38.
51. Vieyra DS, Jackson KA, Goodell MA. Plasticity and tissue regenerative potential of bone marrow-derived cells [Review]. Stem Cell Rev 2005;1:65-69 (Pubitemid 41003466)
52. Warburton D, Koh C, Chung HM, Cha KR, Kim KS. Meeting report: the first international collaborative symposium on stem cell research, Seoul, Korea. Stem Cells 2007;25:1337-1338 (Pubitemid 46684896)
53. Singec I, Jandial R, Crain A, Nikkhah G, Snyder EY. The leading edge of stem cell therapeutics [Review]. Annu Rev Med 2007; 58:313-328 (Pubitemid 46706517)
54. Burt RK, Loh Y, Pearce W, Beohar N, Barr WG, Craig R, et al. Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases [Review]. JAMA 2008; 299:925-936
55. Jawad H, Ali NN, Lyon AR, Chen QZ, Harding SE, Boccaccini AR. Myocardial tissue engineering: a review. J Tissue Eng Regen Med 2007;1:327-342
56. Wu KH, Mo XM, Liu YL, Zhang YS, Han ZC. Stem cells for tissue engineering of myocardial constructs [Review]. Ageing Res Rev 2007;6:289-301. (Pubitemid 350130349)
57. Giraud MN, Armbruster C, Carrel T, Tevaearai HT. Current state of the art in myocardial tissue engineering [Review]. Tissue Eng 2007;13:1825-1836.
58. Chiu RC, Zibaitis A, Kao RL. Cellular cardiomyoplasty: myocardial regeneration with satellite cell implantation. Ann Thorac Surg 1995;60:12-18
59. Taylor DA, Atkins BZ, Hungspreugs P, Jones TR, Reedy MC, Hutcheson KA, et al. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat Med 1998;4:929-933 (Pubitemid 28364032)
60. Hagège AA, Marolleau JP, Vilquin JT, Alhéritière A, Peyrard S, Duboc D, et al. Skeletal myoblast transplantation in ischemic heart failure: long-term follow-up of the first phase I cohort of patients. Circulation 2006;114(Suppl I):108-113
61. Prockop DJ, Olson SD. Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions [Review]. Blood 2007;109:3147-3151
62. McMullen NM, Pasumarthi KB. Donor cell transplantation for myocardial disease: does it complement current pharmacological therapies [Review]?. Can J Physiol Pharmacol 2007;85:1-15.
63. Dib N, Michler RE, Pagani FD, Wright S, Kereiakes DJ, Lengerich R, et al. Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four-year follow-up. Circulation 2005;112:1748-1755 (Pubitemid 41368151)
64. Menasché P, Alfieri O, Janssens S, McKenna W, Reichenspurner H, Trinquart L, et al. The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation 2008;117:1189-1200 (Pubitemid 351552018)
65. Cleland JG, Coletta AP, Abdellah AT, Cullington D, Clark AL, Rigby AS. Clinical trials update from the American Heart Association 2007: CORONA, RethinQ, MASCOT, AF-CHF, HART, MASTER, POISE and stem cell therapy. Eur J Heart Fail 2008;10:102-108
66. Tomita S, Li RK, Weisel RD, Mickle DA, Kim EJ, Sakai T, et al. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 1999;100(Suppl II):247-256
67. Wang JS, Shum-Tim D, Galipeau J, Chedrawy E, Eliopoulos N, Chiu RC. Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages. J Thorac Cardiovasc Surg 2000;120:999-1005.
68. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001;410:701-705
69. Luo J, Chiu RCJ, Tim-Shum D. Bone marrow stromal cells as "universal donar cells" for myocardical regeneration therapy. In: Prakash S, editor. Artificial cells, cell engineering and therapy. Woodhead Publishing Ltd., Cambridge, England, 2007:333-348
70. Schächinger V, Assmus B, Britten MB, Honold J, Lehmann R, Teupe C, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial. J Am Coll Cardiol 2004; 44:1690-1699 (Pubitemid 39369805)
71. Strauer BE, Brehm M, Zeus T, Bartsch T, Schannwell C, Antke C, et al. Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT Study. J Am Coll Cardiol 2005;46:1651-1658 (Pubitemid 41531618)
72. Meyer GP, Wollert KC, Lotz J, Steffens J, Lippolt P, Fichtner S, et al. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation 2006;113:1287-1294 (Pubitemid 43739450)
73. Kang HJ, Lee HY, Na SH, Chang SA, Park KW, Kim HK, et al. Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial. Circulation 2006;114(Suppl I):145-151
74. Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Egeland T, et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 2006;355:1199-1209 (Pubitemid 44427444)
75. Meluzín J, Mayer J, Groch L, Janousek S, Hornácek I, Hlinomaz O, et al. Autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction: the effect of the dose of transplanted cells on myocardial function. Am Heart J 2006;152:975.E9-15
76. Lunde K, Solheim S, Aakhus S, Arnesen H, Moum T, Abdelnoor M, et al. Exercise capacity and quality of life after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: results from the Autologous Stem cell Transplantation in Acute Myocardial Infarction (ASTAMI) randomized controlled trial. Am Heart J 2007;154: 710.e1-8
77. Erbs S, Linke A, Adams V, Lenk K, Thiele H, Diederich KW, et al. Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study. Circ Res 2005;97: 756-762 (Pubitemid 41447125)
78. Janssens S, Dubois C, Bogaert J, Theunissen K, Deroose C, Desmet W, et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 2006;367:113-121 (Pubitemid 43077127)
79. Schächinger V, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Hölschermann H, et al. Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIRAMI trial. Eur Heart J 2006;27:2775-2783 (Pubitemid 44871463)
80. Hirsch A, Nijveldt R, van der Vleuten PA, Biemond BJ, Doevendans PA, van Rossum AC, et al. Intracoronary infusion of autologous mononuclear bone marrow cells or peripheral mononuclear blood cells after primary percutaneous coronary intervention: rationale and design of the HEBE trial - a prospective, multicenter, randomized trial. Am Heart J 2006;152:434-441 (Pubitemid 44233416)
81. Hirsch A, Nijveldt R, van der Vleuten PA, Tio RA, van der Giessen WJ, Marques KM, et al. Intracoronary infusion of autologous mononuclear bone marrow cells in patients with acute myocardial infarction treated with primary PCI: pilot study of the multicenter HEBE trial. Catheter Cardiovasc Interv 2008;71:273-281
82. Nyolczas N, GyöngyösiM, Beran G, Dettke M, Graf S, Sochor H, et al. Design and rationale for the Myocardial Stem Cell Administration After Acute Myocardial Infarction (MYSTAR) Study: a multicenter, prospective, randomized, single-blind trial comparing early and late intracoronary or combined (percutaneous intramyocardial and intracoronary) administration of nonselected autologous bone marrow cells to patients after acute myocardial infarction. Am Heart J 2007; 153:212.e1-7
83. Hristov M, Heussen N, Schober A, Weber C. Intracoronary infusion of autologous bone marrow cells and left ventricular function after acute myocardial infarction: a meta-analysis. J Cell Mol Med 2006;10:727-733 (Pubitemid 44874281)
84. Lipinski MJ, Biondi-Zoccai GG, Abbate A, Khianey R, Sheiban I, Bartunek J, et al. Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials. J Am Coll Cardiol 2007;50:1761-1767 (Pubitemid 47600592)
85. Abdel-Latif A, Bolli R, Tleyjeh IM, Montori VM, Perin EC, Hornung CA, et al. Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med 2007;167:989-997 (Pubitemid 46835786)
86. Müller-Ehmsen J, Krausgrill B, Burst V, Schenk K, Neisen UC, Fries JW, et al. Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction. J Mol Cell Cardiol 2006;41:876-884 (Pubitemid 44635568)
87. Laflamme MA, Zbinden S, Epstein SE, Murry CE. Cell-based therapy for myocardial ischemia and infarction: pathophysiological mechanisms. Annu Rev Pathol 2007;2:307-339 (Pubitemid 46448068)
88. Schuldt AJ, Rosen MR, Gaudette GR, Cohen IS. Repairing damaged myocardium: evaluating cells used for cardiac regeneration. Curr Treat Options Cardiovasc Med 2008;10:59-72.
89. Al Kindi A, Ge Y, Shum-Tim D, Chiu RC. Cellular cardio-myoplasty: routes of cell delivery and retention. Front Biosci 2008;13:2421-2434 (Pubitemid 351599695)
90. Dow J, Simkhovich BZ, Kedes L, Kloner RA. Washout of transplanted cells from the heart: a potential new hurdle for cell transplantation therapy. Cardiovasc Res 2005;67:301-307 (Pubitemid 40943623)
91. Teng CJ, Luo J, Chiu RC, Shum-Tim D. Massive mechanical loss of microspheres with direct intramyocardial injection in the beating heart: implications for cellular cardiomyoplasty. J Thorac Cardiovasc Surg 2006;132:628-632 (Pubitemid 44278933)
92. Anderl JN, Robey TE, Stayton PS, Murry CE. Retention and biodistribution of microspheres injected into ischemic myocardium. J Biomed Mater Res A 2008 Mar 11. 2009; 88:704-710
93. Oh H, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y, et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A 2003;100:12313-12318
94. Oh H, Chi X, Bradfute SB, Mishina Y, Pocius J, Michael LH, et al. Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells. Ann N Y Acad Sci 2004;1015:182-189 (Pubitemid 38879489)
95. Kajstura J, Rota M, Whang B, Cascapera S, Hosoda T, Bearzi C, et al. Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ Res 2005;96:127-137 (Pubitemid 40095762)
96. Rota M, Kajstura J, Hosoda T, Bearzi C, Vitale S, Esposito G, et al. Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci USA 2007;104: 17783-17788 (Pubitemid 350210912)
97. Atoui R, Asenjo JF, Duong M, Chen G, Chiu RC, Shum-Tim D. Marrow stromal cells as universal donor cells for myocardial regenerative therapy: their unique immune tolerance. Ann Thorac Surg 2008;85:571-579 (Pubitemid 351147818)
98. Agbulut O, Vandervelde S, Al Attar N, Larghero J, Ghostine S, Léobon B, et al. Comparison of human skeletal myoblasts and bone marrow-derived CD133+ progenitors for the repair of infarcted myocardium. J Am Coll Cardiol 2004;44:458-463 (Pubitemid 38950611)
99. Guarita-Souza LC, Carvalho KA, Rebelatto C, Senegaglia A, Hansen P, Furuta M, et al. Cell transplantation: differential effects of myoblasts and mesenchymal stem cells. Int J Cardiol 2006;111:423-429 (Pubitemid 44205295)
100. Thompson RB, Emani SM, Davis BH, van den Bos EJ, Morimoto Y, Craig D, et al. Comparison of intracardiac cell transplantation: autologous skeletal myoblasts versus bone marrow cells. Circulation 2003;108(Suppl II):264-271
101. Ye L, Haider HKH, Sim EK. Adult stem cells for cardiac repair: a choice between skeletal myoblasts and bone marrow stem cells [Review]. Exp Biol Med (Maywood) 2006;231:8-19. (Pubitemid 43063973)
102. Assmus B, Honold J, Schächinger V, Britten MB, Fischer- Rasokat U, Lehmann R, et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006;355:1222-1232 (Pubitemid 44427446)
103. Seeger FH, Tonn T, Krzossok N, Zeiher AM, Dimmeler S. Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction. Eur Heart J 2007;28:766-772 (Pubitemid 46439231)
104. Bartunek J, Dimmeler S, Drexler H, Fernández-Avilés F, Galinanes M, Janssens S, et al. The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart. Eur Heart J 2006;27:1338-1340 (Pubitemid 43998109)
105. Dimmeler S, Burchfield J, Zeiher AM. Cell-based therapy of myocardial infarction [Review]. Arterioscler Thromb Vasc Biol 2008;28:208-216 (Pubitemid 351161191)
106. Laflamme MA, Murry CE. Regenerating the heart [Review]. Nat Biotechnol 2005;23:845-856
107. Frangogiannis NG. The mechanistic basis of infarct healing [Review]. Antioxid Redox Signal 2006;8:1907-1939.
108. Li RK, Mickle DA, Weisel RD, Rao V, Jia ZQ. Optimal time for cardiomyocyte transplantation to maximize myocardial function after left ventricular injury. Ann Thorac Surg 2001;72:1957-1963 (Pubitemid 34001449)
109. Frantz S, Bauersachs J, Kelly RA. Innate immunity and the heart [Review]. Curr Pharm Des 2005;11:1279-1290
110. Linde A, Mosier D, Blecha F, Melgarejo T. Innate immunity and inflammation - New frontiers in comparative cardiovascular pathology. Cardiovasc Res 2007;73:26-36. (Pubitemid 44937178)
111. Baumgarten G, Kim SC, Stapel H, Vervólgyi V, Bittig A, Hoeft A, et al. Myocardial injury modulates the innate immune system and changes myocardial sensitivity. Basic Res Cardiol 2006;101:427-435 (Pubitemid 44275876)
112. Torre-Amione G, Kapadia S, Lee J, Durand JB, Bies RD, Young JB, et al. Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation 1996;93:704-711 (Pubitemid 26052456)
113. Kapadia S, Dibbs Z, Kurrelmeyer K, Kalra D, Seta Y, Wang F, et al. The role of cytokines in the failing human heart. Cardiol Clin 1998;16:645-656 (Pubitemid 28509448)
114. Yamazaki T, Seko Y, Tamatani T, Miyasaka M, Yagita H, Okumura K, et al. Expression of intercellular adhesion molecule- 1 in rat heart with ischemia/reperfusion and limitation of infarct size by treatment with antibodies against cell adhesion molecules. Am J Pathol 1993;143:410-418 (Pubitemid 24058196)
115. Kukielka GL, Smith CW, Manning AM, Youker KA, Michael L, Entman ML. Induction of interleukin-6 synthesis in the myocardium. Potential role in postreperfusion inflammatory injury. Circulation 1995;92:1866-1875
116. Kukielka GL, Smith CW, LaRosa GJ, Manning AM, Mendoza LH, Daly TJ, et al. Interleukin-8 gene induction in the myocardium after ischemia and reperfusion in vivo. J Clin Invest 1995;95:89-103.
117. Herskowitz A, Choi S, Ansari AA, Wesselingh S. Cytokine mRNA expression in postischemic/reperfusion myocardium. Am J Pathol 1995;146:419-428
118. Mann DL. Stress activated cytokines and the hearts [Review]. Cytokine Growth Factor Rev 1996;7:341-354
119. Kelly RA, Smith TW. Cytokines and cardiac contractile function [Review]. Circulation 1997;95:778-781 (Pubitemid 27091510)
120. Ono K, Matsumori A, Shioi T, Furukawa Y, Sasayama S. Cytokine gene expression after myocardial infarction in rat hearts: possible implication in left ventricular remodeling. Circulation 1998;98:148-156
121. Medzhitov R, Preston-Hurlburt P, Janeway CA, Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-397
122. Zhang G, Ghosh S. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity [Review]. J Clin Invest 2001;107:13-19 (Pubitemid 32047406)
123. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response [Review]. Nature 2000;406:782-787 (Pubitemid 30671237)
124. Doyle SL, O'Neill LA. Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity [Review]. Biochem Pharmacol 2006;72: 1102-1113
125. Tomchuck SL, Zwezdaryk KJ, Coffelt SB, Waterman RS, Danka ES, Scandurro AB. Toll-like receptors on human mesenchymal stem cells drive their migration and immunomo-dulating responses. Stem Cells 2008;26:99-107.
126. Li C, Browder W, Kao RL. Early activation of transcription factor NF-kappaB during ischemia in perfused rat heart. Am J Physiol 1999;276:H543-52.
127. Li C, Kao RL, Ha T, Kelley J, Browder IW, Williams DL. Early Activation of IKKbeta during in vivo myocardial ischemia. Am J Physiol Heart Circ Physiol 2001;280:H1264-71.
128. Li C, Ha T, Liu L, Browder W, Kao RL. Adenosine prevents activation of transcription factor NF-kappa B and enhances activator protein-1 binding activity in ischemic rat heart. Surgery 2000;127:161-169 (Pubitemid 30091262)
129. Chandrasekar B, Freeman GL. Induction of nuclear factor kappaB and activation protein 1 in postischemic myocardium. FEBS Lett 1997;401:30-34 (Pubitemid 27051252)
130. Chandrasekar B, Streitman JE, Colston JT, Freeman GL. Inhibition of nuclear factor kappaB attenuates proinflammatory cytokine and inducible nitric-oxide synthase expression in postischemic myocardium. Biochim Biophys Acta 1998;1406: 91-106. (Pubitemid 28162315)
131. Sun B, Fan H, Honda T, Fujimaki R, Lafond-Walker A, Masui Y, et al. Activation of NF kappa B and expression of ICAM-1 in ischemic-reperfusion canine myocardium. J Mol Cell Cardiol 2001;33:109-119 (Pubitemid 32127788)
132. Morishita R, Sugimoto T, Aoki M, Kida I, Tomita N, Moriguchi A, et al. In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction. Nat Med 1997;3:894-899
133. Kawano S, Kubota T, Monden Y, Tsutsumi T, Inoue T, Kawamura N, et al. Blockade of NF-kappaB improves cardiac function and survival after myocardial infarction. Am J Physiol Heart Circ Physiol 2006;291:H1337-44.
134. Hua F, Ha T, Ma J, Li Y, Kelley J, Gao X, et al. Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism. J Immunol 2007;178:7317-7324 (Pubitemid 46847459)
135. Shimamoto A, Chong AJ, Yada M, Shomura S, Takayama H, Fleisig AJ, et al. Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury. Circulation 2006;114(Suppl I):270-274
136. Li C, Ha T, Kelley J, Gao X, Qiu Y, Kao RL, et al. Modulating Toll-like receptor mediated signaling by (1→3)-beta-D-glucan rapidly induces cardioprotection. Cardiovasc Res 2004;61: 538-547 (Pubitemid 38210159)
137. Hua F, Ha T, Ma J, Gao X, Kelley J, Williams DL, et al. Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts. Biochem Biophys Res Comm 2005;338:1118-1125 (Pubitemid 41597753)
138. Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, Willnow T, et al. Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress. Circulation 2006;113:1203-1212 (Pubitemid 43754246)
139. Abbate A, Bussani R, Amin MS, Vetrovec GW, Baldi A. Acuta myocardial infarction and heart failure: role of apoptosis. Int J Biochem Cell Biol 2006;38:1834-1840 (Pubitemid 44425247)
140. Kaiser WJ, Offermann MK. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol 2005;174: 4942-4952
141. Fan W, Ha T, Li Y, Ozment-Skelton T, Williams DL, Kelley J, et al. Overexpression of TLR2 and TLR4 susceptibility to serum deprivation-induced apoptosis in CHO cells. Biochem Biophys Res Commun 2005;337:840-848 (Pubitemid 41446990)
142. Haase R, Kirschning CJ, Sing A, Schröttner P, Fukase K, Kusumoto S, et al. A dominant role of Toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages. J Immunol 2003;171:4294-4303 (Pubitemid 37238708)
143. Moynagh PN. TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway. Trends Immunol 2005;26:469-476
144. De Trez C, Pajak B, Brait M, Glaichenhaus N, Urbain J, Moser M, et al. TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo. J Immunol 2005;175:839-846 (Pubitemid 41094966)
145. Cantley LC. The phosphoinositide 3-kinase pathway [Review]. Science 2002;296:1655-1657
146. Takahama H, Minamino T, Hirata A, Ogai A, Asanuma H, Fujita M, et al. Granulocyte colony-stimulating factor mediates cardioprotection against ischemia/reperfusion injury via phosphatidylinositol- 3-kinase/Akt pathway in canine hearts. Cardiovasc Drugs Ther 2006;20:159-65.
147. Ravingerová T, Matejíková J, Neckár J, Andelová E, Kolár F. Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart. Mol Cell Biochem 2007;297:111-120
148. Uccelli A, Pistoia V, Moretta L. Mesenchymal stem cells: a new strategy for immunosuppression [Review]? Trends Immunol 2007;28:219-226 (Pubitemid 46667240)
149. Stagg J. Immune regulation by mesenchymal stem cells: two sides to the coin [Review]. Tissue Antigens 2007;69:1-9. (Pubitemid 46025333)
150. Rasmusson I. Immune modulation by mesenchymal stem cells [Review]. Exp Cell Res 2006;312:2169-2179 (Pubitemid 43928946)
151. Chen X, Armstrong MA, Li G. Mesenchymal stem cells in immunoregulation [Review]. Immunol Cell Biol 2006;84: 413-421 (Pubitemid 44286034)
152. Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, Cazzanti F, et al. Human mesenchymal stem cells modulate B-cell functions. Blood 2006;107:367-372
153. Nauta AJ, Kruisselbrink AB, Lurvink E, Willemze R, Fibbe WE. Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J Immunol 2006;177:2080-2087 (Pubitemid 44200965)
154. Thum T, Bauersachs J, Poole-Wilson PA, Volk HD, Anker SD. The dying stem cell hypothesis: immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle. J Am Coll Cardiol 2005;46:1799-1802 (Pubitemid 41579799)
155. Liu G, Wu C, Wu Y, Zhao Y. Phagocytosis of apoptotic cells and immune regulation. Scand J Immunol 2006;64:1-9. (Pubitemid 44195097)
156. Skoberne M, Beignon AS, Larsson M, Bhardwaj N. Apoptotic cells at the crossroads of tolerance and immunity [Review]. Curr Top Microbiol Immunol 2005;289:259-292 (Pubitemid 40283467)
157. Quah BJ, O'Neill HC. Maturation of function in dendritic cells for tolerance and immunity [Review]. J Cell Mol Med 2005;9: 643-654 (Pubitemid 44151951)
158. Wallet MA, Sen P, Tisch R. Immunoregulation of dendritic cells [Review]. Clin Med Res 2005;3:166-175
159. Taams LS, Akbar AN. Peripheral generation and function of CD4+CD25+regulatory T cells [Review]. Curr Top Microbiol Immunol 2005;293:115-131 (Pubitemid 40791227)
160. Kubach J, Becker C, Schmitt E, Steinbrink K, Huter E, Tuettenberg A, et al. Dendritic cells: sentinels of immunity and tolerance [Review]. Int J Hematol 2005;81:197-203. (Pubitemid 41364484)
161. Ferguson TA, Kazama H. Signals from dying cells: tolerance induction by the dendritic cell [Review]. Immunol Res 2005;32:99-108. (Pubitemid 41153617)
162. Nussbaum J, Minami E, Laflamme MA, Virag JA, Ware CB, Masino A, et al. Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J 2007;21:1345-1357 (Pubitemid 46684837)
163. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676 (Pubitemid 44233629)
164. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131: 861-872 (Pubitemid 350138099)
165. Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007;448:318-324
166. Meissner A, Wernig M, Jaenisch R. Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol 2007;25:1177-1181 (Pubitemid 47538112)
167. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-1920
168. Aoi T, Yae K, Nakagawa M, Ichisaka T, Okita K, Takahashi K, et al. Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 2008;321:699-702.
169. Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK, et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 2007; 25:1015-1024 (Pubitemid 47517637)
170. Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, et al. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc Natl Acad Sci U S A 2006;103:6907-6912
171. Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999;103: 697-705. (Pubitemid 29122423)
172. Fukuhara S, Tomita S, Yamashiro S, Morisaki T, Yutani C, Kitamura S, et al. Direct cell-cell interaction of cardiomyocytes is key for bone marrow stromal cells to go into cardiac lineage in vitro. J Thorac Cardiovasc Surg 2003;125:1470-1480 (Pubitemid 36759250)
173. Lanza R, Rosenthal N. The stem cell challenge. Sci Am 2004; 290:92-99
174. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 2000;6:1282-1286
175. Saito T, Kuang JQ, Bittira B, Al-Khaldi A, Chiu RC. Xenotransplant cardiac chimera: immune tolerance of adult stem cells. Ann Thorac Surg 2002;74:19-24. (Pubitemid 34741999)
176. MacDonald DJ, Luo J, Saito T, Duong M, Bernier PL, Chiu RC, et al. Persistence of marrow stromal cells implanted into acutely infarcted myocardium: observations in a xenotransplant model. J Thorac Cardiovasc Surg 2005;130: 1114-1121 (Pubitemid 41427349)
177. Makkar RR, Price MJ, Lill M, Frantzen M, Takizawa K, Kleisli T, et al. Intramyocardial injection of allogenic bone marrow-derived mesenchymal stem cells without immunosuppression preserves cardiac function in a porcine model of myocardial infarction. J Cardiovasc Pharmacol Ther 2005;10: 225-233 (Pubitemid 43003333)