Senescence, apoptosis, and stem cell biology: The rationale for an expanded view of intracrine action

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 3, 2009, Pages

  Re, Richard N ^a   Cook, Julia L ^a  

^a OCHSNER CLINIC FOUNDATION   (United States)

Author keywords

Atherosclerosis; Laterality

Indexed keywords

ANGIOTENSIN II; ATRIAL NATRIURETIC FACTOR; BETA INTERFERON; CYTOKINE; DNA BINDING PROTEIN; ENDOTHELIN; ENZYME; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 3; GAMMA INTERFERON; GONADORELIN; GROWTH FACTOR; HORMONE; INSULIN; MASPIN; MIDKINE; NERVE GROWTH FACTOR ANTIBODY; NEUROPEPTIDE Y; PEPTIDE DERIVATIVE; PLATELET DERIVED GROWTH FACTOR; PLEIOTROPHIN; PROENKEPHALIN; PROLACTIN; PROTIRELIN; SOMATOMEDIN C; UNINDEXED DRUG; VASCULOTROPIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

APOPTOSIS; CELL COMMUNICATION; EXOSOME; HUMAN; INTRACELLULAR SPACE; INTRACRINE ACTION; PRIORITY JOURNAL; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; SENESCENCE; STEM CELL;

ANIMALS; APOPTOSIS; CARDIOVASCULAR DISEASES; CELL AGING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 69249159945     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00414.2009     Document Type: Review

References (84)

1. Abbott DE, Postovit LM, Seftor EA, Margaryan NV, Seftor RE, Hendrix MJ. Exploiting the convergence of embryonic and tumorigenic signaling pathways to develop new therapeutic targets. Stem Cell Rev 3: 68-78, 2007.
2. Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E., Gil J. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133: 1006-1018, 2008.
3. Acosta JC, O'Loghlen A, Banito A, Raguz S, Gil J. Control of senescence by CXCR2 and its ligands. Cell Cycle 7: 2956-2959, 2008.
4. Aharon A, Tamari T, Brenner B. Monocyte-derived microparticles and exosomes induce procoagulant and apoptotic effects on endothelial cells. Thromb Haemost 100: 878-885, 2008.
5. Alam MM, Mohammad AA, Shuaib U, Wang C, Ghani U, Schwindt B, Todd KG, Shuaib A. Homocysteine reduces endothelial progenitor cells in stroke patients through apoptosis. J Cereb Blood Flow Metab 29: 157-165, 2009.
6. Alberti L, Thomachot MC, Bachelot T, Menetrier-Caux C, Puisieux I, Blay JY. IL-6 as an intracrine growth factor for renal carcinoma cell lines. Int J Cancer 111: 653-661, 2004.
7. Al-Nedawi K, Meehan B, Kerbel RS, Allison AC, Rak J. Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc Natl Acad Sci USA 106: 3794-3799, 2009.
8. Aviv A, Chen W, Gardner JP, Kimura M, Brimacombe M, Cao X, Srinivasan SR, Berenson GS. Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol 169: 323-329, 2009.
9. Aviv A, Shay J, Christensen K, Wright W. The longevity gender gap: are telomeres the explanation? Sci Aging Knowledge Environ 2005: pe16, 2005.
10. Bartek J, Hodny Z, Lukas J. Cytokine loops driving senescence. Nat Cell Biol 10: 887-889, 2008.
11. Bazile F, Pascal A, Arnal I, Le Clainche C, Chesnel F, Kubiak JZ. Complex relationship between TCTP, microtubules and actin microfilaments regulates cell shape in normal and cancer cells. Carcinogenesis 30: 555-565, 2009.
12. Beiko RG, Doolittle WF, Charlebois RL. The impact of reticulate evolution on genome phylogeny. Syst Biol 57: 844-856, 2008.
13. Beliveau A, Bassett E, Lo AT, Garbe J, Rubio MA, Bissell MJ, Campisi J, Yaswen P. p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci USA 104: 4431-4436, 2007.
14. Benetos A, Gardner JP, Zureik M, Labat C, Xiaobin L, Adamopoulos C, Temmar M, Bean KE, Thomas F, Aviv A. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension 43: 182-185, 2004
15. Bergsmedh A, Szeles A, Henriksson M, Bratt A, Folkman MJ, Spetz AL, Holmgren L. Horizontal transfer of oncogenes by uptake of apoptotic bodies. Proc Natl Acad Sci USA 98: 6407-6411, 2001.
16. Block GJ, Ohkouchi S, Fung F, Frenkel J, Gregory C, Pochampally R, Dimattia G, Sullivan DE, Prockop DJ. Multipotent stromal cells (MSCs) are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1 (STC-1). Stem Cells 27: 670-681, 2009.
17. Brouilette SW, Whittaker A, Stevens SE, van der Harst P, Goodall AH, Samani NJ. Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis. Heart 94: 422-425, 2008.
18. Campisi J. Aging and cancer cell biology, 2008. Aging Cell 7: 281-284, 2008.
19. Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8: 729-740, 2007.
20. Chang AC, Cha J, Koentgen F, Reddel RR. The murine stanniocalcin 1 gene is not essential for growth and development. Mol Cell Biol 25: 10604-10610, 2005.
21. Chen W, Gardner JP, Kimura M, Brimacombe M, Cao X, Srinivasan SR, Berenson GS, Aviv A. Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study. Atherosclerosis. In press.
22. Chien Y, Lowe SW. Secreting tumor suppression. Cell 132: 339-341, 2008.
23. Coppé JP, Kauser K, Campisi J, Beauséjour CM. Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem 281: 29568-29574, 2006.
24. Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6: 2853-2868, 2008.
25. Ellard JP, McCudden CR, Tanega C, James KA, Ratkovic S, Staples JF, Wagner GF. The respiratory effects of stanniocalcin-1 (STC-1) on intact mitochondria and cells: STC-1 uncouples oxidative phosphorylation and its actions are modulated by nucleotide triphosphates. Mol Cell Endocrinol 264: 90-101, 2007.
26. Erusalimsky JD, Kurz DJ. Cellular senescence in vivo: its relevance in ageing and cardiovascular disease. Exp Gerontol 40: 634-642, 2005.
27. Erusalimsky JD, Kurz DJ. Endothelial cell senescence. Handb Exp Pharmacol 176: 213-248, 2006.
28. Gagliardi M, Piddini E, Vincent JP. Endocytosis: a positive or a negative influence on Wnt signalling? Traffic 9: 1-9, 2008.
29. Gnecchi M, Zhang Z, Ni A, Dzau VJ. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 103: 1204-1219, 2008.
30. Hasilo CP, McCudden CR, Gillespie JR, James KA, Hirvi ER, Zaidi D, Wagner GF. Nuclear targeting of stanniocalcin to mammary gland alveolar cells during pregnancy and lactation. Am J Physiol Endocrinol Metab 289: E634-E642, 2005.
31. Hayflick L. The illusion of cell immortality. Br J Cancer 83: 841-846, 2000.
32. Hendrix MJ, Seftor EA, Seftor RE, Kasemeier-Kulesa J, Kulesa PM, Postovit LM. Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev Cancer 7: 246-255, 2007.
33. Huang J, Yao JL, Zhang L, Bourne PA, Quinn AM, di Sant'Agnese PA, Reeder JE. Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer. Am J Pathol 166: 1807-1815, 2005.
34. Hung SC, Pochampally RR, Chen SC, Hsu SC, Prockop DJ. Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis. Stem Cells 25: 2363-2370, 2007.
35. Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, Xiao T, Schafer J, Lee ML, Schmittgen TD, Nana-Sinkam SP, Jarjoura D, Marsh CB. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 3: e3694, 2008.
36. Jiang H, Schiffer E, Song Z, Wang J, Zürbig P, Thedieck K, Moes S, Bantel H, Saal N, Jantos J, Brecht M, Jenö P, Hall MN, Hager K, Manns MP, Hecker H, Ganser A, Döhner K, Bartke A, Meissner C, Mischak H, Ju Z, Rudolph KL. Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci USA 105: 11299-11304, 2008.
37. Kirman I, Poltoratskaia N, Sylla P, Whelan RL. Insulin-like growth factor-binding protein 3 inhibits growth of experimental colocarcinoma. Surgery 136: 205-209, 2004.
38. Kostin S, Popescu LM. A distinct type of cell in myocardium: interstitial Cajal-like cells (ICLCs). J Cell Mol Med 13: 295-308, 2009.
39. Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A, Ratajczak J, Ratajczak MZ. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 23: 879-894, 2005.
40. Kuro-O M. Klotho and aging. Biochim Biophys Acta. In press.
41. Kutsukake M, Ishihara R, Yoshie M, Kogo H, Tamura K. Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells. Mol Hum Reprod 13: 737-743, 2007.
42. Lehmann BD, Paine MS, Brooks AM, McCubrey JA, Renegar RH, Wang R, Terrian DM. Senescence-associated exosome release from human prostate cancer cells. Cancer Res 68: 7864-7871, 2008.
43. Lesaffre B, Joliot A, Prochiantz A, Volovitch M. Direct non-cell autonomous Pax6 activity regulates eye development in the zebrafish. Neural Dev 2: 2, 2007.
44. Lespagnol A, Duflaut D, Beekman C, Blanc L, Fiucci G, Marine JC, Vidal M, Amson R, Telerman A. Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ 15: 1723-1733, 2008.
45. Li GZ, Eller MS, Firoozabadi R, Gilchrest BA. Evidence that exposure of the telomere 3′ overhang sequence induces senescence. Proc Natl Acad Sci USA 100: 527-531, 2003.
46. Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, Chen J, Malide D, Rovira II, Schimel D, Kuo CJ, Gutkind JS, Hwang PM, Finkel T. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317: 803-806, 2007.
47. Ma Y, Lu B, Ruan W, Wang H, Lin J, Hu H, Deng H, Huang Q, Lai M. Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cells. Exp Mol Pathol 85: 141-145, 2008.
48. McCudden CR, James KA, Hasilo C, Wagner GF. Characterization of mammalian stanniocalcin receptors. Mitochondrial targeting of ligand and receptor for regulation of cellular metabolism. J Biol Chem 277: 45249-45258, 2002.
49. Mimeault M, Batra SK. Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications. Ageing Res Rev 8: 94-112, 2009.
50. Muck C, Micutkova L, Zwerschke W, Jansen-Durr P. Role of insulin-like growth factor binding protein-3 in human umbilical vein endothelial cell senescence. Rejuvenation Res 11: 449-453, 2008.
51. Pearson BJ, Sánchez Alvarado A. Regeneration, stem cells, and the evolution of tumor suppression. Cold Spring Harb Symp Quant Biol 73: 565-572, 2008.
52. Ponnusamy MP, Batra SK. Ovarian cancer: emerging concept on cancer stem cells. J Ovarian Res 1: 4-12, 2008.
53. Postovit LM, Costa FF, Bischof JM, Seftor EA, Wen B, Seftor RE, Feinberg AP, Soares MB, Hendrix MJ. The commonality of plasticity underlying multipotent tumor cells and embryonic stem cells. J Cell Biochem 101: 908-917, 2007.
54. Postovit LM, Margaryan NV, Seftor EA, Kirschmann DA, Lipavsky A, Wheaton WW, Abbott DE, Seftor RE, Hendrix MJ. Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc Natl Acad Sci USA 105: 4329-4334, 2008.
55. Postovit LM, Seftor EA, Seftor RE, Hendrix MJ. Targeting Nodal in malignant melanoma cells. Expert Opin Ther Targets 11: 497-505, 2007.
56. Rahman R, Forsyth NR, Cui W. Telomeric 3′-overhang length is associated with the size of telomeres. Exp Gerontol 43: 258-265, 2008.
57. Ratajczak J, Miekus K, Kucia M, Zhang J, Reca R, Dvorak P, Ratajczak MZ. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20: 847-856, 2006.
58. Re R. The nature of intracrine peptide hormone action. Hypertension 34: 534-538, 1999.
59. Re RN. The cellular biology of angiotensin: paracrine, autocrine and intracrine actions in cardiovascular tissues. J Mol Cell Cardiol 21, Suppl 5: 63-69, 1989.
60. Re RN. The intracrine hypothesis and intracellular peptide hormone action. Bioessays 25: 401-409, 2003.
61. Re RN. The origins of intracrine hormone action. Am J Med Sci 323: 43-48, 2002.
62. Re RN. Toward a theory of intracrine hormone action. Regul Pept 106: 1-6, 2002.
63. Re RN, Cook JL. The basis of an intracrine pharmacology. J Clin Pharmacol 48: 344-350, 2008.
64. Re RN, Cook JL. The intracrine hypothesis: an update. Regul Pept 133: 1-9, 2006.
65. Re RN, Cook JL. An intracrine view of angiogenesis. Bioessays 28: 943-953, 2006.
66. Re RN, Cook JL. The physiological basis of intracrine stem cell regulation. Am J Physiol Heart Circ Physiol 295: H447-H453, 2008.
67. Rodier F, Campisi J, Bhaumik D. Two faces of p53: aging and tumor suppression. Nucleic Acids Res 35: 7475-7484, 2007.
68. Rustom A, Saffrich R, Markovic I, Walther P, Gerdes HH. Nanotubular highways for intercellular organelle transport. Science 303: 1007-1010, 2004.
69. Sazonova O, James KA, McCudden CR, Segal D, Talebian A, Wagner GF. Stanniocalcin-1 secretion and receptor regulation in kidney cells. Am J Physiol Renal Physiol 294: F788-F794, 2008.
70. Spees JL, Olson SD, Whitney MJ, Prockop DJ. Mitochondrial transfer between cells can rescue aerobic respiration. Proc Natl Acad Sci USA 103: 1283-1288, 2006.
71. Stepanova V, Lebedeva T, Kuo A, Yarovoi S, Tkachuk S, Zaitsev S, Bdeir K, Dumler I, Marks MS, Parfyonova Y, Tkachuk VA, Higazi AA, Cines DB. Nuclear translocation of urokinase-type plasminogen activator. Blood 112: 100-110, 2008.
72. Struewing IT, Toborek A, Mao CD. Mitochondrial and nuclear forms of Wnt13 are generated via alternative promoters, alternative RNA splicing, and alternative translation start sites. J Biol Chem 281: 7282-7293, 2006.
73. Tabas I. Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stress. Antioxid Redox Signal. In press.
74. Tang T, Rector K, Barnett CD, Mao CD. Upstream open reading frames regulate the expression of the nuclear Wnt13 isoforms. Biochem Biophys Res Commun 366: 1081-1088, 2008.
75. Tennant MK, Vessella RL, Sprenger CC, Sikes RA, Hwa V, Baker LD, Plymate SR. Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1/mac 25) is reduced in human prostate cancer and is inversely related to tumor volume and proliferation index in Lucap 23.12 xenografts. Prostate 56: 115-122, 2003.
76. Théry C, Boussac M, Véron P, Ricciardi-Castagnoli P, Raposo G, Garin J, Amigorena S. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J Immunol 166: 7309-7318, 2001.
77. Wagner PL, Hyjek E, Vazquez MF, Meherally D, Liu YF, Chadwick PA, Rengifo T, Sica GL, Port JL, Lee PC, Paul S, Altorki NK, Saqi A. CXCL12 and CXCR4 in adenocarcinoma of the lung: association with metastasis and survival. J Thorac Cardiovasc Surg 137: 615-621, 2009.
78. Wang JG, Strong JA, Xie W, Yang RH, Coyle DE, Wick DM, Dorsey ED, Zhang JM. The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons. Mol Pain 4: 38-52, 2008.
79. Yang Z, Huang X, Jiang H, Zhang Y, Liu H, Qin C, Eisner GM, Jose PA, Rudolph L, Ju Z. Short telomeres and prognosis of hypertension in a Chinese population. Hypertension 53: 639-645, 2009.
80. Yu X, Harris SL, Levine AJ. The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res 66: 4795-4801, 2006.
81. Yuan A, Farber EL, Rapoport AL, Tejada D, Deniskin R, Akhmedov NB, Farber DB. Transfer of microRNAs by embryonic stem cell microvesicles. PLoS One 4: e4722, 2009.
82. Zhang Y, Herbert BS, Rajashekhar G, Ingram DA, Yoder MC, Clauss M, Rehman J. Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-alpha via the p38 mitogen-activated protein kinase pathway. FASEB J 23: 1358-1365, 2009.
83. Zhang Z, Deb A, Zhang Z, Pachori A, He W, Guo J, Pratt R, Dzau VJ. Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. J Mol Cell Cardiol 46: 370 -377, 2009.
84. Zhou H, Cheruvanky A, Hu X, Matsumoto T, Hiramatsu N, Cho ME, Berger A, Leelahavanichkul A, Doi K, Chawla LS, Illei GG, Kopp JB, Balow JE, Austin HA 3rd, Yuen PS, Star RA. Urinary exosomal transcription factors, a new class of biomarkers for renal disease. Kidney Int 74: 613-621, 2008.