Leukocyte telomere dynamics: Longitudinal findings among young adults in the Bogalusa Heart Study

American Journal of Epidemiology

Volumn 169, Issue 3, 2009, Pages 323-329

  Aviv, Abraham ^a   Chen, Wei ^b   Gardner, Jeffrey P ^a   Kimura, Masayuki ^a   Brimacombe, Michael ^a   Cao, Xiaojian ^a   Srinivasan, Sathanur R ^b   Berenson, Gerald S ^b  

^a University of Medicine and Dentistry of New Jersey Medical School   (United States)

^b Tulane Center for Cardiovascular Health   (United States)

Author keywords

Aging; Body mass index; Leukocytes; Oxidative stress; Smoking; Telomere

Indexed keywords

AGING; BIOMARKER; BODY MASS; CHROMOSOME; LONGITUDINAL GRADIENT; OXIDATION; YOUNG POPULATION;

ADULT; AFRICAN AMERICAN; AGED; AGING; ARTICLE; CAUCASIAN; CHROMOSOME SIZE; FEMALE; FOLLOW UP; HUMAN; LEUKOCYTE; LONGITUDINAL STUDY; MALE; NORMAL HUMAN; RACE DIFFERENCE; SMOKING; TELOMERE; ADOLESCENT; BODY MASS; CARDIOVASCULAR DISEASE; CHEMISTRY; CHILD; CLASSIFICATION; DISEASE COURSE; GENETICS; MIDDLE AGED; PRESCHOOL CHILD; SOUTHERN BLOTTING; UNITED STATES;

ADOLESCENT; ADULT; AGING; BLOTTING, SOUTHERN; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; HUMANS; LEUKOCYTES; LONGITUDINAL STUDIES; LOUISIANA; MALE; MIDDLE AGED; TELOMERE; YOUNG ADULT;

EID: 59649089857     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwn338     Document Type: Article

References (43)

1. Okuda K, Bardeguez A, Gardner JP, et al. Telomere length in the newborn. Pediatr Res. 2002;52(3):377-381.
2. Akkad A, Hastings R, Konje JC, et al. Telomere length in small-for-gestational-age babies. BJOG. 2006;113(3):318-323.
3. Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet. 1994;55(5):876-882.
4. Valdes A, Andrew T, Gardner JP, et al. Obesity, cigarette smoking, and telomere length in women. Lancet. 2005;366(9486):662-664.
5. Brouilette SW, Moore JS, McMahon AD, et al. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet. 2007;369(9556):107-114.
6. Nawrot TS, Staessen JA, Gardner JP, et al. Telomere length and possible link to X chromosome. Lancet. 2004;363(9408):507-510.
7. Njajou OT, Cawthon RM, Damcott CM, et al. Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A. 2007;104(29):12135-12139.
8. Demissie S, Levy D, Benjamin EJ, et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell. 2006;5(4):325-330.
9. Fitzpatrick AL, Kronmal RA, Gardner JP, et al. Leukocyte telomere length and cardiovascular disease in the Cardiovascular Health Study. Am J Epidemiol. 2007;165(1):14-21.
10. Benetos A, Gardner JP, Zureik M, et al. Short telomeres are associated with increased carotid artery atherosclerosis in hypertensive subjects. Hypertension. 2004;43(2):182-185.
11. Cawthon RM, Smith KR, O'Brien E, et al. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003;361(9355):393-395.
12. van der Harst P, van der Steege G, de Boer RA, et al. Telomere length of circulating leukocytes is decreased in patients with chronic heart failure. J Am Coll Cardiol. 2007;49(13):1459-1464.
13. Gardner JP, Li S, Srinivasan SR, et al. Rise in insulin resistance and gain in adiposity is associated with escalated telomere attrition. Circulation. 2005;111(17):2171-2177.
14. Vasan RS, Demissie S, Kimura M, et al. Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study. Circulation. 2008;117(4):1138-1144.
15. Hunt SC, Chen W, Gardner JP, et al. Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study. Aging Cell. 2008;7(4):451-458.
16. The Bogalusa Heart Study 20th Anniversary Symposium. Am J Med Sci. 1995;310:S1-S138.
17. Frenck RW Jr, Blackburn EH, Shannon KM. The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A. 1998;95(10):5607-5610.
18. Nordffjäll K, Larefalk A, Limdgern P, et al. Telomere length and heredity: indications of paternal inheritance. Proc Natl Acad Sci U S A. 2005;102(45):16374-16378.
19. Unryn BM, Cook LS, Riabowol KT. Paternal age is positively linked to telomere length of children. Aging Cell. 2005;4(2):97-101.
20. Aviv A, Valdes AM, Spector TD. Human telomere biology: pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol. 2006;35(6):1424-1429.
21. Gardner JP, Kimura M, Chai W, et al. Telomere dynamics in macaques and humans. J Gerontol A Biol Sci Med Sci. 2007;62(4):367-374.
22. Olovnikov AM. A theory of marginotomy. The incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol. 1973;41(1):181-190.
23. Watson ID. Origin of concatemeric T7 DNA. Nat New Biol. 1972;239(94):197-201.
24. op den Buijs J, van den Bosch PP, Musters MW, et al. Mathematical modeling confirms the length-dependency of telomere shortening. Mech Ageing Dev. 2004;125(6):437-444.
25. op den Buijs J, Musters M, Verrips T, et al. Mathematical modeling of vascular endothelial layer maintenance: the role of endothelial cell division, progenitor cell homing, and telomere shortening. Am J Physiol Heart Circ Physiol. 2007;287(6):H2651-H2658.
26. Proctor CJ, Kirkwood TB. Modeling telomere shortening and the role of oxidative stress. Mech Ageing Dev. 2002;123(4):351-363.
27. Martens UM, Zijlmans JM, Poon SS, et al. Short telomeres on human chromosome 17p. Nat Genet. 1998;18(1):76-80.
28. Goldman F, Bouarich R, Kulkarni S, et al. The effect of TERC haploinsufficiency on the inheritance of telomere length. Proc Natl Acad Sci U S A. 2005;102(47):17119-17124.
29. Baird DM, Britt-Compton B, Rowson J, et al. Telomere instability in the male germline. Hum Mol Genet. 2006;15(1):45-51.
30. Kimura M, Barbieri M, Gardner JP, et al. Leukocytes of exceptionally old persons display ultra-short telomeres. Am J Physiol Regul Integr Comp Physiol. 2007;293(6):R2210-R2217.
31. Forsyth NR, Evans AP, Shay JW, et al. Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell. 2003;2(5):235-243.
32. Richter T, von Zglinicki T. A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Exp Gerontol. 2007;42(11):1039-1042.
33. Tchirkov A, Lansdorp PM. Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum Mol Genet. 2003;12(3):227-232.
34. Sitte N, Saretzki G, von Zglinicki T. Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Radic Biol Med. 1998;24(6):885-893.
35. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120(4):483-495.
36. Finch C, Crimmins EM. Inflammatory exposure and historical changes in human life-spans. Science. 2004;305(5691):1736-1739.
37. Aviv A. Telomeres and human somatic fitness. J Gerontol A Biol Sci Med Sci. 2006;61(8):871-873.
38. Hansson GK, Libby P. The immune response in atherosclerosis; a double-edged sword. Nat Rev Immunol. 2006;6(7):508-519.
39. Harrison D, Griendling KK, Landmesser U, et al. Role of oxidative stress in atherosclerosis. Am J Cardiol. 2003;91(3A):7A-11A.
40. Yin T, Li L. The stem cell niches in bone. J Clin Invest. 2006;116(5):1195-1201.
41. Prelog M. Aging of the immune system: a risk factor for autoimmunity? Autoimmun Rev. 2006;5(2):136-139.
42. Caruso C, Lio D, Cavallone L, et al. Aging, longevity, inflammation, and cancer. Ann N Y Acad Sci. 2004;1028:1-13.
43. Dröge W, Schipper HM. Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell. 2007;6(3):361-370.